Margaret A Phillips

ORCID

Publication Activity (10 Years)

Years Active: 2016-2023
Publications (10 Years): 24

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

ACS infectious diseases

Journal of medicinal chemistry

PLoS pathogens

University of Texas Southwestern Department of Biochemistry

UCSF Medical Center (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Texas Southwestern Department of Biochemistry

United States

Professor and Chair :: Biochemistry

University of Texas Southwestern Medical School

United States

Professor :: Pharmacology

Education History

UCSF Medical Center

United States

PHD :: Pharmaceutical Chemistry

Publications

Bin Li, Jue Liang, Hamid R Baniasadi, Margaret A Phillips, Anthony J Michael
Functional polyamine metabolic enzymes and pathways encoded by the virosphere. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Bin Li, Jue Liang, Hamid R Baniasadi, Margaret A Phillips, Anthony J Michael
Functional polyamine metabolic enzymes and pathways encoded by the virosphere. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno F Crespo-Fernandez, Bruce A Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A Winzeler, Benoît Laleu, Joseph M Ready, Margaret A Phillips
Fast-Killing Tyrosine Amide (( S )-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus ( Pf CARL). ACS infectious diseases 9 (3) (2023)
Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno F Crespo-Fernandez, Bruce A Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A Winzeler, Benoît Laleu, Joseph M Ready, Margaret A Phillips
Fast-Killing Tyrosine Amide (( S )-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus ( Pf CARL). ACS infectious diseases (2023)
Bin Li, Jue Liang, Hamid R Baniasadi, Margaret A Phillips, Anthony J Michael
Functional polyamine metabolic enzymes and pathways encoded by the virosphere. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno F Crespo-Fernandez, Bruce A Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A Winzeler, Benoît Laleu, Joseph M Ready, Margaret A Phillips
Fast-Killing Tyrosine Amide (( S )-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus ( Pf CARL). ACS infectious diseases 9 (3) (2023)
Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno F Crespo-Fernandez, Bruce A Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A Winzeler, Benoît Laleu, Joseph M Ready, Margaret A Phillips
Fast-Killing Tyrosine Amide (( S )-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus ( Pf CARL). ACS infectious diseases 9 (3) (2023)
Bin Li, Jue Liang, Hamid R Baniasadi, Margaret A Phillips, Anthony J Michael
Functional polyamine metabolic enzymes and pathways encoded by the virosphere. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Bin Li, Jue Liang, Hamid R Baniasadi, Margaret A Phillips, Anthony J Michael
Functional polyamine metabolic enzymes and pathways encoded by the virosphere. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Thomas A Russo, Timothy C Umland, Xiaoyi Deng, Farah El Mazouni, Sreekanth Kokkonda, Ruth Olson, Ulrike Carlino-MacDonald, Janet Beanan, Cassandra L Alvarado, Diana R Tomchick, Alan D Hutson, Hong Chen, Bruce Posner, Pradipsinh K Rathod, Susan A Charman, Margaret A Phillips
Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii . Proceedings of the National Academy of Sciences of the United States of America 119 (51) (2022)
Thomas A Russo, Timothy C Umland, Xiaoyi Deng, Farah El Mazouni, Sreekanth Kokkonda, Ruth Olson, Ulrike Carlino-MacDonald, Janet Beanan, Cassandra L Alvarado, Diana R Tomchick, Alan D Hutson, Hong Chen, Bruce Posner, Pradipsinh K Rathod, Susan A Charman, Margaret A Phillips
Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii . Proceedings of the National Academy of Sciences of the United States of America 119 (51) (2022)
Thomas A Russo, Timothy C Umland, Xiaoyi Deng, Farah El Mazouni, Sreekanth Kokkonda, Ruth Olson, Ulrike Carlino-MacDonald, Janet Beanan, Cassandra L Alvarado, Diana R Tomchick, Alan D Hutson, Hong Chen, Bruce Posner, Pradipsinh K Rathod, Susan A Charman, Margaret A Phillips
Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii . Proceedings of the National Academy of Sciences of the United States of America 119 (51) (2022)
Thomas A Russo, Timothy C Umland, Xiaoyi Deng, Farah El Mazouni, Sreekanth Kokkonda, Ruth Olson, Ulrike Carlino-MacDonald, Janet Beanan, Cassandra L Alvarado, Diana R Tomchick, Alan D Hutson, Hong Chen, Bruce Posner, Pradipsinh K Rathod, Susan A Charman, Margaret A Phillips
Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii . Proceedings of the National Academy of Sciences of the United States of America 119 (51) (2022)
Thomas A Russo, Timothy C Umland, Xiaoyi Deng, Farah El Mazouni, Sreekanth Kokkonda, Ruth Olson, Ulrike Carlino-MacDonald, Janet Beanan, Cassandra L Alvarado, Diana R Tomchick, Alan D Hutson, Hong Chen, Bruce Posner, Pradipsinh K Rathod, Susan A Charman, Margaret A Phillips
Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii . Proceedings of the National Academy of Sciences of the United States of America 119 (51) (2022)
Thomas A Russo, Timothy C Umland, Xiaoyi Deng, Farah El Mazouni, Sreekanth Kokkonda, Ruth Olson, Ulrike Carlino-MacDonald, Janet Beanan, Cassandra L Alvarado, Diana R Tomchick, Alan D Hutson, Hong Chen, Bruce Posner, Pradipsinh K Rathod, Susan A Charman, Margaret A Phillips
Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii . Proceedings of the National Academy of Sciences of the United States of America 119 (51) (2022)
Michael J Palmer, Xiaoyi Deng, Shawn Watts, Goran Krilov, Aleksey Gerasyuto, Sreekanth Kokkonda, Farah El Mazouni, John White, Karen L White, Josefine Striepen, Jade Bath, Kyra A Schindler, Tomas Yeo, David M Shackleford, Sachel Mok, Ioanna Deni, Aloysus Lawong, Ann Huang, Gong Chen, Wen Wang, Jaya Jayaseelan, Kasiram Katneni, Rahul Patil, Jessica Saunders, Shatrughan P Shahi, Rajesh Chittimalla, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Sergio Wittlin, Patrick K Tumwebaze, Philip J Rosenthal, Roland A Cooper, Anna Caroline Campos Aguiar, Rafael V C Guido, Dhelio B Pereira, Nimisha Mittal, Elizabeth A Winzeler, Diana R Tomchick, Benoît Laleu, Jeremy N Burrows, Pradipsinh K Rathod, David A Fidock, Susan A Charman, Margaret A Phillips
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. Journal of medicinal chemistry 64 (9) (2021)
Aloysus Lawong, Suraksha Gahalawat, John Okombo, Josefine Striepen, Tomas Yeo, Sachel Mok, Ioanna Deni, Jessica L Bridgford, Hanspeter Niederstrasser, Anwu Zhou, Bruce Posner, Sergio Wittlin, Francisco Javier Gamo, Benigno Crespo, Alisje Churchyard, Jake Baum, Nimisha Mittal, Elizabeth A Winzeler, Benoît Laleu, Michael J Palmer, Susan A Charman, David A Fidock, Joseph M Ready, Margaret A Phillips
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum. Journal of medicinal chemistry 64 (5) (2021)
Zhen Zhang, Sneha Ray, Leah Imlay, Lauren T Callaghan, Hanspeter Niederstrasser, Prema Latha Mallipeddi, Bruce A Posner, Dawn M Wetzel, Margaret A Phillips, Myles W Smith
Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity. Chemical science 12 (30) (2021)
Sreekanth Kokkonda, Xiaoyi Deng, Karen L White, Farah El Mazouni, John White, David M Shackleford, Kasiram Katneni, Francis C K Chiu, Helena Barker, Jenna McLaren, Elly Crighton, Gong Chen, Inigo Angulo-Barturen, Maria Belen Jimenez-Diaz, Santiago Ferrer, Leticia Huertas-Valentin, Maria Santos Martinez-Martinez, Maria Jose Lafuente-Monasterio, Rajesh Chittimalla, Shatrughan P Shahi, Sergio Wittlin, David Waterson, Jeremy N Burrows, Dave Matthews, Diana Tomchick, Pradipsinh K Rathod, Michael J Palmer, Susan A Charman, Margaret A Phillips
Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria. Journal of medicinal chemistry 63 (9) (2020)
John White, Satish K Dhingra, Xiaoyi Deng, Farah El Mazouni, Marcus C S Lee, Gustavo A Afanador, Aloysus Lawong, Diana R Tomchick, Caroline L Ng, Jade Bath, Pradipsinh K Rathod, David A Fidock, Margaret A Phillips
Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. ACS infectious diseases 5 (1) (2018)
Manish M Patel, Oleg A Volkov, Christopher Leija, Andrew Lemoff, Margaret A Phillips
A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei. PLoS pathogens 14 (10) (2018)
Oleg A Volkov, Anthony J Brockway, Stephen A Wring, Michael Peel, Zhe Chen, Margaret A Phillips, Jef K De Brabander
Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase. Journal of medicinal chemistry 61 (3) (2018)
Oleg A Volkov, Casey C Cosner, Anthony J Brockway, Martin Kramer, Michael Booker, Shihua Zhong, Ariel Ketcherside, Shuguang Wei, Jamie Longgood, Melissa McCoy, Thomas E Richardson, Stephen A Wring, Michael Peel, Jeffrey D Klinger, Bruce A Posner, Jef K De Brabander, Margaret A Phillips
Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay. ACS infectious diseases 3 (7) (2017)
Oleg A Volkov, Lisa Kinch, Carson Ariagno, Xiaoyi Deng, Shihua Zhong, Nick Grishin, Diana R Tomchick, Zhe Chen, Margaret A Phillips
Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog. eLife 5 (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Margaret A Phillips