Geoffrey L Greene (G L Greene)

Publication Activity (10 Years)

Years Active: 2016-2023
Publications (10 Years): 18

Top Topics

Breast Cancer Cells

Estrogen Receptor

Endoplasmic Reticulum

Top Venues

NPJ breast cancer

Molecular cancer research : MCR

This page only lists publications with an associated author ORCID identifier.

Publications

Rosemary J Huggins, Geoffrey L Greene
ERα/PR crosstalk is altered in the context of the ERα Y537S mutation and contributes to endocrine therapy-resistant tumor proliferation. NPJ breast cancer 9 (1) (2023)
Baylee A Porter, Candace Frerich, Muriel Lainé, Abigail B Clark, Ishrat Durdana, Jeon Lee, Manisha Taya, Sunati Sahoo, Geoffrey L Greene, Lynda Bennett, Suzanne D Conzen
Glucocorticoid Receptor Activation in Lobular Breast Cancer Is Associated with Reduced Cell Proliferation and Promotion of Metastases. Cancers 15 (19) (2023)
G R Hancock, K S Young, D J Hosfield, C Joiner, E A Sullivan, Y Yildiz, M Lainé, Geoffrey L Greene, Sean W Fanning
Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells. NPJ breast cancer 8 (1) (2022)
Thomas E Speltz, Zeyu Qiao, Colin S Swenson, Xianghang Shangguan, John S Coukos, Christopher W Lee, Deborah M Thomas, Jesse Santana, Sean W Fanning, Geoffrey L Greene, Raymond E Moellering
Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains. Nature biotechnology (2022)
David J Hosfield, Sandra Weber, Nan-Sheng Li, Madline Sauvage, Carstyn F Joiner, Govinda R Hancock, Emily A Sullivan, Estelle Ndukwe, Ross Han, Sydney Cush, Muriel Lainé, Sylvie C Mader, Geoffrey L Greene, Sean W Fanning
Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. eLife 11 (2022)
Purab Pal, Alec Millner, Svetlana E Semina, Rosemary J Huggins, Logan Running, Diana S Aga, Debra A Tonetti, Rachel Schiff, Geoffrey L Greene, G Ekin Atilla-Gokcumen, Jonna Frasor
Endocrine Therapy-Resistant Breast Cancer Cells Are More Sensitive to Ceramide Kinase Inhibition and Elevated Ceramide Levels Than Therapy-Sensitive Breast Cancer Cells. Cancers 14 (10) (2022)
G R Hancock, K S Young, D J Hosfield, C Joiner, E A Sullivan, Y Yildiz, M Lainé, Geoffrey L Greene, Sean W Fanning
Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells. NPJ breast cancer 8 (1) (2022)
Robert F Gruener, Alexander L Ling, Ya-Fang Chang, Gladys Morrison, Paul Geeleher, Geoffrey L Greene, Rong Stephanie Huang
Facilitating Drug Discovery in Breast Cancer by Virtually Screening Patients Using In Vitro Drug Response Modeling. Cancers 13 (4) (2021)
Matthew W Boudreau, Darjan Duraki, Lawrence Wang, Chengjian Mao, Ji Eun Kim, Madeline A Henn, Bingtao Tang, Sean W Fanning, Jeffrey Kiefer, Theodore M Tarasow, Elizabeth M Bruckheimer, Ramon Moreno, Spyro Mousses, Geoffrey L Greene, Edward J Roy, Ben Ho Park, Timothy M Fan, Erik Russell Nelson, Paul J Hergenrother, David J Shapiro
A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice. Science translational medicine 13 (603) (2021)
Muriel Lainé, Sean W Fanning, Ya-Fang Chang, Bradley Green, Marianne E Greene, Barry Komm, Justyna D Kurleto, Linda Phung, Geoffrey L Greene
Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer. Breast cancer research : BCR 23 (1) (2021)
Christopher G Mayne, Weiyi Toy, Kathryn E Carlson, Trusha Bhatt, Sean W Fanning, Geoffrey L Greene, Benita S Katzenellenbogen, Sarat Chandarlapaty, John A Katzenellenbogen, Emad Tajkhorshid
Defining the Energetic Basis for a Conformational Switch Mediating Ligand-Independent Activation of Mutant Estrogen Receptors in Breast Cancer. Molecular cancer research : MCR 19 (9) (2021)
Balkees Abderrahman, Philipp Y Maximov, Ramona F Curpan, Sean W Fanning, Jay S Hanspal, Ping Fan, Charles E Foulds, Yue Chen, Anna Malovannaya, Antrix Jain, Rui Xiong, Geoffrey L Greene, Debra A Tonetti, Gregory R J Thatcher, V Craig Jordan
Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer. Molecular cancer therapeutics 20 (1) (2020)
Irida Kastrati, Stacey E P Joosten, Svetlana E Semina, Luis H Alejo, Svitlana D Brovkovych, Joshua D Stender, Hugo Mark Horlings, Marleen Kok, Elaine T Alarid, Geoffrey L Greene, Sabine C Linn, Wilbert Zwart, Jonna Frasor
The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor-Positive Breast Cancers. Molecular cancer research : MCR 18 (7) (2020)
John A Katzenellenbogen, Christopher G Mayne, Benita S Katzenellenbogen, Geoffrey L Greene, Sarat Chandarlapaty
Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance. Nature reviews. Cancer 18 (6) (2019)
Sean W Fanning, Rinath Jeselsohn, Venkatasubramanian Dharmarajan, Christopher G Mayne, Mostafa Karimi, Gilles Buchwalter, René Houtman, Weiyi Toy, Colin E Fowler, Ross Han, Muriel Lainé, Kathryn E Carlson, Teresa A Martin, Jason Nowak, Jerome C Nwachukwu, David J Hosfield, Sarat Chandarlapaty, Emad Tajkhorshid, Kendall W Nettles, Patrick R Griffin, Yang Shen, John A Katzenellenbogen, Myles A Brown, Geoffrey L Greene
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. eLife 7 (2018)
S W Fanning, L Hodges-Gallagher, D C Myles, R Sun, C E Fowler, I N Plant, B D Green, C L Harmon, Geoffrey L Greene, P J Kushner
Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity. Nature communications 9 (1) (2018)
Diana C West, Masha Kocherginsky, Eva Y Tonsing-Carter, D Nesli Dolcen, David J Hosfield, Ricardo R Lastra, Jason P Sinnwell, Kevin J Thompson, Kathleen R Bowie, Ryan V Harkless, Maxwell N Skor, Charles F Pierce, Sarah C Styke, Caroline R Kim, Larischa de Wet, Geoffrey L Greene, Judy C Boughey, Matthew P Goetz, Krishna R Kalari, Liewei Wang, Gini F Fleming, Balázs Györffy, Suzanne D Conzen
Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 24 (14) (2018)
Sean W Fanning, Christopher G Mayne, Venkatasubramanian Dharmarajan, Kathryn E Carlson, Teresa A Martin, Scott J Novick, Weiyi Toy, Bradley Green, Srinivas Panchamukhi, Benita S Katzenellenbogen, Emad Tajkhorshid, Patrick R Griffin, Yang Shen, Sarat Chandarlapaty, John A Katzenellenbogen, Geoffrey L Greene
Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation. eLife 5 (2016)