Drug metabolism and disposition: the biological fate of chemicals

Keyphrases

Publications

volume 52, number 8, 2024

Marysol Almestica-Roberts, Nam D Nguyen, Lili Sun, Samantha N Serna, Emmanuel Rapp, Katherine L Burrell-Gerbers, Tosifa A Memon, Bryan L Stone, Flory L Nkoy, John G Lamb, Cassandra E Deering-Rice, Joseph E Rower, Christopher A Reilly
The Cytochrome P450 2C8*3 Variant (rs11572080) Is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Daniel J Weston, Steve Thomas, Gary W Boyle, Michel Pieren
Alpibectir: Early Qualitative and Quantitative Metabolic Profiling from a First-Time-in-Human Study by Combining 19 F-NMR (Nuclear Magnetic Resonance), 1 H-NMR, and High-Resolution Mass Spectrometric Analyses. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Makiko Shimizu, Miaki Makiguchi, Yasuhiro Uno, Hiroshi Yamazaki
Quinuclidine N -Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Hyunwoo Lee, Xiaotong Yang, Pei-Ru Jin, Kyoung-Jae Won, Chang H Kim, Hyunyoung Jeong
The Discovery of Gut Microbial Metabolites as Modulators of Host Susceptibility to Acetaminophen-Induced Hepatotoxicity. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Jesse Yu, Fei Tang, Fang Ma, Susan Wong, Jing Wang, Justin Ly, Liuxi Chen, Jialin Mao
Human Pharmacokinetic and CYP3A Drug-Drug Interaction Prediction of GDC-2394 Using Physiologically Based Pharmacokinetic Modeling and Biomarker Assessment. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Pooja V Hegde, Bridget L Morse
Mechanistic Account of Distinct Change in Organic Anion Transporting Polypeptide 1B (OATP1B) Substrate Pharmacokinetics during OATP1B-Mediated Drug-Drug Interactions Using Physiologically Based Pharmacokinetic Modeling. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Ankit P Laddha, Hangyu Wu, José E Manautou
Deciphering Acetaminophen-Induced Hepatotoxicity: The Crucial Role of Transcription Factors like Nuclear Factor Erythroid 2-Related Factor 2 as Genetic Determinants of Susceptibility to Drug-Induced Liver Injury. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Ahmad H Alammari, Fadumo Ahmed Isse, Conor O'Croinin, Neal M Davies, Ayman O S Ei-Kadi
Modulation of Angiotensin II-Induced Cellular Hypertrophy by Cannflavin-C: Unveiling the Impact on Cytochrome P450 1B1 and Arachidonic Acid Metabolites. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Jesse Yu, Fei Tang, Fang Ma, Susan Wong, Jing Wang, Justin Ly, Liuxi Chen, Jialin Mao
Human Pharmacokinetic and CYP3A Drug-Drug Interaction Prediction of GDC-2394 Using Physiologically Based Pharmacokinetic Modeling and Biomarker Assessment. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Pooja V Hegde, Bridget L Morse
Mechanistic Account of Distinct Change in Organic Anion Transporting Polypeptide 1B (OATP1B) Substrate Pharmacokinetics during OATP1B-Mediated Drug-Drug Interactions Using Physiologically Based Pharmacokinetic Modeling. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Marysol Almestica-Roberts, Nam D Nguyen, Lili Sun, Samantha N Serna, Emmanuel Rapp, Katherine L Burrell-Gerbers, Tosifa A Memon, Bryan L Stone, Flory L Nkoy, John G Lamb, Cassandra E Deering-Rice, Joseph E Rower, Christopher A Reilly
The Cytochrome P450 2C8*3 Variant (rs11572080) Is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Antonio J López Quiñones, Letícia Salvador Vieira, Joanne Wang
Cardiac Uptake of the Adrenergic Imaging Agent meta -Iodobenzylguanidine (mIBG) Is Mediated by Organic Cation Transporter 3 (Oct3). Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Antonio J López Quiñones, Letícia Salvador Vieira, Joanne Wang
Cardiac Uptake of the Adrenergic Imaging Agent meta -Iodobenzylguanidine (mIBG) Is Mediated by Organic Cation Transporter 3 (Oct3). Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Antonio J López Quiñones, Letícia Salvador Vieira, Joanne Wang
Cardiac Uptake of the Adrenergic Imaging Agent meta -Iodobenzylguanidine (mIBG) Is Mediated by Organic Cation Transporter 3 (Oct3). Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
David A Kukla, David G Belair, David M Stresser
Evaluation and Optimization of a Microcavity Plate-Based Human Hepatocyte Spheroid Model for Predicting Clearance of Slowly Metabolized Drug Candidates. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Yaya Fan, Lin Chen, Qiuyi Jing, Xiaoli Li, Hong Pan, Chao Fang, Jianyong Zhang, Fuguo Shi
Covalent Binding of Reactive Anhydride of Cantharidin to Biological Amines. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Matthijs W van Hoogdalem, Ryota Tanaka, Trevor N Johnson, Alexander A Vinks, Tomoyuki Mizuno
Development and Verification of a Full Physiologically Based Pharmacokinetic Model for Sublingual Buprenorphine in Healthy Adult Volunteers that Accounts for Nonlinear Bioavailability. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Yanhong Chen, Li Wang, Yuchen Wang, Yanyan Fang, Wenyang Shen, Yingxue Si, Xiaoli Zheng, Su Zeng
Integrative Analysis of Histone Acetylation Regulated CYP4F12 in Esophageal Cancer Development. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Hyunwoo Lee, Xiaotong Yang, Pei-Ru Jin, Kyoung-Jae Won, Chang H Kim, Hyunyoung Jeong
The Discovery of Gut Microbial Metabolites as Modulators of Host Susceptibility to Acetaminophen-Induced Hepatotoxicity. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Antonio J López Quiñones, Letícia Salvador Vieira, Joanne Wang
Cardiac Uptake of the Adrenergic Imaging Agent meta -Iodobenzylguanidine (mIBG) Is Mediated by Organic Cation Transporter 3 (Oct3). Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Antonio J López Quiñones, Letícia Salvador Vieira, Joanne Wang
Cardiac Uptake of the Adrenergic Imaging Agent meta -Iodobenzylguanidine (mIBG) Is Mediated by Organic Cation Transporter 3 (Oct3). Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Yanhong Chen, Li Wang, Yuchen Wang, Yanyan Fang, Wenyang Shen, Yingxue Si, Xiaoli Zheng, Su Zeng
Integrative Analysis of Histone Acetylation Regulated CYP4F12 in Esophageal Cancer Development. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Matthijs W van Hoogdalem, Ryota Tanaka, Trevor N Johnson, Alexander A Vinks, Tomoyuki Mizuno
Development and Verification of a Full Physiologically Based Pharmacokinetic Model for Sublingual Buprenorphine in Healthy Adult Volunteers that Accounts for Nonlinear Bioavailability. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Makiko Shimizu, Miaki Makiguchi, Yasuhiro Uno, Hiroshi Yamazaki
Quinuclidine N -Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Marysol Almestica-Roberts, Nam D Nguyen, Lili Sun, Samantha N Serna, Emmanuel Rapp, Katherine L Burrell-Gerbers, Tosifa A Memon, Bryan L Stone, Flory L Nkoy, John G Lamb, Cassandra E Deering-Rice, Joseph E Rower, Christopher A Reilly
The Cytochrome P450 2C8*3 Variant (rs11572080) Is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Hyunwoo Lee, Xiaotong Yang, Pei-Ru Jin, Kyoung-Jae Won, Chang H Kim, Hyunyoung Jeong
The Discovery of Gut Microbial Metabolites as Modulators of Host Susceptibility to Acetaminophen-Induced Hepatotoxicity. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Marysol Almestica-Roberts, Nam D Nguyen, Lili Sun, Samantha N Serna, Emmanuel Rapp, Katherine L Burrell-Gerbers, Tosifa A Memon, Bryan L Stone, Flory L Nkoy, John G Lamb, Cassandra E Deering-Rice, Joseph E Rower, Christopher A Reilly
The Cytochrome P450 2C8*3 Variant (rs11572080) Is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Hyunwoo Lee, Xiaotong Yang, Pei-Ru Jin, Kyoung-Jae Won, Chang H Kim, Hyunyoung Jeong
The Discovery of Gut Microbial Metabolites as Modulators of Host Susceptibility to Acetaminophen-Induced Hepatotoxicity. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Matthijs W van Hoogdalem, Ryota Tanaka, Trevor N Johnson, Alexander A Vinks, Tomoyuki Mizuno
Development and Verification of a Full Physiologically Based Pharmacokinetic Model for Sublingual Buprenorphine in Healthy Adult Volunteers that Accounts for Nonlinear Bioavailability. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Marysol Almestica-Roberts, Nam D Nguyen, Lili Sun, Samantha N Serna, Emmanuel Rapp, Katherine L Burrell-Gerbers, Tosifa A Memon, Bryan L Stone, Flory L Nkoy, John G Lamb, Cassandra E Deering-Rice, Joseph E Rower, Christopher A Reilly
The Cytochrome P450 2C8*3 Variant (rs11572080) Is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Marina-Stefania Stroe, Miao-Chan Huang, Pieter Annaert, Karen Leys, Anne Smits, Karel Allegaert, Lieselotte Van Bockstal, Allan Valenzuela, Miriam Ayuso, Chris Van Ginneken, Steven J Van Cruchten
Drug Disposition in Neonatal Göttingen Minipigs: Exploring Effects of Perinatal Asphyxia and Therapeutic Hypothermia. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Yurong Lai, Xiao-Bo Zhong
Special Section on Mechanisms of Drug Metabolism in Acetaminophen-Induced Hepatotoxicity-Editorial. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Ankit P Laddha, Hangyu Wu, José E Manautou
Deciphering Acetaminophen-Induced Hepatotoxicity: The Crucial Role of Transcription Factors like Nuclear Factor Erythroid 2-Related Factor 2 as Genetic Determinants of Susceptibility to Drug-Induced Liver Injury. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Ahmad H Alammari, Fadumo Ahmed Isse, Conor O'Croinin, Neal M Davies, Ayman O S Ei-Kadi
Modulation of Angiotensin II-Induced Cellular Hypertrophy by Cannflavin-C: Unveiling the Impact on Cytochrome P450 1B1 and Arachidonic Acid Metabolites. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Matthijs W van Hoogdalem, Ryota Tanaka, Trevor N Johnson, Alexander A Vinks, Tomoyuki Mizuno
Development and Verification of a Full Physiologically Based Pharmacokinetic Model for Sublingual Buprenorphine in Healthy Adult Volunteers that Accounts for Nonlinear Bioavailability. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)

volume 52, number 9, 2024

Yasuhiro Uno, Kyoko Tsukiyama-Kohara, Mayumi Ishizuka, Hazuki Mizukawa, Norie Murayama, Hiroshi Yamazaki
Investigation of Functional Cytochrome P450 4A Enzymes in Liver and Kidney of Pigs, Cats, Tree Shrews, and Dogs in Comparison with the Metabolic Capacity of Human P450 4A11. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Cheng Yang, Jingru Gong, Mingzhen Xue, Wensi Huang, Yali Yuan, Chong Chen, Yifei He, Chen Yang, Hongbin Sun, Yongqiang Liu, Yanchun Gong, Yong Wu, Xiaojuan Lai, Dafang Zhong, Xingxing Diao, Huiping Lu, Yuandong Zheng
Effects of the Thiol Methyltransferase Inhibitor (±)-2,3-Dichloro- α -Methylbenzylamine (DCMB) on the Pharmacokinetics and Metabolism of Vicagrel in Rats. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Leslie Z Benet, Jasleen K Sodhi
Commentary: Pharmacokinetic Theory Must Consider Published Experimental Data. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Sungjoon Cho, Lionel Cheruzel, Jingwei Cai, Stephen K Wrigley, Renia T Gemmell, Tetsuo Kokubun, Jonathan C P Steele, Laurent Salphati, Donglu Zhang, S Cyrus Khojasteh
Discovery of Unprecedented Human Stercobilin Conjugates. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Kata W Pedersen, Jeppe D Andersen, Jakob Hansen, Claus Børsting, Jytte Banner, Jørgen B Hasselstrøm, Jakob R Jornil
Investigating the Correlation between Genotypes and Hepatic Protein Expression of CYP2C9, CYP2C19, CYP2D6, and CYP3A5 Using Postmortem Tissue from a Danish Population. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Shunji Imai, Naoki Watanabe, Yuichiro Tone, Rei Mitamura, Jumpei Mori, Tsubasa Kameyama, Tetsuhiro Yamada, Kazutomi Kusano
The Usefulness of Determining Plasma and Tissue Concentrations of Phosphorodiamidate Morpholino Oligonucleotides to Estimate Their Efficacy in Duchenne Muscular Dystrophy Patients. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Yu Wang, Yingying Wang, Yanyan Fang, Huidi Jiang, Lushan Yu, Haihong Hu, Su Zeng
SND1 Regulates Organic Anion Transporter 2 Protein Expression and Sensitivity of Hepatocellular Carcinoma Cells to 5-Fluorouracil. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Leslie Z Benet, Jasleen K Sodhi
Commentary: Pharmacokinetic Theory Must Consider Published Experimental Data. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Yongjun Xue, Linna Wang, Runlan Huo, Mu Chen, Brian Melo, Karen Dingley, Allison Gaudy, Jim X Shen
1β-Hydroxydeoxycholic Acid as an Endogenous Biomarker in Human Plasma for Assessment of CYP3A Clinical Drug-Drug Interaction Potential. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Shiori Hashiba, Masataka Nakano, Itsuki Yokoseki, Etsushi Takahashi, Masayuki Kondo, Yoichi Jimbo, Naoki Ishiguro, Hiroshi Arakawa, Tatsuki Fukami, Miki Nakajima
Cytochrome P450 and UDP-Glucuronosyltransferase Expressions, Activities, and Induction Abilities in 3D-Cultured Human Renal Proximal Tubule Epithelial Cells. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Lloyd Wei Tat Tang, Yuanyuan Shi, Raman Sharma, R Scott Obach
The Drug-Drug Interaction between Erlotinib and OSI-930 Is Mediated through Aldehyde Oxidase Inhibition. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Leslie Z Benet, Jasleen K Sodhi
Commentary: Pharmacokinetic Theory Must Consider Published Experimental Data. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Jonny Kinzi, Janine Hussner, Isabell Seibert, Mirubagini Vythilingam, Celina Vonwyl, Clarisse Gherardi, Pascal Detampel, Oliver Schwardt, Daniel Ricklin, Henriette E Meyer Zu Schwabedissen
Impact of OATP2B1 on Pharmacokinetics of Atorvastatin Investigated in rSlco2b1 -Knockout and SLCO2B1 -Knockin Rats. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Leslie Z Benet, Jasleen K Sodhi
Commentary: Pharmacokinetic Theory Must Consider Published Experimental Data. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Claire Miller, Martin Wild, Zhoupeng Zhang, Roberto Sommavilla, Don Shanahan, Christopher Bailey, Malin Gränfors, Ryan A Bragg, Jin Dong, Sharan Sidhu, Marie Cullberg
A Phase I Study To Determine the Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of Capivasertib in Healthy Male Participants. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)