Philipp Kaldis

ResearcherID Loop profile Scopus Author ID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2014-2024
Publications (10 Years): 39

Top Venues

International journal of molecular sciences

PloS one

Oncogene

Nature communications

Institute of Molecular and Cell Biology (IMCB)

ETH Zürich (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Institute of Molecular and Cell Biology (IMCB) Aug 08 2007

Singapore

Senior Principal Investigator :: Cancer Genetics and Therapeutics

National Cancer Institute (NCI-Frederick) Aug 08 2000 - Jul 31 2007

United States

Principal Investigator :: Mouse Cancer Genetics Program

Yale University School of Medicine Jan 31 1995 - Jul 31 2000

United States

Postdoctoral Fellow/Associate :: Molecular Biophysics and Biochemistry (MB&B)

Education History

ETH Zürich Nov 11 1990 - Apr 04 1994

Switzerland

PHD :: Cell Biology

ETH Zürich Oct 10 1986 - Oct 10 1990

Switzerland

MSC :: Biochemistry

Publications

Philipp Kaldis, Li-Na Zhao
Molecular basis of the reaction mechanism of the methyltransferase HENMT1. PloS one 19 (1) (2024)
Philipp Kaldis, Li-Na Zhao
Molecular basis of the reaction mechanism of the methyltransferase HENMT1. PloS one 19 (1) (2024)
Li-Na Zhao, Ernesto Guccione, Philipp Kaldis
Proof-of-Concept Method to Study Uncharacterized Methyltransferases Using PRDM15. International journal of molecular sciences 24 (2) (2023)
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, María Collantes, Philipp Kaldis, José Alfredo Martínez Hernández, Gema Medina-Gómez, María Jesús Moreno-Aliaga, Xavier Escoté
p27 Kip1 Deficiency Impairs Brown Adipose Tissue Function Favouring Fat Accumulation in Mice. International journal of molecular sciences 24 (3) (2023)
Li-Na Zhao, Ernesto Guccione, Philipp Kaldis
Proof-of-Concept Method to Study Uncharacterized Methyltransferases Using PRDM15. International journal of molecular sciences 24 (2) (2023)
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, María Collantes, Philipp Kaldis, José Alfredo Martínez Hernández, Gema Medina-Gómez, María Jesús Moreno-Aliaga, Xavier Escoté
p27 Kip1 Deficiency Impairs Brown Adipose Tissue Function Favouring Fat Accumulation in Mice. International journal of molecular sciences 24 (3) (2023)
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, María Collantes, Philipp Kaldis, José Alfredo Martínez Hernández, Gema Medina-Gómez, María Jesús Moreno-Aliaga, Xavier Escoté
p27 Kip1 Deficiency Impairs Brown Adipose Tissue Function Favouring Fat Accumulation in Mice. International journal of molecular sciences 24 (3) (2023)
Nathan Palmer, S Zakiah A Talib, Christine M F Goh, Kajal Biswas, Shyam K Sharan, Philipp Kaldis
Identification PMS1 and PMS2 as potential meiotic substrates of CDK2 activity. PloS one 18 (3) (2023)
Li-Na Zhao, Ernesto Guccione, Philipp Kaldis
Proof-of-Concept Method to Study Uncharacterized Methyltransferases Using PRDM15. International journal of molecular sciences 24 (2) (2023)
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, María Collantes, Philipp Kaldis, José Alfredo Martínez Hernández, Gema Medina-Gómez, María Jesús Moreno-Aliaga, Xavier Escoté
p27 Kip1 Deficiency Impairs Brown Adipose Tissue Function Favouring Fat Accumulation in Mice. International journal of molecular sciences 24 (3) (2023)
Li-Na Zhao, Philipp Kaldis
The catalytic mechanism of the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2). PLoS computational biology 18 (5) (2022)
Li-Na Zhao, Philipp Kaldis
Pairing structural reconstruction with catalytic competence to evaluate the mechanisms of key enzymes in the folate-mediated one-carbon pathway. The FEBS journal (2022)
Umur Keles, Jin Rong Ow, Katharina Barbara Kuentzel, Li Na Zhao, Philipp Kaldis
Liver-derived metabolites as signaling molecules in fatty liver disease. Cellular and molecular life sciences : CMLS 80 (1) (2022)
Li-Na Zhao, Dibyendu Mondal, Weifeng Li, Yuguang Mu, Philipp Kaldis
Histidine protonation states are key in the LigI catalytic reaction mechanism. Proteins (2021)
Jose Marcos Sanches, Li-Na Zhao, Albert Salehi, Claes B Wollheim, Philipp Kaldis
Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk. The FEBS journal (2021)
Li-Na Zhao, Mikael Björklund, Matias J Caldez, Jie Zheng, Philipp Kaldis
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential. Oncogene 40 (13) (2021)
Li-Na Zhao, Philipp Kaldis
Cascading proton transfers are a hallmark of the catalytic mechanism of SAM-dependent methyltransferases. FEBS letters (2020)
Xavier Bisteau, Joann Lee, Vinayaka Srinivas, Joanna H S Lee, Joanna Niska-Blakie, Gifford Tan, Shannon Y X Yap, Kevin W Hom, Cheng Kit Wong, Jeongjun Chae, Loo Chien Wang, Jinho Kim, Giulia Rancati, Radoslaw Mikolaj Sobota, Chris S H Tan, Philipp Kaldis
The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis. Oncogene 39 (44) (2020)
Matias J Caldez, Mikael Bjorklund, Philipp Kaldis
Cell cycle regulation in NAFLD: when imbalanced metabolism limits cell division. Hepatology international 14 (4) (2020)
Nathan Palmer, S Zakiah A Talib, Priti Singh, Christine M F Goh, Kui Liu, John C Schimenti, Philipp Kaldis
A novel function for CDK2 activity at meiotic crossover sites. PLoS biology 18 (10) (2020)
Jennifer Qin Jing Zhang, Jane Burgess, Daria Stepanova, Sayanthooran Saravanabavan, Annette T Y Wong, Philipp Kaldis, Gopala K Rangan
Role of cyclin-dependent kinase 2 in the progression of mouse juvenile cystic kidney disease. Laboratory investigation; a journal of technical methods and pathology 100 (5) (2020)
Jin Rong Ow, Matias J Caldez, Gözde Zafer, Juat Chin Foo, Hong Yu Li, Soumita Ghosh, Heike Wollmann, Amaury Cazenave-Gassiot, Chee Bing Ong, Markus R Wenk, Weiping Han, Hyung Won Choi, Philipp Kaldis
Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division. eLife 9 (2020)
Slim Mzoughi, Jia Yi Fong, David Papadopoli, Cheryl M Koh, Laura Hulea, Paolo Pigini, Federico Di Tullio, Giuseppe Andreacchio, Michal Marek Hoppe, Heike Wollmann, Diana Low, Matias J Caldez, Yanfen Peng, Denis Torre, Julia N Zhao, Oro Uchenunu, Gabriele Varano, Corina-Mihaela Motofeanu, Manikandan Lakshmanan, Shun Xie Teo, Cheng Mun Wun, Giovanni Perini, Soo Yong Tan, Chee Bing Ong, Muthafar Al-Haddawi, Ravisankar Rajarethinam, Susan Swee-Shan Hue, Soon Thye Lim, Choon-Kiat Ong, Dachuan Huang, Siok-Bian Ng, Emily Bernstein, Dan Hasson, Keng Boon Wee, Philipp Kaldis, Anand D Jeyasekharan, David Dominguez-Sola, Ivan Topisirovic, Ernesto Guccione
PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis. Nature communications 11 (1) (2020)
Matthew R Dewhurst, Jin Rong Ow, Gözde Zafer, Noémi K M van Hul, Heike Wollmann, Xavier Bisteau, David Brough, Hyung Won Choi, Philipp Kaldis
Loss of hepatocyte cell division leads to liver inflammation and fibrosis. PLoS genetics 16 (11) (2020)
Nathan Palmer, S Zakiah A Talib, Chandrahas Koumar Ratnacaram, Diana Low, Xavier Bisteau, Joanna Hui Si Lee, Elisabeth Pfeiffenberger, Heike Wollmann, Joel Heng Loong Tan, Sheena Wee, Radoslaw Mikolaj Sobota, Jayantha Gunaratne, Daniel M Messerschmidt, Ernesto Guccione, Philipp Kaldis
CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I. The Journal of cell biology 218 (9) (2019)
Priti Singh, Ravi K Patel, Nathan Palmer, Jennifer K Grenier, Darius Paduch, Philipp Kaldis, Andrew Grimson, John C Schimenti
CDK2 kinase activity is a regulator of male germ cell fate. Development (Cambridge, England) 146 (21) (2019)
Nathan Palmer, S Zakiah A Talib, Philipp Kaldis
Diverse roles for CDK-associated activity during spermatogenesis. FEBS letters 593 (20) (2019)
Abdellah Allali-Hassani, Magdalena M Szewczyk, Danton Ivanochko, Shawna L Organ, Jabez Bok, Jessica Sook Yuin Ho, Florence P H Gay, Fengling Li, Levi Blazer, Mohammad S Eram, Levon Halabelian, David Dilworth, Genna M Luciani, Evelyne Lima-Fernandes, Qin Wu, Peter Loppnau, Nathan Palmer, S Zakiah A Talib, Peter J Brown, Matthieu Schapira, Philipp Kaldis, Ronan C O'Hagan, Ernesto Guccione, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, John M Sanders, Solomon D Kattar, David Jonathan Bennett, Benjamin Nicholson, Masoud Vedadi
Discovery of a chemical probe for PRDM9. Nature communications 10 (1) (2019)
Joanna Niska-Blakie, Lakshmi Gopinathan, Kia Ngee Low, Yang Lay Kien, Christine M F Goh, Matias J Caldez, Elisabeth Pfeiffenberger, Oliver S Jones, Chee Bing Ong, Igor V Kurochkin, Vincenzo Coppola, Lino Tessarollo, Hyungwon Choi, Yoganathan Kanagasundaram, Frank Eisenhaber, Sebastian Maurer-Stroh, Philipp Kaldis
Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype. Cellular and molecular life sciences : CMLS 77 (17) (2019)
Radoslaw Szmyd, Joanna Niska-Blakie, M Kasim Diril, Patrícia Renck Nunes, Konstantinos Tzelepis, Aurélie Lacroix, Noémi van Hul, Lih-Wen Deng, Joao Matos, Oliver Dreesen, Xavier Bisteau, Philipp Kaldis
Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality. Oncogene 38 (7) (2018)
Lina Wang, Zhaowei Tu, Chao Liu, Hongbin Liu, Philipp Kaldis, Zijiang Chen, Wei Li
Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis. Cell death and differentiation 25 (6) (2018)
Quentin Marlier, Florian Jibassia, Sébastien Verteneuil, Jérôme Linden, Philipp Kaldis, Laurent Meijer, Laurent Nguyen, Renaud Vandenbosch, Brigitte Malgrange
Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death. Cell death discovery 4 (2018)
Chris Soon Heng Tan, Ka Diam Go, Xavier Bisteau, Lingyun Dai, Chern Han Yong, Nayana Prabhu, Mert Burak Ozturk, Yan Ting Lim, Lekshmy Sreekumar, Johan Lengqvist, Vinay Tergaonkar, Philipp Kaldis, Radoslaw M Sobota, Pär Nordlund
Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells. Science (New York, N.Y.) 359 (6380) (2018)
Akira Takahashi, Mieradili Mulati, Masanori Saito, Hoashi Numata, Yutaka Kobayashi, Hiroki Ochi, Shingo Sato, Philipp Kaldis, Atsushi Okawa, Hiroyuki Inose
Loss of cyclin-dependent kinase 1 impairs bone formation, but does not affect the bone-anabolic effects of parathyroid hormone. The Journal of biological chemistry 293 (50) (2018)
Sanjiv Risal, Jingjing Zhang, Deepak Adhikari, Xiaoman Liu, Jingchen Shao, Mengwen Hu, Kiran Busayavalasa, Zhaowei Tu, Zijiang Chen, Philipp Kaldis, Kui Liu
MASTL is essential for anaphase entry of proliferating primordial germ cells and establishment of female germ cells in mice. Cell discovery 3 (2017)
Shuhui Lim, Akshay Bhinge, Sara Bragado Alonso, Irene Aksoy, Julieta Aprea, Chit Fang Cheok, Federico Calegari, Lawrence W Stanton, Philipp Kaldis
Cyclin-Dependent Kinase-Dependent Phosphorylation of Sox2 at Serine 39 Regulates Neurogenesis. Molecular and cellular biology 37 (16) (2017)
Zhaowei Tu, Mustafa Bilal Bayazit, Hongbin Liu, Jingjing Zhang, Kiran Busayavalasa, Sanjiv Risal, Jingchen Shao, Ande Satyanarayana, Vincenzo Coppola, Lino Tessarollo, Meenakshi Singh, Chunwei Zheng, Chunsheng Han, Zijiang Chen, Philipp Kaldis, Jan-Åke Gustafsson, Kui Liu
Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation. Proceedings of the National Academy of Sciences of the United States of America 114 (3) (2016)
M Kasim Diril, Xavier Bisteau, Mayumi Kitagawa, Matias J Caldez, Sheena Wee, Jayantha Gunaratne, Sang Hyun Lee, Philipp Kaldis
Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint. PLoS genetics 12 (9) (2016)
Anne Margriet Heijink, Vincent A Blomen, Xavier Bisteau, Fabian Degener, Felipe Yu Matsushita, Philipp Kaldis, Floris Foijer, Marcel A T M van Vugt
A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity. Proceedings of the National Academy of Sciences of the United States of America 112 (49) (2015)
Senthil Raja Jayapal, Philipp Kaldis
p57(Kip2) regulates T-cell development and lymphoma. Blood 123 (22) (2014)

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Publication Activity (10 Years)

Top Topics

Top Venues

Philipp Kaldis