Roger L Williams (Roger Williams, R L Williams)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 20

Top Venues

eLife

Science advances

Nature communications

Proceedings of the National Academy of Sciences of the United States of America

Medical Research Council

University of California Riverside (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Medical Research Council May 01 1997

United Kingdom

Group leader :: Laboratory of Molecular Biology

Medical Research Council

United Kingdom

Group leader :: Center for Protein Engineering

Rutgers University Rutgers

United States

Assistant Research Professor :: Center for Advanced Biotechnology and Medicine

Rutgers University

United States

Postdoctoral Associate :: Center for Advanced Biotechnology and Medicine

Cornell University

United States

NIH Postdoctoral Fellow :: Chemistry

Boris Kidric Institute

Serbia

IREX Postdoctoral Fellow :: Theoretical Physics

Education History

University of California Riverside

United States

PHD :: Biochemistry

Eastern Washington University

United States

MSC :: Biology

Purdue University

United States

BSC :: Biology

Publications

Clarissa N Pacyna, Madhanagopal Anandapadamanaban, Kevin W Loudon, Iain M Hay, Olga Perisic, Ruoyan Li, Matthew Byrne, Laura Allen, Kirsty Roberts, Yvette Hooks, Anne Y Warren, Grant D Stewart, Menna R Clatworthy, Sarah A Teichmann, Sam Behjati, Peter J Campbell, Roger L Williams, Thomas J Mitchell
Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis. Oncogene (2024)
Patsy R Tomlinson, Rachel Knox, Olga Perisic, Helen C Su, Gemma V Brierley, Roger L Williams, Robert K Semple
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant. bioRxiv : the preprint server for biology (2023)
Anna C Howes, Olga Perisic, Roger L Williams
Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress. Science advances 9 (39) (2023)
Grace Q Gong, Benoit Bilanges, Ben Allsop, Glenn Robert Masson, Victoria H Roberton, Trevor Askwith, Sally Oxenford, Ralitsa R Madsen, Sarah E Conduit, Dom Bellini, Martina Fitzek, Matt Collier, Osman Najam, Zhenhe He, Ben Wahab, Stephen H McLaughlin, A W Edith Chan, Isabella Feierberg, Andrew Madin, Daniele Morelli, Amandeep Bhamra, Vanesa Vinciauskaite, Karen E Anderson, Silvia Surinova, Nikos Pinotsis, Elena Lopez-Guadamillas, Matthew Wilcox, Alice Hooper, Chandni Patel, Maria A Whitehead, Matilda Katan, Len R Stephens, Phillip T Hawkins, Matilda Katan, Derek M Yellon, Sean M Davidson, David M Smith, James B Phillips, Richard Angell, Roger L Williams, Bart Vanhaesebroeck
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration. Nature (2023)
Wen-Ting Lo, Hassane Belabed, Murat Kücükdisli, Juliane Metag, Yvette Roske, Polina Prokofeva, Yohei Ohashi, André Horatscheck, Davide Cirillo, Michael Krauss, Christopher Schmied, Martin Neuenschwander, Jens Peter von Kries, Guillaume Médard, Bernhard Kuster, Olga Perisic, Roger L Williams, Oliver Daumke, Bernard Payrastre, Sonia Severin, Marc Nazare, Volker Haucke
Development of selective inhibitors of phosphatidylinositol 3-kinase C2α. Nature chemical biology (2022)
Yohei Ohashi, Shirley Tremel, Roger L Williams
Unsaturation, curvature and charge: effects of membrane parameters on PIK3C3/VPS34-containing complexes. Autophagy 17 (3) (2021)
Federico Gulluni, Lorenzo Prever, Huayi Li, Petra Krafcikova, Ilaria Corrado, Wen-Ting Lo, Jean Piero Margaria, Anlu Chen, Maria Chiara De Santis, Sophie Julie A Cnudde, Joseph Fogerty, Alex Yuan, Alberto Massarotti, Nasrin Torabi Sarijalo, Oscar Vadas, Roger L Williams, Marcus Thelen, David R Powell, Markus Schueler, Michael S Wiesener, Tamas Balla, Hagit Baris Feldman, Dov Tiosano, Brian M McDermott, Brian D Perkins, Alessandra Ghigo, Miriam Martini, Volker Haucke, Evzen Boura, Giorgio Roberto Merlo, David A Buchner, Emilio Hirsch
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. Science (New York, N.Y.) 374 (6573) (2021)
Shirley Tremel, Yohei Ohashi, Dustin R Morado, Jessie Bertram, Olga Perisic, Laura T L Brandt, Marie-Kristin von Wrisberg, Zhuo A Chen, Sarah L Maslen, Oleksiy Kovtun, J Mark Skehel, Juri Rappsilber, Kathrin Lang, Sean Munro, John A G Briggs, Roger L Williams
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes. Nature communications 12 (1) (2021)
Maren Heimhalt, Alex Berndt, Jane Wagstaff, Madhanagopal Anandapadamanaban, Olga Perisic, Sarah Maslen, Stephen H McLaughlin, Conny Wing-Heng Yu, Glenn R Masson, Andreas Boland, Xiaodan Ni, Keitaro Yamashita, Garib N Murshudov, Mark Skehel, Stefan M Freund, Roger L Williams
Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. eLife 10 (2021)
Glenn R Masson, Roger L Williams
Structural Mechanisms of PTEN Regulation. Cold Spring Harbor perspectives in medicine 10 (3) (2020)
Natalie K Rynkiewicz, Karen E Anderson, Sabine Suire, Daniel M Collins, Eleftherios Karanasios, Oscar Vadas, Roger L Williams, David Oxley, Jonathan Clark, Len R Stephens, Phillip T Hawkins
Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils. Science signaling 13 (656) (2020)
Madhanagopal Anandapadamanaban, Glenn Robert Masson, Olga Perisic, Alex Berndt, Jonathan G G Kaufman, Christopher M Johnson, Santhanam Balaji, Kacper B Rogala, David M Sabatini, Roger L Williams
Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science (New York, N.Y.) 366 (6462) (2020)
Yohei Ohashi, Shirley Tremel, Glenn Robert Masson, Lauren McGinney, Jerome Boulanger, Ksenia Rostislavleva, Christopher M Johnson, Izabella Niewczas, Jonathan Clark, Roger L Williams
Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes. eLife 9 (2020)
Andrew J Takeda, Timothy J Maher, Yu Zhang, Stephen M Lanahan, Molly L Bucklin, Susan R Compton, Paul M Tyler, William A Comrie, Makoto Matsuda, Kenneth N Olivier, Stefania Pittaluga, Joshua J McElwee, Debra A Long Priel, Douglas B Kuhns, Roger L Williams, Peter J Mustillo, Matthias P Wymann, V Koneti Rao, Carrie L Lucas
Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology. Nature communications 10 (1) (2019)
Heather P Harding, Adriana Ordonez, Felicity Allen, Leopold Parts, Alison J Inglis, Roger L Williams, David Ron
The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells. eLife 8 (2019)
Alison J Inglis, Glenn Robert Masson, Sichen Shao, Olga Perisic, Stephen H McLaughlin, Ramanujan S Hegde, Roger L Williams
Activation of GCN2 by the ribosomal P-stalk. Proceedings of the National Academy of Sciences of the United States of America 116 (11) (2019)
Yohei Ohashi, Shirley Tremel, Roger L Williams
VPS34 complexes from a structural perspective. Journal of lipid research 60 (2) (2018)
N Tsolakos, T N Durrant, T Chessa, S M Suire, D Oxley, S Kulkarni, J Downward, O Perisic, Roger L Williams, L Stephens, P T Hawkins
Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors. Proceedings of the National Academy of Sciences of the United States of America 115 (48) (2018)
Domagoj Baretić, Hannah K Pollard, David I Fisher, Christopher M Johnson, Balaji Santhanam, Caroline M Truman, Tomas Kouba, Alan R Fersht, Christopher Phillips, Roger L Williams
Structures of closed and open conformations of dimeric human ATM. Science advances 3 (5) (2017)
Roger L Williams, Madhanagopal Anandapadamanaban
Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing. Biochemistry 56 (49) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Roger L Williams (Roger Williams, R L Williams)