Sarah Ellen O'connor (Sarah E O' Connor, Sarah E O'Connor, Sarah Ellen O'Connor)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 58

Top Venues

Journal of the American Chemical Society

Nature chemical biology

Proceedings of the National Academy of Sciences of the United States of America

The New phytologist

Max Planck Institute for Chemical Ecology

Massachusetts Institute of Technology (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Max Planck Institute for Chemical Ecology Jul 01 2019

Germany

Director :: Natural Product Biosynthesis

Education History

Massachusetts Institute of Technology

United States

PHD :: Chemistry

University of Chicago

United States

BSC :: Chemistry

Publications

Mai Uzaki, Tetsuya Mori, Mayuko Sato, Mayumi Wakazaki, Noriko Takeda-Kamiya, Kotaro Yamamoto, Akio Murakami, Delia Ayled Serna Guerrero, Chizuko Shichijo, Miwa Ohnishi, Kimitsune Ishizaki, Hidehiro Fukaki, Sarah Ellen O'connor, Kiminori Toyooka, Tetsuro Mimura, Masami Yokota Hirai
Integration of cell differentiation and initiation of monoterpenoid indole alkaloid metabolism in seed germination of Catharanthus roseus. The New phytologist 242 (3) (2024)
Matthew D DeMars, Sarah Ellen O'connor
Evolution and diversification of carboxylesterase-like [4+2] cyclases in aspidosperma and iboga alkaloid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Dagny Grzech, Samuel Jacobus Smit, Ryan M Alam, Marianna Boccia, Yoko Nakamura, Benke Hong, Ranjit Barbole, Sarah Heinicke, Maritta Kunert, Wibke Seibt, Veit Grabe, Lorenzo Caputi, Benjamin R Lichman, Sarah Ellen O'connor, Asaph Aharoni, Prashant D Sonawane
Incorporation of nitrogen in antinutritional Solanum alkaloid biosynthesis. Nature chemical biology (2024)
Anh Hai Vu, Moonyoung Kang, Jens Wurlitzer, Sarah Heinicke, Chenxin Li, Joshua C Wood, Veit Grabe, C Robin Buell, Lorenzo Caputi, Sarah Ellen O'connor
Quantitative Single-Cell Mass Spectrometry Provides a Highly Resolved Analysis of Natural Product Biosynthesis Partitioning in Plants. Journal of the American Chemical Society 146 (34) (2024)
Anh Hai Vu, Moonyoung Kang, Jens Wurlitzer, Sarah Heinicke, Chenxin Li, Joshua C Wood, Veit Grabe, C Robin Buell, Lorenzo Caputi, Sarah Ellen O'connor
Quantitative Single-Cell Mass Spectrometry Provides a Highly Resolved Analysis of Natural Product Biosynthesis Partitioning in Plants. Journal of the American Chemical Society (2024)
Matthew D DeMars, Sarah Ellen O'connor
Evolution and diversification of carboxylesterase-like [4+2] cyclases in aspidosperma and iboga alkaloid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Anh Hai Vu, Moonyoung Kang, Jens Wurlitzer, Sarah Heinicke, Chenxin Li, Joshua C Wood, Veit Grabe, C Robin Buell, Lorenzo Caputi, Sarah Ellen O'connor
Quantitative Single-Cell Mass Spectrometry Provides a Highly Resolved Analysis of Natural Product Biosynthesis Partitioning in Plants. Journal of the American Chemical Society 146 (34) (2024)
Matthew D DeMars, Sarah Ellen O'connor
Evolution and diversification of carboxylesterase-like [4+2] cyclases in aspidosperma and iboga alkaloid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Anh Hai Vu, Moonyoung Kang, Jens Wurlitzer, Sarah Heinicke, Chenxin Li, Joshua C Wood, Veit Grabe, C Robin Buell, Lorenzo Caputi, Sarah Ellen O'connor
Quantitative Single-Cell Mass Spectrometry Provides a Highly Resolved Analysis of Natural Product Biosynthesis Partitioning in Plants. Journal of the American Chemical Society (2024)
Matthew D DeMars, Sarah Ellen O'connor
Evolution and diversification of carboxylesterase-like [4+2] cyclases in aspidosperma and iboga alkaloid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Caiqiong Yang, Rayko Halitschke, Sarah Ellen O'connor
OXIDOSQUALENE CYCLASE 1 and 2 influence triterpene biosynthesis and defense in Nicotiana attenuata. Plant physiology 194 (4) (2024)
Mai Uzaki, Tetsuya Mori, Mayuko Sato, Mayumi Wakazaki, Noriko Takeda-Kamiya, Kotaro Yamamoto, Akio Murakami, Delia Ayled Serna Guerrero, Chizuko Shichijo, Miwa Ohnishi, Kimitsune Ishizaki, Hidehiro Fukaki, Sarah Ellen O'connor, Kiminori Toyooka, Tetsuro Mimura, Masami Yokota Hirai
Integration of cell differentiation and initiation of monoterpenoid indole alkaloid metabolism in seed germination of Catharanthus roseus. The New phytologist (2024)
Mai Uzaki, Tetsuya Mori, Mayuko Sato, Mayumi Wakazaki, Noriko Takeda-Kamiya, Kotaro Yamamoto, Akio Murakami, Delia Ayled Serna Guerrero, Chizuko Shichijo, Miwa Ohnishi, Kimitsune Ishizaki, Hidehiro Fukaki, Sarah Ellen O'connor, Kiminori Toyooka, Tetsuro Mimura, Masami Yokota Hirai
Integration of cell differentiation and initiation of monoterpenoid indole alkaloid metabolism in seed germination of Catharanthus roseus. The New phytologist 242 (3) (2024)
Anh Hai Vu, Moonyoung Kang, Jens Wurlitzer, Sarah Heinicke, Chenxin Li, Joshua C Wood, Veit Grabe, C Robin Buell, Lorenzo Caputi, Sarah Ellen O'connor
Quantitative Single-Cell Mass Spectrometry Provides a Highly Resolved Analysis of Natural Product Biosynthesis Partitioning in Plants. Journal of the American Chemical Society 146 (34) (2024)
Mohamed O Kamileen, Yoko Nakamura, Katrin Luck, Sarah Heinicke, Benke Hong, Maite Colinas, Benjamin R Lichman, Sarah Ellen O'connor
Streamlined screening platforms lead to the discovery of pachysiphine synthase from Tabernanthe iboga. The New phytologist (2024)
Caiqiong Yang, Rayko Halitschke, Sarah Ellen O'connor, Ian Thomas Baldwin
Roles of cytochrome P450 monooxygenases in triterpene biosynthesis and their potential impact on growth and development. Plant physiology (2024)
Matilde Florean, Katrin Luck, Benke Hong, Yoko Nakamura, Sarah Ellen O'connor, Tobias G K Llner
Reinventing metabolic pathways: Independent evolution of benzoxazinoids in flowering plants. Proceedings of the National Academy of Sciences of the United States of America 120 (42) (2023)
Chenxin Li, Joshua C Wood, Anh Hai Vu, John P Hamilton, Carlos Eduardo Rodriguez Lopez, Richard M E Payne, Delia Ayled Serna Guerrero, Klaus Gase, Kotaro Yamamoto, Brieanne Vaillancourt, Lorenzo Caputi, Sarah Ellen O'connor, Carol Robin Buell
Single-cell multi-omics in the medicinal plant Catharanthus roseus. Nature chemical biology (2023)
Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T Dang, Larissa C Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R McCurdy, Sarah Ellen O'connor
Directed Biosynthesis of Mitragynine Stereoisomers. Journal of the American Chemical Society 145 (9) (2023)
Maritta Kunert, Chloe Langley, Rosalind Lucier, Kerstin Ploss, Carlos E Rodríguez López, Delia Ayled Serna Guerrero, Eva Rothe, Sarah Ellen O'connor, Prashant D Sonawane
Promiscuous CYP87A enzyme activity initiates cardenolide biosynthesis in plants. Nature plants (2023)
Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T Dang, Larissa C Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R McCurdy, Sarah Ellen O'connor
Directed Biosynthesis of Mitragynine Stereoisomers. Journal of the American Chemical Society 145 (9) (2023)
Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T Dang, Larissa C Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R McCurdy, Sarah Ellen O'connor
Directed Biosynthesis of Mitragynine Stereoisomers. Journal of the American Chemical Society 145 (9) (2023)
Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T Dang, Larissa C Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R McCurdy, Sarah Ellen O'connor
Directed Biosynthesis of Mitragynine Stereoisomers. Journal of the American Chemical Society 145 (9) (2023)
Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T Dang, Larissa C Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R McCurdy, Sarah Ellen O'connor
Directed Biosynthesis of Mitragynine Stereoisomers. Journal of the American Chemical Society 145 (9) (2023)
Larissa C Laforest, Michelle A Kuntz, Siva Rama Raju Kanumuri, Sushobhan Mukhopadhyay, Abhisheak Sharma, Sarah Ellen O'connor, Christopher R McCurdy, Satya Swathi Nadakuduti
Metabolite and Molecular Characterization of Mitragyna speciosa Identifies Developmental and Genotypic Effects on Monoterpene Indole and Oxindole Alkaloid Composition. Journal of natural products (2023)
Prashant D Sonawane, Sachin A Gharat, Adam Jozwiak, Ranjit Barbole, Sarah Heinicke, Efrat Almekias-Siegl, Sagit Meir, Ilana Rogachev, Sarah Ellen O'connor, Ashok P Giri, Asaph Aharoni
A BAHD-type acyltransferase concludes the biosynthetic pathway of non-bitter glycoalkaloids in ripe tomato fruit. Nature communications 14 (1) (2023)
Emily Amor Stander, Beata Lehka, Inês Carqueijeiro, Clément Cuello, Frederik G Hansson, Hans J Jansen, Thomas Dugé De Bernonville, Caroline Birer Williams, Valentin Vergès, Enzo Lezin, Marcus Daniel Brandbjerg Bohn Lorensen, Thu-Thuy T Dang, Audrey Oudin, Arnaud Lanoue, Mickaël Durand, Nathalie Giglioli-Guivarc'h, Christian Janfelt, Nicolas Papon, Ron P Dirks, Sarah Ellen O'connor, Michael Krogh Jensen, Sébastien Besseau, Vincent Courdavault
The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids. Communications biology 6 (1) (2023)
Samuel A Bradley, Beata J Lehka, Frederik G Hansson, Khem B Adhikari, Daniela Rago, Paulina Rubaszka, Ahmad K Haidar, Ling Chen, Lea G Hansen, Olga Gudich, Konstantina Giannakou, Bettina Lengger, Ryan T Gill, Yoko Nakamura, Thomas Dugé de Bernonville, Konstantinos Koudounas, David Romero-Suarez, Ling Ding, Yijun Qiao, Thomas M Frimurer, Anja A Petersen, Sébastien Besseau, Sandeep Kumar, Nicolas Gautron, Celine Melin, Jillian Marc, Remi Jeanneau, Sarah Ellen O'connor, Vincent Courdavault, Jay D Keasling, Jie Zhang, Michael Krogh Jensen
Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast. Nature chemical biology (2023)
Caiqiong Yang, Rayko Halitschke, Sarah Ellen O'connor
OXIDOSQUALENE CYCLASE 1 and 2 influence triterpene biosynthesis and defense in Nicotiana attenuata. Plant physiology (2023)
Chloe Langley, Evangelos Tatsis, Benke Hong, Yoko Nakamura, Christian Paetz, Clare E M Stevenson, Jerome Basquin, David M Lawson, Lorenzo Caputi, Sarah Ellen O'connor
Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism. Angewandte Chemie (International ed. in English) 61 (48) (2022)
Tobias G K Llner, Anja David, Katrin Luck, Franziska Beran, Grit Kunert, Jing-Jiang Zhou, Lorenzo Caputi, Sarah Ellen O'connor
Biosynthesis of iridoid sex pheromones in aphids. Proceedings of the National Academy of Sciences of the United States of America 119 (42) (2022)
Néstor J Hernández Lozada, Benke Hong, Joshua C Wood, Lorenzo Caputi, Jérôme Basquin, Ling Chuang, Maritta Kunert, Carlos E Rodríguez López, Chloe Langley, Dongyan Zhao, C Robin Buell, Benjamin R Lichman, Sarah Ellen O'connor
Author Correction: Biocatalytic routes to stereo-divergent iridoids. Nature communications 13 (1) (2022)
Benke Hong, Dagny Grzech, Lorenzo Caputi, Prashant Sonawane, Carlos E Rodríguez López, Mohamed Omar Kamileen, Néstor J Hernández Lozada, Veit Grabe, Sarah Ellen O'connor
Biosynthesis of strychnine. Nature 607 (7919) (2022)
Lira Palmer, Ling Chuang, Marlen Siegmund, Maritta Kunert, Kotaro Yamamoto, Prashant Sonawane, Sarah Ellen O'connor
In vivo characterization of key iridoid biosynthesis pathway genes in catnip (Nepeta cataria). Planta 256 (5) (2022)
Quentin M Dudley, Seohyun Jo, Delia Ayled Serna Guerrero, Monika Chhetry, Mark A Smedley, Wendy A Harwood, Nathaniel H Sherden, Sarah Ellen O'connor, Lorenzo Caputi, Nicola Joan Patron
Reconstitution of monoterpene indole alkaloid biosynthesis in genome engineered Nicotiana benthamiana. Communications biology 5 (1) (2022)
Kotaro Yamamoto, Dagny Grzech, Konstantinos Koudounas, Emily Amor Stander, Lorenzo Caputi, Tetsuro Mimura, Vincent Courdavault, Sarah Ellen O'connor
Improved virus-induced gene silencing allows discovery of a serpentine synthase gene in Catharanthus roseus. Plant physiology 187 (2) (2022)
Clément Cuello, Emily Amor Stander, Hans J Jansen, Thomas Dugé de Bernonville, Arnaud Lanoue, Nathalie Giglioli-Guivarc'h, Nicolas Papon, Ron P Dirks, Michael Krogh Jensen, Sarah Ellen O'connor, Sébastien Besseau, Vincent Courdavault
Genome Assembly of the Medicinal Plant Voacanga thouarsii. Genome biology and evolution 14 (11) (2022)
Jie Zhang, Lea G Hansen, Olga Gudich, Konrad Viehrig, Lærke M M Lassen, Lars Schrübbers, Khem B Adhikari, Paulina Rubaszka, Elena Carrasquer-Alvarez, Ling Chen, Vasil D'Ambrosio, Beata Lehka, Ahmad K Haidar, Saranya Nallapareddy, Konstantina Giannakou, Marcos Laloux, Dushica Arsovska, Marcus A K Jørgensen, Leanne Jade G Chan, Mette Kristensen, Hanne B Christensen, Suresh Sudarsan, Emily Amor Stander, Edward Baidoo, Christopher J Petzold, Tune Wulff, Sarah Ellen O'connor, Vincent Courdavault, Michael Krogh Jensen, Jay D Keasling
A microbial supply chain for production of the anti-cancer drug vinblastine. Nature 609 (7926) (2022)
Emily Amor Stander, Clément Cuello, Caroline Birer-Williams, Natalja Kulagina, Hans J Jansen, Inês Carqueijeiro, Louis-Valentin Méteignier, Valentin Vergès, Audrey Oudin, Nicolas Papon, Ron P Dirks, Michael Krogh Jensen, Sarah Ellen O'connor, Thomas Dugé de Bernonville, Sébastien Besseau, Vincent Courdavault
The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis. G3 (Bethesda, Md.) 12 (12) (2022)
Néstor J Hernández Lozada, Benke Hong, Joshua C Wood, Lorenzo Caputi, Jérôme Basquin, Ling Chuang, Maritta Kunert, Carlos E Rodríguez López, Chloe Langley, Dongyan Zhao, C Robin Buell, Benjamin R Lichman, Sarah Ellen O'connor
Biocatalytic routes to stereo-divergent iridoids. Nature communications 13 (1) (2022)
Mohamed O Kamileen, Matthew D DeMars, Benke Hong, Yoko Nakamura, Christian Paetz, Benjamin R Lichman, Prashant D Sonawane, Lorenzo Caputi, Sarah Ellen O'connor
Recycling Upstream Redox Enzymes Expands the Regioselectivity of Cycloaddition in Pseudo-Aspidosperma Alkaloid Biosynthesis. Journal of the American Chemical Society 144 (43) (2022)
Vincent Courdavault, Sarah Ellen O'connor, Michael Krogh Jensen, Nicolas Papon
Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits. Natural product reports (2021)
Francesco Trenti, Kotaro Yamamoto, Benke Hong, Christian Paetz, Yoko Nakamura, Sarah Ellen O'connor
Early and Late Steps of Quinine Biosynthesis. Organic letters 23 (5) (2021)
Carlos E Rodríguez López, Benke Hong, Christian Paetz, Yoko Nakamura, Konstantinos Koudounas, Valentina Passeri, Luciana Baldoni, Fiammetta Alagna, Ornella Calderini, Sarah Ellen O'connor
Two bi-functional cytochrome P450 CYP72 enzymes from olive (Olea europaea) catalyze the oxidative C-C bond cleavage in the biosynthesis of secoxy-iridoids - flavor and quality determinants in olive oil. The New phytologist 229 (4) (2020)
Trinh-Don Nguyen, Sarah Ellen O'connor
The Progesterone 5β-Reductase/Iridoid Synthase Family: A Catalytic Reservoir for Specialized Metabolism across Land Plants. ACS chemical biology 15 (7) (2020)
Benjamin R Lichman, Grant T Godden, John P Hamilton, Lira Palmer, Mohamed O Kamileen, Dongyan Zhao, Brieanne Vaillancourt, Joshua C Wood, Miao Sun, Taliesin J Kinser, Laura K Henry, Carlos Rodriguez-Lopez, Natalia Dudareva, Douglas Edward Soltis, Pamela S Soltis, Carol Robin Buell, Sarah Ellen O'connor
The evolutionary origins of the cat attractant nepetalactone in catnip. Science advances 6 (20) (2020)
Manish Walia, Christiana N Teijaro, Alex Gardner, Thi Tran, Jinfeng Kang, Senzhi Zhao, Sarah Ellen O'connor, Vincent Courdavault, Rodrigo B Andrade
Synthesis of (-)-Melodinine K: A Case Study of Efficiency in Natural Product Synthesis. Journal of natural products 83 (8) (2020)
Lorenzo Caputi, Jakob Franke, Kate Bussey, Scott C Farrow, Ivo Jose Curcino Vieira, Clare E M Stevenson, David M Lawson, Sarah Ellen O'connor
Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids. Nature chemical biology 16 (4) (2020)
Scott C Farrow, Mohamed O Kamileen, Lorenzo Caputi, Kate Bussey, Julia E A Mundy, Rory C McAtee, Corey R J Stephenson, Sarah Ellen O'connor
Biosynthesis of an Anti-Addiction Agent from the Iboga Plant. Journal of the American Chemical Society 141 (33) (2019)
Benjamin R Lichman, Sarah Ellen O'connor, Hajo Kries
Biocatalytic Strategies towards [4+2] Cycloadditions. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (28) (2019)
Scott C Farrow, Mohamed O Kamileen, Jessica Meades, Belinda Ameyaw, Youli Xiao, Sarah Ellen O'connor
Cytochrome P450 and O-methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from Tabernanthe iboga. The Journal of biological chemistry 293 (36) (2018)
Benjamin R Lichman, Mohamed O Kamileen, Gabriel R Titchiner, Gerhard Saalbach, Clare E M Stevenson, David M Lawson, Sarah Ellen O'connor
Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis. Nature chemical biology 15 (1) (2018)
Thu-Thuy T Dang, Jakob Franke, Ines Soares Teto Carqueijeiro, Chloe Langley, Vincent Courdavault, Sarah Ellen O'connor
Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes. Nature chemical biology 14 (8) (2018)
Anna K Stavrinides, Evangelos C Tatsis, Thu-Thuy Dang, Lorenzo Caputi, Clare E M Stevenson, David M Lawson, Bernd Schneider, Sarah Ellen O'connor
Discovery of a Short-Chain Dehydrogenase from Catharanthus roseus that Produces a New Monoterpene Indole Alkaloid. Chembiochem : a European journal of chemical biology 19 (9) (2018)
Lorenzo Caputi, Jakob Franke, Scott C Farrow, Khoa Chung, Richard M E Payne, Trinh-Don Nguyen, Thu-Thuy T Dang, Inês Carqueijeiro, Konstantinos Koudounas, Thomas Dugé de Bernonville, Belinda Ameyaw, D Marc Jones, Ivo José Curcino Vieira, Vincent Courdavault, Sarah Ellen O'connor
Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle. Science (New York, N.Y.) 360 (6394) (2018)
Jakob Franke, Jeongwoon Kim, John P Hamilton, Dongyan Zhao, Gina M Pham, Krystle Wiegert-Rininger, Emily Crisovan, Linsey Newton, Brieanne Vaillancourt, Evangelos Tatsis, C Robin Buell, Sarah Ellen O'connor
Gene Discovery in Gelsemium Highlights Conserved Gene Clusters in Monoterpene Indole Alkaloid Biosynthesis. Chembiochem : a European journal of chemical biology 20 (1) (2018)
Evangelos C Tatsis, Inês Carqueijeiro, Thomas Dugé de Bernonville, Jakob Franke, Thu-Thuy T Dang, Audrey Oudin, Arnaud Lanoue, Florent Lafontaine, Anna K Stavrinides, Marc Clastre, Vincent Courdavault, Sarah Ellen O'connor
A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate. Nature communications 8 (1) (2017)
Thu-Thuy T Dang, Jakob Franke, Evangelos Tatsis, Sarah Ellen O'connor
Dual Catalytic Activity of a Cytochrome P450 Controls Bifurcation at a Metabolic Branch Point of Alkaloid Biosynthesis in Rauwolfia serpentina. Angewandte Chemie (International ed. in English) 56 (32) (2017)

Sarah Ellen O'connor.css-eqlu8i{font-size:small;padding-left:4px;} (Sarah E O' Connor, Sarah E O'Connor, Sarah Ellen O'Connor)

Publication Activity (10 Years)

Top Topics

Top Venues

Sarah Ellen O'connor (Sarah E O' Connor, Sarah E O'Connor, Sarah Ellen O'Connor)