David Ron (D Ron)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 38

Top Venues

eLife

The EMBO journal

Proceedings of the National Academy of Sciences of the United States of America

EMBO molecular medicine

University of Cambridge

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Cambridge Oct 01 2010

United Kingdom

Lab Head (Professor) :: Clinical Bochemistry

NYU Langone Medical Center Sep 01 1992 - Sep 30 2010

United States

Lab Head (Professor) :: Medicine/Skirball Institute

Harvard Medical School Jul 01 1988 - Jul 31 1992

United States

Research Fellow :: Genetics & HHMI

Massachusetts General Hospital Jul 01 1987 - Jun 30 1989

United States

Endocrine Fellow (clinical) :: Medicine

Mount Sinai Hospital Jul 01 1984 - Jun 30 1987

United States

Resident in Medicine :: Medicine

Publications

Yahui Yan, Maithili Shetty, Heather P Harding, Ginto George, Alisa F Zyryanova, Katherine Labbé, Amirhossein Mafi, Qi Hao, Carmela Sidrauski, David Ron
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response. Proceedings of the National Academy of Sciences of the United States of America 121 (14) (2024)
Yahui Yan, Maithili Shetty, Heather P Harding, Ginto George, Alisa F Zyryanova, Katherine Labbé, Amirhossein Mafi, Qi Hao, Carmela Sidrauski, David Ron
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response. Proceedings of the National Academy of Sciences of the United States of America 121 (14) (2024)
Joanne Tung, Lei Huang, Ginto George, Heather P Harding, David Ron, Adriana Ordonez
A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α. eLife 13 (2024)
Yahui Yan, Maithili Shetty, Heather P Harding, Ginto George, Alisa F Zyryanova, Katherine Labbé, Amirhossein Mafi, Qi Hao, Carmela Sidrauski, David Ron
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response. Proceedings of the National Academy of Sciences of the United States of America 121 (14) (2024)
Joanne Tung, Lei Huang, Ginto George, Heather P Harding, David Ron, Adriana Ordonez
A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α. eLife 13 (2024)
Yahui Yan, Maithili Shetty, Heather P Harding, Ginto George, Alisa F Zyryanova, Katherine Labbé, Amirhossein Mafi, Qi Hao, Carmela Sidrauski, David Ron
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response. Proceedings of the National Academy of Sciences of the United States of America 121 (14) (2024)
Anja F Kueck, Johannes van den Boom, Sandra Koska, David Ron, Hemmo Meyer
Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatases. Proceedings of the National Academy of Sciences of the United States of America 121 (36) (2024)
Joanne Tung, Lei Huang, Ginto George, Heather P Harding, David Ron, Adriana Ordonez
A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α. eLife 13 (2024)
Yahui Yan, Maithili Shetty, Heather P Harding, Ginto George, Alisa F Zyryanova, Katherine Labbé, Amirhossein Mafi, Qi Hao, Carmela Sidrauski, David Ron
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response. Proceedings of the National Academy of Sciences of the United States of America 121 (14) (2024)
Joanne Tung, Lei Huang, Ginto George, Heather P Harding, David Ron, Adriana Ordonez
A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α. eLife 13 (2024)
Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, Stephen H McLaughlin, Sophie Janssens, David Ron
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells. The EMBO journal (2023)
Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, Stephen H McLaughlin, Sophie Janssens, David Ron
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells. The EMBO journal (2023)
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP. EMBO molecular medicine 15 (3) (2023)
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP. EMBO molecular medicine (2023)
Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, Stephen H McLaughlin, Sophie Janssens, David Ron
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells. The EMBO journal (2023)
Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, Stephen H McLaughlin, Sophie Janssens, David Ron
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells. The EMBO journal 43 (5) (2023)
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP. EMBO molecular medicine 15 (3) (2023)
Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, Stephen H McLaughlin, Sophie Janssens, David Ron
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells. The EMBO journal 43 (5) (2023)
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP. EMBO molecular medicine 15 (3) (2023)
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP. EMBO molecular medicine 15 (3) (2023)
Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, Stephen H McLaughlin, Sophie Janssens, David Ron
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells. The EMBO journal (2023)
Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, Stephen H McLaughlin, Sophie Janssens, David Ron
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells. The EMBO journal 43 (5) (2023)
Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, Stephen H McLaughlin, Sophie Janssens, David Ron
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells. The EMBO journal 43 (5) (2023)
Luke A Perera, David Ron
AMPylation and Endoplasmic Reticulum Protein Folding Homeostasis. Cold Spring Harbor perspectives in biology (2022)
Luke A Perera, Steffen Preissler, Nathan R Zaccai, Sylvain François Prévost, Juliette M Devos, Michael Haertlein, David Ron
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD. Nature communications 12 (1) (2021)
Yahui Yan, Heather P Harding, David Ron
Higher-order phosphatase-substrate contacts terminate the integrated stress response. Nature structural & molecular biology 28 (10) (2021)
Stefan John Marciniak, Joseph E Chambers, David Ron
Pharmacological targeting of endoplasmic reticulum stress in disease. Nature reviews. Drug discovery (2021)
Steffen Preissler, Cláudia Rato, Yahui Yan, Luke A Perera, Aron Czako, David Ron
Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes. eLife 9 (2020)
Niko Amin-Wetzel, Lisa Neidhardt, Yahui Yan, Matthias P Mayer, David Ron
Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR. eLife 8 (2019)
Luke A Perera, Cláudia Rato, Yahui Yan, Lisa Neidhardt, Stephen H McLaughlin, Randy J Read, Steffen Preissler, David Ron
An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP. The EMBO journal 38 (21) (2019)
Heather P Harding, Adriana Ordonez, Felicity Allen, Leopold Parts, Alison J Inglis, Roger L Williams, David Ron
The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells. eLife 8 (2019)
Yahui Yan, Cláudia Rato, Lukas Rohland, Steffen Preissler, David Ron
MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nature communications 10 (1) (2019)
Alisa F Zyryanova, Felix Weis, Alexandre Faille, Akeel Abo Alard, Ana Crespillo-Casado, Yusuke Sekine, Heather P Harding, Felicity Allen, Leopold Parts, Christophe Fromont, Peter M Fischer, Alan John Warren, David Ron
Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B. Science (New York, N.Y.) 359 (6383) (2018)
David Holcman, Pierre Parutto, Joseph E Chambers, Marcus Fantham, Laurence J Young, Stefan J Marciniak, Clemens F Kaminski, David Ron, Edward Avezov
Single particle trajectories reveal active endoplasmic reticulum luminal flow. Nature cell biology 20 (10) (2018)
Ana Crespillo-Casado, Joseph E Chambers, Peter M Fischer, Stefan John Marciniak, David Ron
PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz. eLife 6 (2017)
Markus Tschurtschenthaler, Timon E Adolph, Jonathan W Ashcroft, Lukas Niederreiter, Richa Bharti, Svetlana Saveljeva, Joya Bhattacharyya, Magdalena B Flak, David Q Shih, Gwenny M Fuhler, Miles Parkes, Kenji Kohno, Takao Iwawaki, Christien J van der Woude, Heather P Harding, Andrew Mark Smith, Maikel Petrus Peppelenbosch, Stephan R Targan, David Ron, Philip C Rosenstiel, Richard S Blumberg, Arthur Kaser
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis. The Journal of experimental medicine 214 (2) (2017)
Steffen Preissler, Lukas Rohland, Yahui Yan, Ruming Chen, Randy J Read, David Ron
AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation. eLife 6 (2017)
Yusuke Sekine, Alisa F Zyryanova, Ana Crespillo-Casado, Niko Amin-Wetzel, Heather P Harding, David Ron
Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells. PloS one 11 (11) (2016)
Steffen Preissler, Cláudia Rato, Ruming Chen, Robin Antrobus, Shujing Ding, Ian M Fearnley, David Ron
AMPylation matches BiP activity to client protein load in the endoplasmic reticulum. eLife 4 (2015)
Joseph E Chambers, Lucy E Dalton, Hanna J Clarke, Elke Malzer, Caia S Dominicus, Vruti Patel, Greg Moorhead, David Ron, Stefan John Marciniak
Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation. eLife 4 (2015)
M Halliday, H Radford, Y Sekine, J Moreno, N Verity, J le Quesne, C A Ortori, D A Barrett, C Fromont, P M Fischer, H P Harding, David Ron, G R Mallucci
Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell death & disease 6 (2015)
Ruming Chen, Cláudia Rato, Yahui Yan, Ana Crespillo-Casado, Hanna J Clarke, Heather P Harding, Stefan John Marciniak, Randy J Read, David Ron
G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases. eLife 4 (2015)
Steffen Preissler, Joseph E Chambers, Ana Crespillo-Casado, Edward Avezov, Elena Miranda, Juan Perez, Linda M Hendershot, Heather P Harding, David Ron
Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker. eLife 4 (2015)

David Ron.css-eqlu8i{font-size:small;padding-left:4px;} (D Ron)

Publication Activity (10 Years)

Top Topics

Top Venues

David Ron (D Ron)