James A Wells

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 86

Top Topics

Highly Efficient

Protein Protein

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature chemical biology

Cancer immunology research

This page only lists publications with an associated author ORCID identifier.

Publications

Xiao Xie, Patrick J Moon, Steven W M Crossley, Amanda J Bischoff, Dan He, Gen Li, Nam Dao, Angel Gonzalez-Valero, Audrey G Reeves, Jeffery M McKenna, Susanna K Elledge, James A Wells, F Dean Toste, Christopher J Chang
Oxidative cyclization reagents reveal tryptophan cation-π interactions. Nature 627 (8004) (2024)
Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology (2024)
Jiuling Yang, Li Wang, James R Byrnes, Lisa L Kirkemo, Hannah Driks, Cassandra D Belair, Oscar A Aguilar, Lewis L Lanier, James A Wells, Lawrence Fong, Robert Blelloch
PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways. Cancer immunology research (2024)
Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology 20 (8) (2024)
Xiao Xie, Patrick J Moon, Steven W M Crossley, Amanda J Bischoff, Dan He, Gen Li, Nam Dao, Angel Gonzalez-Valero, Audrey G Reeves, Jeffery M McKenna, Susanna K Elledge, James A Wells, F Dean Toste, Christopher J Chang
Oxidative cyclization reagents reveal tryptophan cation-π interactions. Nature 627 (8004) (2024)
Xiao Xie, Patrick J Moon, Steven W M Crossley, Amanda J Bischoff, Dan He, Gen Li, Nam Dao, Angel Gonzalez-Valero, Audrey G Reeves, Jeffery M McKenna, Susanna K Elledge, James A Wells, F Dean Toste, Christopher J Chang
Oxidative cyclization reagents reveal tryptophan cation-π interactions. Nature 627 (8004) (2024)
Jiuling Yang, Li Wang, James R Byrnes, Lisa L Kirkemo, Hannah Driks, Cassandra D Belair, Oscar A Aguilar, Lewis L Lanier, James A Wells, Lawrence Fong, Robert Blelloch
PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways. Cancer immunology research 12 (5) (2024)
Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology (2024)
Xin X Zhou, Sophie Kong, Allison Maker, Soumya G Remesh, Kevin K Leung, Kliment A Verba, James A Wells
Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4. Nature chemical biology (2024)
Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology (2024)
Jie Zhou, Chau Q Le, Yun Zhang, James A Wells
A general approach for selection of epitope-directed binders to proteins. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Xiao Xie, Patrick J Moon, Steven W M Crossley, Amanda J Bischoff, Dan He, Gen Li, Nam Dao, Angel Gonzalez-Valero, Audrey G Reeves, Jeffery M McKenna, Susanna K Elledge, James A Wells, F Dean Toste, Christopher J Chang
Oxidative cyclization reagents reveal tryptophan cation-π interactions. Nature 627 (8004) (2024)
Xiao Xie, Patrick J Moon, Steven W M Crossley, Amanda J Bischoff, Dan He, Gen Li, Nam Dao, Angel Gonzalez-Valero, Audrey G Reeves, Jeffery M McKenna, Susanna K Elledge, James A Wells, F Dean Toste, Christopher J Chang
Oxidative cyclization reagents reveal tryptophan cation-π interactions. Nature 627 (8004) (2024)
Xiao Xie, Patrick J Moon, Steven W M Crossley, Amanda J Bischoff, Dan He, Gen Li, Nam Dao, Angel Gonzalez-Valero, Audrey G Reeves, Jeffery M McKenna, Susanna K Elledge, James A Wells, F Dean Toste, Christopher J Chang
Oxidative cyclization reagents reveal tryptophan cation-π interactions. Nature 627 (8004) (2024)
Jiuling Yang, Li Wang, James R Byrnes, Lisa L Kirkemo, Hannah Driks, Cassandra D Belair, Oscar A Aguilar, Lewis L Lanier, James A Wells, Lawrence Fong, Robert Blelloch
PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways. Cancer immunology research 12 (5) (2024)
Jiuling Yang, Li Wang, James R Byrnes, Lisa L Kirkemo, Hannah Driks, Cassandra D Belair, Oscar A Aguilar, Lewis L Lanier, James A Wells, Lawrence Fong, Robert Blelloch
PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways. Cancer immunology research (2024)
Xiao Xie, Patrick J Moon, Steven W M Crossley, Amanda J Bischoff, Dan He, Gen Li, Nam Dao, Angel Gonzalez-Valero, Audrey G Reeves, Jeffery M McKenna, Susanna K Elledge, James A Wells, F Dean Toste, Christopher J Chang
Oxidative cyclization reagents reveal tryptophan cation-π interactions. Nature 627 (8004) (2024)
Jie Zhou, Chau Q Le, Yun Zhang, James A Wells
A general approach for selection of epitope-directed binders to proteins. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Xin X Zhou, Sophie Kong, Allison Maker, Soumya G Remesh, Kevin K Leung, Kliment A Verba, James A Wells
Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4. Nature chemical biology 20 (6) (2024)
Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology (2024)
Xiao Xie, Patrick J Moon, Steven W M Crossley, Amanda J Bischoff, Dan He, Gen Li, Nam Dao, Angel Gonzalez-Valero, Audrey G Reeves, Jeffery M McKenna, Susanna K Elledge, James A Wells, F Dean Toste, Christopher J Chang
Oxidative cyclization reagents reveal tryptophan cation-π interactions. Nature (2024)
Jiuling Yang, Li Wang, James R Byrnes, Lisa L Kirkemo, Hannah Driks, Cassandra D Belair, Oscar A Aguilar, Lewis L Lanier, James A Wells, Lawrence Fong, Robert Blelloch
PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways. Cancer immunology research 12 (5) (2024)
Jiuling Yang, Li Wang, James R Byrnes, Lisa L Kirkemo, Hannah Driks, Cassandra D Belair, Oscar A Aguilar, Lewis L Lanier, James A Wells, Lawrence Fong, Robert Blelloch
PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways. Cancer immunology research 12 (5) (2024)
Corleone S Delaveris, Sophie Kong, Jeff E Glasgow, Rita P Loudermilk, Lisa L Kirkemo, Fangzhu Zhao, Fernando Salangsang, Paul Phojanakong, Juan Antonio Camara Serrano, Veronica Steri, James A Wells
Chemoproteomics reveals immunogenic and tumor-associated cell surface substrates of ectokinase CK2α. bioRxiv : the preprint server for biology (2024)
Zhi Lin, Kaitlin Schaefer, Irene Lui, Zi Yao, Andrea Fossati, Danielle L Swaney, Ajikarunia Palar, Andrej Sali, James A Wells
Multiscale photocatalytic proximity labeling reveals cell surface neighbors on and between cells. Science (New York, N.Y.) 385 (6706) (2024)
Xiao Xie, Patrick J Moon, Steven W M Crossley, Amanda J Bischoff, Dan He, Gen Li, Nam Dao, Angel Gonzalez-Valero, Audrey G Reeves, Jeffery M McKenna, Susanna K Elledge, James A Wells, F Dean Toste, Christopher J Chang
Oxidative cyclization reagents reveal tryptophan cation-π interactions. Nature 627 (8004) (2024)
Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology (2024)
Xin X Zhou, Sophie Kong, Allison Maker, Soumya G Remesh, Kevin K Leung, Kliment A Verba, James A Wells
Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4. Nature chemical biology 20 (6) (2024)
Zhi Lin, Kaitlin Schaefer, Irene Lui, Zi Yao, Andrea Fossati, Danielle L Swaney, Ajikarunia Palar, Andrej Sali, James A Wells
Multiscale photocatalytic proximity labeling reveals cell surface neighbors on and between cells. Science (New York, N.Y.) 385 (6706) (2024)
Jie Zhou, Chau Q Le, Yun Zhang, James A Wells
A general approach for selection of epitope-directed binders to proteins. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Corleone S Delaveris, Sophie Kong, Jeff E Glasgow, Rita P Loudermilk, Lisa L Kirkemo, Fangzhu Zhao, Fernando Salangsang, Paul Phojanakong, Juan Antonio Camara Serrano, Veronica Steri, James A Wells
Chemoproteomics reveals immunogenic and tumor-associated cell surface substrates of ectokinase CK2α. bioRxiv : the preprint server for biology (2024)
Xin X Zhou, Sophie Kong, Allison Maker, Soumya G Remesh, Kevin K Leung, Kliment A Verba, James A Wells
Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4. Nature chemical biology 20 (6) (2024)
John V Pluvinage, Thomas Ngo, Camille Fouassier, Maura McDonagh, Brandon B Holmes, Christopher M Bartley, Sravani Kondapavulur, Charlotte Hurabielle, Aaron Bodansky, Vincent Pai, Samuel S Hinman, Ava Aslanpour, Bonny D Alvarenga, Kelsey C Zorn, Colin R Zamecnik, Adrian McCann, Andoni I Asencor, Trung Huynh, Weston Browne, Asritha Tubati, Michael S Haney, Vanja C Douglas, Martineau Louine, Bruce Anthony Campbell Cree, Stephen L Hauser, William W Seeley, Sergio E Baranzini, James A Wells, Serena Spudich, Shelli F Farhadian, Prashanth S Ramachandran, Leslie Gillum, Chadwick M Hales, Julie Zikherman, Mark S Anderson, Rebecca Grainger, Bryan R Smith, Avindra Nath, Gina A Suh, Eoin Patrick Flanagan, Ari J Green, Ralph Green, Jeffrey Marc Gelfand, Joseph L Derisi, Samuel J Pleasure, Michael R Wilson
Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Science translational medicine 16 (753) (2024)
Corleone S Delaveris, Sophie Kong, Jeff E Glasgow, Rita P Loudermilk, Lisa L Kirkemo, Fangzhu Zhao, Fernando Salangsang, Paul Phojanakong, Juan Antonio Camara Serrano, Veronica Steri, James A Wells
Chemoproteomics reveals immunogenic and tumor-associated cell surface substrates of ectokinase CK2α. bioRxiv : the preprint server for biology (2024)
Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology 20 (8) (2024)
John V Pluvinage, Thomas Ngo, Camille Fouassier, Maura McDonagh, Brandon B Holmes, Christopher M Bartley, Sravani Kondapavulur, Charlotte Hurabielle, Aaron Bodansky, Vincent Pai, Samuel S Hinman, Ava Aslanpour, Bonny D Alvarenga, Kelsey C Zorn, Colin R Zamecnik, Adrian McCann, Andoni I Asencor, Trung Huynh, Weston Browne, Asritha Tubati, Michael S Haney, Vanja C Douglas, Martineau Louine, Bruce Anthony Campbell Cree, Stephen L Hauser, William W Seeley, Sergio E Baranzini, James A Wells, Serena Spudich, Shelli F Farhadian, Prashanth S Ramachandran, Leslie Gillum, Chadwick M Hales, Julie Zikherman, Mark S Anderson, Rebecca Grainger, Bryan R Smith, Avindra Nath, Gina A Suh, Eoin Patrick Flanagan, Ari J Green, Ralph Green, Jeffrey Marc Gelfand, Joseph L Derisi, Samuel J Pleasure, Michael R Wilson
Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Science translational medicine 16 (753) (2024)
Xin X Zhou, Sophie Kong, Allison Maker, Soumya G Remesh, Kevin K Leung, Kliment A Verba, James A Wells
Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4. Nature chemical biology 20 (6) (2024)
Shalini Chopra, Kai Trepka, Sasank Sakhamuri, Alberto Carretero-González, Jun Zhu, Emily A Egusa, Jie Zhou, Kevin K Leung, Ning Zhao, Nima Hooshdaran, Felix Y Feng, James A Wells, Jonathan Chou, Kenneth W Bayles
Theranostic targeting of CUB domain containing protein 1 (CDCP1) in multiple subtypes of bladder cancer. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Thomas G Bartholow, Paul W W Burroughs, Susanna K Elledge, James R Byrnes, Lisa L Kirkemo, Virginia Garda, Kevin K Leung, James A Wells
Photoproximity Labeling from Single Catalyst Sites Allows Calibration and Increased Resolution for Carbene Labeling of Protein Partners In Vitro and on Cells. ACS central science 10 (1) (2023)
Nicholas J Rettko, Lisa L Kirkemo, James A Wells
Secreted HLA-Fc fusion profiles immunopeptidome in hypoxic PDAC and cellular senescence. PNAS nexus 2 (12) (2023)
James A Wells, Kaan Kumru
Extracellular targeted protein degradation: an emerging modality for drug discovery. Nature reviews. Drug discovery (2023)
Shalini Chopra, Kai Trepka, Sasank Sakhamuri, Alberto Carretero-González, Jun Zhu, Emily A Egusa, Jie Zhou, Kevin K Leung, Ning Zhao, Nima Hooshdaran, Felix Y Feng, James A Wells, Jonathan Chou, Kenneth W Bayles
Theranostic targeting of CUB domain containing protein 1 (CDCP1) in multiple subtypes of bladder cancer. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Thomas G Bartholow, Paul W W Burroughs, Susanna K Elledge, James R Byrnes, Lisa L Kirkemo, Virginia Garda, Kevin K Leung, James A Wells
Photoproximity Labeling from Single Catalyst Sites Allows Calibration and Increased Resolution for Carbene Labeling of Protein Partners In Vitro and on Cells. ACS central science 10 (1) (2023)
Nicholas J Rettko, Lisa L Kirkemo, James A Wells
Secreted HLA-Fc fusion profiles immunopeptidome in hypoxic PDAC and cellular senescence. PNAS nexus 2 (12) (2023)
Paige E Solomon, Colton J Bracken, Jacqueline A Carozza, Haoqing Wang, Elizabeth P Young, Alon Wellner, Chang C Liu, E Alejandro Sweet-Cordero, Lingyin Li, James A Wells
Discovery of VH domains that allosterically inhibit ENPP1. Nature chemical biology (2023)
Thomas G Bartholow, Paul W W Burroughs, Susanna K Elledge, James R Byrnes, Lisa L Kirkemo, Virginia Garda, Kevin K Leung, James A Wells
Photoproximity Labeling from Single Catalyst Sites Allows Calibration and Increased Resolution for Carbene Labeling of Protein Partners In Vitro and on Cells. ACS central science 10 (1) (2023)
Nicholas J Rettko, Lisa L Kirkemo, James A Wells
Secreted HLA-Fc fusion profiles immunopeptidome in hypoxic PDAC and cellular senescence. PNAS nexus 2 (12) (2023)
Nicholas J Rettko, Lisa L Kirkemo, James A Wells
Secreted HLA-Fc fusion profiles immunopeptidome in hypoxic PDAC and cellular senescence. PNAS nexus 2 (12) (2023)
Zhi Lin, Kaitlin Schaefer, Irene Lui, Zi Yao, Andrea Fossati, Danielle L Swaney, Ajikarunia Palar, Andrej Sali, James A Wells
Multi-scale photocatalytic proximity labeling reveals cell surface neighbors on and between cells. bioRxiv : the preprint server for biology (2023)
Nicholas J Rettko, Lisa L Kirkemo, James A Wells
Secreted HLA-Fc fusion profiles immunopeptidome in hypoxic PDAC and cellular senescence. PNAS nexus 2 (12) (2023)
Katarina Pance, Josef A Gramespacher, James R Byrnes, Fernando Salangsang, Juan-Antonio C Serrano, Adam D Cotton, Veronica Steri, James A Wells
Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins. Nature biotechnology (2022)
Alexander J Martinko, Erin F Simonds, Suchitra Prasad, Alberto Ponce, Colton J Bracken, Junnian Wei, Yung-Hua Wang, Tiffany-Lynn Chow, Zhong Huang, Kenneth W Bayles, James A Wells, Zachary B Hill
Switchable assembly and function of antibody complexes in vivo using a small molecule. Proceedings of the National Academy of Sciences of the United States of America 119 (9) (2022)
Josef A Gramespacher, Adam D Cotton, Paul W W Burroughs, Ian B Seiple, James A Wells
Roadmap for Optimizing and Broadening Antibody-Based PROTACs for Degradation of Cell Surface Proteins. ACS chemical biology 17 (5) (2022)
Avi J Samelson, Quang Dinh Tran, Rémy Robinot, Lucia Carrau, Veronica V Rezelj, Alice Mac Kain, Merissa Chen, Gokul N Ramadoss, Xiaoyan Guo, Shion An Lim, Irene Lui, James K Nuñez, Sarah J Rockwood, Jianhui Wang, Na Liu, Jared Carlson-Stevermer, Jennifer Oki, Travis Maures, Kevin Holden, Jonathan S Weissman, James A Wells, Bruce R Conklin, Benjamin R tenOever, Lisa A Chakrabarti, Marco Vignuzzi, Ruilin Tian, Martin Edward Kampmann
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2. Nature cell biology 24 (1) (2022)
Ian D Ferguson, Bonell Patiño Escobar, Sami T Tuomivaara, Yu-Hsiu Tony Lin, Matthew A Nix, Kevin K Leung, Corynn Kasap, Emilio Ramos, Wilson Nieves Vasquez, Alexis Talbot, Martina Hale, Akul Naik, Audrey Kishishita, Priya Choudhry, Antonia Lopez-Girona, Weili Miao, Sandy W Wong, Jeffrey L Wolf, Thomas G Martin, Nina Shah, Scott Vandenberg, Sonam Prakash, Lenka Besse, Christoph Driessen, Avery D Posey, R Dyche Mullins, Justin Eyquem, James A Wells, Arun P Wiita
The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance. Nature communications 13 (1) (2022)
Lisa L Kirkemo, Susanna K Elledge, Jiuling Yang, James R Byrnes, Jeff E Glasgow, Robert Blelloch, James A Wells
Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells. eLife 11 (2022)
Lauren E Stopfer, Nicholas J Rettko, Owen Leddy, Joshua M Mesfin, Eric N Brown, Shannon Winski, Bryan D Bryson, James A Wells, Forest M White
MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas. Proceedings of the National Academy of Sciences of the United States of America 119 (49) (2022)
Nicholas J Rettko, Judith Campisi, James A Wells
Engineering Antibodies Targeting p16 MHC-Peptide Complexes. ACS chemical biology 17 (3) (2022)
Kaitlin Schaefer, Irene Lui, James R Byrnes, Emily Kang, Jie Zhou, Amy M Weeks, James A Wells
Direct Identification of Proteolytic Cleavages on Living Cells Using a Glycan-Tethered Peptide Ligase. ACS central science 8 (10) (2022)
Ziwen Jiang, Yu-Hsuan Kuo, Mengqi Zhong, Jianchao Zhang, Xin X Zhou, Lijuan Xing, James A Wells, Yanzhuang Wang, Michelle R Arkin
Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein-Protein Interactions. Journal of the American Chemical Society 144 (29) (2022)
Zhipeng Li, Lucas Ferguson, Kirandeep K Deol, Melissa A Roberts, Leslie Magtanong, Joseph M Hendricks, Gergey Alzaem Mousa, Seda Kilinc, Kaitlin Schaefer, James A Wells, Michael C Bassik, Andrei Goga, Scott J Dixon, Nicholas T Ingolia, James A Olzmann
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability. Nature chemical biology 18 (7) (2022)
Emily Kang, Cigall Kadoch, James L Rubenstein, Lewis L Lanier, James A Wells
A functional mammalian display screen identifies rare antibodies that stimulate NK cell-mediated cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America 118 (31) (2021)
Jeff E Glasgow, Anum Azam Glasgow, Tanja Kortemme, James A Wells
Reply to Liu et al.: Specific mutations matter in specificity and catalysis in ACE2. Proceedings of the National Academy of Sciences of the United States of America 118 (15) (2021)
Susanna K Elledge, Xin X Zhou, James R Byrnes, Alexander J Martinko, Irene Lui, Katarina Pance, Shion A Lim, Jeff E Glasgow, Anum Azam Glasgow, Keirstinne Turcios, Nikita S Iyer, Leonel Torres, Michael J Peluso, Timothy J Henrich, Taia T Wang, Cristina M Tato, Kevin K Leung, Bryan Greenhouse, James A Wells
Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. Nature biotechnology 39 (8) (2021)
Wentao Chen, Kurt Yun Mou, Paige Solomon, Rahul R Aggarwal, Kevin K Leung, James A Wells
Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy. Proceedings of the National Academy of Sciences of the United States of America 118 (4) (2021)
Michael J Peluso, Saki Takahashi, Jill Hakim, J Daniel Kelly, Leonel Torres, Nikita S Iyer, Keirstinne Turcios, Owen Janson, Sadie E Munter, Cassandra Thanh, Joanna Donatelli, Christopher C Nixon, Rebecca Hoh, Viva Tai, Emily A Fehrman, Yanel Hernandez, Matthew A Spinelli, Monica Gandhi, Mary-Ann Palafox, Ana S Vallari, Mary A Rodgers, John Prostko, John Hackett, Lan Trinh, Terri Wrin, Christos J Petroupoulos, Charles Y Chiu, Phillip J Norris, Clara DiGermanio, Mars Stone, Michael P Busch, Susanna K Elledge, Xin X Zhou, James A Wells, Albert Shu, Theodore W Kurtz, John E Pak, Wesley Wu, Peter Denis Burbelo, Jeffrey I Cohen, Rachel L Rutishauser, Jeffrey N Martin, Steven G Deeks, Timothy J Henrich, Isabel Rodriguez-Barraquer, Bryan Greenhouse
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay. Science advances 7 (31) (2021)
Yuan Ma, Kangfu Chen, Fan Xia, Randy Atwal, Hansen Wang, Sharif U Ahmed, Lia Cardarelli, Irene Lui, Bill Duong, Zongjie Wang, James A Wells, Sachdev S Sidhu, Shana O Kelley
Phage-Based Profiling of Rare Single Cells Using Nanoparticle-Directed Capture. ACS nano (2021)
Adam D Cotton, Duy P Nguyen, Josef A Gramespacher, Ian B Seiple, James A Wells
Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1. Journal of the American Chemical Society 143 (2) (2021)
Amy M Weeks, James R Byrnes, Irene Lui, James A Wells
Mapping proteolytic neo-N termini at the surface of living cells. Proceedings of the National Academy of Sciences of the United States of America 118 (8) (2021)
Adam D Cotton, James A Wells, Ian B Seiple
Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules. ACS chemical biology (2021)
Daniel C Lim, Vladimir Joukov, T Justin Rettenmaier, Akiko Kumagai, William G Dunphy, James A Wells, Micheal B Yaffe
Redox priming promotes Aurora A activation during mitosis. Science signaling 13 (641) (2020)
Colton J Bracken, Shion An Lim, Paige Solomon, Nicholas J Rettko, Duy P Nguyen, Beth Shoshana Zha, Kaitlin Schaefer, James R Byrnes, Jie Zhou, Irene Lui, Jia Liu, Katarina Pance, null null, Xin X Zhou, Kevin K Leung, James A Wells
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nature chemical biology 17 (1) (2020)
Jie Zhou, Shantao Li, Kevin K Leung, Brian O'Donovan, James Y Zou, Joseph L DeRisi, James A Wells
Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries. Proceedings of the National Academy of Sciences of the United States of America 117 (41) (2020)
Kevin K Leung, Gary M Wilson, Lisa L Kirkemo, Nicholas M Riley, Joshua J Coon, James A Wells
Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. Proceedings of the National Academy of Sciences of the United States of America 117 (14) (2020)
Jacob Kagan, Robert L Moritz, Richard Mazurchuk, Je Hyuk Lee, Peter Vasili Kharchenko, Orit Rozenblatt-Rosen, Eytan Ruppin, Fredrik Edfors, Fiona Ginty, Yury Goltsev, James A Wells, John LaCava, Jessica L Riesterer, Ronald N Germain, Tujin Shi, Mark S Chee, Bogdan A Budnik, John Yates Iii, Brian T Chait, Jeffery R Moffitt, Richard D Smith, Sudhir Srivastava
National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions. Journal of proteome research 19 (5) (2020)
Xin X Zhou, Colton J Bracken, Kaihua Zhang, Jie Zhou, Kurt Yun Mou, Lei Wang, Yifan Cheng, Kevin K Leung, James A Wells
Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps. Journal of the American Chemical Society 142 (41) (2020)
Anum Azam Glasgow, Jeff E Glasgow, Daniel Limonta, Paige Solomon, Irene Lui, Sunny Zhang, Matthew A Nix, Nicholas J Rettko, Beth Shoshanna Zha, Rachel Yamin, Kevin Kao, Oren S Rosenberg, Jeffrey V Ravetch, Arun P Wiita, Kevin K Leung, Shion An Lim, Xin X Zhou, Tom C Hobman, Tanja Kortemme, James A Wells
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 117 (45) (2020)
James R Byrnes, Xin X Zhou, Irene Lui, Susanna K Elledge, Jeff E Glasgow, Shion An Lim, Rita P Loudermilk, Charles Y Chiu, Taia T Wang, Michael R Wilson, Kevin K Leung, James A Wells
Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding. mSphere 5 (5) (2020)
Susanna K Elledge, Hai L Tran, Alec H Christian, Veronica Steri, Byron Hann, F Dean Toste, Christopher J Chang, James A Wells
Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation. Proceedings of the National Academy of Sciences of the United States of America 117 (11) (2020)
Amy M Weeks, James A Wells
Subtiligase-Catalyzed Peptide Ligation. Chemical reviews 120 (6) (2019)
Kevin K Leung, Aaron Nguyen, Tao Shi, Lin Tang, Xiaochun Ni, Laure Escoubet, Kyle J MacBeth, Jorge DiMartino, James A Wells
Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome. Proceedings of the National Academy of Sciences of the United States of America 116 (2) (2018)
Alexander J Martinko, Charles Truillet, Olivier Julien, Juan E Diaz, Max A Horlbeck, Gordon Whiteley, Josip Blonder, Jonathan S Weissman, Sourav Bandyopadhyay, Michael J Evans, James A Wells
Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins. eLife 7 (2018)
Samuel B Pollock, Amy Hu, Yun Mou, Alexander J Martinko, Olivier Julien, Michael Hornsby, Lynda Ploder, Jarrett J Adams, Huimin Geng, Markus Müschen, Sachdev S Sidhu, Jason Moffat, James A Wells
Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies. Proceedings of the National Academy of Sciences of the United States of America 115 (11) (2018)
Andrew R Henderson, Matthew J Henley, Nicholas J Foster, Amanda L Peiffer, Matthew S Beyersdorf, Kevon D Stanford, Steven M Sturlis, Brian M Linhares, Zachary B Hill, James A Wells, Tomasz Cierpicki, Charles L Brooks, Carol A Fierke, Anna K Mapp
Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators. Proceedings of the National Academy of Sciences of the United States of America 115 (36) (2018)
Daniel A Keedy, Zachary B Hill, Justin T Biel, Emily Kang, T Justin Rettenmaier, José Brandão-Neto, Nicholas M Pearce, Frank von Delft, James A Wells, Brian K Shoichet
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. eLife 7 (2018)
Shixian Lin, Xiaoyu Yang, Shang Jia, Amy M Weeks, Michael Hornsby, Peter S Lee, Rita V Nichiporuk, Anthony T Iavarone, James A Wells, F Dean Toste, Christopher J Chang
Redox-based reagents for chemoselective methionine bioconjugation. Science (New York, N.Y.) 355 (6325) (2017)