Gregory R J Thatcher

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 27

Top Venues

Journal of medicinal chemistry

ACS medicinal chemistry letters

PLoS pathogens

Proceedings of the National Academy of Sciences of the United States of America

University of Illinois at Chicago

University of Toronto (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Illinois at Chicago Jan 01 2003

United States

Professor and Director :: University of Illinois College of Pharmacy

Education History

University of Toronto Sep 05 1981 - Mar 01 2016

Canada

PHD :: Chemistry

Publications

Ganga Reddy Velma, Zhengnan Shen, Cameron Holberg, Jiqiang Fu, Farinaz Soleymani, Laura Cooper, Omar Lozano Ramos, Divakar Indukuri, Soumya Reddy Musku, Pavel Rychetsky, Steve Slilaty, Zuomei Li, Kiira Ratia, Lijun Rong, Dominik Schenten, Rui Xiong, Gregory R J Thatcher
Non-Covalent Inhibitors of SARS-CoV-2 Papain-Like Protease (PLpro): In Vitro and In Vivo Antiviral Activity. Journal of medicinal chemistry 67 (16) (2024)
Ganga Reddy Velma, Megan S Laham, Cutler Lewandowski, Ana C Valencia-Olvera, Deebika Balu, Annabelle Moore, Martha Ackerman-Berrier, Pavel Rychetsky, Christopher Penton, Soumya Reddy Musku, Anandhan Annadurai, Maha Ibrahim Sulaiman, Nina Ma, Gregory R J Thatcher
Nonlipogenic ABCA1 Inducers (NLAI) for Alzheimer's Disease Validated in a Mouse Model Expressing Human APOE3/APOE4 . Journal of medicinal chemistry (2024)
Ganga Reddy Velma, Zhengnan Shen, Cameron Holberg, Jiqiang Fu, Farinaz Soleymani, Laura Cooper, Omar Lozano Ramos, Divakar Indukuri, Soumya Reddy Musku, Pavel Rychetsky, Steve Slilaty, Zuomei Li, Kiira Ratia, Lijun Rong, Dominik Schenten, Rui Xiong, Gregory R J Thatcher
Non-Covalent Inhibitors of SARS-CoV-2 Papain-Like Protease (PLpro): In Vitro and In Vivo Antiviral Activity. Journal of medicinal chemistry 67 (16) (2024)
Ganga Reddy Velma, Zhengnan Shen, Cameron Holberg, Jiqiang Fu, Farinaz Soleymani, Laura Cooper, Omar Lozano Ramos, Divakar Indukuri, Soumya Reddy Musku, Pavel Rychetsky, Steve Slilaty, Zuomei Li, Kiira Ratia, Lijun Rong, Dominik Schenten, Rui Xiong, Gregory R J Thatcher
Non-Covalent Inhibitors of SARS-CoV-2 Papain-Like Protease (PLpro): In Vitro and In Vivo Antiviral Activity. Journal of medicinal chemistry (2024)
Yangfeng Li, Zhengnan Shen, Kiira Ratia, Jiong Zhao, Fei Huang, Oleksii Dubrovyskyii, Divakar Indukuri, Jiqiang Fu, Omar Lozano Ramos, Gregory R J Thatcher, Rui Xiong
Structure-Guided Design and Synthesis of Pyridinone-Based Selective Bromodomain and Extra-Terminal Domain (BET)-First Bromodomain (BD1) Inhibitors. Journal of medicinal chemistry 67 (4) (2024)
Matteo Ardini, Sammy Y Aboagye, Valentina Z Petukhova, Irida Kastrati, Rodolfo Ippoliti, Gregory R J Thatcher, Pavel A Petukhov, David L Williams, Francesco Angelucci
The "Doorstop Pocket" In Thioredoxin Reductases─An Unexpected Druggable Regulator of the Catalytic Machinery. Journal of medicinal chemistry (2024)
Yangfeng Li, Zhengnan Shen, Kiira Ratia, Jiong Zhao, Fei Huang, Oleksii Dubrovyskyii, Divakar Indukuri, Jiqiang Fu, Omar Lozano Ramos, Gregory R J Thatcher, Rui Xiong
Structure-Guided Design and Synthesis of Pyridinone-Based Selective Bromodomain and Extra-Terminal Domain (BET)-First Bromodomain (BD1) Inhibitors. Journal of medicinal chemistry (2024)
Jesse M Gordon-Blake, Kiira Ratia, Victoria Weidig, Ganga Reddy Velma, Martha Ackerman-Berrier, Christopher Penton, Soumya Reddy Musku, Erick T M Alves, Tom G Driver, Leon Tai, Gregory R J Thatcher
Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. ACS medicinal chemistry letters 15 (2) (2024)
Jesse M Gordon-Blake, Kiira Ratia, Victoria Weidig, Ganga Reddy Velma, Martha Ackerman-Berrier, Christopher Penton, Soumya Reddy Musku, Erick T M Alves, Tom G Driver, Leon Tai, Gregory R J Thatcher
Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. ACS medicinal chemistry letters 15 (2) (2024)
Ganga Reddy Velma, Zhengnan Shen, Cameron Holberg, Jiqiang Fu, Farinaz Soleymani, Laura Cooper, Omar Lozano Ramos, Divakar Indukuri, Soumya Reddy Musku, Pavel Rychetsky, Steve Slilaty, Zuomei Li, Kiira Ratia, Lijun Rong, Dominik Schenten, Rui Xiong, Gregory R J Thatcher
Non-Covalent Inhibitors of SARS-CoV-2 Papain-Like Protease (PLpro): In Vitro and In Vivo Antiviral Activity. Journal of medicinal chemistry 67 (16) (2024)
Ganga Reddy Velma, Zhengnan Shen, Cameron Holberg, Jiqiang Fu, Farinaz Soleymani, Laura Cooper, Omar Lozano Ramos, Divakar Indukuri, Soumya Reddy Musku, Pavel Rychetsky, Steve Slilaty, Zuomei Li, Kiira Ratia, Lijun Rong, Dominik Schenten, Rui Xiong, Gregory R J Thatcher
Non-Covalent Inhibitors of SARS-CoV-2 Papain-Like Protease (PLpro): In Vitro and In Vivo Antiviral Activity. Journal of medicinal chemistry 67 (16) (2024)
Yangfeng Li, Zhengnan Shen, Kiira Ratia, Jiong Zhao, Fei Huang, Oleksii Dubrovyskyii, Divakar Indukuri, Jiqiang Fu, Omar Lozano Ramos, Gregory R J Thatcher, Rui Xiong
Structure-Guided Design and Synthesis of Pyridinone-Based Selective Bromodomain and Extra-Terminal Domain (BET)-First Bromodomain (BD1) Inhibitors. Journal of medicinal chemistry 67 (4) (2024)
Zhengnan Shen, Kiira Ratia, Isabella S Krider, Martha Ackerman-Berrier, Christopher Penton, Soumya Reddy Musku, Jesse M Gordon-Blake, Megan S Laham, Nicholas Christie, Nina Ma, Jiqiang Fu, Rui Xiong, Jenna M Courey, Ganga Reddy Velma, Gregory R J Thatcher
Synthesis, Optimization, and Structure-Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs). Journal of medicinal chemistry (2023)
Saad Alqarni, Laura Cooper, Jazmin Galván Achi, Ryan Bott, Veeresh Kumar Sali, Andrew Brown, Bernard D Santarsiero, Aleksej Krunic, Balaji Manicassamy, Norton P Peet, Pin Zhang, Gregory R J Thatcher, Irina N Gaisina, Lijun Rong, Terry W Moore
Synthesis, Optimization, and Structure-Activity Relationships of Imidazo[1,2- a ]pyrimidines as Inhibitors of Group 2 Influenza A Viruses. Journal of medicinal chemistry 65 (20) (2022)
Daniel R Principe, Rui Xiong, Yangfeng Li, Thao N D Pham, Suneel D Kamath, Oleksii Dubrovskyi, Kiira Ratia, Fei Huang, Jiong Zhao, Zhengnan Shen, Dinesh Thummuri, Zhou Daohong, Patrick W Underwood, Jose Trevino, Hidayatullah G Munshi, Gregory R J Thatcher, Ajay Rana
XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America 119 (4) (2022)
Zhengnan Shen, Kiira Ratia, Laura Cooper, Deyu Kong, Hyun Lee, Youngjin Kwon, Yangfeng Li, Saad Alqarni, Fei Huang, Oleksii Dubrovskyi, Lijun Rong, Gregory R J Thatcher, Rui Xiong
Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity. Journal of medicinal chemistry (2021)
Adam Schafer, Rui Xiong, Laura M Cooper, Raghad Nowar, Hyun Lee, Yangfeng Li, Benjamin E Ramirez, Norton P Peet, Michael Caffrey, Gregory R J Thatcher, Erica Ollmann Saphire, Han Cheng, Lijun Rong
Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry. PLoS pathogens 17 (2) (2021)
Irina N Gaisina, Norton P Peet, Han Cheng, Ping Li, Ruikun Du, Qinghua Cui, Kevin Furlong, Balaji Manicassamy, Michael Caffrey, Gregory R J Thatcher, Lijun Rong
Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir. Journal of medicinal chemistry 63 (6) (2020)
Haining Lyu, Pavel A Petukhov, Paul R Banta, Ajit Jadhav, Wendy A Lea, Qing Cheng, Elias S J Arnér, Anton Simeonov, Gregory R J Thatcher, Francesco Angelucci, David L Williams
Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis. ACS infectious diseases 6 (3) (2020)
Laura Cooper, Adam Schafer, Yangfeng Li, Han Cheng, Bani Medegan Fagla, Zhengnan Shen, Raghad Nowar, Katherine Dye, Manu Anantpadma, Robert A Davey, Gregory R J Thatcher, Lijun Rong, Rui Xiong
Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. Journal of medicinal chemistry 63 (19) (2020)
Yangfeng Li, Jiong Zhao, Lauren M Gutgesell, Zhengnan Shen, Kiira Ratia, Katherine Dye, Oleksii Dubrovskyi, Huiping Zhao, Fei Huang, Debra A Tonetti, Gregory R J Thatcher, Rui Xiong
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. Journal of medicinal chemistry 63 (13) (2020)
Irina N Gaisina, Norton P Peet, Letitia Wong, Adam M Schafer, Han Cheng, Manu Anantpadma, Robert A Davey, Gregory R J Thatcher, Lijun Rong
Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. Journal of medicinal chemistry 63 (13) (2020)
Yunlong Lu, Lauren M Gutgesell, Rui Xiong, Jiong Zhao, Yangfeng Li, Carlo I Rosales, Michael Hollas, Zhengnan Shen, Jesse Gordon-Blake, Katherine Dye, Yueting Wang, Sue Lee, Hu Chen, Donghong He, Oleksii Dubrovyskyii, Huiping Zhao, Fei Huang, Amy W Lasek, Debra A Tonetti, Gregory R J Thatcher
Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer. Journal of medicinal chemistry 62 (24) (2019)
Ilaria Silvestri, Haining Lyu, Francesca Fata, Giovanna Boumis, Adriana E Miele, Matteo Ardini, Rodolfo Ippoliti, Andrea Bellelli, Ajit Jadhav, Wendy A Lea, Anton Simeonov, Qing Cheng, Elias S J Arnér, Gregory R J Thatcher, Pavel A Petukhov, David L Williams, Francesco Angelucci
Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. ACS chemical biology 13 (8) (2018)
Irina N Gaisina, Sue H Lee, Navneet A Kaidery, Manel Ben Aissa, Manuj Ahuja, Natalya N Smirnova, Sushama Wakade, Arsen Gaisin, Megan W Bourassa, Rajiv R Ratan, Sergey V Nikulin, Andrey A Poloznikov, Bobby Thomas, Gregory R J Thatcher, Irina G Gazaryan
Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors. ACS chemical neuroscience 9 (5) (2018)
Rui Xiong, Jiong Zhao, Lauren M Gutgesell, Yueting Wang, Sue Lee, Bhargava Karumudi, Huiping Zhao, Yunlong Lu, Debra A Tonetti, Gregory R J Thatcher
Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer. Journal of medicinal chemistry 60 (4) (2017)
Yao Yao, Loruhama Delgado-Rivera, Hamid Samareh Afsari, Liang Yin, Gregory R J Thatcher, Terry W Moore, Lawrence W Miller
Time-Gated Luminescence Detection of Enzymatically Produced Hydrogen Sulfide: Design, Synthesis, and Application of a Lanthanide-Based Probe. Inorganic chemistry 57 (2) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Gregory R J Thatcher