Gebhard Thoma

Publication Activity (10 Years)

Years Active: 2021-2024
Publications (10 Years): 15

Top Topics

Atopic Dermatitis

Top Venues

Journal of medicinal chemistry

Clinical and translational science

Expert opinion on drug discovery

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

Gebhard Thoma, Wolfgang Miltz, Honnappa Srinivas, Carlos A Penno, Michael Kiffe, Monika Gajewska, Kai Klein, Amanda Evans, Christian Beerli, Till A Röhn
Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor. Journal of medicinal chemistry (2024)
Christian Loesche, Damien Picard, Benjamin Van Hoorick, Imelda Schuhmann, Petra Jäger, Kai Klein, Carole Schuhler, Gebhard Thoma, Christian Markert, Birk Poller, Natasa Zamurovic, H Markus Weiss, Heike Otto, Martin Fink, Till A Röhn
LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial. Clinical and translational science 17 (2) (2024)
Christian Loesche, Damien Picard, Benjamin Van Hoorick, Imelda Schuhmann, Petra Jäger, Kai Klein, Carole Schuhler, Gebhard Thoma, Christian Markert, Birk Poller, Natasa Zamurovic, H Markus Weiss, Heike Otto, Martin Fink, Till A Röhn
LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial. Clinical and translational science 17 (2) (2024)
Gebhard Thoma, Wolfgang Miltz, Honnappa Srinivas, Carlos A Penno, Michael Kiffe, Monika Gajewska, Kai Klein, Amanda Evans, Christian Beerli, Till A Röhn
Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor. Journal of medicinal chemistry 67 (6) (2024)
Christian Loesche, Damien Picard, Benjamin Van Hoorick, Imelda Schuhmann, Petra Jäger, Kai Klein, Carole Schuhler, Gebhard Thoma, Christian Markert, Birk Poller, Natasa Zamurovic, H Markus Weiss, Heike Otto, Martin Fink, Till A Röhn
LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial. Clinical and translational science 17 (2) (2024)
Gebhard Thoma, Wolfgang Miltz, Honnappa Srinivas, Carlos A Penno, Michael Kiffe, Monika Gajewska, Kai Klein, Amanda Evans, Christian Beerli, Till A Röhn
Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor. Journal of medicinal chemistry 67 (6) (2024)
Christian Loesche, Damien Picard, Benjamin Van Hoorick, Imelda Schuhmann, Petra Jäger, Kai Klein, Carole Schuhler, Gebhard Thoma, Christian Markert, Birk Poller, Natasa Zamurovic, H Markus Weiss, Heike Otto, Martin Fink, Till A Röhn
LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial. Clinical and translational science 17 (2) (2024)
Gebhard Thoma, Odile Decoret, Eric Vangrevelinghe, Markus Trunzer, Andrea Decker, Anette Orjuela Leon, Christian Beerli, Sandro Bruno, Alice Hauchard, Guido Paulat, Hans-Guenter Zerwes, Feriel Hacini-Rachinel
Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood. Journal of medicinal chemistry (2023)
Gebhard Thoma, Rudolf O Duthaler, Rudolf Waelchli, Alice Hauchard, Sandro Bruno, Ulrike Strittmatter-Keller, Anette Orjuela Leon, Sabine Viebrock, Reiner Aichholz, Karen Beltz, Kerri Grove, Shaila Hoque, Patrick J Rudewicz, Hans-Guenter Zerwes
Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis. Journal of medicinal chemistry 66 (3) (2023)
Gebhard Thoma, Rudolf O Duthaler, Rudolf Waelchli, Alice Hauchard, Sandro Bruno, Ulrike Strittmatter-Keller, Anette Orjuela Leon, Sabine Viebrock, Reiner Aichholz, Karen Beltz, Kerri Grove, Shaila Hoque, Patrick J Rudewicz, Hans-Guenter Zerwes
Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis. Journal of medicinal chemistry 66 (3) (2023)
Gebhard Thoma, Rudolf O Duthaler, Rudolf Waelchli, Alice Hauchard, Sandro Bruno, Ulrike Strittmatter-Keller, Anette Orjuela Leon, Sabine Viebrock, Reiner Aichholz, Karen Beltz, Kerri Grove, Shaila Hoque, Patrick J Rudewicz, Hans-Guenter Zerwes
Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis. Journal of medicinal chemistry 66 (3) (2023)
Gebhard Thoma, Rudolf O Duthaler, Rudolf Waelchli, Alice Hauchard, Sandro Bruno, Ulrike Strittmatter-Keller, Anette Orjuela Leon, Sabine Viebrock, Reiner Aichholz, Karen Beltz, Kerri Grove, Shaila Hoque, Patrick J Rudewicz, Hans-Guenter Zerwes
Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis. Journal of medicinal chemistry (2023)
Gebhard Thoma, Christian Markert, Rainer Lueoend, Wolfgang Miltz, Carsten Spanka, Birgit Bollbuck, Romain M Wolf, Honnappa Srinivas, Carlos A Penno, Michael Kiffe, Monika Gajewska, Dallas Bednarczyk, Grazyna Wieczorek, Amanda Evans, Christian Beerli, Till A Röhn
Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase. Journal of medicinal chemistry (2023)
Gebhard Thoma, Eric Vangrevelinghe, Alexandre Luneau, Philippe Piechon, Christian Beerli, Hans-Guenter Zerwes
Novel Concept for Super-Soft Topical Drugs: Deactivation by an Enzyme-Induced Switch into an Inactive Conformation. ACS medicinal chemistry letters 14 (6) (2023)
Till A Röhn, Shin Numao, Heike Otto, Christian Loesche, Gebhard Thoma
Drug discovery strategies for novel leukotriene A4 hydrolase inhibitors. Expert opinion on drug discovery 16 (12) (2021)