Douglas A Mitchell

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 92

Top Venues

ACS chemical biology

Journal of the American Chemical Society

Biochemistry

bioRxiv : the preprint server for biology

University of Illinois at Urbana-Champaign

University of California Berkeley (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Illinois at Urbana-Champaign Aug 01 2015 - Aug 15 2018

United States

Associate Professor :: Chemistry

University of Illinois at Urbana-Champaign Aug 01 2009 - Aug 01 2015

United States

Assistant Professor :: Chemistry

Education History

University of California Berkeley Aug 01 2002 - Nov 01 2006

United States

PHD :: Chemistry

Carnegie Mellon University Aug 01 1998 - May 01 2002

United States

BSC :: Chemsitry

Publications

Hengqian Ren, Chunshuai Huang, Yuwei Pan, Shravan R Dommaraju, Haiyang Cui, Mao-Lin Li, Mayuresh G Gadgil, Douglas A Mitchell, Huimin Zhao
Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides. Nature chemistry 16 (8) (2024)
Dinh T Nguyen, Douglas A Mitchell, Wilfred A van der Donk
Genome Mining for New Enzyme Chemistry. ACS catalysis 14 (7) (2024)
Dinh T Nguyen, Douglas A Mitchell, Wilfred A van der Donk
Genome Mining for New Enzyme Chemistry. ACS catalysis 14 (7) (2024)
Austin M Woodard, Francesca Peccati, Claudio D Navo, Gonzalo Jiménez-Osés, Douglas A Mitchell
Darobactin Substrate Engineering and Computation Show Radical Stability Governs Ether versus C-C Bond Formation. Journal of the American Chemical Society 146 (20) (2024)
Hannah N Fernandez, Ashley M Kretsch, Sylvia Kunakom, Adjo E Kadjo, Douglas A Mitchell, Alessandra S Eustáquio
High-Yield Lasso Peptide Production in a Burkholderia Bacterial Host by Plasmid Copy Number Engineering. ACS synthetic biology (2024)
Aileen R Lee, Riley S Carter, Aman S Imani, Shravan R Dommaraju, Graham A Hudson, Douglas A Mitchell, Michael F Freeman
Discovery of Borosin Catalytic Strategies and Function through Bioinformatic Profiling. ACS chemical biology 19 (5) (2024)
Lonnie A Harris, Hamada Saad, Kyle E Shelton, Lingyang Zhu, Xiaorui Guo, Douglas A Mitchell
Tryptophan-Centric Bioinformatics Identifies New Lasso Peptide Modifications. Biochemistry 63 (7) (2024)
Hengqian Ren, Chunshuai Huang, Yuwei Pan, Shravan R Dommaraju, Haiyang Cui, Mao-Lin Li, Mayuresh G Gadgil, Douglas A Mitchell, Huimin Zhao
Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides. Nature chemistry (2024)
Hannah N Fernandez, Ashley M Kretsch, Sylvia Kunakom, Adjo E Kadjo, Douglas A Mitchell, Alessandra S Eustáquio
High-Yield Lasso Peptide Production in a Burkholderia Bacterial Host by Plasmid Copy Number Engineering. ACS synthetic biology 13 (1) (2024)
Aileen R Lee, Riley S Carter, Aman S Imani, Shravan R Dommaraju, Graham A Hudson, Douglas A Mitchell, Michael F Freeman
Discovery of Borosin Catalytic Strategies and Function through Bioinformatic Profiling. ACS chemical biology 19 (5) (2024)
Aileen R Lee, Riley S Carter, Aman S Imani, Shravan R Dommaraju, Graham A Hudson, Douglas A Mitchell, Michael F Freeman
Discovery of Borosin Catalytic Strategies and Function through Bioinformatic Profiling. ACS chemical biology 19 (5) (2024)
Aileen R Lee, Riley S Carter, Aman S Imani, Shravan R Dommaraju, Graham A Hudson, Douglas A Mitchell, Michael F Freeman
Computationally guided exploration of borosin biosynthetic strategies. bioRxiv : the preprint server for biology (2024)
Hengqian Ren, Chunshuai Huang, Yuwei Pan, Shravan R Dommaraju, Haiyang Cui, Mao-Lin Li, Mayuresh G Gadgil, Douglas A Mitchell, Huimin Zhao
Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides. Nature chemistry (2024)
Dinh T Nguyen, Lingyang Zhu, Danielle L Gray, Toby J Woods, Chandrashekhar Padhi, Kristen M Flatt, Douglas A Mitchell, Wilfred A van der Donk
Biosynthesis of Macrocyclic Peptides with C-Terminal β-Amino-α-keto Acid Groups by Three Different Metalloenzymes. ACS central science 10 (5) (2024)
Dinh T Nguyen, Lingyang Zhu, Danielle L Gray, Toby J Woods, Chandrashekhar Padhi, Kristen M Flatt, Douglas A Mitchell, Wilfred A van der Donk
Biosynthesis of Macrocyclic Peptides with C-Terminal β-Amino-α-keto Acid Groups by Three Different Metalloenzymes. ACS central science 10 (5) (2024)
Hengqian Ren, Chunshuai Huang, Yuwei Pan, Shravan R Dommaraju, Haiyang Cui, Mao-Lin Li, Mayuresh G Gadgil, Douglas A Mitchell, Huimin Zhao
Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides. Nature chemistry (2024)
Dinh T Nguyen, Lingyang Zhu, Danielle L Gray, Toby J Woods, Chandrashekhar Padhi, Kristen M Flatt, Douglas A Mitchell, Wilfred A van der Donk
Biosynthesis of Macrocyclic Peptides with C-Terminal β-Amino-α-keto Acid Groups by Three Different Metalloenzymes. ACS central science 10 (5) (2024)
Lonnie A Harris, Hamada Saad, Kyle E Shelton, Lingyang Zhu, Xiaorui Guo, Douglas A Mitchell
Tryptophan-Centric Bioinformatics Identifies New Lasso Peptide Modifications. Biochemistry 63 (7) (2024)
Austin M Woodard, Francesca Peccati, Claudio D Navo, Gonzalo Jiménez-Osés, Douglas A Mitchell
Darobactin Substrate Engineering and Computation Show Radical Stability Governs Ether versus C-C Bond Formation. Journal of the American Chemical Society (2024)
Aileen R Lee, Riley S Carter, Aman S Imani, Shravan R Dommaraju, Graham A Hudson, Douglas A Mitchell, Michael F Freeman
Discovery of Borosin Catalytic Strategies and Function through Bioinformatic Profiling. ACS chemical biology 19 (5) (2024)
Lonnie A Harris, Hamada Saad, Kyle E Shelton, Lingyang Zhu, Xiaorui Guo, Douglas A Mitchell
Tryptophan-Centric Bioinformatics Identifies New Lasso Peptide Modifications. Biochemistry (2024)
Dinh T Nguyen, Douglas A Mitchell, Wilfred A van der Donk
Genome Mining for New Enzyme Chemistry. ACS catalysis 14 (7) (2024)
Hannah N Fernandez, Ashley M Kretsch, Sylvia Kunakom, Adjo E Kadjo, Douglas A Mitchell, Alessandra S Eustáquio
High-Yield Lasso Peptide Production in a Burkholderia Bacterial Host by Plasmid Copy Number Engineering. ACS synthetic biology 13 (1) (2024)
Aileen R Lee, Riley S Carter, Aman S Imani, Shravan R Dommaraju, Graham A Hudson, Douglas A Mitchell, Michael F Freeman
Discovery of Borosin Catalytic Strategies and Function through Bioinformatic Profiling. ACS chemical biology (2024)
Austin M Woodard, Francesca Peccati, Claudio D Navo, Gonzalo Jiménez-Osés, Douglas A Mitchell
Darobactin Substrate Engineering and Computation Show Radical Stability Governs Ether versus C-C Bond Formation. Journal of the American Chemical Society 146 (20) (2024)
Susanna E Barrett, Song Yin, Peter Jordan, John K Brunson, Jessica Gordon-Nunez, Gabriella Costa Machado da Cruz, Christopher Rosario, Bethany K Okada, Kelsey Anderson, Thomas A Pires, Ruoyang Wang, Diwakar Shukla, Mark J Burk, Douglas A Mitchell
Substrate interactions guide cyclase engineering and lasso peptide diversification. Nature chemical biology (2024)
Hannah N Fernandez, Ashley M Kretsch, Sylvia Kunakom, Adjo E Kadjo, Douglas A Mitchell, Alessandra S Eustáquio
High-Yield Lasso Peptide Production in a Burkholderia Bacterial Host by Plasmid Copy Number Engineering. ACS synthetic biology 13 (1) (2024)
Hengqian Ren, Chunshuai Huang, Yuwei Pan, Shravan R Dommaraju, Haiyang Cui, Mao-Lin Li, Mayuresh G Gadgil, Douglas A Mitchell, Huimin Zhao
Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides. Nature chemistry (2024)
Dinh T Nguyen, Lingyang Zhu, Danielle L Gray, Toby J Woods, Chandrashekhar Padhi, Kristen M Flatt, Douglas A Mitchell, Wilfred A van der Donk
Biosynthesis of Macrocyclic Peptides with C-Terminal β-Amino-α-keto Acid Groups by Three Different Metalloenzymes. ACS central science 10 (5) (2024)
Aileen R Lee, Riley S Carter, Aman S Imani, Shravan R Dommaraju, Graham A Hudson, Douglas A Mitchell, Michael F Freeman
Discovery of Borosin Catalytic Strategies and Function through Bioinformatic Profiling. ACS chemical biology 19 (5) (2024)
Aileen R Lee, Riley S Carter, Aman S Imani, Shravan R Dommaraju, Graham A Hudson, Douglas A Mitchell, Michael F Freeman
Computationally guided exploration of borosin biosynthetic strategies. bioRxiv : the preprint server for biology (2024)
Austin M Woodard, Francesca Peccati, Claudio D Navo, Gonzalo Jiménez-Osés, Douglas A Mitchell
Darobactin Substrate Engineering and Computation Show Radical Stability Governs Ether versus C-C Bond Formation. Journal of the American Chemical Society 146 (20) (2024)
Hannah N Fernandez, Ashley M Kretsch, Sylvia Kunakom, Adjo E Kadjo, Douglas A Mitchell, Alessandra S Eustáquio
High-Yield Lasso Peptide Production in a Burkholderia Bacterial Host by Plasmid Copy Number Engineering. ACS synthetic biology 13 (1) (2024)
Hannah N Fernandez, Ashley M Kretsch, Sylvia Kunakom, Adjo E Kadjo, Douglas A Mitchell, Alessandra S Eustáquio
High-Yield Lasso Peptide Production in a Burkholderia Bacterial Host by Plasmid Copy Number Engineering. ACS synthetic biology 13 (1) (2024)
Dinh T Nguyen, Lingyang Zhu, Danielle L Gray, Toby J Woods, Chandrashekhar Padhi, Kristen M Flatt, Douglas A Mitchell, Wilfred A van der Donk
Biosynthesis of Macrocyclic Peptides with C-Terminal β-Amino-α-keto Acid Groups by Three Different Metalloenzymes. ACS central science 10 (5) (2024)
Hengqian Ren, Chunshuai Huang, Yuwei Pan, Shravan R Dommaraju, Haiyang Cui, Mao-Lin Li, Mayuresh G Gadgil, Douglas A Mitchell, Huimin Zhao
Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides. Nature chemistry 16 (8) (2024)
Lonnie A Harris, Hamada Saad, Kyle E Shelton, Lingyang Zhu, Xiaorui Guo, Douglas A Mitchell
Tryptophan-Centric Bioinformatics Identifies New Lasso Peptide Modifications. Biochemistry 63 (7) (2024)
Aileen R Lee, Riley S Carter, Aman S Imani, Shravan R Dommaraju, Graham A Hudson, Douglas A Mitchell, Michael F Freeman
Discovery of Borosin Catalytic Strategies and Function through Bioinformatic Profiling. ACS chemical biology 19 (5) (2024)
Hannah N Fernandez, Ashley M Kretsch, Sylvia Kunakom, Adjo E Kadjo, Douglas A Mitchell, Alessandra S Eustáquio
High-Yield Lasso Peptide Production in a Burkholderia Bacterial Host by Plasmid Copy Number Engineering. ACS synthetic biology 13 (1) (2024)
Aileen R Lee, Riley S Carter, Aman S Imani, Shravan R Dommaraju, Graham A Hudson, Douglas A Mitchell, Michael F Freeman
Discovery of Borosin Catalytic Strategies and Function through Bioinformatic Profiling. ACS chemical biology 19 (5) (2024)
Lonnie A Harris, Hamada Saad, Kyle E Shelton, Lingyang Zhu, Xiaorui Guo, Douglas A Mitchell
Tryptophan-Centric Bioinformatics Identifies New Lasso Peptide Modifications. Biochemistry 63 (7) (2024)
Dinh T Nguyen, Douglas A Mitchell, Wilfred A van der Donk
Genome Mining for New Enzyme Chemistry. ACS catalysis 14 (7) (2024)
Aileen R Lee, Riley S Carter, Aman S Imani, Shravan R Dommaraju, Graham A Hudson, Douglas A Mitchell, Michael F Freeman
Discovery of Borosin Catalytic Strategies and Function through Bioinformatic Profiling. ACS chemical biology 19 (5) (2024)
Dinh T Nguyen, Lingyang Zhu, Douglas A Mitchell, Wilfred A van der Donk
Discovery of biaryl macrocyclic peptides with C-terminal β-amino-α-keto acid groups. bioRxiv : the preprint server for biology (2023)
Hamada Saad, Thomas Majer, Keshab Bhattarai, Sarah Lampe, Dinh T Nguyen, Markus Kramer, Jan Straetener, Heike Br Tz-Oesterhelt, Douglas A Mitchell, Harald Gross
Bioinformatics-Guided Discovery of Biaryl-Tailored Lasso Peptides. bioRxiv : the preprint server for biology (2023)
Austin M Woodard, Francesca Peccati, Claudio D Navo, Gonzalo Jiménez-Osés, Douglas A Mitchell
Benzylic Radical Stabilization Permits Ether Formation During Darobactin Biosynthesis. bioRxiv : the preprint server for biology (2023)
Ashley M Kretsch, Mayuresh G Gadgil, Adam J DiCaprio, Susanna E Barrett, Bryce L Kille, Yuanyuan Si, Lingyang Zhu, Douglas A Mitchell
Peptidase Activation by a Leader Peptide-Bound RiPP Recognition Element. Biochemistry (2023)
Grayson L Chadwick, Aaron M N Joiner, Sangeetha Ramesh, Douglas A Mitchell, Dipti D Nayak
McrD binds asymmetrically to methyl-coenzyme M reductase improving active-site accessibility during assembly. Proceedings of the National Academy of Sciences of the United States of America 120 (25) (2023)
Timothy W Precord, Sangeetha Ramesh, Shravan R Dommaraju, Lonnie A Harris, Bryce L Kille, Douglas A Mitchell
Catalytic Site Proximity Profiling for Functional Unification of Sequence-Diverse Radical S -Adenosylmethionine Enzymes. ACS bio & med chem Au 3 (3) (2023)
Hengqian Ren, Shravan R Dommaraju, Chunshuai Huang, Haiyang Cui, Yuwei Pan, Marko Nesic, Lingyang Zhu, David Sarlah, Douglas A Mitchell, Huimin Zhao
Genome mining unveils a class of ribosomal peptides with two amino termini. bioRxiv : the preprint server for biology (2023)
Ashley M Kretsch, Mayuresh G Gadgil, Adam J DiCaprio, Susanna E Barrett, Bryce L Kille, Yuanyuan Si, Lingyang Zhu, Douglas A Mitchell
Peptidase Activation by a Leader Peptide-Bound RiPP Recognition Element. Biochemistry 62 (4) (2023)
Hengqian Ren, Chunshuai Huang, Yuwei Pan, Haiyang Cui, Shravan R Dommaraju, Douglas A Mitchell, Huimin Zhao
Non-modular Fatty Acid Synthases Yield Unique Acylation in Ribosomal Peptides. bioRxiv : the preprint server for biology (2023)
Ashley M Kretsch, Mayuresh G Gadgil, Adam J DiCaprio, Susanna E Barrett, Bryce L Kille, Yuanyuan Si, Lingyang Zhu, Douglas A Mitchell
Peptidase Activation by a Leader Peptide-Bound RiPP Recognition Element. Biochemistry 62 (4) (2023)
Timothy W Precord, Sangeetha Ramesh, Shravan R Dommaraju, Lonnie A Harris, Bryce L Kille, Douglas A Mitchell
Catalytic Site Proximity Profiling for Functional Unification of Sequence-Diverse Radical S -Adenosylmethionine Enzymes. ACS bio & med chem Au 3 (3) (2023)
Hengqian Ren, Shravan R Dommaraju, Chunshuai Huang, Haiyang Cui, Yuwei Pan, Marko Nesic, Lingyang Zhu, David Sarlah, Douglas A Mitchell, Huimin Zhao
Genome mining unveils a class of ribosomal peptides with two amino termini. bioRxiv : the preprint server for biology (2023)
Hengqian Ren, Shravan R Dommaraju, Chunshuai Huang, Haiyang Cui, Yuwei Pan, Marko Nesic, Lingyang Zhu, David Sarlah, Douglas A Mitchell, Huimin Zhao
Genome mining unveils a class of ribosomal peptides with two amino termini. Nature communications 14 (1) (2023)
Dinh T Nguyen, Tung T Le, Andrew J Rice, Graham A Hudson, Wilfred A van der Donk, Douglas A Mitchell
Accessing Diverse Pyridine-Based Macrocyclic Peptides by a Two-Site Recognition Pathway. Journal of the American Chemical Society 144 (25) (2022)
Andrew J Rice, Jarrett M Pelton, Nicholas J Kramer, Daniel S Catlin, Satish K Nair, Taras V Pogorelov, Douglas A Mitchell, Albert A Bowers
Enzymatic Pyridine Aromatization during Thiopeptide Biosynthesis. Journal of the American Chemical Society 144 (46) (2022)
Chayanid Ongpipattanakul, Emily K Desormeaux, Adam J DiCaprio, Wilfred A van der Donk, Douglas A Mitchell, Satish K Nair
Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides. Chemical reviews 122 (18) (2022)
Richard S Ayikpoe, Chengyou Shi, Alexander J Battiste, Sara M Eslami, Sangeetha Ramesh, Max A Simon, Ian R Bothwell, Hyunji Lee, Andrew J Rice, Hengqian Ren, Qiqi Tian, Lonnie A Harris, Raymond Sarksian, Lingyang Zhu, Autumn M Frerk, Timothy W Precord, Wilfred A van der Donk, Douglas A Mitchell, Huimin Zhao
A scalable platform to discover antimicrobials of ribosomal origin. Nature communications 13 (1) (2022)
Andi Liu, Yuanyuan Si, Shi-Hui Dong, Nilkamal Mahanta, Haley N Penkala, Satish K Nair, Douglas A Mitchell
Functional elucidation of TfuA in peptide backbone thioamidation. Nature chemical biology 17 (5) (2021)
Xiaorui Guo, Jiabao Zhang, Xinyi Li, Emily Xiao, Justin D Lange, Chad M Rienstra, Martin D Burke, Douglas A Mitchell
Sterol Sponge Mechanism Is Conserved for Glycosylated Polyene Macrolides. ACS central science 7 (5) (2021)
Sangeetha Ramesh, Xiaorui Guo, Adam J DiCaprio, Ashley M De Lio, Lonnie A Harris, Bryce L Kille, Taras V Pogorelov, Douglas A Mitchell
Bioinformatics-Guided Expansion and Discovery of Graspetides. ACS chemical biology (2021)
Timothy W Precord, Nilkamal Mahanta, Douglas A Mitchell
Correction to "Reconstitution and Substrate Specificity of the Thioether-Forming Radical S-Adenosylmethionine Enzyme in Freyrasin Biosynthesis". ACS chemical biology 16 (9) (2021)
Graham A Hudson, Brandon J Burkhart, Adam J DiCaprio, Christopher J Schwalen, Bryce Kille, Taras V Pogorelov, Douglas A Mitchell
Correction to "Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides". Journal of the American Chemical Society 143 (27) (2021)
Yuanyuan Si, Ashley M Kretsch, Laura M Daigh, Mark J Burk, Douglas A Mitchell
Cell-Free Biosynthesis to Evaluate Lasso Peptide Formation and Enzyme-Substrate Tolerance. Journal of the American Chemical Society 143 (15) (2021)
Nils Oberg, Timothy W Precord, Douglas A Mitchell, John A Gerlt
RadicalSAM.org: A Resource to Interpret Sequence-Function Space and Discover New Radical SAM Enzyme Chemistry. ACS bio & med chem Au 2 (1) (2021)
Simon Sieber, Simone M Grendelmeier, Lonnie A Harris, Douglas A Mitchell, Karl Gademann
Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach. Journal of natural products 83 (2) (2020)
Mark C Walker, Sara M Eslami, Kenton J Hetrick, Sarah E Ackenhusen, Douglas A Mitchell, Wilfred A van der Donk
Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family. BMC genomics 21 (1) (2020)
Matthew A Georgiou, Shravan R Dommaraju, Xiaorui Guo, David H Mast, Douglas A Mitchell
Bioinformatic and Reactivity-Based Discovery of Linaridins. ACS chemical biology 15 (11) (2020)
Alexander M Kloosterman, Kyle E Shelton, Gilles P van Wezel, Marnix H Medema, Douglas A Mitchell
RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery. mSystems 5 (5) (2020)
Lonnie A Harris, Patricia M B Saint-Vincent, Xiaorui Guo, Graham A Hudson, Adam J DiCaprio, Lingyang Zhu, Douglas A Mitchell
Reactivity-Based Screening for Citrulline-Containing Natural Products Reveals a Family of Bacterial Peptidyl Arginine Deiminases. ACS chemical biology 15 (12) (2020)
Graham A Hudson, Annie R Hooper, Adam J DiCaprio, David Sarlah, Douglas A Mitchell
Structure Prediction and Synthesis of Pyridine-Based Macrocyclic Peptide Natural Products. Organic letters 23 (2) (2020)
Dipti D Nayak, Andi Liu, Neha Agrawal, Roy Rodriguez-Carerro, Shi-Hui Dong, Douglas A Mitchell, Satish K Nair, William W Metcalf
Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans. PLoS biology 18 (2) (2020)
Timothy W Precord, Nilkamal Mahanta, Douglas A Mitchell
Reconstitution and Substrate Specificity of the Thioether-Forming Radical S-Adenosylmethionine Enzyme in Freyrasin Biosynthesis. ACS chemical biology 14 (9) (2019)
Graham A Hudson, Brandon J Burkhart, Adam J DiCaprio, Christopher J Schwalen, Bryce Kille, Taras V Pogorelov, Douglas A Mitchell
Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides. Journal of the American Chemical Society 141 (20) (2019)
Joel O Melby, Xiangpo Li, Douglas A Mitchell
Correction to "Orchestration of Enzymatic Processing by Thiazole/Oxazole-Modified Microcin Dehydrogenases". Biochemistry 59 (4) (2019)
Nilkamal Mahanta, D Miklos Szantai-Kis, E James Petersson, Douglas A Mitchell
Biosynthesis and Chemical Applications of Thioamides. ACS chemical biology 14 (2) (2019)
Julian D Hegemann, Christopher J Schwalen, Douglas A Mitchell, Wilfred A van der Donk
Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin. Chemical communications (Cambridge, England) 54 (65) (2018)
Adam J DiCaprio, Arash Firouzbakht, Graham A Hudson, Douglas A Mitchell
Enzymatic Reconstitution and Biosynthetic Investigation of the Lasso Peptide Fusilassin. Journal of the American Chemical Society 141 (1) (2018)
Nilkamal Mahanta, Andi Liu, Shi-Hui Dong, Satish K Nair, Douglas A Mitchell
Enzymatic reconstitution of ribosomal peptide backbone thioamidation. Proceedings of the National Academy of Sciences of the United States of America 115 (12) (2018)
Christopher J Schwalen, Graham A Hudson, Bryce Kille, Douglas A Mitchell
Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics. Journal of the American Chemical Society 140 (30) (2018)
Nilkamal Mahanta, Graham A Hudson, Douglas A Mitchell
Correction to Radical S-Adenosylmethionine Enzymes Involved in RiPP Biosynthesis. Biochemistry 56 (45) (2017)
Nilkamal Mahanta, Graham A Hudson, Douglas A Mitchell
Radical S-Adenosylmethionine Enzymes Involved in RiPP Biosynthesis. Biochemistry 56 (40) (2017)
Christopher J Schwalen, Graham A Hudson, Simone Kosol, Nilkamal Mahanta, Gregory L Challis, Douglas A Mitchell
In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily. Journal of the American Chemical Society 139 (50) (2017)
Nilkamal Mahanta, Zhengan Zhang, Graham A Hudson, Wilfred A van der Donk, Douglas A Mitchell
Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine Thiazole C-Methyltransferase in Thiomuracin Biosynthesis. Journal of the American Chemical Society 139 (12) (2017)
Tong Si, Bin Li, Troy J Comi, Yuwei Wu, Pingfan Hu, Yuying Wu, Yuhao Min, Douglas A Mitchell, Huimin Zhao, Jonathan V Sweedler
Profiling of Microbial Colonies for High-Throughput Engineering of Multistep Enzymatic Reactions via Optically Guided Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. Journal of the American Chemical Society 139 (36) (2017)
Dillon P Cogan, Graham A Hudson, Zhengan Zhang, Taras V Pogorelov, Wilfred A van der Donk, Douglas A Mitchell, Satish K Nair
Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 114 (49) (2017)
Jonathan I Tietz, Christopher J Schwalen, Parth S Patel, Tucker Maxson, Patricia M Blair, Hua-Chia Tai, Uzma I Zakai, Douglas A Mitchell
A new genome-mining tool redefines the lasso peptide biosynthetic landscape. Nature chemical biology 13 (5) (2017)
Zhengan Zhang, Nilkamal Mahanta, Graham A Hudson, Douglas A Mitchell, Wilfred A van der Donk
Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase. Journal of the American Chemical Society 139 (51) (2017)
Dipti D Nayak, Nilkamal Mahanta, Douglas A Mitchell, William W Metcalf
Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea. eLife 6 (2017)
Brandon J Burkhart, Christopher J Schwalen, Greg Mann, James H Naismith, Douglas A Mitchell
YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function. Chemical reviews 117 (8) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Douglas A Mitchell