Clinical and translational science

Keyphrases

Publications

volume 17, number 8, 2024

Gabriela Ribeiro Silva, Luciana Bueno Ferreira, Etel Rodrigues Pereira Gimba
Expression and prognostic potential of osteopontin splice variants in malignant melanoma. Clinical and translational science 17 (8) (2024)
Hidetoshi Shimizu, Michael A Tortorici, Yoshiyasu Ohta, Kei Ogawa, Sheikh Mohammed Ashfaq Rahman, Aya Fujii, Yuki Hiraga, Mizue Kawai, Kanami Sugimoto-Kawabata, Mattheus Thijs van Iersel, Jan Jaap van Lier, Stephen Djedjos, B T Slingsby, David M Rodman
First-in-human study evaluating safety, pharmacokinetics, and pharmacodynamics of lorundrostat, a novel and highly selective aldosterone synthase inhibitor. Clinical and translational science 17 (8) (2024)
Gabriela Ribeiro Silva, Luciana Bueno Ferreira, Etel Rodrigues Pereira Gimba
Expression and prognostic potential of osteopontin splice variants in malignant melanoma. Clinical and translational science 17 (8) (2024)
Jinkun Xia, Boqi Fu, Zhe Wang, Gaolin Wen, Quanshui Gu, Dayu Chen, Hao-Zhen Ren
MVP enhances FGF21-induced ferroptosis in hepatocellular carcinoma by increasing lipid peroxidation through regulation of NOX4. Clinical and translational science 17 (8) (2024)
Hidetoshi Shimizu, Michael A Tortorici, Yoshiyasu Ohta, Kei Ogawa, Sheikh Mohammed Ashfaq Rahman, Aya Fujii, Yuki Hiraga, Mizue Kawai, Kanami Sugimoto-Kawabata, Mattheus Thijs van Iersel, Jan Jaap van Lier, Stephen Djedjos, B T Slingsby, David M Rodman
First-in-human study evaluating safety, pharmacokinetics, and pharmacodynamics of lorundrostat, a novel and highly selective aldosterone synthase inhibitor. Clinical and translational science 17 (8) (2024)
Larisa H Cavallari, And Craig R Lee, Francesco Franchi, Ellen C Keeley, Joseph S Rossi, Cameron D Thomas, Yan Gong, Caitrin W McDonough, Petr Starostik, Maryam Jamal AlSaeed, Latonya Been, Natasha Kulick, Jean Gabriel Malave, Ian R Mulrenin, Anh B Nguyen, Joshua N Terrell, Grace Tillotson, Amber L Beitelshees, Almut G Winterstein, George A Stouffer, Dominick J Angiolillo
Precision Antiplatelet Therapy after Percutaneous Coronary Intervention (Precision PCI) Registry - Informing optimal antiplatelet strategies. Clinical and translational science 17 (8) (2024)
Jinkun Xia, Boqi Fu, Zhe Wang, Gaolin Wen, Quanshui Gu, Dayu Chen, Hao-Zhen Ren
MVP enhances FGF21-induced ferroptosis in hepatocellular carcinoma by increasing lipid peroxidation through regulation of NOX4. Clinical and translational science 17 (8) (2024)
Chun-Kai Wang, Teng-Huang Tsai, Chung-Hsi Lee
Regulation of exosomes as biologic medicines: Regulatory challenges faced in exosome development and manufacturing processes. Clinical and translational science 17 (8) (2024)
Luca Marzano, Adam S Darwich, Asaf Dan, Salomon Tendler, Rolf Lewensohn, Luigi De Petris, Jayanth Raghothama, Sebastiaan Meijer
Exploring the discrepancies between clinical trials and real-world data: A small-cell lung cancer study. Clinical and translational science 17 (8) (2024)
Casey Patrick, Utibeabasi Ettah, Vu Nguyen, Caitlin Hart, Evan Atchley, Krishna M G Mallela, Robert I Scheinman, Andrew A Monte
Functional differences in the mu opioid receptor SNP 118A>G are dependent on receptor splice-variant and agonist-specific recruitment of β-arrestin. Clinical and translational science 17 (8) (2024)
Nicolas Hohmann, Anna S Friedrichs, Juergen Burhenne, Antje Blank, Gerd Mikus, Walter Emil Haefeli
Dose-dependent induction of CYP3A activity by St. John's wort alone and in combination with rifampin. Clinical and translational science 17 (8) (2024)
Jean De Dieu Ndayishimiye, Mari A S Cayabyab, Glenda Hoffecker, Victoria Wittner, null null, Sony Tuteja
A call for reporting of tumor-specific outcomes in studies of DPYD genotyping. Clinical and translational science 17 (8) (2024)
Nicolas Hohmann, Anna S Friedrichs, Juergen Burhenne, Antje Blank, Gerd Mikus, Walter Emil Haefeli
Dose-dependent induction of CYP3A activity by St. John's wort alone and in combination with rifampin. Clinical and translational science 17 (8) (2024)
Larisa H Cavallari, And Craig R Lee, Francesco Franchi, Ellen C Keeley, Joseph S Rossi, Cameron D Thomas, Yan Gong, Caitrin W McDonough, Petr Starostik, Maryam Jamal AlSaeed, Latonya Been, Natasha Kulick, Jean Gabriel Malave, Ian R Mulrenin, Anh B Nguyen, Joshua N Terrell, Grace Tillotson, Amber L Beitelshees, Almut G Winterstein, George A Stouffer, Dominick J Angiolillo
Precision Antiplatelet Therapy after Percutaneous Coronary Intervention (Precision PCI) Registry - Informing optimal antiplatelet strategies. Clinical and translational science 17 (8) (2024)
Jean De Dieu Ndayishimiye, Mari A S Cayabyab, Glenda Hoffecker, Victoria Wittner, null null, Sony Tuteja
A call for reporting of tumor-specific outcomes in studies of DPYD genotyping. Clinical and translational science 17 (8) (2024)
Larisa H Cavallari, And Craig R Lee, Francesco Franchi, Ellen C Keeley, Joseph S Rossi, Cameron D Thomas, Yan Gong, Caitrin W McDonough, Petr Starostik, Maryam Jamal AlSaeed, Latonya Been, Natasha Kulick, Jean Gabriel Malave, Ian R Mulrenin, Anh B Nguyen, Joshua N Terrell, Grace Tillotson, Amber L Beitelshees, Almut G Winterstein, George A Stouffer, Dominick J Angiolillo
Precision Antiplatelet Therapy after Percutaneous Coronary Intervention (Precision PCI) Registry - Informing optimal antiplatelet strategies. Clinical and translational science 17 (8) (2024)
Jean De Dieu Ndayishimiye, Mari A S Cayabyab, Glenda Hoffecker, Victoria Wittner, null null, Sony Tuteja
A call for reporting of tumor-specific outcomes in studies of DPYD genotyping. Clinical and translational science 17 (8) (2024)
Ezhilpavai Mohanan, Guofang Shen, Su-Ping Ren, Hsuan-Hao Fan, Kao Tang Ying Moua, Aleksandra Karolak, Russell C Rockne, Ryotaro Nakamura, David A Horne, Christopher G Kanakry, Donald E Mager, Jeannine S McCune
Challenges with sirolimus experimental data to inform QSP model of post-transplantation cyclophosphamide regimens. Clinical and translational science 17 (8) (2024)
Casey Patrick, Utibeabasi Ettah, Vu Nguyen, Caitlin Hart, Evan Atchley, Krishna M G Mallela, Robert I Scheinman, Andrew A Monte
Functional differences in the mu opioid receptor SNP 118A>G are dependent on receptor splice-variant and agonist-specific recruitment of β-arrestin. Clinical and translational science 17 (8) (2024)
Qiudi Jiang, Yuchen Zhang, Dan Duan, Sylvie Retout, Ruchi Upmanyu, Katerina Glavini, Miriam Triyatni, Yonghong Zhu, Joseph F Grippo, Yuyan Jin
Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu-like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll-like receptor 7 agonist ruzotolimod. Clinical and translational science 17 (8) (2024)
Qiudi Jiang, Yuchen Zhang, Dan Duan, Sylvie Retout, Ruchi Upmanyu, Katerina Glavini, Miriam Triyatni, Yonghong Zhu, Joseph F Grippo, Yuyan Jin
Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu-like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll-like receptor 7 agonist ruzotolimod. Clinical and translational science 17 (8) (2024)
Andreas Halman, Sebastian Lunke, Simon Sadedin, Claire Moore, Rachel Conyers
Benchmarking pharmacogenomics genotyping tools: Performance analysis on short-read sequencing samples and depth-dependent evaluation. Clinical and translational science 17 (8) (2024)
Yi Liu, Bo Pan, Jie Liu, Jun Zhang
Early administration of ketorolac after cardiac surgery and postoperative complications: Analysis of the MIMIC-IV database. Clinical and translational science 17 (8) (2024)
Luca Marzano, Adam S Darwich, Asaf Dan, Salomon Tendler, Rolf Lewensohn, Luigi De Petris, Jayanth Raghothama, Sebastiaan Meijer
Exploring the discrepancies between clinical trials and real-world data: A small-cell lung cancer study. Clinical and translational science 17 (8) (2024)
Yi Liu, Bo Pan, Jie Liu, Jun Zhang
Early administration of ketorolac after cardiac surgery and postoperative complications: Analysis of the MIMIC-IV database. Clinical and translational science 17 (8) (2024)
Devon Noonan, Wendy K K Lam, James Goodrich, Sydney Sullivan, Keisha L Bentley-Edwards, Dwight D Koeberl, Anushka Palipana, F Joseph McClernon
A case study of inclusion of rural populations in research: Implications for science and health equity. Clinical and translational science 17 (8) (2024)
Florencia A Tettamanti, Holly Kimko, Shringi Sharma, Giovanni Di Veroli
Predicting progression-free survival from measurable residual disease in chronic lymphocytic leukemia. Clinical and translational science 17 (8) (2024)
Andreas Halman, Sebastian Lunke, Simon Sadedin, Claire Moore, Rachel Conyers
Benchmarking pharmacogenomics genotyping tools: Performance analysis on short-read sequencing samples and depth-dependent evaluation. Clinical and translational science 17 (8) (2024)
Chun-Kai Wang, Teng-Huang Tsai, Chung-Hsi Lee
Regulation of exosomes as biologic medicines: Regulatory challenges faced in exosome development and manufacturing processes. Clinical and translational science 17 (8) (2024)
Golnoosh Alipour-Haris, Xinyue Liu, Virginia Acha, Almut G Winterstein, Mehmet Burcu
Real-world evidence to support regulatory submissions: A landscape review and assessment of use cases. Clinical and translational science 17 (8) (2024)
Golnoosh Alipour-Haris, Xinyue Liu, Virginia Acha, Almut G Winterstein, Mehmet Burcu
Real-world evidence to support regulatory submissions: A landscape review and assessment of use cases. Clinical and translational science 17 (8) (2024)
Tomohiro Kamimura, Neil J Hounslow, Hideki Suganami, Ryohei Tanigawa
Drug-drug interactions between pemafibrate and statins on pharmacokinetics in healthy male volunteers: Open-label, randomized, 6-sequence, 3-period crossover studies. Clinical and translational science 17 (8) (2024)
Sonal Singh, Gabriele Stocco, Katherine N Theken, Alyson L Dickson, QiPing Feng, Jason H Karnes, Jonathan D Mosley, Nihal El Rouby
Pharmacogenomics polygenic risk score: Ready or not for prime time? Clinical and translational science 17 (8) (2024)

volume 17, number 9, 2024

Yvonne Boyle, Hemme J Hijma, Jamie Rees, Jagtar Nijjar, Eirini Panoilia, Yolanda Alvarez, Sarah Siederer, Emma Greening, Edward C Emery, Kathy Abbott Banner, Geert Jan Groeneveld
Randomized, placebo-controlled study on the effects of intravenous GSK3858279 (anti-CCL17) on a battery of evoked pain tests in healthy participants. Clinical and translational science 17 (9) (2024)
Felix Huth, Ulrike Glaenzel, Anton Drollmann, Wendy Weis, Julia Zack, Lidiya Bebrevska
Drug-drug interactions of icenticaftor (QBW251) with a 5-probe cytochrome P450 cocktail and oral contraceptives. Clinical and translational science 17 (9) (2024)
Keneuoe Cecilia Nthontho, Andrew Khulekani Ndlovu, Giacomo Maria Paganotti
Inadequate representation of individuals of African ancestry in pharmacogenetics of tamoxifen research. Clinical and translational science 17 (9) (2024)
William K Schmidt, Irene Cortés-Puch, Cindy B McReynolds, Glenn E Croston, Sung Hee Hwang, Jun Yang, Theresa L Pedersen, Karen M Wagner, Theresa T Pham, Thomas Hunt, Bruce D Hammock
Randomized, double-blind, phase 1a single-ascending dose and food effect studies assessing safety and pharmacokinetics of EC5026 in healthy volunteers. Clinical and translational science 17 (9) (2024)
Hengbang Wang, Yun Yang, Zi Chen, Lei Tommy Fu, Min Yu, Lixin Jiang, Cunlin Wang, Lichuang Men, Ilisse Minto, Dajun Yang, Yifan Zhai
Pharmacokinetics of olverembatinib (HQP1351) in the presence of a strong CYP3A4 inhibitor (itraconazole) or inducer (rifampin) in healthy volunteers. Clinical and translational science 17 (9) (2024)
Yuan Jian, Feifei Han, Ying Zhu, Chuanying Geng, Yanru Zhang, Yin Wu, Yun Leng, Wenming Chen, Zhuoling An, Hong-Hu Zhu
Paired comparisons of venetoclax concentration in cerebrospinal fluid, bone marrow, and plasma in acute leukemia patients. Clinical and translational science 17 (9) (2024)
Christina A Clarke, Breeana L Mitchell, Girish Putcha, Emma Alme, Peter Bach, Jonathan P Beer, Tomasz M Beer, Michelle A Beidelschies, Jody Hoyos, Eric Klein, Peter Kuhn, Nancy Krunic, Kathryn Lang, Jerry S H Lee, Dorys Lopez Ramos, David Morgenstern, Elissa Quinn, Victoria M Raymond, Wendy S Rubinstein, Stephanie A Sanchez, Ryan Serra, Mark D Stewart, Lauren C Leiman
Lexicon for blood-based early detection and screening: BLOODPAC consensus document. Clinical and translational science 17 (9) (2024)
Federico Amato, Rainer Strotmann, Roberto Castello, Rolf Bruns, Vishal Ghori, Andreas Johne, Karin Berghoff, Karthik Venkatakrishnan, Nadia Terranova
Explainable machine learning prediction of edema adverse events in patients treated with tepotinib. Clinical and translational science 17 (9) (2024)
Flavia Hodel, Maria B De Min, Christian Wandall Thorball, Claire Redin, Peter Vollenweider, François R Girardin, Jacques Fellay
Prevalence of actionable pharmacogenetic variants and high-risk drug prescriptions: A Swiss hospital-based cohort study. Clinical and translational science 17 (9) (2024)
Amanda Long, Ikuo Yamamiya, Michelle Valentine, Ziv Machnes, Nanae Hangai, Bailey Anderson, Volker Wacheck, Ling Gao
A phase I drug-drug interaction study to assess the effect of futibatinib on P-gp and BCRP substrates and of P-gp inhibition on the pharmacokinetics of futibatinib. Clinical and translational science 17 (9) (2024)
Nabila Ibnou Zekri Lassout, Vishal Goyal, Edrich Krantz, Francois Simon, Anouk Neven, Johanna Eriksson, Amaria Saayman, Vijay Satam, Carol Ruffell, Sarika Victor, Marylore Chenel, Aljosa Celebic, Henri Caplain, Jean-Yves Gillon, Abhijit Deshmukh, Amit Antarkar, Eric Sjögren, Isabela Ribeiro
Bioavailability of a novel sustained-release pellet formulation of 5-flucytosine in healthy-fed participants for use in patients with cryptococcal meningitis. Clinical and translational science 17 (9) (2024)
Monika Tomaszewska-Kiecana, Elisabete Carapuça, Amalia Florez-Igual, Javier Queiruga-Parada
MB09, a denosumab biosimilar candidate: Biosimilarity demonstration in a phase I study in healthy subjects. Clinical and translational science 17 (9) (2024)
Caroline M Junker Mentzel, Yan Hui, Tanja Maria Stentoft Hammerich, Malene Klug-Dambmann, Yi Liu, Line Sidsel Fisker Zachariassen, Lars Hestbjerg Hansen, Antonios Aslampaloglou, Maria Kiersgaard, Dennis Sandris Nielsen, Axel Kornerup Hansen, Lukasz Krych
Low-gainer diet-induced obese microbiota transplanted mice exhibit increased fighting. Clinical and translational science 17 (9) (2024)
Weijie Zhang, Adam M Lee, Lauren Lee, Scott M Dehm, Rong Stephanie Huang
Computational drug discovery pipelines identify NAMPT as a therapeutic target in neuroendocrine prostate cancer. Clinical and translational science 17 (9) (2024)
Hengbang Wang, Yun Yang, Zi Chen, Lei Tommy Fu, Min Yu, Lixin Jiang, Cunlin Wang, Lichuang Men, Ilisse Minto, Dajun Yang, Yifan Zhai
Pharmacokinetics of olverembatinib (HQP1351) in the presence of a strong CYP3A4 inhibitor (itraconazole) or inducer (rifampin) in healthy volunteers. Clinical and translational science 17 (9) (2024)
Sophia Hernandez, Lucia A Hindorff, Joannella Morales, Erin M Ramos, Teri A Manolio
Patterns of pharmacogenetic variation in nine biogeographic groups. Clinical and translational science 17 (9) (2024)
Sean Khozin
From organs to algorithms: Redefining cancer classification in the age of artificial intelligence. Clinical and translational science 17 (9) (2024)