Francisco León (Lance R McMahon, Francisco Leon)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 31

Top Venues

Molecules (Basel, Switzerland)

Journal of the American Chemical Society

ACS medicinal chemistry letters

Journal of medicinal chemistry

University of South Carolina

Universidad de La Laguna (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of South Carolina Aug 20 2020

United States

Assistant Professor :: Drug Discovery and Biomedical Sciences

University of Florida Jun 19 2017 - May 30 2019

United States

Assistant Scientist :: Medicinal Chemistry

University of Mississippi School of Pharmacy - Jun 16 2017

United States

Research Scientist :: BioMolecular Sciences

Instituto de Productos Naturales y Agrobiología

Spain

Doctor :: Fitoquimica

University of Mississippi School of Pharmacy

United States

Postdoctoral Associate :: Medicinal Chemistry

Universidad Europea de Madrid

Spain

Postdoc :: Politecnico

Universidad de La Laguna Facultad de Química

Spain

postdoc :: Instituto Universitario de Bioorganica Antonio Gonzalez

Education History

Universidad de La Laguna

Spain

PHD :: Organic Chemistry

Publications

Jorge Ivan Castillo-Arellano, Zachary Stryker, Michael D Wyatt, Francisco León
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones. ACS medicinal chemistry letters 15 (5) (2024)
Jorge Ivan Castillo-Arellano, Zachary Stryker, Michael D Wyatt, Francisco León
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones. ACS medicinal chemistry letters 15 (5) (2024)
Jorge Ivan Castillo-Arellano, Zachary Stryker, Michael D Wyatt, Francisco León
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones. ACS medicinal chemistry letters 15 (5) (2024)
Farida Larit, Francisco León
Therapeutics to Treat Psychiatric and Neurological Disorders: A Promising Perspective from Algerian Traditional Medicine. Plants (Basel, Switzerland) 12 (22) (2023)
Nelson Jeng-Yeou Chear, Tan Ai Fein Ching-Ga, Kooi Yeong Khaw, Francisco León, Tan Wen Nee, Siti R Yusof, Christopher R McCurdy, Vikneswaran Murugaiyah, Surash Ramanathan
Natural Corynanthe-Type Cholinesterase Inhibitors from Malaysian Uncaria attenuata Korth.: Isolation, Characterization, In Vitro and In Silico Studies. Metabolites 13 (3) (2023)
Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T Dang, Larissa C Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R McCurdy, Sarah Ellen O'connor
Directed Biosynthesis of Mitragynine Stereoisomers. Journal of the American Chemical Society 145 (9) (2023)
Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T Dang, Larissa C Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R McCurdy, Sarah Ellen O'connor
Directed Biosynthesis of Mitragynine Stereoisomers. Journal of the American Chemical Society 145 (9) (2023)
Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T Dang, Larissa C Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R McCurdy, Sarah Ellen O'connor
Directed Biosynthesis of Mitragynine Stereoisomers. Journal of the American Chemical Society 145 (9) (2023)
Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T Dang, Larissa C Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R McCurdy, Sarah Ellen O'connor
Directed Biosynthesis of Mitragynine Stereoisomers. Journal of the American Chemical Society 145 (9) (2023)
Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T Dang, Larissa C Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R McCurdy, Sarah Ellen O'connor
Directed Biosynthesis of Mitragynine Stereoisomers. Journal of the American Chemical Society 145 (9) (2023)
Jorge Ivan Castillo-Arellano, Ana Canseco-Alba, Stephen J Cutler, Francisco León
The Polypharmacological Effects of Cannabidiol. Molecules (Basel, Switzerland) 28 (7) (2023)
Nelson Jeng-Yeou Chear, Tan Ai Fein Ching-Ga, Kooi Yeong Khaw, Francisco León, Tan Wen Nee, Siti R Yusof, Christopher R McCurdy, Vikneswaran Murugaiyah, Surash Ramanathan
Natural Corynanthe-Type Cholinesterase Inhibitors from Malaysian Uncaria attenuata Korth.: Isolation, Characterization, In Vitro and In Silico Studies. Metabolites 13 (3) (2023)
Shyam H Kamble, Samuel Obeng, Francisco León, Luis F Restrepo, Tamara I King, Erin C Berthold, Siva Rama Raju Kanumuri, Lea R Gamez-Jimenez, Victoria Lc Pallares, Avi Patel, Nicholas P Ho, Aidan Hampson, Christopher R McCurdy, Lance R McMahon, Jenny L Wilkerson, Abhisheak Sharma, Takato Hiranita
Pharmacokinetic and Pharmacodynamic Consequences of CYP3A Inhibition on Mitragynine Metabolism in Rats . The Journal of pharmacology and experimental therapeutics (2023)
Nelson Jeng-Yeou Chear, Tan Ai Fein Ching-Ga, Kooi Yeong Khaw, Francisco León, Tan Wen Nee, Siti R Yusof, Christopher R McCurdy, Vikneswaran Murugaiyah, Surash Ramanathan
Natural Corynanthe-Type Cholinesterase Inhibitors from Malaysian Uncaria attenuata Korth.: Isolation, Characterization, In Vitro and In Silico Studies. Metabolites 13 (3) (2023)
Samuel Obeng, Francisco León, Avi Patel, Julio D Zuarth Gonzalez, Lucas Chaves Da Silva, Luis F Restrepo, Lea R Gamez-Jimenez, Nicholas P Ho, Maria P Guerrero Calvache, Victoria L C Pallares, Justin A Helmes, Sakura K Shiomitsu, Paul L Soto, Christopher R McCurdy, Lance R McMahon, Jenny L Wilkerson, Takato Hiranita
Interactive Effects of µ -Opioid and Adrenergic- α 2 Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine. The Journal of pharmacology and experimental therapeutics 383 (3) (2022)
Narayan D Chaurasiya, Francisco León, Ilias Muhammad, Babu L Tekwani
Natural Products Inhibitors of Monoamine Oxidases-Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma. Molecules (Basel, Switzerland) 27 (13) (2022)
Mengzi Zhang, Abhisheak Sharma, Francisco León, Bonnie Avery, Roger Kjelgren, Christopher R McCurdy, Brian J Pearson
Plant growth and phytoactive alkaloid synthesis in kratom [Mitragyna speciosa (Korth.)] in response to varying radiance. PloS one 17 (4) (2022)
Nelson Jeng-Yeou Chear, Francisco León, Abhisheak Sharma, Siva Rama Raju Kanumuri, Grant Zwolinski, Khalil A Abboud, Darshan Singh, Luis F Restrepo, Avi Patel, Takato Hiranita, Surash Ramanathan, Aidan J Hampson, Lance R McMahon, Christopher R McCurdy
Exploring the Chemistry of Alkaloids from Malaysian Mitragyna speciosa (Kratom) and the Role of Oxindoles on Human Opioid Receptors. Journal of natural products 84 (4) (2021)
Farida Larit, Khaled M Elokely, Manal A Nael, Samira Benyahia, Francisco León, Stephen J Cutler, Mohammed M Ghoneim
Proposed Mechanism for the Antitrypanosomal Activity of Quercetin and Myricetin Isolated from Hypericum afrum Lam.: Phytochemistry, In Vitro Testing and Modeling Studies. Molecules (Basel, Switzerland) 26 (4) (2021)
Shyam H Kamble, Erin C Berthold, Tamara I King, Siva Rama Raju Kanumuri, Raluca Popa, Julius R Herting, Francisco León, Abhisheak Sharma, Lance R McMahon, Bonnie A Avery, Christopher R McCurdy
Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. Journal of natural products 84 (4) (2021)
Francisco León, Samuel Obeng, Marco Mottinelli, Yiming Chen, Tamara I King, Erin C Berthold, Shyam H Kamble, Luis F Restrepo, Avi Patel, Lea R Gamez-Jimenez, Carolina Lopera-Londoño, Takato Hiranita, Abhisheak Sharma, Aidan J Hampson, Clinton E Canal, Lance R McMahon, Christopher R McCurdy
Activity of Mitragyna speciosa ("Kratom") Alkaloids at Serotonin Receptors. Journal of medicinal chemistry 64 (18) (2021)
Vedanjali Gogineni, Manal A Nael, Narayan D Chaurasiya, Khaled M Elokely, Christopher R McCurdy, John M Rimoldi, Stephen J Cutler, Babu L Tekwani, Francisco León
Computationally Assisted Lead Optimization of Novel Potent and Selective MAO-B Inhibitors. Biomedicines 9 (10) (2021)
Samuel Obeng, Takato Hiranita, Francisco León, Francisco León, Christopher R McCurdy
Novel Approaches, Drug Candidates, and Targets in Pain Drug Discovery. Journal of medicinal chemistry 64 (10) (2021)
Mohamed Jahan, Francisco León, Frank R Fronczek, Khaled M Elokely, John Rimoldi, Shabana I Khan, Mitchell A Avery
Structure-Activity Relationships of the Antimalarial Agent Artemisinin 10. Synthesis and Antimalarial Activity of Enantiomers of rac-5β-Hydroxy-d-Secoartemisinin and Analogs: Implications Regarding the Mechanism of Action. Molecules (Basel, Switzerland) 26 (14) (2021)
Erin C Berthold, Shyam H Kamble, Kanumuri S Raju, Michelle A Kuntz, Alexandria S Senetra, Marco Mottinelli, Francisco León, Luis F Restrepo, Avi Patel, Nicholas P Ho, Takato Hiranita, Abhisheak Sharma, Lance R McMahon, Christopher R McCurdy
The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study. Drug metabolism and disposition: the biological fate of chemicals (2021)
Francisco Estévez-Sarmiento, Ester Saavedra, Mercedes Ruiz-Estévez, Francisco León, José Quintana, Ignacio Brouard, Francisco Estévez
Chlorinated Guaiane-Type Sesquiterpene Lactones as Cytotoxic Agents against Human Tumor Cells. International journal of molecular sciences 21 (24) (2020)
Farida Larit, Francisco León, Samira Benyahia, Stephen J Cutler
Total Phenolic and Flavonoid Content and Biological Activities of Extracts and Isolated Compounds of Cytisus villosus Pourr. Biomolecules 9 (11) (2019)
Isabel Gómez-Betancur, Vedanjali Gogineni, Andrea Salazar-Ospina, Francisco León
Perspective on the Therapeutics of Anti-Snake Venom. Molecules (Basel, Switzerland) 24 (18) (2019)
Samuel Obeng, Shyam H Kamble, Morgan E Reeves, Luis F Restrepo, Avi Patel, Mira Behnke, Nelson J-Y Chear, Surash Ramanathan, Abhisheak Sharma, Francisco León, Takato Hiranita, Bonnie A Avery, Lance R McMahon, Christopher R McCurdy
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. Journal of medicinal chemistry 63 (1) (2019)
Neha Rana, Jason M Conley, Monica Soto-Velasquez, Francisco León, Stephen J Cutler, Val J Watts, Markus A Lill
Molecular Modeling Evaluation of the Enantiomers of a Novel Adenylyl Cyclase 2 Inhibitor. Journal of chemical information and modeling 57 (2) (2017)
Narayan D Chaurasiya, Francisco León, Yuanqing Ding, Isabel Gómez-Betancur, Dora Benjumea, Larry A Walker, Stephen J Cutler, Babu L Tekwani
Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B. Evidence-based complementary and alternative medicine : eCAM 2017 (2017)

Francisco León.css-eqlu8i{font-size:small;padding-left:4px;} (Lance R McMahon, Francisco Leon)

Publication Activity (10 Years)

Top Topics

Top Venues

Francisco León (Lance R McMahon, Francisco Leon)