Guang Lei

Publication Activity (10 Years)

Years Active: 2021-2024
Publications (10 Years): 27

Top Topics

Cell Cycle Arrest

Oxidative Stress

Preterm Infants

Top Venues

Nature cell biology

Nature communications

Cancer discovery

This page only lists publications with an associated author ORCID identifier.

Publications

Hyemin Lee, Amber D Horbath, Lavanya Kondiparthi, Jitendra Kumar Meena, Guang Lei, Shayani Dasgupta, Xiaoguang Liu, Li Zhuang, Pranavi Koppula, Mi Li, Iqbal Mahmud, Bo Wei, Philip L Lorenzi, Khandan Keyomarsi, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan
Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance. Nature communications 15 (1) (2024)
Guang Lei, Chao Mao, Amber D Horbath, Yuelong Yan, Shirong Cai, Yao Jun, Yan Jiang, Mingchuang Sun, Xiaoguang Liu, Jun Cheng, Zhihao Xu, Hyemin Lee, Qidong Li, Zhengze Lu, Li Zhuang, Mei-Kuang Chen, Anagha Alapati, Timothy Anthony Yap, Mien-Chie Hung, Mingjian James You, Helen Piwnica-Worms, Boyi Gan
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer discovery 14 (8) (2024)
Guang Lei, Chao Mao, Amber D Horbath, Yuelong Yan, Shirong Cai, Yao Jun, Yan Jiang, Mingchuang Sun, Xiaoguang Liu, Jun Cheng, Zhihao Xu, Hyemin Lee, Qidong Li, Zhengze Lu, Li Zhuang, Mei-Kuang Chen, Anagha Alapati, Timothy Anthony Yap, Mien-Chie Hung, Mingjian James You, Helen Piwnica-Worms, Boyi Gan
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer discovery 14 (8) (2024)
Hyemin Lee, Amber D Horbath, Lavanya Kondiparthi, Jitendra Kumar Meena, Guang Lei, Shayani Dasgupta, Xiaoguang Liu, Li Zhuang, Pranavi Koppula, Mi Li, Iqbal Mahmud, Bo Wei, Philip L Lorenzi, Khandan Keyomarsi, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan
Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance. Nature communications 15 (1) (2024)
Guang Lei, Chao Mao, Amber D Horbath, Yuelong Yan, Shirong Cai, Yao Jun, Yan Jiang, Mingchuang Sun, Xiaoguang Liu, Jun Cheng, Zhihao Xu, Hyemin Lee, Qidong Li, Zhengze Lu, Li Zhuang, Mei-Kuang Chen, Anagha Alapati, Timothy Anthony Yap, Mien-Chie Hung, Mingjian James You, Helen Piwnica-Worms, Boyi Gan
BRCA1-mediated dual regulation of ferroptosis exposes a vulnerability to GPX4 and PARP co-inhibition in BRCA1-deficient cancers. Cancer discovery (2024)
Hyemin Lee, Amber D Horbath, Lavanya Kondiparthi, Jitendra Kumar Meena, Guang Lei, Shayani Dasgupta, Xiaoguang Liu, Li Zhuang, Pranavi Koppula, Mi Li, Iqbal Mahmud, Bo Wei, Philip L Lorenzi, Khandan Keyomarsi, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan
Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance. Nature communications 15 (1) (2024)
Hyemin Lee, Amber D Horbath, Lavanya Kondiparthi, Jitendra Kumar Meena, Guang Lei, Shayani Dasgupta, Xiaoguang Liu, Li Zhuang, Pranavi Koppula, Mi Li, Iqbal Mahmud, Bo Wei, Philip L Lorenzi, Khandan Keyomarsi, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan
Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance. Nature communications 15 (1) (2024)
Hyemin Lee, Amber D Horbath, Lavanya Kondiparthi, Jitendra Kumar Meena, Guang Lei, Shayani Dasgupta, Xiaoguang Liu, Li Zhuang, Pranavi Koppula, Mi Li, Iqbal Mahmud, Bo Wei, Philip L Lorenzi, Khandan Keyomarsi, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan
Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance. Nature communications 15 (1) (2024)
Guang Lei, Chao Mao, Amber D Horbath, Yuelong Yan, Shirong Cai, Yao Jun, Yan Jiang, Mingchuang Sun, Xiaoguang Liu, Jun Cheng, Zhihao Xu, Hyemin Lee, Qidong Li, Zhengze Lu, Li Zhuang, Mei-Kuang Chen, Anagha Alapati, Timothy Anthony Yap, Mien-Chie Hung, Mingjian James You, Helen Piwnica-Worms, Boyi Gan
BRCA1-mediated dual regulation of ferroptosis exposes a vulnerability to GPX4 and PARP co-inhibition in BRCA1-deficient cancers. Cancer discovery (2024)
Guang Lei, Boyi Gan
Exploring Ferroptosis-Inducing Therapies for Cancer Treatment: Challenges and Opportunities. Cancer research 84 (7) (2024)
Guang Lei, Chao Mao, Amber D Horbath, Yuelong Yan, Shirong Cai, Yao Jun, Yan Jiang, Mingchuang Sun, Xiaoguang Liu, Jun Cheng, Zhihao Xu, Hyemin Lee, Qidong Li, Zhengze Lu, Li Zhuang, Mei-Kuang Chen, Anagha Alapati, Timothy Anthony Yap, Mien-Chie Hung, Mingjian James You, Helen Piwnica-Worms, Boyi Gan
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer discovery 14 (8) (2024)
Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V Poyurovsky, M James You, Traver Hart, Daniel D Billadeau, Junjie Chen, Boyi Gan
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nature cell biology 25 (3) (2023)
Yuelong Yan, Hongqi Teng, Qinglei Hang, Lavanya Kondiparthi, Guang Lei, Amber D Horbath, Xiaoguang Liu, Chao Mao, Shiqi Wu, Li Zhuang, M James You, Masha V Poyurovsky, Li Ma, Kellen Olszewski, Boyi Gan
SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells. Nature communications 14 (1) (2023)
Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V Poyurovsky, M James You, Traver Hart, Daniel D Billadeau, Junjie Chen, Boyi Gan
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nature cell biology 25 (3) (2023)
Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V Poyurovsky, M James You, Traver Hart, Daniel D Billadeau, Junjie Chen, Boyi Gan
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nature cell biology 25 (3) (2023)
Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V Poyurovsky, M James You, Traver Hart, Daniel D Billadeau, Junjie Chen, Boyi Gan
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nature cell biology (2023)
Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V Poyurovsky, M James You, Traver Hart, Daniel D Billadeau, Junjie Chen, Boyi Gan
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nature cell biology 25 (3) (2023)
Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V Poyurovsky, M James You, Traver Hart, Daniel D Billadeau, Junjie Chen, Boyi Gan
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nature cell biology (2023)
Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V Poyurovsky, M James You, Traver Hart, Daniel D Billadeau, Junjie Chen, Boyi Gan
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nature cell biology (2023)
Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V Poyurovsky, M James You, Traver Hart, Daniel D Billadeau, Junjie Chen, Boyi Gan
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nature cell biology (2023)
Guang Lei, Li Zhuang, Boyi Gan
Targeting ferroptosis as a vulnerability in cancer. Nature reviews. Cancer 22 (7) (2022)
Pranavi Koppula, Guang Lei, Yilei Zhang, Yuelong Yan, Chao Mao, Lavanya Kondiparthi, Jiejun Shi, Xiaoguang Liu, Amber D Horbath, Molina Das, Weibo Xie, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan
A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers. Nature communications 13 (1) (2022)
Chao Mao, Guang Lei, Li Zhuang, Boyi Gan
Phospholipase iPLA2β acts as a guardian against ferroptosis. Cancer communications (London, England) 41 (11) (2021)
Chao Mao, Xiaoguang Liu, Yilei Zhang, Guang Lei, Yuelong Yan, Hyemin Lee, Pranavi Koppula, Shiqi Wu, Li Zhuang, Bingliang Fang, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature 593 (7860) (2021)
Yilei Zhang, Robert V Swanda, Litong Nie, Xiaoguang Liu, Chao Wang, Hyemin Lee, Guang Lei, Chao Mao, Pranavi Koppula, Weijie Cheng, Jie Zhang, Zhenna Xiao, Li Zhuang, Bingliang Fang, Junjie Chen, Shu-Bing Qian, Boyi Gan
mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nature communications 12 (1) (2021)
Yuelong Yan, Guang Lei, Boyi Gan
A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis. Molecular & cellular oncology 8 (3) (2021)
Guang Lei, Yilei Zhang, Ting Hong, Xudong Zhang, Xiaoguang Liu, Chao Mao, Yuelong Yan, Pranavi Koppula, Weijie Cheng, Anil K Sood, Jinsong Liu, Boyi Gan
Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity. Oncogene 40 (20) (2021)