Frederic Rousseau

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 41

Top Topics

Multiple Myeloma

Mild Cognitive Impairment

Top Venues

Nature communications

Proceedings of the National Academy of Sciences of the United States of America

Science (New York, N.Y.)

Bioinformatics (Oxford, England)

This page only lists publications with an associated author ORCID identifier.

Publications

Ramon Duran-Romaña, Bert Houben, Matthias De Vleeschouwer, Nikolaos N Louros, Matthew P Wilson, Gert Matthijs, Joost Schymkowitz, Frederic Rousseau
N-glycosylation as a eukaryotic protective mechanism against protein aggregation. Science advances 10 (5) (2024)
Katrien Princen, Tom Van Dooren, Marit van Gorsel, Nikolaos N Louros, Xiaojuan Yang, Michael Dumbacher, Ilse Bastiaens, Kristel Coupet, Shana Dupont, Eva Cuveliers, Annick Lauwers, Mohamed Laghmouchi, Thomas Vanwelden, Sofie Carmans, Nele Van Damme, Hein Duhamel, Seppe Vansteenkiste, Jovan Prerad, Karolien Pipeleers, Olivier Rodiers, Liese De Ridder, Sofie Claes, Yoni Busschots, Lentel Pringels, Vanessa Verhelst, Eveline Debroux, Marinka Brouwer, Sam Lievens, Jan Tavernier, Melissa Farinelli, Sandrine Hughes-Asceri, Marieke Voets, Joris Winderickx, Stefaan Wera, Joris de Wit, Joost Schymkowitz, Frederic Rousseau, Henrik Zetterberg, Jeffrey L Cummings, Wim Annaert, Tom Cornelissen, Hans De Winter, Koen De Witte, Marc Fivaz, Gerard Griffioen
Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease. Science (New York, N.Y.) 384 (6699) (2024)
Nikolaos N Louros, Frederic Rousseau, Joost Schymkowitz
CORDAX web server: an online platform for the prediction and 3D visualization of aggregation motifs in protein sequences. Bioinformatics (Oxford, England) 40 (5) (2024)
Nikolaos N Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D'Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R Mackenzie, Rosa Rademakers, Neil A Ranson, Sheena E Radford, Frederic Rousseau, Joost Schymkowitz
Local structural preferences in shaping tau amyloid polymorphism. Nature communications 15 (1) (2024)
Nikolaos N Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D'Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R Mackenzie, Rosa Rademakers, Neil A Ranson, Sheena E Radford, Frederic Rousseau, Joost Schymkowitz
Local structural preferences in shaping tau amyloid polymorphism. Nature communications 15 (1) (2024)
Nikolaos N Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D'Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R Mackenzie, Rosa Rademakers, Neil A Ranson, Sheena E Radford, Frederic Rousseau, Joost Schymkowitz
Local structural preferences in shaping tau amyloid polymorphism. Nature communications 15 (1) (2024)
Katrien Princen, Tom Van Dooren, Marit van Gorsel, Nikolaos N Louros, Xiaojuan Yang, Michael Dumbacher, Ilse Bastiaens, Kristel Coupet, Shana Dupont, Eva Cuveliers, Annick Lauwers, Mohamed Laghmouchi, Thomas Vanwelden, Sofie Carmans, Nele Van Damme, Hein Duhamel, Seppe Vansteenkiste, Jovan Prerad, Karolien Pipeleers, Olivier Rodiers, Liese De Ridder, Sofie Claes, Yoni Busschots, Lentel Pringels, Vanessa Verhelst, Eveline Debroux, Marinka Brouwer, Sam Lievens, Jan Tavernier, Melissa Farinelli, Sandrine Hughes-Asceri, Marieke Voets, Joris Winderickx, Stefaan Wera, Joris de Wit, Joost Schymkowitz, Frederic Rousseau, Henrik Zetterberg, Jeffrey L Cummings, Wim Annaert, Tom Cornelissen, Hans De Winter, Koen De Witte, Marc Fivaz, Gerard Griffioen
Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease. Science (New York, N.Y.) 384 (6699) (2024)
Ramon Duran-Romaña, Bert Houben, Matthias De Vleeschouwer, Nikolaos N Louros, Matthew P Wilson, Gert Matthijs, Joost Schymkowitz, Frederic Rousseau
N-glycosylation as a eukaryotic protective mechanism against protein aggregation. Science advances 10 (5) (2024)
Ramon Duran-Romaña, Bert Houben, Matthias De Vleeschouwer, Nikolaos N Louros, Matthew P Wilson, Gert Matthijs, Joost Schymkowitz, Frederic Rousseau
N-glycosylation as a eukaryotic protective mechanism against protein aggregation. Science advances 10 (5) (2024)
Nikolaos N Louros, Frederic Rousseau, Joost Schymkowitz
CORDAX web server: an online platform for the prediction and 3D visualization of aggregation motifs in protein sequences. Bioinformatics (Oxford, England) 40 (5) (2024)
Katrien Princen, Tom Van Dooren, Marit van Gorsel, Nikolaos N Louros, Xiaojuan Yang, Michael Dumbacher, Ilse Bastiaens, Kristel Coupet, Shana Dupont, Eva Cuveliers, Annick Lauwers, Mohamed Laghmouchi, Thomas Vanwelden, Sofie Carmans, Nele Van Damme, Hein Duhamel, Seppe Vansteenkiste, Jovan Prerad, Karolien Pipeleers, Olivier Rodiers, Liese De Ridder, Sofie Claes, Yoni Busschots, Lentel Pringels, Vanessa Verhelst, Eveline Debroux, Marinka Brouwer, Sam Lievens, Jan Tavernier, Melissa Farinelli, Sandrine Hughes-Asceri, Marieke Voets, Joris Winderickx, Stefaan Wera, Joris de Wit, Joost Schymkowitz, Frederic Rousseau, Henrik Zetterberg, Jeffrey L Cummings, Wim Annaert, Tom Cornelissen, Hans De Winter, Koen De Witte, Marc Fivaz, Gerard Griffioen
Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease. Science (New York, N.Y.) 384 (6699) (2024)
Katrien Princen, Tom Van Dooren, Marit van Gorsel, Nikolaos N Louros, Xiaojuan Yang, Michael Dumbacher, Ilse Bastiaens, Kristel Coupet, Shana Dupont, Eva Cuveliers, Annick Lauwers, Mohamed Laghmouchi, Thomas Vanwelden, Sofie Carmans, Nele Van Damme, Hein Duhamel, Seppe Vansteenkiste, Jovan Prerad, Karolien Pipeleers, Olivier Rodiers, Liese De Ridder, Sofie Claes, Yoni Busschots, Lentel Pringels, Vanessa Verhelst, Eveline Debroux, Marinka Brouwer, Sam Lievens, Jan Tavernier, Melissa Farinelli, Sandrine Hughes-Asceri, Marieke Voets, Joris Winderickx, Stefaan Wera, Joris de Wit, Joost Schymkowitz, Frederic Rousseau, Henrik Zetterberg, Jeffrey L Cummings, Wim Annaert, Tom Cornelissen, Hans De Winter, Koen De Witte, Marc Fivaz, Gerard Griffioen
Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease. Science (New York, N.Y.) 384 (6699) (2024)
Nikolaos N Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D'Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R Mackenzie, Rosa Rademakers, Neil A Ranson, Sheena E Radford, Frederic Rousseau, Joost Schymkowitz
Local structural preferences in shaping tau amyloid polymorphism. Nature communications 15 (1) (2024)
Nikolaos N Louros, Frederic Rousseau, Joost Schymkowitz
CORDAX web server: an online platform for the prediction and 3D visualization of aggregation motifs in protein sequences. Bioinformatics (Oxford, England) 40 (5) (2024)
Nikolaos N Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D'Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R Mackenzie, Rosa Rademakers, Neil A Ranson, Sheena E Radford, Frederic Rousseau, Joost Schymkowitz
Local structural preferences in shaping tau amyloid polymorphism. Nature communications 15 (1) (2024)
Evelyne Naus, Marleen Derweduwe, Youlia Lampi, Annelies Claeys, Jarne Pauwels, Tobias Langenberg, Filip Claes, Jie Xu, Veerle Haemels, Zeynep Kalender Atak, Rob van der Kant, Joost Van Durme, Greet De Baets, Keith L Ligon, Mark Fiers, Kris Gevaert, Stein Aerts, Frederic Rousseau, Joost Schymkowitz, Frederik De Smet
Reduced Levels of Misfolded and Aggregated Mutant p53 by Proteostatic Activation. Cells 12 (6) (2023)
Kobe Janssen, Filip Claes, Dido Van de Velde, Vanessa L Wehbi, Bert Houben, Yulia Lampi, Mieke Nys, Laleh Khodaparast, Ladan Khodaparast, Nikolaos Louros, Rob van der Kant, Joffre Verniers, Teresa Garcia, Meine Ramakers, Katerina Konstantoulea, Katerina Maragkou, Ramon Duran-Romaña, Mónica Musteanu, Mariano Barbacid, Bernard Scorneaux, Els Beirnaert, Joost Schymkowitz, Frederic Rousseau
Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Kobe Janssen, Filip Claes, Dido Van de Velde, Vanessa L Wehbi, Bert Houben, Yulia Lampi, Mieke Nys, Laleh Khodaparast, Ladan Khodaparast, Nikolaos Louros, Rob van der Kant, Joffre Verniers, Teresa Garcia, Meine Ramakers, Katerina Konstantoulea, Katerina Maragkou, Ramon Duran-Romaña, Mónica Musteanu, Mariano Barbacid, Bernard Scorneaux, Els Beirnaert, Joost Schymkowitz, Frederic Rousseau
Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Kobe Janssen, Filip Claes, Dido Van de Velde, Vanessa L Wehbi, Bert Houben, Yulia Lampi, Mieke Nys, Laleh Khodaparast, Ladan Khodaparast, Nikolaos Louros, Rob van der Kant, Joffre Verniers, Teresa Garcia, Meine Ramakers, Katerina Konstantoulea, Katerina Maragkou, Ramon Duran-Romaña, Mónica Musteanu, Mariano Barbacid, Bernard Scorneaux, Els Beirnaert, Joost Schymkowitz, Frederic Rousseau
Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz
Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding. Nature communications 14 (1) (2023)
Nicole Heinzl, Elisabeth Maritschnegg, Katarzyna Koziel, Christine Schilhart-Wallisch, Georg Heinze, Wei-Lei Yang, Robert C Bast, Jalid Sehouli, Elena I Braicu, Ignace Vergote, Toon Van Gorp, Sven Mahner, Valentina Paspalj, Christoph Grimm, Eva Obermayr, Eva Schuster, Barbara Holzer, Frederic Rousseau, Joost Schymkowitz, Nicole Concin, Robert Zeillinger
Amyloid-like p53 as prognostic biomarker in serous ovarian cancer-a study of the OVCAD consortium. Oncogene (2023)
Kobe Janssen, Filip Claes, Dido Van de Velde, Vanessa L Wehbi, Bert Houben, Yulia Lampi, Mieke Nys, Laleh Khodaparast, Ladan Khodaparast, Nikolaos Louros, Rob van der Kant, Joffre Verniers, Teresa Garcia, Meine Ramakers, Katerina Konstantoulea, Katerina Maragkou, Ramon Duran-Romaña, Mónica Musteanu, Mariano Barbacid, Bernard Scorneaux, Els Beirnaert, Joost Schymkowitz, Frederic Rousseau
Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Evelyne Naus, Marleen Derweduwe, Youlia Lampi, Annelies Claeys, Jarne Pauwels, Tobias Langenberg, Filip Claes, Jie Xu, Veerle Haemels, Zeynep Kalender Atak, Rob van der Kant, Joost Van Durme, Greet De Baets, Keith L Ligon, Mark Fiers, Kris Gevaert, Stein Aerts, Frederic Rousseau, Joost Schymkowitz, Frederik De Smet
Reduced Levels of Misfolded and Aggregated Mutant p53 by Proteostatic Activation. Cells 12 (6) (2023)
Nikolaos N Louros, Joost Schymkowitz, Frederic Rousseau
Mechanisms and pathology of protein misfolding and aggregation. Nature reviews. Molecular cell biology (2023)
Sandra O Tomé, Grigoria Tsaka, Alicja Ronisz, Simona Ospitalieri, Klara Gawor, Luis Aragão Gomes, Markus Otto, Christine A F von Arnim, Philip Van Damme, Ludo Van Den Bosch, Estifanos Ghebremedhin, Celeste Laureyssen, Kristel Sleegers, Rik Vandenberghe, Frederic Rousseau, Joost Schymkowitz, Dietmar Rudolf Thal
TDP-43 pathology is associated with increased tau burdens and seeding. Molecular neurodegeneration 18 (1) (2023)
Emiel Michiels, Kenny Roose, Rodrigo U Gallardo, Ladan Khodaparast, Laleh Khodaparast, Rob van der Kant, Maxime Siemons, Bert Houben, Meine Ramakers, Hannah Wilkinson, Patricia Guerreiro, Nikolaos Louros, Suzanne J F Kaptein, Lorena Itatí Ibañez, Anouk Smet, Pieter Baatsen, Shu Liu, Ina Maja Vorberg, Guy Bormans, Johan Neyts, Xavier Saelens, Frederic Rousseau, Joost Schymkowitz
Author Correction: Reverse engineering synthetic antiviral amyloids. Nature communications 14 (1) (2023)
Kobe Janssen, Filip Claes, Dido Van de Velde, Vanessa L Wehbi, Bert Houben, Yulia Lampi, Mieke Nys, Laleh Khodaparast, Ladan Khodaparast, Nikolaos Louros, Rob van der Kant, Joffre Verniers, Teresa Garcia, Meine Ramakers, Katerina Konstantoulea, Katerina Maragkou, Ramon Duran-Romaña, Mónica Musteanu, Mariano Barbacid, Bernard Scorneaux, Els Beirnaert, Joost Schymkowitz, Frederic Rousseau
Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Evelyne Naus, Marleen Derweduwe, Youlia Lampi, Annelies Claeys, Jarne Pauwels, Tobias Langenberg, Filip Claes, Jie Xu, Veerle Haemels, Zeynep Kalender Atak, Rob van der Kant, Joost Van Durme, Greet De Baets, Keith L Ligon, Mark Fiers, Kris Gevaert, Stein Aerts, Frederic Rousseau, Joost Schymkowitz, Frederik De Smet
Reduced Levels of Misfolded and Aggregated Mutant p53 by Proteostatic Activation. Cells 12 (6) (2023)
Nikolaos N Louros, Meine Ramakers, Emiel Michiels, Katerina Konstantoulea, Chiara Morelli, Teresa Garcia, Nele Moonen, Sam D'Haeyer, Vera Goossens, Dietmar Rudolf Thal, Dominique Audenaert, Frederic Rousseau, Joost Schymkowitz
Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers. Nature communications 13 (1) (2022)
Christine Helsen, Tien Nguyen Truong, Xiao Yin Lee, Roy Eerlings, Nikolaos N Louros, Joost Schymkowitz, Frederic Rousseau, Frank Claessens, Arnout R D Voet
Exploiting Ligand-binding Domain Dimerization for Development of Novel Androgen Receptor Inhibitors. Molecular cancer therapeutics 21 (12) (2022)
Gabriele Orlando, Daniele Raimondi, Ramon Duran-Romaña, Yves Moreau, Joost Schymkowitz, Frederic Rousseau
PyUUL provides an interface between biological structures and deep learning algorithms. Nature communications 13 (1) (2022)
Jessica Wagner, Karoline Degenhardt, Marleen Veit, Nikolaos N Louros, Katerina Konstantoulea, Angelos Skodras, Katleen Wild, Ping Liu, Ulrike Obermüller, Vikas Bansal, Anupriya Dalmia, Lisa M Häsler, Marius Lambert, Matthias De Vleeschouwer, Hannah A Davies, Jillian Madine, Deborah Kronenberg-Versteeg, Regina Feederle, Domenico Del Turco, K Peter R Nilsson, Tammaryn Lashley, Thomas Deller, Marla Gearing, Lary C Walker, Peter Heutink, Frederic Rousseau, Joost Schymkowitz, Mathias Jucker, Jonas J Neher
Medin co-aggregates with vascular amyloid-β in Alzheimer's disease. Nature 612 (7938) (2022)
Nikolaos N Louros, Rob van der Kant, Joost Schymkowitz, Frederic Rousseau
StAmP-DB: a platform for structures of polymorphic amyloid fibril cores. Bioinformatics (Oxford, England) 38 (9) (2022)
Nicolas Rosa, Hristina Ivanova, Larry E Wagner, Justin Kale, Rita La Rovere, Kirsten Welkenhuyzen, Nikolaos N Louros, Spyridoula Karamanou, Victoria Shabardina, Irma Lemmens, Elien Vandermarliere, Kozo Hamada, Hideaki Ando, Frederic Rousseau, Joost Schymkowitz, Jan Tavernier, Katsuhiko Mikoshiba, Anastassios Economou, David W Andrews, Jan B Parys, David I Yule, Geert Bultynck
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis. Cell death and differentiation (2021)
Katerina Konstantoulea, Patricia Guerreiro, Meine Ramakers, Nikolaos Louros, Liam D Aubrey, Bert Houben, Emiel Michiels, Matthias De Vleeschouwer, Yulia Lampi, Luís F Ribeiro, Joris de Wit, Wei-Feng Xue, Joost Schymkowitz, Frederic Rousseau
Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure. The EMBO journal (2021)
Anita Pras, Bert Houben, Francesco Antonio Aprile, Renée Seinstra, Rodrigo Gallardo, Leen Janssen, Wytse Hogewerf, Christian Gallrein, Matthias De Vleeschouwer, Alejandro Mata-Cabana, Mandy Koopman, Esther Stroo, Minke de Vries, Samantha Louise Edwards, Janine Kirstein, Christopher M Dobson, Salvatore Fabio Falsone, Frederic Rousseau, Joost Schymkowitz, Ellen A A Nollen
The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation. The EMBO journal 40 (21) (2021)
Emiel Michiels, Kenny Roose, Rodrigo U Gallardo, Ladan Khodaparast, Laleh Khodaparast, Rob van der Kant, Maxime Siemons, Bert Houben, Meine Ramakers, Hannah Wilkinson, Patricia Guerreiro, Nikolaos Louros, Suzanne J F Kaptein, Lorena Itatí Ibañez, Anouk Smet, Pieter Baatsen, Shu Liu, Ina Maja Vorberg, Guy Bormans, Johan Neyts, Xavier Saelens, Frederic Rousseau, Joost Schymkowitz
Reverse engineering synthetic antiviral amyloids. Nature communications 11 (1) (2020)
Bert Houben, Emiel Michiels, Meine Ramakers, Katerina Konstantoulea, Nikolaos N Louros, Joffré Verniers, Rob van der Kant, Matthias De Vleeschouwer, Nuno Chicória, Thomas Vanpoucke, Rodrigo U Gallardo, Joost Schymkowitz, Frederic Rousseau
Autonomous aggregation suppression by acidic residues explains why chaperones favour basic residues. The EMBO journal 39 (11) (2020)
Nikolaos Louros, Gabriele Orlando, Matthias De Vleeschouwer, Frederic Rousseau, Joost Schymkowitz
Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities. Nature communications 11 (1) (2020)
Laura Kasak, Constantina Bakolitsa, Zhiqiang Hu, Changhua Yu, Jasper Rine, Dago F Dimster-Denk, Gaurav Pandey, Greet De Baets, Yana Bromberg, Chen Cao, Emidio Capriotti, Rita Casadio, Joost Van Durme, Manuel Giollo, Rachel Karchin, Panagiostis Katsonis, Emanuela Leonardi, Olivier Lichtarge, Pier Luigi Martelli, David Masica, Sean D Mooney, Ayodeji Olatubosun, Predrag Radivojac, Frederic Rousseau, Lipika R Pal, Castrense Savojardo, Joost Schymkowitz, Janita Thusberg, Silvio C E Tosatto, Mauno Vihinen, Jouni Väliaho, Susanna Repo, John Moult, Steven E Brenner, Iddo Friedberg
Assessing computational predictions of the phenotypic effect of cystathionine-beta-synthase variants. Human mutation 40 (9) (2019)
Koen C Demaegd, Joost Schymkowitz, Frederic Rousseau
Transcellular Spreading of Tau in Tauopathies. Chembiochem : a European journal of chemical biology 19 (23) (2018)