Ken-Ichi Kusakabe (Kenichi Kusakabe)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 16

Top Venues

Journal of medicinal chemistry

ACS medicinal chemistry letters

ChemMedChem

Expert opinion on therapeutic patents

Shionogi & Co., Ltd.

Kumamoto University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Shionogi & Co., Ltd. Apr 01 2000

Japan

Head of Neuroscience Chemistry 1 Group :: Medicinal Chemistry

Education History

Kumamoto University - Jan 09 2014

Japan

PHD :: Pharmaceutical Sciences

Tokyo University of Science Apr 01 1995 - Mar 31 2000

Japan

MSC :: Chemistry

Publications

Takuya Oguma, Kohei Jino, Kenji Nakahara, Hidetsugu Asada, Kouki Fuchino, Kotaro Nagatani, Kensuke Kouki, Ryuji Okamoto, Nozomi Takai, Ken Koda, Sayaka Fujita, Yusuke Sekiguchi, Kazuya Yasuo, Kei Mayumi, Ayane Abe, Masaaki Imono, Naotaka Horiguchi, So Iwata, Ken-Ichi Kusakabe
Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis. Journal of medicinal chemistry (2024)
Takuya Oguma, Kohei Jino, Kenji Nakahara, Hidetsugu Asada, Kouki Fuchino, Kotaro Nagatani, Kensuke Kouki, Ryuji Okamoto, Nozomi Takai, Ken Koda, Sayaka Fujita, Yusuke Sekiguchi, Kazuya Yasuo, Kei Mayumi, Ayane Abe, Masaaki Imono, Naotaka Horiguchi, So Iwata, Ken-Ichi Kusakabe
Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis. Journal of medicinal chemistry 67 (16) (2024)
Takuya Oguma, Kohei Jino, Kenji Nakahara, Hidetsugu Asada, Kouki Fuchino, Kotaro Nagatani, Kensuke Kouki, Ryuji Okamoto, Nozomi Takai, Ken Koda, Sayaka Fujita, Yusuke Sekiguchi, Kazuya Yasuo, Kei Mayumi, Ayane Abe, Masaaki Imono, Naotaka Horiguchi, So Iwata, Ken-Ichi Kusakabe
Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis. Journal of medicinal chemistry 67 (16) (2024)
Takuya Oguma, Shota Uehara, Kenji Nakahara, Yuya Okuyama, Kouki Fuchino, Naoyuki Suzuki, Yukiko Kan, Naoki Kanegawa, Yuki Ogata, Ken-Ichi Kusakabe
A Quantum Mechanics-Based Method to Predict Intramolecular Hydrogen Bond Formation Reflecting P-glycoprotein Recognition. ACS medicinal chemistry letters 14 (2) (2023)
Takuya Oguma, Shota Uehara, Kenji Nakahara, Yuya Okuyama, Kouki Fuchino, Naoyuki Suzuki, Yukiko Kan, Naoki Kanegawa, Yuki Ogata, Ken-Ichi Kusakabe
A Quantum Mechanics-Based Method to Predict Intramolecular Hydrogen Bond Formation Reflecting P-glycoprotein Recognition. ACS medicinal chemistry letters 14 (2) (2023)
Frederik J R Rombouts, Ken-Ichi Kusakabe, Richard Alexander, Nigel Austin, Herman Borghys, Michel De Cleyn, Deborah Dhuyvetter, Harrie J M Gijsen, Brian Hrupka, Tom Jacobs, Soufyan Jerhaoui, Lieve Lammens, Laurent Leclercq, Koichi Tsubone, Tatsuhiko Ueno, Kenji Morimoto, Shunsuke Einaru, Hirokazu Sumiyoshi, An Van den Bergh, Ann Vos, Michel Surkyn, Ard Teisman, Diederik Moechars
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate. Journal of medicinal chemistry 64 (19) (2021)
Yuji Koriyama, Akihiro Hori, Hisanori Ito, Shuji Yonezawa, Yoshiyasu Baba, Norihiko Tanimoto, Tatsuhiko Ueno, Shiho Yamamoto, Takahiko Yamamoto, Naoya Asada, Kenji Morimoto, Shunsuke Einaru, Katsunori Sakai, Takushi Kanazu, Akihiro Matsuda, Yoshitaka Yamaguchi, Takuya Oguma, Maarten Timmers, Luc Tritsmans, Ken-Ichi Kusakabe, Akira Kato, Gaku Sakaguchi
Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial. Journal of medicinal chemistry 64 (4) (2021)
Tatsuhiko Ueno, Eriko Matsuoka, Naoya Asada, Shiho Yamamoto, Naoki Kanegawa, Mana Ito, Hisanori Ito, Diederik Moechars, Frederik J R Rombouts, Harrie J M Gijsen, Ken-Ichi Kusakabe
Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions. Journal of medicinal chemistry 64 (19) (2021)
Kazuki Fujimoto, Shuhei Yoshida, Genta Tadano, Naoya Asada, Kouki Fuchino, Shinji Suzuki, Eriko Matsuoka, Takahiko Yamamoto, Shiho Yamamoto, Shigeru Ando, Naoki Kanegawa, Yutaka Tonomura, Hisanori Ito, Diederik Moechars, Frederik J R Rombouts, Harrie J M Gijsen, Ken-Ichi Kusakabe
Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2. Journal of medicinal chemistry 64 (6) (2021)
Frederik J R Rombouts, Ken-Ichi Kusakabe, Chien-Chi Hsiao, Harrie J M Gijsen
Small-molecule BACE1 inhibitors: a patent literature review (2011 to 2020). Expert opinion on therapeutic patents 31 (1) (2020)
Kosuke Anan, Yasuyoshi Iso, Takuya Oguma, Kenji Nakahara, Shinji Suzuki, Takahiko Yamamoto, Eriko Matsuoka, Hisanori Ito, Gaku Sakaguchi, Shigeru Ando, Kenji Morimoto, Naoki Kanegawa, Yasuto Kido, Tomoyuki Kawachi, Tamio Fukushima, Ard Teisman, Vijay Urmaliya, Deborah Dhuyvetter, Herman Borghys, Nigel Austin, An Van Den Bergh, Peter Verboven, Francois Bischoff, Harrie J M Gijsen, Yoshinori Yamano, Ken-Ichi Kusakabe
Trifluoromethyl Dihydrothiazine-Based β-Secretase (BACE1) Inhibitors with Robust Central β-Amyloid Reduction and Minimal Covalent Binding Burden. ChemMedChem 14 (22) (2019)
Genta Tadano, Kazuo Komano, Shuhei Yoshida, Shinji Suzuki, Kenji Nakahara, Kouki Fuchino, Kazuki Fujimoto, Eriko Matsuoka, Takahiko Yamamoto, Naoya Asada, Hisanori Ito, Gaku Sakaguchi, Naoki Kanegawa, Yasuto Kido, Shigeru Ando, Tamio Fukushima, Ard Teisman, Vijay Urmaliya, Deborah Dhuyvetter, Herman Borghys, An Van Den Bergh, Nigel Austin, Harrie J M Gijsen, Yoshinori Yamano, Yasuyoshi Iso, Ken-Ichi Kusakabe
Discovery of an Extremely Potent Thiazine-Based β-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose. Journal of medicinal chemistry 62 (20) (2019)
Kazuki Fujimoto, Eriko Matsuoka, Naoya Asada, Genta Tadano, Takahiko Yamamoto, Kenji Nakahara, Kouki Fuchino, Hisanori Ito, Naoki Kanegawa, Diederik Moechars, Harrie J M Gijsen, Ken-Ichi Kusakabe
Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2. Journal of medicinal chemistry 62 (10) (2019)
Takuya Oguma, Kosuke Anan, Shinji Suzuki, Shinya Hisakawa, Akihiro Takada, Masayoshi Ogawa, Ken-Ichi Kusakabe
Synthesis of a 6-CF3-Substituted 2-Amino-dihydro-1,3-thiazine β-Secretase Inhibitor by N, N-Diethylaminosulfur Trifluoride-Mediated Chemoselective Cyclization. The Journal of organic chemistry 84 (8) (2018)
Kenji Nakahara, Kouki Fuchino, Kazuo Komano, Naoya Asada, Genta Tadano, Tsuyoshi Hasegawa, Takahiko Yamamoto, Yusuke Sako, Masayoshi Ogawa, Chie Unemura, Motoko Hosono, Hisanori Ito, Gaku Sakaguchi, Shigeru Ando, Shuichi Ohnishi, Yasuto Kido, Tamio Fukushima, Deborah Dhuyvetter, Herman Borghys, Harrie J M Gijsen, Yoshinori Yamano, Yasuyoshi Iso, Ken-Ichi Kusakabe
Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization. Journal of medicinal chemistry 61 (13) (2018)
Kouki Fuchino, Yasunori Mitsuoka, Moriyasu Masui, Noriyuki Kurose, Shuhei Yoshida, Kazuo Komano, Takahiko Yamamoto, Masayoshi Ogawa, Chie Unemura, Motoko Hosono, Hisanori Ito, Gaku Sakaguchi, Shigeru Ando, Shuichi Ohnishi, Yasuto Kido, Tamio Fukushima, Hirofumi Miyajima, Shuichi Hiroyama, Kiyotaka Koyabu, Deborah Dhuyvetter, Herman Borghys, Harrie J M Gijsen, Yoshinori Yamano, Yasuyoshi Iso, Ken-Ichi Kusakabe
Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain. Journal of medicinal chemistry 61 (12) (2018)

Ken-Ichi Kusakabe.css-eqlu8i{font-size:small;padding-left:4px;} (Kenichi Kusakabe)

Publication Activity (10 Years)

Top Topics

Top Venues

Ken-Ichi Kusakabe (Kenichi Kusakabe)