Frederik J R Rombouts (Frederik Rombouts)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2021
Publications (10 Years): 11

Top Venues

Journal of medicinal chemistry

Chemistry (Weinheim an der Bergstrasse, Germany)

Expert opinion on therapeutic patents

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

Frederik J R Rombouts, Ken-Ichi Kusakabe, Richard Alexander, Nigel Austin, Herman Borghys, Michel De Cleyn, Deborah Dhuyvetter, Harrie J M Gijsen, Brian Hrupka, Tom Jacobs, Soufyan Jerhaoui, Lieve Lammens, Laurent Leclercq, Koichi Tsubone, Tatsuhiko Ueno, Kenji Morimoto, Shunsuke Einaru, Hirokazu Sumiyoshi, An Van den Bergh, Ann Vos, Michel Surkyn, Ard Teisman, Diederik Moechars
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate. Journal of medicinal chemistry 64 (19) (2021)
Mary-Ambre Carvalho, Samuël Demin, Carolina Martinez-Lamenca, Fedor Romanov-Michailidis, Kevin Lam, Frederik J R Rombouts, Morgan Lecomte
Expedient Access to Cyanated N-Heterocycles by Direct Flow-Electrochemical C(sp2 )-H Activation. Chemistry (Weinheim an der Bergstrasse, Germany) (2021)
Tatsuhiko Ueno, Eriko Matsuoka, Naoya Asada, Shiho Yamamoto, Naoki Kanegawa, Mana Ito, Hisanori Ito, Diederik Moechars, Frederik J R Rombouts, Harrie J M Gijsen, Ken-Ichi Kusakabe
Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions. Journal of medicinal chemistry 64 (19) (2021)
Aldo Peschiulli, Daniel Oehlrich, Michiel Van Gool, Nigel Austin, Sven Van Brandt, Michel Surkyn, Michel De Cleyn, Ann Vos, Gary John Tresadern, Frederik J R Rombouts, Gregor J Macdonald, Diederik Moechars, Andres A Trabanco, Harrie J M Gijsen
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo. ACS medicinal chemistry letters 13 (1) (2021)
Kazuki Fujimoto, Shuhei Yoshida, Genta Tadano, Naoya Asada, Kouki Fuchino, Shinji Suzuki, Eriko Matsuoka, Takahiko Yamamoto, Shiho Yamamoto, Shigeru Ando, Naoki Kanegawa, Yutaka Tonomura, Hisanori Ito, Diederik Moechars, Frederik J R Rombouts, Harrie J M Gijsen, Ken-Ichi Kusakabe
Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2. Journal of medicinal chemistry 64 (6) (2021)
Frederik J R Rombouts, Ken-Ichi Kusakabe, Chien-Chi Hsiao, Harrie J M Gijsen
Small-molecule BACE1 inhibitors: a patent literature review (2011 to 2020). Expert opinion on therapeutic patents 31 (1) (2020)
Frederik J R Rombouts, Lieven Declercq, José-Ignacio Andrés, Astrid Bottelbergs, Lu Chen, Laura Iturrino, Joseph E Leenaerts, Jonas Mariën, Fengbin Song, Cindy Wintmolders, Stijn Wuyts, Chunfang A Xia, Paula Te Riele, Guy Bormans, Rik Vandenberghe, Hartmuth Kolb, Diederik Moechars
Correction to Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer. Journal of medicinal chemistry 63 (4) (2020)
Frederik J R Rombouts, Lieven Declercq, José-Ignacio Andrés, Astrid Bottelbergs, Lu Chen, Laura Iturrino, Joseph E Leenaerts, Jonas Mariën, Fengbin Song, Cindy Wintmolders, Stijn Wuyts, Chunfang A Xia, Paula Te Riele, Guy Bormans, Rik Vandenberghe, Hartmuth Kolb, Diederik Moechars
Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer. Journal of medicinal chemistry 62 (6) (2019)
Harrie J M Gijsen, Sergio A Alonso de Diego, Michel De Cleyn, Aránzazu García-Molina, Gregor J Macdonald, Carolina Martínez-Lamenca, Daniel Oehlrich, Hana Prokopcova, Frederik J R Rombouts, Michel Surkyn, Andres A Trabanco, Sven Van Brandt, Dries Van den Bossche, Michiel Van Gool, Nigel Austin, Herman Borghys, Deborah Dhuyvetter, Diederik Moechars
Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate. Journal of medicinal chemistry 61 (12) (2018)
Harrie J M Gijsen, Sergio A Alonso de Diego, Michel De Cleyn, Aránzazu García-Molina, Gregor J Macdonald, Carolina Martinez-Lamenca, Daniel Oehlrich, Hana Prokopcova, Frederik J R Rombouts, Michel Surkyn, Andres A Trabanco, Sven Van Brandt, Dries Van den Bossche, Michiel Van Gool, Nigel Austin, Herman Borghys, Deborah Dhuyvetter, Vijay Urmaliya, Ard Teisman, Diederik Moechars
Correction to Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate. Journal of medicinal chemistry 61 (24) (2018)
Frederik J R Rombouts, José-Ignacio Andrés, Manuela Ariza, José Manuel Alonso, Nigel Austin, Astrid Bottelbergs, Lu Chen, Vladimir Chupakhin, Erna Cleiren, Katleen Fierens, Alberto Fontana, Xavier Langlois, Joseph E Leenaerts, Jonas Mariën, Carolina Martínez Lamenca, Rhys Salter, Mark E Schmidt, Paula Te Riele, Cindy Wintmolders, Andres A Trabanco, Wei Zhang, Gregor Macdonald, Dieder Moechars
Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease. Journal of medicinal chemistry 60 (4) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Frederik J R Rombouts (Frederik Rombouts)