David Michael Sansom (David M Sansom, D M Sansom)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2023
Publications (10 Years): 16

Top Venues

The EMBO journal

Nature communications

Blood

Proceedings of the National Academy of Sciences of the United States of America

University of Birmingham

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Birmingham Oct 1o 1999 - Jan 1o 2013

United Kingdom

Professor of Immune Cell Biology :: Immunity and Infection

Publications

Alan Kennedy, Maximillian A Robinson, Claudia Hinze, Erin Waters, Cayman Williams, Neil Halliday, Simon Dovedi, David Michael Sansom
The CTLA-4 immune checkpoint protein regulates PD-L1:PD-1 interaction via transendocytosis of its ligand CD80. The EMBO journal (2023)
Alan Kennedy, Maximillian A Robinson, Claudia Hinze, Erin Waters, Cayman Williams, Neil Halliday, Simon Dovedi, David Michael Sansom
The CTLA-4 immune checkpoint protein regulates PD-L1:PD-1 interaction via transendocytosis of its ligand CD80. The EMBO journal 42 (5) (2023)
Alan Kennedy, Maximillian A Robinson, Claudia Hinze, Erin Waters, Cayman Williams, Neil Halliday, Simon Dovedi, David Michael Sansom
The CTLA-4 immune checkpoint protein regulates PD-L1:PD-1 interaction via transendocytosis of its ligand CD80. The EMBO journal 42 (5) (2023)
Alan Kennedy, Maximillian A Robinson, Claudia Hinze, Erin Waters, Cayman Williams, Neil Halliday, Simon Dovedi, David Michael Sansom
The CTLA-4 immune checkpoint protein regulates PD-L1:PD-1 interaction via transendocytosis of its ligand CD80. The EMBO journal 42 (5) (2023)
Alan Kennedy, Maximillian A Robinson, Claudia Hinze, Erin Waters, Cayman Williams, Neil Halliday, Simon Dovedi, David Michael Sansom
The CTLA-4 immune checkpoint protein regulates PD-L1:PD-1 interaction via transendocytosis of its ligand CD80. The EMBO journal 42 (5) (2023)
Brianna M Lax, Joseph R Palmeri, Emi A Lutz, Allison Sheen, Jordan A Stinson, Lauren Duhamel, Luciano Santollani, Alan Kennedy, Adrienne M Rothschilds, Stefani Spranger, David Michael Sansom, Karl Dane Wittrup
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies. Proceedings of the National Academy of Sciences of the United States of America 120 (31) (2023)
Thomas Andrew Fox, Benjamin Christopher Houghton, Lina Petersone, Erin Waters, Natalie Mona Edner, Alex McKenna, Olivier Preham, Claudia Hinze, Cayman Williams, Adriana Silva de Albuquerque, Alan Kennedy, Anne Maria Pesenacker, Pietro Genovese, Lucy Sarah Kate Walker, Siobhan Oisin Burns, David Michael Sansom, Claire Booth, Emma Catherine Morris
Therapeutic gene editing of T cells to correct CTLA-4 insufficiency. Science translational medicine 14 (668) (2022)
Alan Kennedy, Erin Waters, Behzad Rowshanravan, Claudia Hinze, Cayman Williams, Daniel Janman, Thomas Andrew Fox, Claire Booth, Anne Maria Pesenacker, Neil Halliday, Blagoje Soskic, Satdip Kaur, Omar S Qureshi, Emma Catherine Morris, Shinji Ikemizu, Christopher Paluch, Jiandong Huo, Simon J Davis, Emmanuel Boucrot, Lucy Sarah Kate Walker, David Michael Sansom
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation. Nature immunology 23 (9) (2022)
Daniel Janman, Claudia Hinze, Alan Kennedy, Neil Halliday, Erin Waters, Cayman Williams, Behzad Rowshanravan, Tie Zheng Hou, Shane Minogue, Omar S Qureshi, David Michael Sansom
Regulation of CTLA-4 recycling by LRBA and Rab11. Immunology 164 (1) (2021)
Dafni A Glinos, Blagoje Soskic, Cayman Williams, Alan Kennedy, Luke Jostins, David Michael Sansom, Gosia Trynka
Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation. Genes and immunity 21 (6-8) (2020)
Nina Kathrin Serwas, Birgit Hoeger, Rico C Ardy, Sigrun V Stulz, Zhenhua Sui, Anette Melk, Marie Meeths, Ana Krolo, Özlem Yüce Petronczki, Laurène Pfajfer, Tie Z Hou, Neil Halliday, Elisangela Santos-Valente, Artem Kalinichenko, Alan Kennedy, Emily M Mace, Malini Mukherjee, Bianca Tesi, Anna Schrempf, Winfried F Pickl, Joanna I Loizou, Renate Kain, Bettina Bidmon-Fliegenschnee, Jean-Nicolas Schickel, Salomé Glauzy, Jakob Huemer, Wojciech Garncarz, Elisabeth Salzer, Iro Pierides, Ivan Bilic, Jens Thiel, Peter Priftakis, Pinaki P Banerjee, Elisabeth Förster-Waldl, David Medgyesi, Wolf-Dietrich Huber, Jordan S Orange, Eric Meffre, David Michael Sansom, Yenan T Bryceson, Amnon Altman, Kaan Boztug
Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nature communications 10 (1) (2019)
Nina Kathrin Serwas, Birgit Hoeger, Rico C Ardy, Sigrun V Stulz, Zhenhua Sui, Anette Melk, Marie Meeths, Ana Krolo, Özlem Yüce Petronczki, Laurène Pfajfer, Tie Z Hou, Neil Halliday, Elisangela Santos-Valente, Artem Kalinichenko, Alan Kennedy, Emily M Mace, Malini Mukherjee, Bianca Tesi, Anna Schrempf, Winfried F Pickl, Joanna I Loizou, Renate Kain, Bettina Bidmon-Fliegenschnee, Jean-Nicolas Schickel, Salomé Glauzy, Jakob Huemer, Wojciech Garncarz, Elisabeth Salzer, Iro Pierides, Ivan Bilic, Jens Thiel, Peter Priftakis, Pinaki P Banerjee, Elisabeth Förster-Waldl, David Medgyesi, Wolf-Dietrich Huber, Jordan S Orange, Eric Meffre, David Michael Sansom, Yenan T Bryceson, Amnon Altman, Kaan Boztug
Publisher Correction: Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nature communications 10 (1) (2019)
Tie Zheng Hou, Nisha Verma, Jennifer Wanders, Alan Kennedy, Blagoje Soskic, Daniel Janman, Neil Halliday, Behzad Rowshanravan, Austen Worth, Waseem Qasim, Helen Baxendale, Hans Stauss, Suranjith Seneviratne, Olaf Neth, Peter Olbrich, Sophie Hambleton, Peter D Arkwright, Siobhan O Burns, Lucy S K Walker, David Michael Sansom
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations. Blood 129 (11) (2017)
N Verma, S O Burns, L S K Walker, David Michael Sansom
Immune deficiency and autoimmunity in patients with CTLA-4 (CD152) mutations. Clinical and experimental immunology 190 (1) (2017)
Behzad Rowshanravan, Neil Halliday, David Michael Sansom
CTLA-4: a moving target in immunotherapy. Blood 131 (1) (2017)
Julie Douthwaite, Jacques Moisan, Cyril Privezentzev, Blagoje Soskic, Shereen Sabbah, E Suzanne Cohen, Andie Collinson, Elizabeth England, Catherine Chaillan Huntington, Ben Kemp, Li Zhuang, Suzanne Hudak, D Gareth Rees, Debbie Goldberg, Chris Barton, Linda Chang, Inna Vainshtein, Meina Liang, Laurie Iciek, Philip Ambery, Mark Peakman, Tristan J Vaughan, Timothy I M Tree, David Michael Sansom, Michael A Bowen, Ralph R Minter, Lutz Jermutus
A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding. Journal of immunology (Baltimore, Md. : 1950) 198 (1) (2016)

David Michael Sansom.css-eqlu8i{font-size:small;padding-left:4px;} (David M Sansom, D M Sansom)

Publication Activity (10 Years)

Top Topics

Top Venues

David Michael Sansom (David M Sansom, D M Sansom)