Felix Hausch

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 31

Top Topics

Molecular Docking

Binding Protein

Posttraumatic Stress Disorder

Top Venues

Journal of medicinal chemistry

Chemistry (Weinheim an der Bergstrasse, Germany)

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Vanessa Buffa, Christian Meyners, Wisely Oki Sugiarto, Michael Bauder, Steffen Gaali, Felix Hausch
1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. ChemMedChem (2024)
Vanessa Buffa, Christian Meyners, Wisely Oki Sugiarto, Michael Bauder, Steffen Gaali, Felix Hausch
1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. ChemMedChem 19 (17) (2024)
Christian Brudy, Carlo Walz, Moritz Spiske, Johannes K Dreizler, Felix Hausch
The Missing Link(er): A Roadmap to Macrocyclization in Drug Discovery. Journal of medicinal chemistry (2024)
Anna Charalampidou, Thomas Nehls, Christian Meyners, Satish Gandhesiri, Sebastian J Pomplun, Bradley L Pentelute, Frederik Lermyte, Felix Hausch
Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets. ACS central science 10 (3) (2024)
Vanessa Buffa, Christian Meyners, Wisely Oki Sugiarto, Michael Bauder, Steffen Gaali, Felix Hausch
1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. ChemMedChem 19 (17) (2024)
Patryk Krajczy, Christian Meyners, Maximilian L Repity, Felix Hausch
Structure-Based Design of Ultrapotent Tricyclic Ligands for FK506-Binding Proteins. Chemistry (Weinheim an der Bergstrasse, Germany) (2024)
Patryk Krajczy, Christian Meyners, Maximilian L Repity, Felix Hausch
Structure-Based Design of Ultrapotent Tricyclic Ligands for FK506-Binding Proteins. Chemistry (Weinheim an der Bergstrasse, Germany) 30 (45) (2024)
Anna Charalampidou, Thomas Nehls, Christian Meyners, Satish Gandhesiri, Sebastian J Pomplun, Bradley L Pentelute, Frederik Lermyte, Felix Hausch
Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets. ACS central science 10 (3) (2024)
Patrick L Purder, Christian Meyners, Wisely Oki Sugiarto, Jürgen Kolos, Frank Loehr, Jakob Gebel, Thomas Nehls, Volker Dötsch, Frederik Lermyte, Felix Hausch
Deconstructing Protein Binding of Sulfonamides and Sulfonamide Analogues. JACS Au 3 (9) (2023)
Asat Baischew, Sarah Engel, Martha C Taubert, Thomas M Geiger, Felix Hausch
Large-scale, in-cell photocrosslinking at single-residue resolution reveals the molecular basis for glucocorticoid receptor regulation by immunophilins. Nature structural & molecular biology (2023)
Asat Baischew, Sarah Engel, Thomas M Geiger, Martha C Taubert, Felix Hausch
Structural and biochemical insights into FKBP51 as a Hsp90 co-chaperone. Journal of cellular biochemistry (2023)
Vanessa Buffa, Fabian H Knaup, Tim Heymann, Margherita Springer, Mathias V Schmidt, Felix Hausch
Analysis of the Selective Antagonist SAFit2 as a Chemical Probe for the FK506-Binding Protein 51. ACS pharmacology & translational science 6 (3) (2023)
Fabian H Knaup, Christian Meyners, Wisely Oki Sugiarto, Saskia Wedel, Margherita Springer, Carlo Walz, Thomas M Geiger, Mathias Schmidt, Marco Sisignano, Felix Hausch
Structure-Based Discovery of a New Selectivity-Enabling Motif for the FK506-Binding Protein 51. Journal of medicinal chemistry (2023)
Vanessa Buffa, Fabian H Knaup, Tim Heymann, Margherita Springer, Mathias V Schmidt, Felix Hausch
Analysis of the Selective Antagonist SAFit2 as a Chemical Probe for the FK506-Binding Protein 51. ACS pharmacology & translational science 6 (3) (2023)
Patrick L Purder, Christian Meyners, Sergii Krysenko, Jonathan Funk, Wolfgang Wohlleben, Felix Hausch
Mechanism-Based Design of the First GlnA4-Specific Inhibitors. Chembiochem : a European journal of chemical biology 23 (19) (2022)
Michael Bauder, Christian Meyners, Patrick L Purder, Stephanie Merz, Wisely Oki Sugiarto, Andreas M Voll, Tim Heymann, Felix Hausch
Structure-Based Design of High-Affinity Macrocyclic FKBP51 Inhibitors. Journal of medicinal chemistry 64 (6) (2021)
Monika T Gnatzy, Thomas M Geiger, Angela Kuehn, Niklas Gutfreund, Michael Walz, Jürgen M Kolos, Felix Hausch
Development of NanoBRET-Binding Assays for FKBP-Ligand Profiling in Living Cells. Chembiochem : a European journal of chemical biology 22 (13) (2021)
Barbara J Bailus, Stephen M Scheeler, Jesse Simons, Maria A Sanchez, Kizito-Tshitoko Tshilenge, Jordi Creus-Muncunill, Swati Naphade, Alejandro Lopez-Ramirez, Ningzhe Zhang, Kuruwitage Lakshika Madushani, Stanislav Moroz, Ashley Loureiro, Katherine H Schreiber, Felix Hausch, Brian K Kennedy, Michelle E Ehrlich, Lisa M Ellerby
Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels. Autophagy (2021)
Andreas M Voll, Christian Meyners, Martha C Taubert, Thomas Bajaj, Tim Heymann, Stephanie Merz, Anna Charalampidou, Jürgen Kolos, Patrick L Purder, Thomas M Geiger, Pablo Wessig, Nils C Gassen, Andreas Bracher, Felix Hausch
Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity. Angewandte Chemie (International ed. in English) 60 (24) (2021)
Jürgen M Kolos, Sebastian J Pomplun, Sascha Jung, Benedikt Rieß, Patrick L Purder, Andreas M Voll, Stephanie Merz, Monika Gnatzy, Thomas M Geiger, Ingrid Quist-Løkken, Jerome Jatzlau, Petra Knaus, Toril Holien, Andreas Bracher, Christian Meyners, Paul Czodrowski, Vera Krewald, Felix Hausch
Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides. Chemical science 12 (44) (2021)
Fabian H Knaup, Christian Meyners, Anna Charalampidou, Patryk Krajczy, Patrick L Purder, Tatjana Ross, Felix Hausch
Med Chem Remote: The Frontiers in Medicinal Chemistry 2021. ChemMedChem 16 (15) (2021)
Silvia Martinelli, Elmira A Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E Heinz, Tim Ebert, Jakob Hartmann, Thomas M Geiger, Michael Döngi, Kathrin Hafner, Max L Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W Turck, Mathias V Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils Christian Gassen
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion. Nature communications 12 (1) (2021)
Matthias Bischoff, Peter Mayer, Christian Meyners, Felix Hausch
Enantioselective Synthesis of a Tricyclic, sp3 -Rich Diazatetradecanedione: an Amino Acid-Based Natural Product-Like Scaffold. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (21) (2020)
Pravin Kumar Ankush Jagtap, Tomáš Kubelka, Komal Soni, Cindy L Will, Divita Garg, Claudia Sippel, Tobias G Kapp, Harish Kumar Potukuchi, Kenji Schorpp, Kamyar Hadian, Horst Kessler, Reinhard Lührmann, Felix Hausch, Thorsten Bach, Michael Sattler
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly. Nature communications 11 (1) (2020)
Andreas Hähle, Stephanie Merz, Christian Meyners, Felix Hausch
The Many Faces of FKBP51. Biomolecules 9 (1) (2019)
Daniel Tietze, Desireé Kaufmann, Alesia A Tietze, Andreas Voll, Raphael Reher, Gabriele König, Felix Hausch
Structural and Dynamical Basis of G Protein Inhibition by YM-254890 and FR900359: An Inhibitor in Action. Journal of chemical information and modeling 59 (10) (2019)
Xixi Feng, Claudia Sippel, Fabian H Knaup, Andreas Bracher, Stefania Staibano, Maria F Romano, Felix Hausch
A Novel Decalin-Based Bicyclic Scaffold for FKBP51-Selective Ligands. Journal of medicinal chemistry 63 (1) (2019)
Paolo D'Arrigo, Marina Digregorio, Simona Romano, Martina Tufano, Anna Rea, Felix Hausch, Matthias Dedobbeleer, Vincenza Vigorito, Salvatore Russo, Michael Bauder, Bernard Rogister, Maria Fiammetta Romano
The splicing FK506-binding protein-51 isoform plays a role in glioblastoma resistance through programmed cell death ligand-1 expression regulation. Cell death discovery 5 (2019)
Andreas Hähle, Thomas M Geiger, Stephanie Merz, Christian Meyners, Mao Tianqi, Jürgen Kolos, Felix Hausch
FKBP51 and FKBP12.6-Novel and tight interactors of Glomulin. PloS one 14 (9) (2019)
Sebastian Pomplun, Claudia Sippel, Andreas Hähle, Donald Tay, Kensuke Shima, Alina Klages, Can Murat Ünal, Benedikt Rieß, Hui Ting Toh, Guido Hansen, Ho Sup Yoon, Andreas Bracher, Peter Preiser, Jan Rupp, Michael Steinert, Felix Hausch
Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins. Journal of medicinal chemistry 61 (8) (2018)
Felix Hausch
Cryo-EM Structures of Class B GPCR Reveal the Activation Mechanism. Angewandte Chemie (International ed. in English) 56 (41) (2017)