David Brough

ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 52

Top Venues

Cell death discovery

bioRxiv : the preprint server for biology

Disease models & mechanisms

Nature communications

University of Manchester

University of Manchester (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Manchester Aug 01 2018

United Kingdom

Professor of Neuroinflammation :: Faculty of Biology, Medicine and Health

University of Manchester Aug 01 2016 - Jul 31 2018

United Kingdom

Senior Lecturer :: Faculty of Biology, Medicine and Health

University of Manchester Mar 01 2013 - Jul 31 2016

United Kingdom

Lecturer :: Life Sciences

Education History

University of Manchester Sep 01 1999 - Oct 01 2002

United Kingdom

PHD

Robert Gordon University Sep 01 1994 - Jun 01 1999

United Kingdom

BSC

Publications

Tara A Gleeson, Christina Kaiser, Catherine B Lawrence, David Brough, Stuart M Allan, Jack P Green
The NLRP3 inflammasome is essential for IL-18 production in a model of macrophage activation syndrome. Disease models & mechanisms (2024)
Siyi Bai, Fatima Martin-Sanchez, David Brough, Gloria Lopez-Castejon
Pyroptosis leads to loss of centrosomal integrity in macrophages. Cell death discovery 10 (1) (2024)
Siyi Bai, Fatima Martin-Sanchez, David Brough, Gloria Lopez-Castejon
Pyroptosis leads to loss of centrosomal integrity in macrophages. Cell death discovery 10 (1) (2024)
Rose Wellens, Victor S Tapia, Paula I Seoane, Hayley Bennett, Antony D Adamson, Graham Coutts, Jack Rivers-Auty, Martin Lowe, Jack P Green, Gloria Lopez-Castejon, David Brough, Christopher Hoyle
Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions. Nature communications 15 (1) (2024)
Tara A Gleeson, Christina Kaiser, Catherine B Lawrence, David Brough, Stuart M Allan, Jack P Green
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome. Disease models & mechanisms 17 (7) (2024)
Michael J Haley, Leoma Bere, James Minshull, Sokratia Georgaka, Natalia Garcia-Martin, Gareth Howell, David J Coope, Federico Roncaroli, Andrew King, David C Wedge, Stuart M Allan, Omar N Pathmanaban, David Brough, Kevin N Couper
Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival. Science advances 10 (20) (2024)
Tara A Gleeson, Christina Kaiser, Catherine B Lawrence, David Brough, Stuart M Allan, Jack P Green
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome. bioRxiv : the preprint server for biology (2024)
Tara A Gleeson, Christina Kaiser, Catherine B Lawrence, David Brough, Stuart M Allan, Jack P Green
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome. bioRxiv : the preprint server for biology (2024)
Michael J Haley, Leoma Bere, James Minshull, Sokratia Georgaka, Natalia Garcia-Martin, Gareth Howell, David J Coope, Federico Roncaroli, Andrew King, David C Wedge, Stuart M Allan, Omar N Pathmanaban, David Brough, Kevin N Couper
Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival. Science advances 10 (20) (2024)
Michael J Haley, Leoma Bere, James Minshull, Sokratia Georgaka, Natalia Garcia-Martin, Gareth Howell, David J Coope, Federico Roncaroli, Andrew King, David C Wedge, Stuart M Allan, Omar N Pathmanaban, David Brough, Kevin N Couper
Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival. Science advances 10 (20) (2024)
Jiayu Cao, Stefan Roth, Sijia Zhang, Anna Kopczak, Samira Mami, Yaw Asare, Marios K Georgakis, Denise Messerer, Amit Horn, Ruth Shemer, Charlene Jacqmarcq, Audrey Picot, Jack P Green, Christina Schlegl, Xinghai Li, Lukas Tomas, Alexander Dutsch, Thomas G Liman, Matthias Endres, Saskia R Wernsdorf, Christina Fürle, Olga Carofiglio, Jie Zhu, David Brough, null null, Veit Hornung, Martin Dichgans, Denis Vivien, Christian Schulz, Yuval Dor, Steffen Tiedt, Hendrik B Sager, Gerrit Maximilian Grosse, Arthur Liesz
DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Nature (2024)
Tara A Gleeson, Christina Kaiser, Catherine B Lawrence, David Brough, Stuart M Allan, Jack P Green
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome. Disease models & mechanisms 17 (7) (2024)
Tara A Gleeson, Christina Kaiser, Catherine B Lawrence, David Brough, Stuart M Allan, Jack P Green
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome. bioRxiv : the preprint server for biology (2024)
Tara A Gleeson, Christina Kaiser, Catherine B Lawrence, David Brough, Stuart M Allan, Jack P Green
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome. bioRxiv : the preprint server for biology (2024)
Eloïse Lemarchand, Alba Grayston, Raymond Wong, Miyako Rogers, Blake Ouvrier, Benjamin Llewellyn, Freddie Webb, Nikolett Lenart, Adam Denes, David Brough, Stuart M Allan, Gregory Jaye Bix, Emmanuel Pinteaux
Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but regulates neurorepair processes after experimental ischemic stroke. bioRxiv : the preprint server for biology (2024)
Tara A Gleeson, Christina Kaiser, Catherine B Lawrence, David Brough, Stuart M Allan, Jack P Green
The NLRP3 inflammasome is essential for IL-18 production in a model of macrophage activation syndrome. Disease models & mechanisms (2024)
Siyi Bai, Fatima Martin-Sanchez, David Brough, Gloria Lopez-Castejon
Pyroptosis leads to loss of centrosomal integrity in macrophages. Cell death discovery 10 (1) (2024)
Rose Wellens, Victor S Tapia, Paula I Seoane, Hayley Bennett, Antony D Adamson, Graham Coutts, Jack Rivers-Auty, Martin Lowe, Jack P Green, Gloria Lopez-Castejon, David Brough, Christopher Hoyle
Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions. Nature communications 15 (1) (2024)
Rose Wellens, Victor S Tapia, Paula I Seoane, Hayley Bennett, Antony D Adamson, Graham Coutts, Jack Rivers-Auty, Martin Lowe, Jack P Green, Gloria Lopez-Castejon, David Brough, Christopher Hoyle
Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions. Nature communications 15 (1) (2024)
Tara A Gleeson, Christina Kaiser, Catherine B Lawrence, David Brough, Stuart M Allan, Jack P Green
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome. Disease models & mechanisms 17 (7) (2024)
Jiayu Cao, Stefan Roth, Sijia Zhang, Anna Kopczak, Samira Mami, Yaw Asare, Marios K Georgakis, Denise Messerer, Amit Horn, Ruth Shemer, Charlene Jacqmarcq, Audrey Picot, Jack P Green, Christina Schlegl, Xinghai Li, Lukas Tomas, Alexander Dutsch, Thomas G Liman, Matthias Endres, Saskia R Wernsdorf, Christina Fürle, Olga Carofiglio, Jie Zhu, David Brough, null null, Veit Hornung, Martin Dichgans, Denis Vivien, Christian Schulz, Yuval Dor, Steffen Tiedt, Hendrik B Sager, Gerrit Maximilian Grosse, Arthur Liesz
DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Nature (2024)
Eloïse Lemarchand, Alba Grayston, Raymond Wong, Miyako Rogers, Blake Ouvrier, Benjamin Llewellyn, Freddie Webb, Nikolett Lenart, Adam Denes, David Brough, Stuart M Allan, Gregory Jaye Bix, Emmanuel Pinteaux
Selective deletion of interleukin-1 alpha in microglia regulates neuronal responses and neurorepair processes after experimental ischemic stroke. bioRxiv : the preprint server for biology (2024)
Tara A Gleeson, Christina Kaiser, Catherine B Lawrence, David Brough, Stuart M Allan, Jack P Green
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome. Disease models & mechanisms 17 (7) (2024)
Paula I Seoane, James A Beswick, Andrew G Leach, Tessa Swanton, Lucy V Morris, Kevin Couper, Martin Lowe, Sally Freeman, David Brough
Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium. Cell death discovery 9 (1) (2023)
Bali Lee, Christopher Hoyle, Rose Wellens, Jack P Green, Fatima Martin-Sanchez, Daniel M Williams, Billie J Matchett, Paula I Seoane, Hayley Bennett, Antony D Adamson, Gloria Lopez-Castejon, Martin Lowe, David Brough
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome. Science signaling 16 (773) (2023)
Bali Lee, Christopher Hoyle, Rose Wellens, Jack P Green, Fatima Martin-Sanchez, Daniel M Williams, Billie J Matchett, Paula I Seoane, Hayley Bennett, Antony D Adamson, Gloria Lopez-Castejon, Martin Lowe, David Brough
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome. Science signaling 16 (773) (2023)
Paula I Seoane, James A Beswick, Andrew G Leach, Tessa Swanton, Lucy V Morris, Kevin Couper, Martin Lowe, Sally Freeman, David Brough
Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium. Cell death discovery 9 (1) (2023)
Paula I Seoane, James A Beswick, Andrew G Leach, Tessa Swanton, Lucy V Morris, Kevin Couper, Martin Lowe, Sally Freeman, David Brough
Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium. Cell death discovery 9 (1) (2023)
Bali Lee, Christopher Hoyle, Rose Wellens, Jack P Green, Fatima Martin-Sanchez, Daniel M Williams, Billie J Matchett, Paula I Seoane, Hayley Bennett, Antony D Adamson, Gloria Lopez-Castejon, Martin Lowe, David Brough
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome. Science signaling 16 (773) (2023)
Bali Lee, Christopher Hoyle, Rose Wellens, Jack P Green, Fatima Martin-Sanchez, Daniel M Williams, Billie J Matchett, Paula I Seoane, Hayley Bennett, Antony D Adamson, Gloria Lopez-Castejon, Martin Lowe, David Brough
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome. Science signaling 16 (773) (2023)
Sarah Fox, Laura J E Brown, Steven Antrobus, David Brough, Richard James Drake, Francine Jury, Iracema Leroi, Adrian R Parry-Jones, Matthew Machin
Co-design of a Smartphone App for People Living With Dementia by Applying Agile, Iterative Co-design Principles: Development and Usability Study. JMIR mHealth and uHealth 10 (1) (2022)
Christopher Hoyle, Jack P Green, Stuart M Allan, David Brough, Eloise Lemarchand
Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages. Immunology 165 (4) (2022)
Samuel Drinkall, Catherine B Lawrence, Bernadino Ossola, Samuel Russell, Clare Bender, Nicola B Brice, Lee A Dawson, Michael Harte, David Brough
The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation. Glia 70 (7) (2022)
Jack Rivers-Auty, Victor S Tapia, Claire S White, Michael J D Daniels, Samuel Drinkall, Paul T Kennedy, Harry G Spence, Shi Yu, Jack P Green, Christopher Hoyle, James R Cook, Amy Bradley, Alison E Mather, Ruth Peters, Te-Chen Tzeng, Margaret J Gordon, John H Beattie, David Brough, Catherine B Lawrence
Zinc Status Alters Alzheimer's Disease Progression through NLRP3-Dependent Inflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience 41 (13) (2021)
Tessa Swanton, James A Beswick, Halah Hammadi, Lucy Morris, Daniel Williams, Stephane de Cesco, Lina El-Sharkawy, Shi Yu, Jack Green, John B Davis, Catherine B Lawrence, David Brough, Sally Freeman
Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl- channel modulation. Chemical science 11 (43) (2020)
Christopher Hoyle, Elena Redondo-Castro, James Cook, Te-Chen Tzeng, Stuart M Allan, David Brough, Eloise Lemarchand
Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture. Immunology 161 (1) (2020)
Jack P Green, Tessa Swanton, Lucy V Morris, Lina Y El-Sharkawy, James Cook, Shi Yu, James Beswick, Antony D Adamson, Neil E Humphreys, Richard Bryce, Sally Freeman, Catherine Lawrence, David Brough
LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation. eLife 9 (2020)
Shi Yu, Jack P Green, Rose Wellens, Gloria Lopez-Castejon, David Brough
Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification. The FEBS journal 288 (10) (2020)
Helen Parker, Stuart M Ellison, Rebecca J Holley, Claire O'Leary, Aiyin Liao, Jalal Asadi, Emily Glover, Arunabha Ghosh, Simon Jones, Fiona L Wilkinson, David Brough, Emmanuel Pinteaux, Hervé Boutin, Brian W Bigger
Haematopoietic stem cell gene therapy with IL-1Ra rescues cognitive loss in mucopolysaccharidosis IIIA. EMBO molecular medicine 12 (3) (2020)
Sohaib Nizami, Kanisa Arunasalam, Jack Green, James Cook, Catherine B Lawrence, Tryfon Zarganes-Tzitzikas, John B Davis, Elena Di Daniel, David Brough
Inhibition of the NLRP3 inflammasome by HSP90 inhibitors. Immunology 162 (1) (2020)
Matthew R Dewhurst, Jin Rong Ow, Gözde Zafer, Noémi K M van Hul, Heike Wollmann, Xavier Bisteau, David Brough, Hyung Won Choi, Philipp Kaldis
Loss of hepatocyte cell division leads to liver inflammation and fibrosis. PLoS genetics 16 (11) (2020)
Alistair L Chenery, Rafid Alhallaf, Zainab Agha, Jesuthas Ajendra, James E Parkinson, Martha M Cooper, Brian H K Chan, Ramon M Eichenberger, Lindsay A Dent, Avril A B Robertson, Andreas Kupz, David Brough, Alex Loukas, Tara E Sutherland, Judith E Allen, Paul R Giacomin
Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung. Journal of immunology (Baltimore, Md. : 1950) 203 (10) (2019)
Brian J McHugh, Rongling Wang, Hsin-Ni Li, Paula E Beaumont, Rebekah Kells, Holly Stevens, Lisa Young, Adriano G Rossi, Robert D Gray, Julia R Dorin, Emily Gwyer Findlay, David Brough, Donald J Davidson
Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa. PLoS pathogens 15 (4) (2019)
Christopher Hoyle, Jack Rivers-Auty, Eloïse Lemarchand, Sandra Vranic, Emily Wang, Maurizio Buggio, Nancy J Rothwell, Stuart M Allan, Kostas Kostarelos, David Brough
Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 via Metabolic Reprogramming. ACS nano 12 (12) (2018)
Alex G Baldwin, Victor S Tapia, Tessa Swanton, Claire S White, James A Beswick, David Brough, Sally Freeman
Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome. ChemMedChem 13 (4) (2018)
Elena Redondo-Castro, Dorte Faust, Simon Fox, Alex G Baldwin, Simon Osborne, Michael J Haley, Eric Karran, Hugh Nuthall, Peter J Atkinson, Lee A Dawson, Carol Routledge, Stuart M Allan, Sally Freeman, Janet Brownlees, David Brough
Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses. Scientific reports 8 (1) (2018)
Pablo Palazón-Riquelme, Jonathan D Worboys, Jack Green, Ana Valera, Fatima Martín-Sánchez, Carolina Pellegrini, David Brough, Gloria Lopez-Castejon
USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation. EMBO reports 19 (10) (2018)
Tessa Swanton, James R Cook, James A Beswick, Sally Freeman, Catherine B Lawrence, David Brough
Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery? SLAS discovery : advancing life sciences R & D 23 (10) (2018)
Jack Rivers-Auty, Michael J D Daniels, Isaac Colliver, David L Robertson, David Brough
Redefining the ancestral origins of the interleukin-1 superfamily. Nature communications 9 (1) (2018)
Jack P Green, Shi Yu, Fátima Martín-Sánchez, Pablo Pelegrin, Gloria Lopez-Castejon, Catherine B Lawrence, David Brough
Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming. Proceedings of the National Academy of Sciences of the United States of America 115 (40) (2018)
Patrick Strangward, Michael J Haley, Manuel G Albornoz, Jack Barrington, Tovah Shaw, Rebecca Dookie, Leo Zeef, Syed M Baker, Emma Winter, Te-Chen Tzeng, Douglas T Golenbock, Sheena M Cruickshank, Stuart M Allan, Alister Craig, Foo Y Liew, David Brough, Kevin N Couper
Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America 115 (28) (2018)
David Brough, Pablo Pelegrin, Walter Nickel
An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β. Journal of cell science 130 (19) (2017)
Michelle E Edye, David Brough, Stuart M Allan
Acid-dependent Interleukin-1 (IL-1) Cleavage Limits Available Pro-IL-1β for Caspase-1 Cleavage. The Journal of biological chemistry 290 (42) (2015)

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Publication Activity (10 Years)

Top Topics

Top Venues

David Brough