Harrie J M Gijsen (Harrie Gijsen)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2023
Publications (10 Years): 12

Top Venues

Journal of medicinal chemistry

ChemMedChem

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

Amjad Ali, Marcus Bauser, Sophie M Bertrand, Wesley Blackaby, Christoph Boss, Martin Bossart, Adrian Hall, Hayley Binch, Werngard Czechtizky, Harrie J M Gijsen, Helmut Haning, Ingo V Hartung, Paul Kilburn, Gilbert Lassalle, Ulrich Lücking, Jürgen Mack, Martin Missbach, Leena Otsomaa, Antoni Torrens, Michael Wagner, Magnus Walter, Harald Weinstabl, Luc van Hijfte, Franz von Nussbaum
European Medicinal Chemistry Leaders in Industry (EMCL) - On the Status and Future of Medicinal Chemistry Research in Europe. ChemMedChem (2023)
Frederik J R Rombouts, Ken-Ichi Kusakabe, Richard Alexander, Nigel Austin, Herman Borghys, Michel De Cleyn, Deborah Dhuyvetter, Harrie J M Gijsen, Brian Hrupka, Tom Jacobs, Soufyan Jerhaoui, Lieve Lammens, Laurent Leclercq, Koichi Tsubone, Tatsuhiko Ueno, Kenji Morimoto, Shunsuke Einaru, Hirokazu Sumiyoshi, An Van den Bergh, Ann Vos, Michel Surkyn, Ard Teisman, Diederik Moechars
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate. Journal of medicinal chemistry 64 (19) (2021)
Tatsuhiko Ueno, Eriko Matsuoka, Naoya Asada, Shiho Yamamoto, Naoki Kanegawa, Mana Ito, Hisanori Ito, Diederik Moechars, Frederik J R Rombouts, Harrie J M Gijsen, Ken-Ichi Kusakabe
Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions. Journal of medicinal chemistry 64 (19) (2021)
Aldo Peschiulli, Daniel Oehlrich, Michiel Van Gool, Nigel Austin, Sven Van Brandt, Michel Surkyn, Michel De Cleyn, Ann Vos, Gary John Tresadern, Frederik J R Rombouts, Gregor J Macdonald, Diederik Moechars, Andres A Trabanco, Harrie J M Gijsen
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo. ACS medicinal chemistry letters 13 (1) (2021)
Kazuki Fujimoto, Shuhei Yoshida, Genta Tadano, Naoya Asada, Kouki Fuchino, Shinji Suzuki, Eriko Matsuoka, Takahiko Yamamoto, Shiho Yamamoto, Shigeru Ando, Naoki Kanegawa, Yutaka Tonomura, Hisanori Ito, Diederik Moechars, Frederik J R Rombouts, Harrie J M Gijsen, Ken-Ichi Kusakabe
Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2. Journal of medicinal chemistry 64 (6) (2021)
Kosuke Anan, Yasuyoshi Iso, Takuya Oguma, Kenji Nakahara, Shinji Suzuki, Takahiko Yamamoto, Eriko Matsuoka, Hisanori Ito, Gaku Sakaguchi, Shigeru Ando, Kenji Morimoto, Naoki Kanegawa, Yasuto Kido, Tomoyuki Kawachi, Tamio Fukushima, Ard Teisman, Vijay Urmaliya, Deborah Dhuyvetter, Herman Borghys, Nigel Austin, An Van Den Bergh, Peter Verboven, Francois Bischoff, Harrie J M Gijsen, Yoshinori Yamano, Ken-Ichi Kusakabe
Trifluoromethyl Dihydrothiazine-Based β-Secretase (BACE1) Inhibitors with Robust Central β-Amyloid Reduction and Minimal Covalent Binding Burden. ChemMedChem 14 (22) (2019)
Genta Tadano, Kazuo Komano, Shuhei Yoshida, Shinji Suzuki, Kenji Nakahara, Kouki Fuchino, Kazuki Fujimoto, Eriko Matsuoka, Takahiko Yamamoto, Naoya Asada, Hisanori Ito, Gaku Sakaguchi, Naoki Kanegawa, Yasuto Kido, Shigeru Ando, Tamio Fukushima, Ard Teisman, Vijay Urmaliya, Deborah Dhuyvetter, Herman Borghys, An Van Den Bergh, Nigel Austin, Harrie J M Gijsen, Yoshinori Yamano, Yasuyoshi Iso, Ken-Ichi Kusakabe
Discovery of an Extremely Potent Thiazine-Based β-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose. Journal of medicinal chemistry 62 (20) (2019)
Kazuki Fujimoto, Eriko Matsuoka, Naoya Asada, Genta Tadano, Takahiko Yamamoto, Kenji Nakahara, Kouki Fuchino, Hisanori Ito, Naoki Kanegawa, Diederik Moechars, Harrie J M Gijsen, Ken-Ichi Kusakabe
Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2. Journal of medicinal chemistry 62 (10) (2019)
Harrie J M Gijsen, Sergio A Alonso de Diego, Michel De Cleyn, Aránzazu García-Molina, Gregor J Macdonald, Carolina Martínez-Lamenca, Daniel Oehlrich, Hana Prokopcova, Frederik J R Rombouts, Michel Surkyn, Andres A Trabanco, Sven Van Brandt, Dries Van den Bossche, Michiel Van Gool, Nigel Austin, Herman Borghys, Deborah Dhuyvetter, Diederik Moechars
Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate. Journal of medicinal chemistry 61 (12) (2018)
Harrie J M Gijsen, Sergio A Alonso de Diego, Michel De Cleyn, Aránzazu García-Molina, Gregor J Macdonald, Carolina Martinez-Lamenca, Daniel Oehlrich, Hana Prokopcova, Frederik J R Rombouts, Michel Surkyn, Andres A Trabanco, Sven Van Brandt, Dries Van den Bossche, Michiel Van Gool, Nigel Austin, Herman Borghys, Deborah Dhuyvetter, Vijay Urmaliya, Ard Teisman, Diederik Moechars
Correction to Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate. Journal of medicinal chemistry 61 (24) (2018)
Kenji Nakahara, Kouki Fuchino, Kazuo Komano, Naoya Asada, Genta Tadano, Tsuyoshi Hasegawa, Takahiko Yamamoto, Yusuke Sako, Masayoshi Ogawa, Chie Unemura, Motoko Hosono, Hisanori Ito, Gaku Sakaguchi, Shigeru Ando, Shuichi Ohnishi, Yasuto Kido, Tamio Fukushima, Deborah Dhuyvetter, Herman Borghys, Harrie J M Gijsen, Yoshinori Yamano, Yasuyoshi Iso, Ken-Ichi Kusakabe
Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization. Journal of medicinal chemistry 61 (13) (2018)
Kouki Fuchino, Yasunori Mitsuoka, Moriyasu Masui, Noriyuki Kurose, Shuhei Yoshida, Kazuo Komano, Takahiko Yamamoto, Masayoshi Ogawa, Chie Unemura, Motoko Hosono, Hisanori Ito, Gaku Sakaguchi, Shigeru Ando, Shuichi Ohnishi, Yasuto Kido, Tamio Fukushima, Hirofumi Miyajima, Shuichi Hiroyama, Kiyotaka Koyabu, Deborah Dhuyvetter, Herman Borghys, Harrie J M Gijsen, Yoshinori Yamano, Yasuyoshi Iso, Ken-Ichi Kusakabe
Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain. Journal of medicinal chemistry 61 (12) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Harrie J M Gijsen (Harrie Gijsen)