Gregory L Challis (G L Challis)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 46

Top Venues

Journal of the American Chemical Society

Nucleic acids research

Journal of the American Society for Mass Spectrometry

Nature chemical biology

Monash University

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Monash University Jul 01 2016

Australia

Monash Warwick Alliance Professor of Sustainable Chemistry (Chemical and Synthetic Biology) :: Biochemistry and Molecular Biology

University of Warwick Jul 01 2016

United Kingdom

Monash Warwick Alliance Professor of Sustainable Chemistry (Chemical and Synthetic Biology) :: Chemistry

Publications

Xinyun Jian, Fang Pang, Christian Hobson, Matthew Jenner, Lona M Alkhalaf, Gregory L Challis
Antibiotic Skeletal Diversification via Differential Enoylreductase Recruitment and Module Iteration in trans -Acyltransferase Polyketide Synthases. Journal of the American Chemical Society 146 (9) (2024)
Yousef Dashti, Fatemeh Mohammadipanah, Yu Zhang, Pietra M Cerqueira Diaz, Anthony Vocat, Daniel Zabala, Christopher D Fage, Isolda Romero-Canelon, Boyke Bunk, Cathrin Spröer, Lona M Alkhalaf, Jörg Overmann, Stewart T Cole, Gregory L Challis
Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active Against Multidrug Resistant Tuberculosis. ACS infectious diseases (2024)
Kairui Wang, Ning Liu, Minghao Liu, Pan Zhao, Naiqin Zhong, Gregory L Challis, Ying Huang
Discovery and Biosynthesis of Streptolateritic Acids A-D: Acyclic Pentacarboxylic Acids from Streptomyces sp. FXJ1.172 with Promising Activity against Potato Common Scab. Journal of agricultural and food chemistry 72 (26) (2024)
Xinyun Jian, Fang Pang, Christian Hobson, Matthew Jenner, Lona M Alkhalaf, Gregory L Challis
Antibiotic Skeletal Diversification via Differential Enoylreductase Recruitment and Module Iteration in trans -Acyltransferase Polyketide Synthases. Journal of the American Chemical Society 146 (9) (2024)
Cameron Baines, Jacob Sargeant, Christopher D Fage, Hannah Pugh, Lona M Alkhalaf, Gregory L Challis, Neil J Oldham
Native ESI-MS and Collision-Induced Unfolding (CIU) of the Complex between Bacterial Elongation Factor-Tu and the Antibiotic Enacyloxin IIa. Journal of the American Society for Mass Spectrometry 35 (7) (2024)
Cameron Baines, Jacob Sargeant, Christopher D Fage, Hannah Pugh, Lona M Alkhalaf, Gregory L Challis, Neil J Oldham
Native ESI-MS and Collision-Induced Unfolding (CIU) of the Complex between Bacterial Elongation Factor-Tu and the Antibiotic Enacyloxin IIa. Journal of the American Society for Mass Spectrometry 35 (7) (2024)
Cameron Baines, Jacob Sargeant, Christopher D Fage, Hannah Pugh, Lona M Alkhalaf, Gregory L Challis, Neil J Oldham
Native ESI-MS and Collision-Induced Unfolding (CIU) of the Complex between Bacterial Elongation Factor-Tu and the Antibiotic Enacyloxin IIa. Journal of the American Society for Mass Spectrometry 35 (7) (2024)
Xinyun Jian, Fang Pang, Christian Hobson, Matthew Jenner, Lona M Alkhalaf, Gregory L Challis
Antibiotic Skeletal Diversification via Differential Enoylreductase Recruitment and Module Iteration in trans -Acyltransferase Polyketide Synthases. Journal of the American Chemical Society 146 (9) (2024)
Xinyun Jian, Fang Pang, Christian Hobson, Matthew Jenner, Lona M Alkhalaf, Gregory L Challis
Antibiotic Skeletal Diversification via Differential Enoylreductase Recruitment and Module Iteration in trans -Acyltransferase Polyketide Synthases. Journal of the American Chemical Society 146 (9) (2024)
Yousef Dashti, Fatemeh Mohammadipanah, Yu Zhang, Pietra M Cerqueira Diaz, Anthony Vocat, Daniel Zabala, Christopher D Fage, Isolda Romero-Canelon, Boyke Bunk, Cathrin Spröer, Lona M Alkhalaf, Jörg Overmann, Stewart T Cole, Gregory L Challis
Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active Against Multidrug Resistant Tuberculosis. ACS infectious diseases (2024)
Xinyun Jian, Fang Pang, Christian Hobson, Matthew Jenner, Lona M Alkhalaf, Gregory L Challis
Antibiotic Skeletal Diversification via Differential Enoylreductase Recruitment and Module Iteration in trans -Acyltransferase Polyketide Synthases. Journal of the American Chemical Society (2024)
Xinyun Jian, Fang Pang, Christian Hobson, Matthew Jenner, Lona M Alkhalaf, Gregory L Challis
Antibiotic Skeletal Diversification via Differential Enoylreductase Recruitment and Module Iteration in trans -Acyltransferase Polyketide Synthases. Journal of the American Chemical Society 146 (9) (2024)
Kairui Wang, Ning Liu, Minghao Liu, Pan Zhao, Naiqin Zhong, Gregory L Challis, Ying Huang
Discovery and Biosynthesis of Streptolateritic Acids A-D: Acyclic Pentacarboxylic Acids from Streptomyces sp. FXJ1.172 with Promising Activity against Potato Common Scab. Journal of agricultural and food chemistry (2024)
Cameron Baines, Jacob Sargeant, Christopher D Fage, Hannah Pugh, Lona M Alkhalaf, Gregory L Challis, Neil J Oldham
Native ESI-MS and Collision-Induced Unfolding (CIU) of the Complex between Bacterial Elongation Factor-Tu and the Antibiotic Enacyloxin IIa. Journal of the American Society for Mass Spectrometry (2024)
Chuan Huang, Daniel Zabala, Emmanuel L C de Los Santos, Lijiang Song, Christophe Corre, Lona M Alkhalaf, Gregory L Challis
Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis. Nucleic acids research (2023)
Chuan Huang, Daniel Zabala, Emmanuel L C de Los Santos, Lijiang Song, Christophe Corre, Lona M Alkhalaf, Gregory L Challis
Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis. Nucleic acids research 51 (3) (2023)
Chuan Huang, Daniel Zabala, Emmanuel L C de Los Santos, Lijiang Song, Christophe Corre, Lona M Alkhalaf, Gregory L Challis
Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis. Nucleic acids research (2023)
Sarah R Messenger, Edward M R McGuinniety, Luke J Stevenson, Jeremy G Owen, Gregory L Challis, David F Ackerley, Mark J Calcott
Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides. Nature chemical biology (2023)
Chuan Huang, Daniel Zabala, Emmanuel L C de Los Santos, Lijiang Song, Christophe Corre, Lona M Alkhalaf, Gregory L Challis
Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis. Nucleic acids research (2023)
Christopher D Fage, Munro Passmore, Ben P Tatman, Helen G Smith, Xinyun Jian, Upeksha C Dissanayake, Gerardo Andrés Cisneros, Gregory L Challis, Jozef R Lewandowski, Matthew Jenner
Molecular basis for short-chain thioester hydrolysis by acyl hydrolase domains in trans -acyltransferase polyketide synthases. bioRxiv : the preprint server for biology (2023)
Chuan Huang, Daniel Zabala, Emmanuel L C de Los Santos, Lijiang Song, Christophe Corre, Lona M Alkhalaf, Gregory L Challis
Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis. Nucleic acids research 51 (3) (2023)
Chuan Huang, Daniel Zabala, Emmanuel L C de Los Santos, Lijiang Song, Christophe Corre, Lona M Alkhalaf, Gregory L Challis
Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis. Nucleic acids research 51 (3) (2023)
Yoana D Petrova, Jinlian Zhao, Gordon Webster, Alex J Mullins, Katherine Williams, Amal S Alswat, Gregory L Challis, Andrew M Bailey, Eshwar Mahenthiralingam
Cloning and expression of Burkholderia polyyne biosynthetic gene clusters in Paraburkholderia hosts provides a strategy for biopesticide development. Microbial biotechnology 15 (10) (2022)
Christian Hobson, Matthew Jenner, Xinyun Jian, Daniel Griffiths, Douglas M Roberts, Matias Rey-Carrizo, Gregory L Challis
Diene incorporation by a dehydratase domain variant in modular polyketide synthases. Nature chemical biology 18 (12) (2022)
Thierry Izoré, Y T Candace Ho, Joe A Kaczmarski, Athina Gavriilidou, Ka Ho Chow, David L Steer, Robert J A Goode, Ralf Bernd Schittenhelm, Julien Tailhades, Manuela Tosin, Gregory L Challis, Elizabeth H Krenske, Nadine Ziemert, Colin J Jackson, Max J Cryle
Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity. Nature communications 12 (1) (2021)
Jieyan Lim, Venkaiah Chintalapudi, Haraldur G Gudmundsson, Minh Tran, Alice Bernasconi, Araceli Blanco, Lijiang Song, Gregory L Challis, Edward A Anderson
Synthesis of the C1-C27 Fragment of Stambomycin D Validates Modular Polyketide Synthase-Based Stereochemical Assignments. Organic letters 23 (19) (2021)
Rakesh Saroay, Gheorghe-Doru Roiban, Lona M Alkhalaf, Gregory L Challis
Expanding the Substrate Scope of Nitrating Cytochrome P450 TxtE by Active Site Engineering of a Reductase Fusion. Chembiochem : a European journal of chemical biology 22 (13) (2021)
Shanshan Zhou, Hussain Bhukya, Nicolas Malet, Peter J Harrison, Dean Rea, Matthew J Belousoff, Hariprasad Venugopal, Paulina K Sydor, Kathryn M Styles, Lijiang Song, Max J Cryle, Lona M Alkhalaf, Vilmos Fülöp, Gregory L Challis, Christophe Corre
Molecular basis for control of antibiotic production by a bacterial hormone. Nature 590 (7846) (2021)
Helen G Smith, Matthew J Beech, Jozef R Lewandowski, Gregory L Challis, Matthew Jenner
Docking domain-mediated subunit interactions in natural product megasynth(et)ases. Journal of industrial microbiology & biotechnology 48 (3-4) (2021)
Paul G Becher, Vasiliki Verschut, Maureen J Bibb, Matthew J Bush, Béla P Molnár, Elisabeth Barane, Mahmoud M Al-Bassam, Govind Chandra, Lijiang Song, Gregory L Challis, Mark J Buttner, Klas Flärdh
Developmentally regulated volatiles geosmin and 2-methylisoborneol attract a soil arthropod to Streptomyces bacteria promoting spore dispersal. Nature microbiology 5 (6) (2020)
Ioanna T Nakou, Matthew Jenner, Yousef Dashti, Isolda Romero-Canelon, Joleen Masschelein, Eshwar Mahenthiralingam, Gregory L Challis
Genomics-Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism. Angewandte Chemie (International ed. in English) 59 (51) (2020)
Alex J Mullins, Cerith Jones, Matthew J Bull, Gordon Webster, Julian Parkhill, Thomas Richard Connor, James A H Murray, Gregory L Challis, Eshwar Mahenthiralingam
Genomic Assemblies of Members of Burkholderia and Related Genera as a Resource for Natural Product Discovery. Microbiology resource announcements 9 (42) (2020)
Yousef Dashti, Ioanna T Nakou, Alex J Mullins, Gordon Webster, Xinyun Jian, Eshwar Mahenthiralingam, Gregory L Challis
Discovery and Biosynthesis of Bolagladins: Unusual Lipodepsipeptides from Burkholderia gladioli Clinical Isolates*. Angewandte Chemie (International ed. in English) 59 (48) (2020)
Savvas Louka, Sarah M Barry, Derren J Heyes, M Qadri E Mubarak, Hafiz Saqib Ali, Lona M Alkhalaf, Andrew W Munro, Nigel S Scrutton, Gregory L Challis, Sam P De Visser
Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate. Journal of the American Chemical Society 142 (37) (2020)
Joleen Masschelein, Paulina K Sydor, Christian Hobson, Rhiannon Howe, Cerith Jones, Douglas M Roberts, Zhong Ling Yap, Julian Parkhill, Eshwar Mahenthiralingam, Gregory L Challis
A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis. Nature chemistry 11 (10) (2019)
Shanshan Zhou, Lijiang Song, Joleen Masschelein, Felaine A M Sumang, Irene A Papa, Teofila O Zulaybar, Aileen B Custodio, Daniel Zabala, Edwin P Alcantara, Emmanuel L C de Los Santos, Gregory L Challis
Pentamycin Biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-Catalyzed Installation of the C-14 Hydroxyl Group. ACS chemical biology 14 (6) (2019)
Matthew Jenner, Xinyun Jian, Yousef Dashti, Joleen Masschelein, Christian Hobson, Douglas M Roberts, Cerith Jones, Simon R Harris, Julian Parkhill, Huzefa A Raja, Nicholas H Oberliels, Cedric J Pearce, Eshwar Mahenthiralingam, Gregory L Challis
An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles 'fungal' icosalide antibiotics. Chemical science 10 (21) (2019)
Jade L Ronan, Nadia Kadi, Stephen A McMahon, James H Naismith, Lona M Alkhalaf, Gregory L Challis
Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 373 (1748) (2019)
Simone Kosol, Angelo Gallo, Daniel Griffiths, Timothy R Valentic, Joleen Masschelein, Matthew Jenner, Emmanuel L C de Los Santos, Lucio Manzi, Paulina K Sydor, Dean Rea, Shanshan Zhou, Vilmos Fülöp, Neil J Oldham, Shiou-Chuan Tsai, Gregory L Challis, Jozef R Lewandowski
Structural basis for chain release from the enacyloxin polyketide synthase. Nature chemistry 11 (10) (2019)
Alex J Mullins, James A H Murray, Matthew J Bull, Matthew Jenner, Cerith Jones, Gordon Webster, Angharad E Green, Daniel R Neill, Thomas Richard Connor, Julian Parkhill, Gregory L Challis, Eshwar Mahenthiralingam
Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria. Nature microbiology 4 (6) (2019)
Matthew Jenner, Simone Kosol, Daniel Griffiths, Panward Prasongpholchai, Lucio Manzi, Andrew S Barrow, John E Moses, Neil J Oldham, Jozef R Lewandowski, Gregory L Challis
Mechanism of intersubunit ketosynthase-dehydratase interaction in polyketide synthases. Nature chemical biology 14 (3) (2018)
Lona M Alkhalaf, Sarah M Barry, Dean Rea, Angelo Gallo, Daniel Griffiths, Józef R Lewandowski, Vilmos Fulop, Gregory L Challis
Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC. Journal of the American Chemical Society 141 (1) (2018)
J Masschelein, Matthew Jenner, Gregory L Challis
Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights. Natural product reports 34 (7) (2017)
Yuki Inahashi, Shanshan Zhou, Maureen J Bibb, Lijiang Song, Mahmoud M Al-Bassam, Mervyn J Bibb, Gregory L Challis
Watasemycin biosynthesis in Streptomyces venezuelae: thiazoline C-methylation by a type B radical-SAM methylase homologue. Chemical science 8 (4) (2017)
Lijiang Song, Matthew Jenner, Joleen Masschelein, Cerith Jones, Matthew J Bull, Simon R Harris, Ruben C Hartkoorn, Anthony Vocat, Isolda Romero-Canelon, Paul Coupland, Gordon Webster, Matthew Dunn, Rebecca Weiser, Christopher Paisey, Stewart T Cole, Julian Parkhill, Eshwar Mahenthiralingam, Gregory L Challis
Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis. Journal of the American Chemical Society 139 (23) (2017)
Christopher J Schwalen, Graham A Hudson, Simone Kosol, Nilkamal Mahanta, Gregory L Challis, Douglas A Mitchell
In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily. Journal of the American Chemical Society 139 (50) (2017)

Gregory L Challis.css-eqlu8i{font-size:small;padding-left:4px;} (G L Challis)

Publication Activity (10 Years)

Top Topics

Top Venues

Gregory L Challis (G L Challis)