Daniel A Keedy

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 49

Top Venues

bioRxiv : the preprint server for biology

eLife

Acta crystallographica. Section F, Structural biology communications

Communications biology

CUNY Advanced Science Research Center

Duke University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

CUNY Advanced Science Research Center

United States

Assistant Professor :: Structural Biology Initiative

University of California, San Francisco

United States

A.P. Giannini Postdoctoral Fellow :: Bioengineering and Therapeutic Sciences

Education History

Duke University

United States

PHD :: Biochemistry

Publications

Liliana Guerrero, Ali Ebrahim, Blake T Riley, Minyoung Kim, Qingqiu Huang, Aaron D Finke, Daniel A Keedy
Pushed to extremes: distinct effects of high temperature versus pressure on the structure of STEP. Communications biology 7 (1) (2024)
Shivani Sharma, Tamar Skaist Mehlman, Reddy Sudheer Sagabala, Benoit Boivin, Daniel A Keedy
High-resolution double vision of the allosteric phosphatase PTP1B. Acta crystallographica. Section F, Structural biology communications (2024)
Stephanie A Wankowicz, Ashraya Ravikumar, Shivani Sharma, Blake Riley, Akshay Raju, Daniel W Hogan, Jessica Flowers, Henry van den Bedem, Daniel A Keedy, Brian K Shoichet
Automated multiconformer model building for X-ray crystallography and cryo-EM. eLife 12 (2024)
Liliana Guerrero, Ali Ebrahim, Blake T Riley, Minyoung Kim, Qingqiu Huang, Aaron D Finke, Daniel A Keedy
Pushed to extremes: distinct effects of high temperature versus pressure on the structure of STEP. Communications biology 7 (1) (2024)
Cassandra A Chartier, Virgil A Woods, Yunyao Xu, Anne E van Vlimmeren, Marko Jovanovic, Ann E McDermott, Daniel A Keedy, Neel H Shah
Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction. bioRxiv : the preprint server for biology (2024)
Cassandra A Chartier, Virgil A Woods, Yunyao Xu, Anne E van Vlimmeren, Marko Jovanovic, Ann E McDermott, Daniel A Keedy, Neel H Shah
Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction. bioRxiv : the preprint server for biology (2024)
Shivani Sharma, Tamar Skaist Mehlman, Reddy Sudheer Sagabala, Benoit Boivin, Daniel A Keedy
High-resolution double vision of the allosteric phosphatase PTP1B. Acta crystallographica. Section F, Structural biology communications 80 (Pt 1) (2024)
Tamar Skaist Mehlman, Helen Mary Ginn, Daniel A Keedy
An expanded view of ligandability in the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data. bioRxiv : the preprint server for biology (2024)
Shivani Sharma, Tamar Skaist Mehlman, Reddy Sudheer Sagabala, Benoit Boivin, Daniel A Keedy
High-resolution double vision of the allosteric phosphatase PTP1B. Acta crystallographica. Section F, Structural biology communications (2024)
Virgil A Woods, Rinat R Abzalimov, Daniel A Keedy
Native dynamics and allosteric responses in PTP1B probed by high-resolution HDX-MS. Protein science : a publication of the Protein Society 33 (6) (2024)
Liliana Guerrero, Ali Ebrahim, Blake T Riley, Minyoung Kim, Qingqiu Huang, Aaron D Finke, Daniel A Keedy
Pushed to extremes: distinct effects of high temperature versus pressure on the structure of STEP. Communications biology 7 (1) (2024)
Tamar Skaist Mehlman, Helen Mary Ginn, Daniel A Keedy
An expanded view of ligandability in the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data. bioRxiv : the preprint server for biology (2024)
Virgil A Woods, Rinat R Abzalimov, Daniel A Keedy
Native dynamics and allosteric responses in PTP1B probed by high-resolution HDX-MS. Protein science : a publication of the Protein Society 33 (6) (2024)
Shivani Sharma, Tamar Skaist Mehlman, Reddy Sudheer Sagabala, Benoit Boivin, Daniel A Keedy
High-resolution double vision of the allosteric phosphatase PTP1B. Acta crystallographica. Section F, Structural biology communications 80 (Pt 1) (2024)
Stephanie A Wankowicz, Ashraya Ravikumar, Shivani Sharma, Blake Riley, Akshay Raju, Daniel W Hogan, Jessica Flowers, Henry van den Bedem, Daniel A Keedy, Brian K Shoichet
Automated multiconformer model building for X-ray crystallography and cryo-EM. eLife 12 (2024)
Liliana Guerrero, Ali Ebrahim, Blake T Riley, Minyoung Kim, Qingqiu Huang, Aaron D Finke, Daniel A Keedy
Pushed to extremes: distinct effects of high temperature versus pressure on the structure of STEP. Communications biology 7 (1) (2024)
Tamar Skaist Mehlman, Helen Mary Ginn, Daniel A Keedy
An expanded view of ligandability in the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data. bioRxiv : the preprint server for biology (2024)
Stephanie A Wankowicz, Ashraya Ravikumar, Shivani Sharma, Blake Riley, Akshay Raju, Daniel W Hogan, Jessica Flowers, Henry van den Bedem, Daniel A Keedy, Brian K Shoichet
Automated multiconformer model building for X-ray crystallography and cryo-EM. eLife 12 (2024)
Aliki Perdikari, Virgil A Woods, Ali Ebrahim, Katherine L Lawler, Rebecca Bounds, Nathanael I Singh, Tamar Skaist Mehlman, Blake T Riley, Shivani Sharma, Jackson W Morris, Julia M Keogh, Elana Henning, Miriam Smith, David R FitzPatrick, Daniel A Keedy
Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy. bioRxiv : the preprint server for biology (2024)
Shivani Sharma, Tamar Skaist Mehlman, Reddy Sudheer Sagabala, Benoit Boivin, Daniel A Keedy
High-resolution double vision of the allosteric phosphatase PTP1B. Acta crystallographica. Section F, Structural biology communications 80 (Pt 1) (2024)
Liliana Guerrero, Ali Ebrahim, Blake T Riley, Minyoung Kim, Qingqiu Huang, Aaron D Finke, Daniel A Keedy
Pushed to extremes: distinct effects of high temperature versus pressure on the structure of STEP. Communications biology 7 (1) (2024)
Virgil A Woods, Rinat R Abzalimov, Daniel A Keedy
Native dynamics and allosteric responses in PTP1B probed by high-resolution HDX-MS. Protein science : a publication of the Protein Society 33 (6) (2024)
Virgil A Woods, Rinat R Abzalimov, Daniel A Keedy
Native dynamics and allosteric responses in PTP1B probed by high-resolution HDX-MS. Protein science : a publication of the Protein Society 33 (6) (2024)
Liliana Guerrero, Ali Ebrahim, Blake T Riley, Minyoung Kim, Qingqiu Huang, Aaron D Finke, Daniel A Keedy
Pushed to extremes: distinct effects of high temperature versus pressure on the structure of STEP. Communications biology 7 (1) (2024)
Aliki Perdikari, Virgil A Woods, Ali Ebrahim, Katherine L Lawler, Rebecca Bounds, Nathanael I Singh, Tamar Skaist Mehlman, Blake T Riley, Shivani Sharma, Jackson W Morris, Julia M Keogh, Elana Henning, Miriam Smith, David R FitzPatrick, Daniel A Keedy
Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy. bioRxiv : the preprint server for biology (2024)
Shivani Sharma, Tamar Skaist Mehlman, Reddy Sudheer Sagabala, Benoit Boivin, Daniel A Keedy
High-resolution double vision of the allosteric phosphatase PTP1B. Acta crystallographica. Section F, Structural biology communications 80 (Pt 1) (2024)
Liliana Guerrero, Ali Ebrahim, Blake T Riley, Minyoung Kim, Qingqiu Huang, Aaron D Finke, Daniel A Keedy
Pushed to extremes: distinct effects of high temperature versus pressure on the structure of STEP. Communications biology 7 (1) (2024)
Shivani Sharma, Tamar Skaist Mehlman, Reddy Sudheer Sagabala, Benoit Boivin, Daniel A Keedy
High-resolution double vision of the allosteric phosphatase PTP1B. Acta crystallographica. Section F, Structural biology communications 80 (Pt 1) (2024)
Tamar Skaist Mehlman, Helen Mary Ginn, Daniel A Keedy
An expanded view of ligandability in the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data. bioRxiv : the preprint server for biology (2024)
Liliana Guerrero, Ali Ebrahim, Blake T Riley, Minyoung Kim, Qingqiu Huang, Aaron D Finke, Daniel A Keedy
Pushed to extremes: distinct effects of high temperature versus pressure on the structure of STEP. Communications biology 7 (1) (2024)
Stephanie A Wankowicz, Ashraya Ravikumar, Shivani Sharma, Blake Riley, Akshay Raju, Daniel W Hogan, Jessica Flowers, Henry van den Bedem, Daniel A Keedy, Brian K Shoichet
Automated multiconformer model building for X-ray crystallography and cryo-EM. eLife 12 (2024)
Tamar Skaist Mehlman, Justin T Biel, Syeda Maryam Azeem, Elliot R Nelson, Sakib Hossain, Louise Dunnett, Neil G Paterson, Alice Douangamath, Romain Talon, Danny Axford, Helen Orins, Frank von Delft, Daniel A Keedy
Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B. eLife 12 (2023)
Shivani Sharma, Ali Ebrahim, Daniel A Keedy
Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B. Acta crystallographica. Section F, Structural biology communications 79 (Pt 1) (2023)
Tamar Skaist Mehlman, Justin T Biel, Syeda Maryam Azeem, Elliot R Nelson, Sakib Hossain, Louise Dunnett, Neil G Paterson, Alice Douangamath, Romain Talon, Danny Axford, Helen Orins, Frank von Delft, Daniel A Keedy
Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B. eLife 12 (2023)
Virgil A Woods, Rinat R Abzalimov, Daniel A Keedy
Native dynamics and allosteric responses in PTP1B probed by high-resolution HDX-MS. bioRxiv : the preprint server for biology (2023)
Liliana Guerrero, Ali Ebrahim, Blake T Riley, Minyoung Kim, Qingqiu Huang, Aaron D Finke, Daniel A Keedy
Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase. bioRxiv : the preprint server for biology (2023)
Stephanie A Wankowicz, Ashraya Ravikumar, Shivani Sharma, Blake T Riley, Akshay Raju, Daniel W Hogan, Henry van den Bedem, Daniel A Keedy, Brian K Shoichet
Uncovering Protein Ensembles: Automated Multiconformer Model Building for X-ray Crystallography and Cryo-EM. bioRxiv : the preprint server for biology (2023)
Shivani Sharma, Ali Ebrahim, Daniel A Keedy
Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B. Acta crystallographica. Section F, Structural biology communications 79 (Pt 1) (2023)
Shivani Sharma, Ali Ebrahim, Daniel A Keedy
Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B. Acta crystallographica. Section F, Structural biology communications 79 (Pt 1) (2023)
Tamar Skaist Mehlman, Justin T Biel, Syeda Maryam Azeem, Elliot R Nelson, Sakib Hossain, Louise Dunnett, Neil G Paterson, Alice Douangamath, Romain Talon, Danny Axford, Helen Orins, Frank von Delft, Daniel A Keedy
Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B. eLife 12 (2023)
Tamar Skaist Mehlman, Justin T Biel, Syeda Maryam Azeem, Elliot R Nelson, Sakib Hossain, Louise Dunnett, Neil G Paterson, Alice Douangamath, Romain Talon, Danny Axford, Helen Orins, Frank von Delft, Daniel A Keedy
Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B. eLife 12 (2023)
Liliana Guerrero, Ali Ebrahim, Blake T Riley, Minyoung Kim, Qingqiu Huang, Aaron D Finke, Daniel A Keedy
Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase. bioRxiv : the preprint server for biology (2023)
Tamar Skaist Mehlman, Justin T Biel, Syeda Maryam Azeem, Elliot R Nelson, Sakib Hossain, Louise Dunnett, Neil G Paterson, Alice Douangamath, Romain Talon, Danny Axford, Helen Orins, Frank von Delft, Daniel A Keedy
Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B. eLife 12 (2023)
Tamar Skaist Mehlman, Justin T Biel, Syeda Maryam Azeem, Elliot R Nelson, Sakib Hossain, Louise Dunnett, Neil G Paterson, Alice Douangamath, Romain Talon, Danny Axford, Helen Orins, Frank von Delft, Daniel A Keedy
Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B. eLife 12 (2023)
Shivani Sharma, Ali Ebrahim, Daniel A Keedy
Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B. Acta crystallographica. Section F, Structural biology communications 79 (Pt 1) (2023)
Ali Ebrahim, Blake T Riley, Desigan Kumaran, Babak Andi, Martin R Fuchs, Sean M McSweeney, Daniel A Keedy
The tem-per-ature-dependent conformational ensemble of SARS-CoV-2 main protease (M pro ). IUCrJ 9 (Pt 5) (2022)
Ali Ebrahim, Blake T Riley, Desigan Kumaran, Babak Andi, Martin R Fuchs, Sean M McSweeney, Daniel A Keedy
The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (M pro ). bioRxiv : the preprint server for biology (2021)
Blake T Riley, Stephanie A Wankowicz, Saulo H P de Oliveira, Gydo C P van Zundert, Daniel W Hogan, Brian K Shoichet, Daniel A Keedy, Henry van den Bedem
qFit 3: Protein and ligand multiconformer modeling for X-ray crystallographic and single-particle cryo-EM density maps. Protein science : a publication of the Protein Society 30 (1) (2020)
Daniel A Keedy, Zachary B Hill, Justin T Biel, Emily Kang, T Justin Rettenmaier, José Brandão-Neto, Nicholas M Pearce, Frank von Delft, James A Wells, Brian K Shoichet
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. eLife 7 (2018)
Daniel A Keedy, Lillian R Kenner, Matthew Warkentin, Rahel A Woldeyes, Jesse B Hopkins, Michael C Thompson, Aaron S Brewster, Andrew H Van Benschoten, Elizabeth L Baxter, Monarin Uervirojnangkoorn, Scott E McPhillips, Jinhu Song, Roberto Alonso-Mori, James M Holton, William I Weis, Axel T Brunger, S Michael Soltis, Henrik Lemke, Ana Gonzalez, Nicholas K Sauter, Aina E Cohen, Henry van den Bedem, Robert E Thorne, Brian K Shoichet
Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography. eLife 4 (2015)

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Publication Activity (10 Years)

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Daniel A Keedy