Savvas N Savvides

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 39

Top Topics

Structural Basis

Top Venues

Nature structural & molecular biology

Nature communications

The ISME journal

Nature reviews. Molecular cell biology

This page only lists publications with an associated author ORCID identifier.

Publications

Yehudi Bloch, Jan Felix, Romain Merceron, Mathias Provost, Royan Alipour Symakani, Robin De Backer, Elisabeth Lambert, Ahmad R Mehdipour, Savvas N Savvides
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nature structural & molecular biology (2024)
Yehudi Bloch, Jan Felix, Romain Merceron, Mathias Provost, Royan Alipour Symakani, Robin De Backer, Elisabeth Lambert, Ahmad R Mehdipour, Savvas N Savvides
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nature structural & molecular biology 31 (4) (2024)
Yehudi Bloch, Jan Felix, Romain Merceron, Mathias Provost, Royan Alipour Symakani, Robin De Backer, Elisabeth Lambert, Ahmad R Mehdipour, Savvas N Savvides
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nature structural & molecular biology 31 (4) (2024)
Logan H Hodgskiss, Michael Melcher, Melina Kerou, Weiqiang Chen, Rafael I Ponce-Toledo, Savvas N Savvides, Stefanie Wienkoop, Markus Hartl, Christa Schleper
Correction to: Unexpected complexity of the ammonia monooxygenase in archaea. The ISME journal (2023)
Logan H Hodgskiss, Michael Melcher, Melina Kerou, Weiqiang Chen, Rafael I Ponce-Toledo, Savvas N Savvides, Stefanie Wienkoop, Markus Hartl, Christa Schleper
Unexpected complexity of the ammonia monooxygenase in archaea. The ISME journal 17 (4) (2023)
Manoël Prouteau, Clélia Bourgoint, Jan Felix, Lenny Bonadei, Yashar Sadian, Caroline Gabus, Savvas N Savvides, Irina Gutsche, Ambroise Desfosses, Robbie Loewith
EGOC inhibits TOROID polymerization by structurally activating TORC1. Nature structural & molecular biology 30 (3) (2023)
Nathaniel R Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne K Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance J Stewart, Frank DiMaio, Steven De Munck, Savvas N Savvides, Julien S Baker
Improving de novo protein binder design with deep learning. Nature communications 14 (1) (2023)
Manoël Prouteau, Clélia Bourgoint, Jan Felix, Lenny Bonadei, Yashar Sadian, Caroline Gabus, Savvas N Savvides, Irina Gutsche, Ambroise Desfosses, Robbie Loewith
EGOC inhibits TOROID polymerization by structurally activating TORC1. Nature structural & molecular biology 30 (3) (2023)
Logan H Hodgskiss, Michael Melcher, Melina Kerou, Weiqiang Chen, Rafael I Ponce-Toledo, Savvas N Savvides, Stefanie Wienkoop, Markus Hartl, Christa Schleper
Correction to: Unexpected complexity of the ammonia monooxygenase in archaea. The ISME journal (2023)
Logan H Hodgskiss, Michael Melcher, Melina Kerou, Weiqiang Chen, Rafael I Ponce-Toledo, Savvas N Savvides, Stefanie Wienkoop, Markus Hartl, Christa Schleper
Unexpected complexity of the ammonia monooxygenase in archaea. The ISME journal 17 (4) (2023)
Logan H Hodgskiss, Michael Melcher, Melina Kerou, Weiqiang Chen, Rafael I Ponce-Toledo, Savvas N Savvides, Stefanie Wienkoop, Markus Hartl, Christa Schleper
Unexpected complexity of the ammonia monooxygenase in archaea. The ISME journal (2023)
Nathaniel R Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne K Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance J Stewart, Frank DiMaio, Steven De Munck, Savvas N Savvides, Julien S Baker
Improving de novo protein binder design with deep learning. Nature communications 14 (1) (2023)
Logan H Hodgskiss, Michael Melcher, Melina Kerou, Weiqiang Chen, Rafael I Ponce-Toledo, Savvas N Savvides, Stefanie Wienkoop, Markus Hartl, Christa Schleper
Unexpected complexity of the ammonia monooxygenase in archaea. The ISME journal (2023)
Nathaniel R Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne K Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance J Stewart, Frank DiMaio, Steven De Munck, Savvas N Savvides, Julien S Baker
Improving de novo protein binder design with deep learning. Nature communications 14 (1) (2023)
Logan H Hodgskiss, Michael Melcher, Melina Kerou, Weiqiang Chen, Rafael I Ponce-Toledo, Savvas N Savvides, Stefanie Wienkoop, Markus Hartl, Christa Schleper
Unexpected complexity of the ammonia monooxygenase in archaea. The ISME journal 17 (4) (2023)
Manoël Prouteau, Clélia Bourgoint, Jan Felix, Lenny Bonadei, Yashar Sadian, Caroline Gabus, Savvas N Savvides, Irina Gutsche, Ambroise Desfosses, Robbie Loewith
EGOC inhibits TOROID polymerization by structurally activating TORC1. Nature structural & molecular biology (2023)
Alexandra Tsirigotaki, Ann Dansercoer, Koen H G Verschueren, Iva Marković, Christoph Pollmann, Maximillian Hafer, Jan Felix, Catherine Birck, Wouter Van Putte, Dominiek Catteeuw, Jan Tavernier, J Fernando Bazan, Jacob Piehler, Savvas N Savvides, Kenneth Verstraete
Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nature structural & molecular biology (2023)
Manoël Prouteau, Clélia Bourgoint, Jan Felix, Lenny Bonadei, Yashar Sadian, Caroline Gabus, Savvas N Savvides, Irina Gutsche, Ambroise Desfosses, Robbie Loewith
EGOC inhibits TOROID polymerization by structurally activating TORC1. Nature structural & molecular biology 30 (3) (2023)
Manoël Prouteau, Clélia Bourgoint, Jan Felix, Lenny Bonadei, Yashar Sadian, Caroline Gabus, Savvas N Savvides, Irina Gutsche, Ambroise Desfosses, Robbie Loewith
EGOC inhibits TOROID polymerization by structurally activating TORC1. Nature structural & molecular biology 30 (3) (2023)
Nathaniel R Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne K Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance J Stewart, Frank DiMaio, Steven De Munck, Savvas N Savvides, Julien S Baker
Improving de novo protein binder design with deep learning. Nature communications 14 (1) (2023)
Peter Vandenabeele, Geert Bultynck, Savvas N Savvides
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways. Nature reviews. Molecular cell biology (2022)
Maximilian Brinkhaus, Erwin Pannecoucke, Elvera J van der Kooi, Arthur E H Bentlage, Ninotska I L Derksen, Julie Andries, Bianca Balbino, Magdalena Sips, Peter Ulrichts, Peter Verheesen, Hans de Haard, Theo Rispens, Savvas N Savvides, Gestur Vidarsson
The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement. Nature communications 13 (1) (2022)
Peter Vandenabeele, Geert Bultynck, Savvas N Savvides
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways. Nature reviews. Molecular cell biology (2022)
Peter Vandenabeele, Geert Bultynck, Savvas N Savvides
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways. Nature reviews. Molecular cell biology (2022)
Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, William Sheffler, Joon Sung Park, Kevin M Jude, Iva Marković, Rameshwar U Kadam, Koen H G Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora K Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D DeBouver, Allison Pires, Asim K Bera, Samer Halabiya, Bradley Hammerson, Wei Yang, Steffen Bernard, Lance J Stewart, Ian A Wilson, Hannele Ruohola-Baker, Joseph Schlessinger, Sangwon Lee, Savvas N Savvides, K Christopher Garcia, Julien S Baker
Design of protein-binding proteins from the target structure alone. Nature 605 (7910) (2022)
Erwin Pannecoucke, Maaike Van Trimpont, Johan Desmet, Tim Pieters, Lindy Reunes, Lisa Demoen, Marnik Vuylsteke, Stefan Loverix, Karen Vandenbroucke, Philippe Alard, Paula Henderikx, Sabrina Deroo, Franky Baatz, Eric Lorent, Sophie Thiolloy, Klaartje Somers, Yvonne McGrath, Pieter Van Vlierberghe, Ignace Lasters, Savvas N Savvides
Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting. Science advances 7 (13) (2021)
Thomas Naert, Dieter Tulkens, Tom Van Nieuwenhuysen, Joanna Przybyl, Suzan Demuynck, Matt van de Rijn, Mushriq Al-Jazrawe, Benjamin A Alman, Paul J Coucke, Kim De Leeneer, Christian Vanhove, Savvas N Savvides, David Creytens, Kris Vleminckx
CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping. Proceedings of the National Academy of Sciences of the United States of America 118 (47) (2021)
Kenneth Verstraete, Koen H G Verschueren, Ann Dansercoer, Savvas N Savvides
Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase. Nature structural & molecular biology 28 (8) (2021)
Klaas Yperman, Jie Wang, Dominique Eeckhout, Joanna Winkler, Lam Dai Vu, Michaël Vandorpe, Peter Grones, Evelien Mylle, Michael Kraus, Romain Merceron, Jonah Nolf, Eliana Mor, Pieter De Bruyn, Remy Loris, Martin Potocký, Savvas N Savvides, Bert De Rybel, Geert De Jaeger, Daniёl Van Damme, Roman Pleskot
Molecular architecture of the endocytic TPLATE complex. Science advances 7 (9) (2021)
Klaas Yperman, Anna C Papageorgiou, Romain Merceron, Steven De Munck, Yehudi Bloch, Dominique Eeckhout, Qihang Jiang, Pieter Tack, Rosa Grigoryan, Thomas Evangelidis, Jelle Van Leene, Laszlo Vincze, Peter Vandenabeele, Frank Vanhaecke, Martin Potocký, Geert De Jaeger, Savvas N Savvides, Konstantinos Tripsianes, Roman Pleskot, Daniёl Van Damme
Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding. Nature communications 12 (1) (2021)
Erwin Pannecoucke, Laurens Raes, Savvas N Savvides
Engineering and crystal structure of a monomeric FLT3 ligand variant. Acta crystallographica. Section F, Structural biology communications 77 (Pt 4) (2021)
Steven De Munck, Mathias Provost, Michiko Kurikawa, Ikuko Omori, Junko Mukohyama, Jan Felix, Yehudi Bloch, Omar Abdel-Wahab, J Fernando Bazan, Akihide Yoshimi, Savvas N Savvides
Structural basis of cytokine-mediated activation of ALK family receptors. Nature 600 (7887) (2021)
Sandra Kozak, Yehudi Bloch, Steven De Munck, Aleksandra Mikula, Isabel Bento, Savvas N Savvides, Rob Meijers
Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis. Acta crystallographica. Section D, Structural biology 76 (Pt 12) (2020)
Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N Savvides, Albert J R Heck, Peter Vandenabeele, Igor E Brodsky, Mathieu J M Bertrand
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation. Nature communications 10 (1) (2019)
Wim Dejonghe, Isha Sharma, Bram Denoo, Steven De Munck, Qing Lu, Kiril Mishev, Haydar Bulut, Evelien Mylle, Riet De Rycke, Mina Vasileva, Daniel V Savatin, Wim Nerinckx, An Staes, Andrzej Drozdzecki, Dominique Audenaert, Klaas Yperman, Annemieke Madder, Jiří Friml, Daniёl Van Damme, Kris Gevaert, Volker Haucke, Savvas N Savvides, Johan Winne, Eugenia Russinova
Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nature chemical biology 15 (6) (2019)
Karolina Slowicka, Inmaculada Serramito-Gómez, Emilio Boada-Romero, Arne Martens, Mozes Sze, Ioanna Petta, Hanna K Vikkula, Riet De Rycke, Eef Parthoens, Saskia Lippens, Savvas N Savvides, Andy Wullaert, Lars Vereecke, Felipe X Pimentel-Muiños, Geert van Loo
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis. Nature communications 10 (1) (2019)
Emma K Persson, Kenneth Verstraete, Ines Heyndrickx, Elien Gevaert, Helena Aegerter, Jean-Michel Percier, Kim Deswarte, Koen H G Verschueren, Ann Dansercoer, Delphine Gras, Pascal Chanez, Claus Bachert, Amanda Gonçalves, Hanne Van Gorp, Hans De Haard, Christophe Blanchetot, Michael Saunders, Hamida Hammad, Savvas N Savvides, Bart N Lambrecht
Protein crystallization promotes type 2 immunity and is reversible by antibody treatment. Science (New York, N.Y.) 364 (6442) (2019)
Stephanie Lienart, Romain Merceron, Christophe Vanderaa, Fanny Lambert, Didier Colau, Julie Stockis, Bas van der Woning, Hans De Haard, Michael Saunders, Pierre G Coulie, Savvas N Savvides, Sophie Lucas
Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells. Science (New York, N.Y.) 362 (6417) (2018)
Kiril Mishev, Qing Lu, Bram Denoo, François Peurois, Wim Dejonghe, Jan Hullaert, Teddy Jégu, Sjef Boeren, Marine Bretou, Steven De Munck, Isha Sharma, Kaija Goodman, Kamila Kalinowska, Veronique Storme, Le Son Long Nguyen, Andrzej Drozdzecki, Sara Martins, Wim Nerinckx, Dominique Audenaert, Grégory Vert, Annemieke Madder, Marisa S Otegui, Erika Isono, Savvas N Savvides, Wim Annaert, Sacco C de Vries, Jacqueline Cherfils, Johan M Winne, Eugenia Russinova
Nonselective Chemical Inhibition of Sec7 Domain-Containing ARF GTPase Exchange Factors. The Plant cell 30 (10) (2018)