Jef K De Brabander (Jef De Brabander)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 16

Top Topics

Low Density Lipoprotein

Toxoplasma Gondii

Peripheral Nerve

Top Venues

Journal of medicinal chemistry

ACS chemical biology

Nature communications

Organic letters

This page only lists publications with an associated author ORCID identifier.

Publications

Panayotis C Theodoropoulos, Holly H Guo, Wentian Wang, Eric Crossley, Giomar Rivera Cancel, Min Fang, Thu Nguyen, Hamid Baniasadi, Noelle S Williams, Joseph M Ready, Jef K De Brabander, Deepak Nijhawan
Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers. ACS chemical biology 19 (6) (2024)
Panayotis C Theodoropoulos, Holly H Guo, Wentian Wang, Eric Crossley, Giomar Rivera Cancel, Min Fang, Thu Nguyen, Hamid Baniasadi, Noelle S Williams, Joseph M Ready, Jef K De Brabander, Deepak Nijhawan
Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers. ACS chemical biology 19 (6) (2024)
Hua-Yu Wang, Thu P Nguyen, Alex C Sternisha, Christopher L Carroll, Bethany Cross, Lorraine Morlock, Noelle S Williams, Samuel McBrayer, Deepak Nijhawan, Jef K De Brabander
Discovery and Optimization of N-Arylated Tetracyclic Dicarboximides That Target Primary Glioma Stem-like Cells. Journal of medicinal chemistry (2024)
Hua-Yu Wang, Thu P Nguyen, Alex C Sternisha, Christopher L Carroll, Bethany Cross, Lorraine Morlock, Noelle S Williams, Samuel McBrayer, Deepak Nijhawan, Jef K De Brabander
Discovery and Optimization of N-Arylated Tetracyclic Dicarboximides That Target Primary Glioma Stem-like Cells. Journal of medicinal chemistry 67 (11) (2024)
Panayotis C Theodoropoulos, Holly H Guo, Wentian Wang, Eric Crossley, Giomar Rivera Cancel, Min Fang, Thu Nguyen, Hamid Baniasadi, Noelle S Williams, Joseph M Ready, Jef K De Brabander, Deepak Nijhawan
Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers. ACS chemical biology (2024)
Yu Sun, Alok Ranjan, Ryan K Tisdale, Shun-Chieh Ma, Sunmee Park, Meghan Haire, Jasmine Heu, Stephen R Morairty, Xiaoyu Wang, Daniel M Rosenbaum, Noelle S Williams, Jef K De Brabander, Thomas S Kilduff
Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK-925 and ARN-776 in narcoleptic orexin/tTA; TetO-DTA mice. Journal of sleep research (2023)
Jie Yin, Yanyong Kang, Aaron P McGrath, Karen Chapman, Megan Sjodt, Eiji Kimura, Atsutoshi Okabe, Tatsuki Koike, Yuhei Miyanohana, Yuji Shimizu, Rameshu Rallabandi, Peng Lian, Xiao-Chen Bai, Mack Flinspach, Jef K De Brabander, Daniel M Rosenbaum
Reply to: The G protein preference of orexin receptors is currently an unresolved issue. Nature communications 14 (1) (2023)
Yun-Zu Pan, Qiren Liang, Diana R Tomchick, Jef K De Brabander, Josep Rizo
Structural insights for selective disruption of Beclin 1 binding to Bcl-2. Communications biology 6 (1) (2023)
Xiaonan Dong, Qiren Liang, Yun-Zu Pan, Xiaoyu Wang, Yi-Chun Kuo, Wei-Chung Chiang, Xuewu Zhang, Noelle S Williams, Josep Rizo, Beth Levine, Jef K De Brabander
Novel Bcl-2 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2-Beclin 1 Protein-Protein Interaction. ACS medicinal chemistry letters 13 (9) (2022)
Jie Yin, Yanyong Kang, Aaron P McGrath, Karen Chapman, Megan Sjodt, Eiji Kimura, Atsutoshi Okabe, Tatsuki Koike, Yuhei Miyanohana, Yuji Shimizu, Rameshu Rallabandi, Peng Lian, Xiao-Chen Bai, Mack Flinspach, Jef K De Brabander, Daniel M Rosenbaum
Molecular mechanism of the wake-promoting agent TAK-925. Nature communications 13 (1) (2022)
Juan Manuel Povedano, Rameshu Rallabandi, Xin Bai, Xuecheng Ye, Joel Liou, Hong Chen, Jiwoong Kim, Yang Xie, Bruce Posner, Luke Rice, Jef K De Brabander, David G McFadden
A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins. Journal of medicinal chemistry 63 (22) (2020)
Panayotis C Theodoropoulos, Wentian Wang, Albert Budhipramono, Bonne M Thompson, Nikhil Madhusudhan, Matthew A Mitsche, Jeffrey G McDonald, Jef K De Brabander, Deepak Nijhawan
A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins. Journal of the American Chemical Society 142 (13) (2020)
Wentian Wang, Lu Zhang, Lorraine Morlock, Noelle S Williams, Jerry W Shay, Jef K De Brabander
Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC). Journal of medicinal chemistry 62 (10) (2019)
Junyu Gong, Wei Li, Peng Fu, John B MacMillan, Jef K De Brabander
Isolation, Structure, and Total Synthesis of the Marine Macrolide Mangrolide D. Organic letters 21 (8) (2019)
Oleg A Volkov, Anthony J Brockway, Stephen A Wring, Michael Peel, Zhe Chen, Margaret A Phillips, Jef K De Brabander
Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase. Journal of medicinal chemistry 61 (3) (2018)
Yingfeng Deng, Zhao V Wang, Ruth Gordillo, Yu A An, Chen Zhang, Qiren Liang, Jun Yoshino, Kelly M Cautivo, Jef K De Brabander, Joel K Elmquist, Jay D Horton, Joseph A Hill, Samuel Klein, Jan-Bernd Funcke
An adipo-biliary-uridine axis that regulates energy homeostasis. Science (New York, N.Y.) 355 (6330) (2017)