Jeffrey N Johnston

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 40

Top Venues

Journal of the American Chemical Society

Chemical science

Molecular pharmacology

Journal of medicinal chemistry

Vanderbilt University

The Ohio State University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Vanderbilt University Jan 01 2006

United States

Professor :: Chemistry

Indiana University Bloomington Jul 01 1999 - Dec 31 2005

United States

Professor :: Chemistry

Education History

The Ohio State University Aug 01 1992 - Jul 01 1997

United States

PHD :: Chemistry

Xavier University Aug 01 1989 - Jun 01 1992

United States

BSC :: Chemistry

Publications

Madelaine P Thorpe, Daniel J Blackwell, Bjorn C Knollmann, Jeffrey N Johnston
Backbone-Determined Antiarrhythmic Structure-Activity Relationships for a Mirror Image, Oligomeric Depsipeptide Natural Product. Journal of medicinal chemistry 67 (14) (2024)
Aaron Gochman, Tri Q Do, Kyungsoo Kim, Jacob A Schwarz, Madelaine P Thorpe, Daniel J Blackwell, Paxton A Ritschel, Abigail N Smith, Robyn T Rebbeck, Wendell S Akers, Razvan L Cornea, Derek R Laver, Jeffrey N Johnston, Björn C Knollmann
ent -Verticilide B1 Inhibits Type 2 Ryanodine Receptor Channels and is Antiarrhythmic in Casq2 -/- Mice. Molecular pharmacology 105 (3) (2024)
Aaron Gochman, Tri Q Do, Kyungsoo Kim, Jacob A Schwarz, Madelaine P Thorpe, Daniel J Blackwell, Paxton A Ritschel, Abigail N Smith, Robyn T Rebbeck, Wendell S Akers, Razvan L Cornea, Derek R Laver, Jeffrey N Johnston, Björn C Knollmann
ent -Verticilide B1 Inhibits Type 2 Ryanodine Receptor Channels and is Antiarrhythmic in Casq2 -/- Mice. Molecular pharmacology 105 (3) (2024)
Madelaine P Thorpe, Daniel J Blackwell, Bjorn C Knollmann, Jeffrey N Johnston
Backbone-Determined Antiarrhythmic Structure-Activity Relationships for a Mirror Image, Oligomeric Depsipeptide Natural Product. Journal of medicinal chemistry 67 (14) (2024)
Zihang Deng, Melanie A Padalino, Julius E L Jan, Sangjun Park, Michael W Danneman, Jeffrey N Johnston
Generality-Driven Catalyst Development: A Universal Catalyst for Enantioselective Nitroalkene Reduction. Journal of the American Chemical Society (2024)
Zihang Deng, Melanie A Padalino, Julius E L Jan, Sangjun Park, Michael W Danneman, Jeffrey N Johnston
Generality-Driven Catalyst Development: A Universal Catalyst for Enantioselective Nitroalkene Reduction. Journal of the American Chemical Society 146 (2) (2024)
Zihang Deng, Melanie A Padalino, Julius E L Jan, Sangjun Park, Michael W Danneman, Jeffrey N Johnston
Generality-Driven Catalyst Development: A Universal Catalyst for Enantioselective Nitroalkene Reduction. Journal of the American Chemical Society 146 (2) (2024)
Madelaine P Thorpe, Daniel J Blackwell, Bjorn C Knollmann, Jeffrey N Johnston
Backbone-Determined Antiarrhythmic Structure-Activity Relationships for a Mirror Image, Oligomeric Depsipeptide Natural Product. Journal of medicinal chemistry 67 (14) (2024)
Madelaine P Thorpe, Abigail N Smith, Daniel J Blackwell, Corey R Hopkins, Björn C Knollmann, Wendell S Akers, Jeffrey N Johnston
The backbone constitution drives passive permeability independent of side chains in depsipeptide and peptide macrocycles inspired by ent -verticilide. Chemical science (2024)
Aaron Gochman, Tri Q Do, Kyungsoo Kim, Jacob A Schwarz, Madelaine P Thorpe, Daniel J Blackwell, Paxton A Ritschel, Abigail N Smith, Robyn T Rebbeck, Wendell S Akers, Razvan L Cornea, Derek R Laver, Jeffrey N Johnston, Björn C Knollmann
ent -Verticilide B1 Inhibits Type 2 Ryanodine Receptor Channels and is Antiarrhythmic in Casq2 -/- Mice. Molecular pharmacology 105 (3) (2024)
Aaron Gochman, Tri Q Do, Kyungsoo Kim, Jacob A Schwarz, Madelaine P Thorpe, Daniel J Blackwell, Paxton A Ritschel, Abigail N Smith, Robyn T Rebbeck, Wendell S Akers, Razvan L Cornea, Derek R Laver, Jeffrey N Johnston, Björn C Knollmann
ent -Verticilide B1 Inhibits Type 2 Ryanodine Receptor Channels and is Antiarrhythmic in Casq2 -/- Mice. Molecular pharmacology 105 (3) (2024)
Zihang Deng, Melanie A Padalino, Julius E L Jan, Sangjun Park, Michael W Danneman, Jeffrey N Johnston
Generality-Driven Catalyst Development: A Universal Catalyst for Enantioselective Nitroalkene Reduction. Journal of the American Chemical Society 146 (2) (2024)
Madelaine P Thorpe, Daniel J Blackwell, Bjorn C Knollmann, Jeffrey N Johnston
Backbone-Determined Antiarrhythmic Structure-Activity Relationships for a Mirror Image, Oligomeric Depsipeptide Natural Product. Journal of medicinal chemistry (2024)
Aaron Gochman, Tri Q Do, Kyungsoo Kim, Jacob A Schwarz, Madelaine P Thorpe, Daniel J Blackwell, Paxton A Ritschel, Abigail N Smith, Robyn T Rebbeck, Wendell S Akers, Razvan L Cornea, Derek R Laver, Jeffrey N Johnston, Björn C Knollmann
ent -Verticilide B1 Inhibits Type 2 Ryanodine Receptor Channels and is Antiarrhythmic in Casq2 -/- Mice. Molecular pharmacology 105 (3) (2024)
Madelaine P Thorpe, Daniel J Blackwell, Bjorn C Knollmann, Jeffrey N Johnston
Backbone-Determined Antiarrhythmic Structure-Activity Relationships for a Mirror Image, Oligomeric Depsipeptide Natural Product. Journal of medicinal chemistry 67 (14) (2024)
Madelaine P Thorpe, Abigail N Smith, Daniel J Blackwell, Corey R Hopkins, Björn C Knollmann, Wendell S Akers, Jeffrey N Johnston
The backbone constitution drives passive permeability independent of side chains in depsipeptide and peptide macrocycles inspired by ent -verticilide. Chemical science (2024)
Aaron Gochman, Tri Q Do, Kyungsoo Kim, Jacob A Schwarz, Madelaine P Thorpe, Daniel J Blackwell, Paxton A Ritschel, Abigail N Smith, Robyn T Rebbeck, Wendell S Akers, Razvan L Cornea, Derek R Laver, Jeffrey N Johnston, Björn C Knollmann
ent -Verticilide B1 Inhibits Type 2 Ryanodine Receptor Channels and is Antiarrhythmic in Casq2 -/- Mice. Molecular pharmacology 105 (3) (2024)
Jade A Bing, Jeffrey N Johnston
Enantioselective Synthesis of cis - and trans -Cycloheptyl β-Fluoro Amines by Sequential aza-Henry Addition/Ring-Closing Metathesis. Organic letters (2023)
Ivor Smajlagic, Jeffrey N Johnston, Travis Dudding
Secondary Orbital Effect Involving Fluorine is Responsible for Substrate-Controlled Diastereodivergence in the Catalyzed syn-aza-Henry Reaction of α-Fluoronitroalkanes. Chemistry (Weinheim an der Bergstrasse, Germany) (2023)
Jaroslava Šeflová, Jacob A Schwarz, Abigail N Smith, Bengt Svensson, Daniel J Blackwell, Taylor A Phillips, Roman Nikolaienko, Elisa Bovo, Robyn T Rebbeck, Aleksey V Zima, David Dt Thomas, Filip Van Petegem, Björn C Knollmann, Jeffrey N Johnston, Seth L Robia, Razvan L Cornea
RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET. ACS chemical biology (2023)
Jade A Bing, Jeffrey N Johnston
Enantioselective Synthesis of cis - and trans -Cycloheptyl β-Fluoro Amines by Sequential aza-Henry Addition/Ring-Closing Metathesis. Organic letters 25 (6) (2023)
Chantal J M van Opbergen, Navratan Bagwan, Svetlana R Maurya, Joon-Chul Kim, Abigail N Smith, Daniel J Blackwell, Jeffrey N Johnston, Björn C Knollmann, Marina Cerrone, Alicia Lundby, Mario Delmar
Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2-Deficient Hearts. Circulation 145 (19) (2022)
Madelaine P Thorpe, Abigail N Smith, Michael S Crocker, Jeffrey N Johnston
Resolving Bromonitromethane Sourcing by Synthesis: Preparation at the Decagram Scale. The Journal of organic chemistry 87 (8) (2022)
Michael S Crocker, Zihang Deng, Jeffrey N Johnston
Preparation of N -Aryl Amides by Epimerization-Free Umpolung Amide Synthesis. Journal of the American Chemical Society 144 (37) (2022)
Jade A Bing, Nathan D Schley, Jeffrey N Johnston
Fluorine-induced diastereodivergence discovered in an equally rare enantioselective syn -aza-Henry reaction. Chemical science 13 (9) (2022)
Abigail N Smith, Madelaine P Thorpe, Daniel J Blackwell, Suzanne M Batiste, Corey R Hopkins, Nathan D Schley, Bjorn C Knollmann, Jeffrey N Johnston
Structure-Activity Relationships for the N -Me- Versus N -H-Amide Modification to Macrocyclic ent -Verticilide Antiarrhythmics. ACS medicinal chemistry letters 13 (11) (2022)
Jenna L Payne, Zihang Deng, Andrew L Flach, Jeffrey N Johnston
Enantioselective iodolactonization to prepare ε-lactone rings using hypervalent iodine. Chemical science 13 (24) (2022)
Thomas J Struble, Ivor Smajlagic, Hayden Foy, Travis Dudding, Jeffrey N Johnston
DFT-Based Stereochemical Rationales for the Bifunctional Brønsted Acid/Base-Catalyzed Diastereodivergent and Enantioselective aza-Henry Reactions of α-Nitro Esters. The Journal of organic chemistry 86 (21) (2021)
Abigail N Smith, Daniel J Blackwell, Bjorn C Knollmann, Jeffrey N Johnston
Ring Size as an Independent Variable in Cyclooligomeric Depsipeptide Antiarrhythmic Activity. ACS medicinal chemistry letters 12 (12) (2021)
Abigail N Smith, Jeffrey N Johnston
The Formation of Impossible Rings in Macrocyclooligomerizations for Cyclodepsipeptide Synthesis: The 18-from-12 Paradox. The Journal of organic chemistry 86 (12) (2021)
Suzanne M Batiste, Jeffrey N Johnston
Correction to "Evidence for Ion-Templation During Macrocyclooligomerization of Depsipeptides". Journal of the American Chemical Society 143 (17) (2021)
Daniel J Sprague, Jeffrey N Johnston
Substituted Imidazoline Synthesis: A Diastereo- and Enantioselective aza-Henry Route to a Human Proteasome Modulator. Organic letters 22 (21) (2020)
Suzanne M Batiste, Daniel J Blackwell, Kyungsoo Kim, Dmytro O Kryshtal, Nieves Gomez-Hurtado, Robyn T Rebbeck, Razvan L Cornea, Jeffrey N Johnston, Björn C Knollmann
Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic. Proceedings of the National Academy of Sciences of the United States of America 116 (11) (2019)
Matthew T Knowe, Michael W Danneman, Sarah Sun, Maren Pink, Jeffrey N Johnston
Biomimetic Desymmetrization of a Carboxylic Acid. Journal of the American Chemical Society 140 (6) (2018)
Suzanne M Batiste, Jeffrey N Johnston
Evidence for Ion-Templation During Macrocyclooligomerization of Depsipeptides. Journal of the American Chemical Society 140 (13) (2018)
Mahesh Vishe, Jeffrey N Johnston
The inverted ketene synthon: a double umpolung approach to enantioselective β2,3-amino amide synthesis. Chemical science 10 (4) (2018)
Daniel J Sprague, Anand Singh, Jeffrey N Johnston
Diastereo- and enantioselective additions of α-nitro esters to imines for anti-α,β-diamino acid synthesis with α-alkyl-substitution. Chemical science 9 (8) (2018)
Thomas J Struble, Hannah M Lankswert, Maren Pink, Jeffrey N Johnston
Enantioselective Organocatalytic Amine-Isocyanate Capture-Cyclization: Regioselective Alkene Iodoamination for the Synthesis of Chiral Cyclic Ureas. ACS catalysis 8 (12) (2018)
Roozbeh Yousefi, Thomas J Struble, Jenna L Payne, Mahesh Vishe, Nathan D Schley, Jeffrey N Johnston
Catalytic, Enantioselective Synthesis of Cyclic Carbamates from Dialkyl Amines by CO2-Capture: Discovery, Development, and Mechanism. Journal of the American Chemical Society 141 (1) (2018)
Kazuyuki Tokumaru, Jeffrey N Johnston
A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions. Chemical science 8 (4) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Jeffrey N Johnston