David L Williams

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 7

Top Topics

Trypanosoma Cruzi

Mass Spectrometry

Infectious Diseases

Top Venues

ACS infectious diseases

ACS chemical biology

Journal of helminthology

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Matteo Ardini, Sammy Y Aboagye, Valentina Z Petukhova, Irida Kastrati, Rodolfo Ippoliti, Gregory R J Thatcher, Pavel A Petukhov, David L Williams, Francesco Angelucci
The "Doorstop Pocket" In Thioredoxin Reductases─An Unexpected Druggable Regulator of the Catalytic Machinery. Journal of medicinal chemistry (2024)
Valentina Z Petukhova, Samuel Yaw Aboagye, Matteo Ardini, Rachel P Lullo, Francesca Fata, Margaret E Byrne, Federica Gabriele, Lucy M Martin, Luke N M Harding, Vamshikrishna Gone, Bikash Dangi, Daniel D Lantvit, Dejan Nikolic, Rodolfo Ippoliti, Gregory Effantin, Wai Li Ling, Jeremy J Johnson, Gregory R J Thatcher, Francesco Angelucci, David L Williams, Pavel A Petukhov
Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo. Nature communications 14 (1) (2023)
Caroline De Souza Pereira, Helenita Costa Quadros, Samuel Yaw Aboagye, Diana Fontinha, Sarah D'Alessandro, Margaret Elizabeth Byrne, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Diogo Rodrigo de Magalhães Moreira, Nicoletta Basilico, David L Williams, Miguel Prudncio, Bruno Pradines, Maribel Navarro
A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis. Pharmaceutics 14 (6) (2022)
Fidensio K Ndegwa, Chaitanya Kondam, Samuel Yaw Aboagye, Taiwo E Esan, Zohra Sattar Waxali, Margaret E Miller, Nicholas K Gikonyo, Paul K Mbugua, Paul O Okemo, David L Williams, Timothy J Hagen
Traditional Kenyan herbal medicine: exploring natural products' therapeutics against schistosomiasis. Journal of helminthology 96 (2022)
Francesca Fata, Ilaria Silvestri, Matteo Ardini, Rodolfo Ippoliti, Luana Di Leandro, Nicola Demitri, Maurizio Polentarutti, Adele Di Matteo, Haining Lyu, Gregory R J Thatcher, Pavel A Petukhov, David L Williams, Francesco Angelucci
Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments. ACS infectious diseases 7 (7) (2021)
Haining Lyu, Pavel A Petukhov, Paul R Banta, Ajit Jadhav, Wendy A Lea, Qing Cheng, Elias S J Arnér, Anton Simeonov, Gregory R J Thatcher, Francesco Angelucci, David L Williams
Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis. ACS infectious diseases 6 (3) (2020)
Ilaria Silvestri, Haining Lyu, Francesca Fata, Giovanna Boumis, Adriana E Miele, Matteo Ardini, Rodolfo Ippoliti, Andrea Bellelli, Ajit Jadhav, Wendy A Lea, Anton Simeonov, Qing Cheng, Elias S J Arnér, Gregory R J Thatcher, Pavel A Petukhov, David L Williams, Francesco Angelucci
Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. ACS chemical biology 13 (8) (2018)