Jian Li

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 54

Top Topics

Endometrial Cancer

Plasmodium Falciparum

Fluorescent Probe

Structure Activity Relationship

Top Venues

Journal of medicinal chemistry

ACS chemical neuroscience

Nature chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Sicheng Yang, Donghuan Sun, Ying Wu, Shuqiang Chen, Yuan Guo, Jian Li, Guoqiang Dong, Chunquan Sheng
Discovery of a Potent Nicotinamide Phosphoribosyltransferase Activator for Improving Aging-associated Dysfunctions. Journal of medicinal chemistry 67 (5) (2024)
Xiaoyu Zhou, Cheng Zhao, Haiyan Xu, Yixiang Xu, Li Zhan, Pei Wang, Jingyi He, Taotao Lu, Yueling Gu, Yan Yang, Chanjuan Xu, Yiyang Chen, Yuxuan Liu, Yue Zeng, Fuyun Tian, Qian Chen, Xin Xie, Jianfeng Liu, Hailan Hu, Jian Li, Yue-Ming Zheng, Jiang Tao Guo, Zhaobing Gao
Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses. Nature chemical biology (2024)
Xiaoyu Zhou, Cheng Zhao, Haiyan Xu, Yixiang Xu, Li Zhan, Pei Wang, Jingyi He, Taotao Lu, Yueling Gu, Yan Yang, Chanjuan Xu, Yiyang Chen, Yuxuan Liu, Yue Zeng, Fuyun Tian, Qian Chen, Xin Xie, Jianfeng Liu, Hailan Hu, Jian Li, Yue-Ming Zheng, Jiang Tao Guo, Zhaobing Gao
Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses. Nature chemical biology (2024)
Xiangran Lu, Rongrong Wang, Yao Yu, Jinlian Wei, Yixiang Xu, Luoyifan Zhou, Fei Mao, Jian Li, Xiaokang Li, Xin-Ming Jia
Drug Repurposing of ACT001 to Discover Novel Promising Sulfide Prodrugs with Improved Safety and Potent Activity for Neutrophil-Mediated Antifungal Immunotherapy. Journal of medicinal chemistry 67 (7) (2024)
Xiaoyu Zhou, Cheng Zhao, Haiyan Xu, Yixiang Xu, Li Zhan, Pei Wang, Jingyi He, Taotao Lu, Yueling Gu, Yan Yang, Chanjuan Xu, Yiyang Chen, Yuxuan Liu, Yue Zeng, Fuyun Tian, Qian Chen, Xin Xie, Jianfeng Liu, Hailan Hu, Jian Li, Yue-Ming Zheng, Jiang Tao Guo, Zhaobing Gao
Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses. Nature chemical biology 20 (7) (2024)
Xianwu Ling, Jiahui Zhang, Lingyi Song, Huiwen Wu, Qi Wang, Xiaohu Liu, Wei Ni, Jian Li, Yudong Wang, Fei Mao
Discovery of Novel Azaphenothiazine Derivatives to Suppress Endometrial Cancer by Targeting GRP75 to Impair Its Interaction with IP3R and Mitochondrial Ca 2+ Homeostasis. Journal of medicinal chemistry 67 (16) (2024)
Yunyuan Huang, Xin Chen, Jin Yang, Yue Yao, Manjiong Wang, Taotao Lu, Xiao Li, Jiqun Wang, Sicong Qiao, Donglei Shi, Xiaokang Li, Jian Li, Yixiang Xu
Novel Combination Therapy for Heart Failure: Trimebutine-Methoxsalen Identified through Synergistic Network Virtual Screening and Experimental Validation. Journal of chemical information and modeling (2024)
Xiangran Lu, Rongrong Wang, Yao Yu, Jinlian Wei, Yixiang Xu, Luoyifan Zhou, Fei Mao, Jian Li, Xiaokang Li, Xin-Ming Jia
Drug Repurposing of ACT001 to Discover Novel Promising Sulfide Prodrugs with Improved Safety and Potent Activity for Neutrophil-Mediated Antifungal Immunotherapy. Journal of medicinal chemistry 67 (7) (2024)
Sicheng Yang, Donghuan Sun, Ying Wu, Shuqiang Chen, Yuan Guo, Jian Li, Guoqiang Dong, Chunquan Sheng
Discovery of a Potent Nicotinamide Phosphoribosyltransferase Activator for Improving Aging-associated Dysfunctions. Journal of medicinal chemistry 67 (5) (2024)
Jiqun Wang, Wenwen Liu, Yunyuan Huang, Guangwei Wang, Xiaobo Guo, Donglei Shi, Tianyue Sun, Chaojiang Xiao, Chao Zhang, Bei Jiang, Yuan Guo, Jian Li
A Senomorphlytic Three-Drug Combination Discovered in Salsola collina for Delaying Aging Phenotypes and Extending Healthspan. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2024)
Xiaoyu Zhou, Cheng Zhao, Haiyan Xu, Yixiang Xu, Li Zhan, Pei Wang, Jingyi He, Taotao Lu, Yueling Gu, Yan Yang, Chanjuan Xu, Yiyang Chen, Yuxuan Liu, Yue Zeng, Fuyun Tian, Qian Chen, Xin Xie, Jianfeng Liu, Hailan Hu, Jian Li, Yue-Ming Zheng, Jiang Tao Guo, Zhaobing Gao
Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses. Nature chemical biology 20 (7) (2024)
Xianwu Ling, Jiahui Zhang, Lingyi Song, Huiwen Wu, Qi Wang, Xiaohu Liu, Wei Ni, Jian Li, Yudong Wang, Fei Mao
Discovery of Novel Azaphenothiazine Derivatives to Suppress Endometrial Cancer by Targeting GRP75 to Impair Its Interaction with IP3R and Mitochondrial Ca 2+ Homeostasis. Journal of medicinal chemistry 67 (16) (2024)
Xianwu Ling, Jiahui Zhang, Lingyi Song, Huiwen Wu, Qi Wang, Xiaohu Liu, Wei Ni, Jian Li, Yudong Wang, Fei Mao
Discovery of Novel Azaphenothiazine Derivatives to Suppress Endometrial Cancer by Targeting GRP75 to Impair Its Interaction with IP3R and Mitochondrial Ca 2+ Homeostasis. Journal of medicinal chemistry (2024)
Xiangran Lu, Rongrong Wang, Yao Yu, Jinlian Wei, Yixiang Xu, Luoyifan Zhou, Fei Mao, Jian Li, Xiaokang Li, Xin-Ming Jia
Drug Repurposing of ACT001 to Discover Novel Promising Sulfide Prodrugs with Improved Safety and Potent Activity for Neutrophil-Mediated Antifungal Immunotherapy. Journal of medicinal chemistry (2024)
Sicheng Yang, Donghuan Sun, Ying Wu, Shuqiang Chen, Yuan Guo, Jian Li, Guoqiang Dong, Chunquan Sheng
Discovery of a Potent Nicotinamide Phosphoribosyltransferase Activator for Improving Aging-associated Dysfunctions. Journal of medicinal chemistry (2024)
Donglei Shi, Wenwen Liu, Ying Gao, Xinming Li, Yunyuan Huang, Xiaokang Li, Tony David James, Yuan Guo, Jian Li
Photoactivatable senolysis with single-cell resolution delays aging. Nature aging 3 (3) (2023)
Donglei Shi, Wenwen Liu, Ying Gao, Xinming Li, Yunyuan Huang, Xiaokang Li, Tony David James, Yuan Guo, Jian Li
Photoactivatable senolysis with single-cell resolution delays aging. Nature aging 3 (3) (2023)
Donglei Shi, Wenwen Liu, Ying Gao, Xinming Li, Yunyuan Huang, Xiaokang Li, Tony David James, Yuan Guo, Jian Li
Photoactivatable senolysis with single-cell resolution delays aging. Nature aging 3 (3) (2023)
Donglei Shi, Wenwen Liu, Ying Gao, Xinming Li, Yunyuan Huang, Xiaokang Li, Tony David James, Yuan Guo, Jian Li
Photoactivatable senolysis with single-cell resolution delays aging. Nature aging 3 (3) (2023)
Donglei Shi, Wenwen Liu, Ying Gao, Xinming Li, Yunyuan Huang, Xiaokang Li, Tony David James, Yuan Guo, Jian Li
Photoactivatable senolysis with single-cell resolution delays aging. Nature aging 3 (3) (2023)
Shuaishuai Ni, Qian Liu, Xin Chen, Lele Ding, Lili Cai, Fei Mao, Donglei Shi, Robert M Hoffman, Jian Li, Lijun Jia
Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells. Signal transduction and targeted therapy 7 (1) (2022)
Keting Bao, Wenwen Liu, Zhouzhi Song, Jiali Feng, Zhifan Mao, Lingyuan Bao, Tianyue Sun, Zelan Hu, Jian Li
Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9. eLife 11 (2022)
Wang Li, Zhaolin Yun, Changjin Ji, Jie Tu, Wanzhen Yang, Jian Li, Na Liu, Chunquan Sheng
Discovery of Novel Sertraline Derivatives as Potent Anti- Cryptococcus Agents. Journal of medicinal chemistry 65 (9) (2022)
Manjiong Wang, Tongke Tang, Ruoxi Li, Zhenghui Huang, Dazheng Ling, Lulu Zheng, Yan Ding, Taiping Liu, Wenyue Xu, Feng Zhu, Hui Min, Rachasak Boonhok, Fei Mao, Jin Zhu, Xiaokang Li, Lubin Jiang, Jian Li
Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety. Journal of medicinal chemistry 65 (5) (2022)
Yunyuan Huang, Haiyan Xu, Pei Wang, Rurong Gu, Xiaokang Li, Yixiang Xu, Jiqun Wang, Sicong Qiao, Donglei Shi, Zhaobing Gao, Jian Li
Identification of Guaifenesin-Andrographolide as a Novel Combinatorial Drug Therapy for Epilepsy Using Network Virtual Screening and Experimental Validation. ACS chemical neuroscience 13 (7) (2022)
Yihe Song, Xinming Li, Donglei Shi, Tianyue Sun, Wenwen Liu, Xiaokang Li, Sicong Qiao, Xin Chen, Yuan Guo, Jian Li
A senolysis-based theragnostic prodrug strategy towards chronic renal failure. Chemical science 13 (40) (2022)
Jiqun Wang, Yunyuan Huang, Kaixuan Shi, Lingyuan Bao, Chao-Jiang Xiao, Tianyue Sun, Zhifan Mao, Jiali Feng, Zelan Hu, Zhenghan Guo, Jing Li, Bei Jiang, Wenwen Liu, Jian Li
Nicandra physalodes Extract Exerts Antiaging Effects in Multiple Models and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1. Oxidative medicine and cellular longevity 2022 (2022)
Wenwen Liu, Yunhui Guan, Sicong Qiao, Jiqun Wang, Keting Bao, Zhifan Mao, Liang Liao, Aleksey Igorevich Moskalev, Bei Jiang, Jin Zhu, Cong-Long Xia, Jian Li, Zelan Hu
Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice. Oxidative medicine and cellular longevity 2021 (2021)
Yunyuan Huang, Jiqun Wang, Jiaqi Liu, Donglei Shi, Xiaokang Li, Manjiong Wang, Taotao Lu, Bei Jiang, Conglong Xia, Hou-Wen Lin, Yixiang Xu, Jian Li
Rapid Repurposing of Novel Combination Drugs for the Treatment of Heart Failure via a Computationally Guided Network Screening Approach. Journal of chemical information and modeling (2021)
Keting Bao, Yongyun Li, Jinlian Wei, Ruoxi Li, Jie Yang, Jiahao Shi, Baoli Li, Jin Zhu, Fei Mao, Renbing Jia, Jian Li
Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway. Cell death & disease 12 (4) (2021)
Jingye Tian, Donglei Shi, Yanhui Zhang, Xiaokang Li, Xinming Li, Hao Teng, Tony David James, Jian Li, Yuan Guo
Stress response decay with aging visualized using a dual-channel logic-based fluorescent probe. Chemical science 12 (40) (2021)
Wanzhen Yang, Jie Tu, Changjin Ji, Zhuang Li, Guiyan Han, Na Liu, Jian Li, Chunquan Sheng
Discovery of Piperidol Derivatives for Combinational Treatment of Azole-Resistant Candidiasis. ACS infectious diseases 7 (3) (2021)
Ying Gao, Yulu Hu, Qimeng Liu, Xiaokang Li, Xinming Li, Chu-Young Kim, Tony David James, Jian Li, Xi Chen, Yuan Guo
Two-Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence. Angewandte Chemie (International ed. in English) 60 (19) (2021)
Ruoxi Li, Dazheng Ling, Tongke Tang, Zhenghui Huang, Manjiong Wang, Yan Ding, Taiping Liu, Hanwen Wei, Wenyue Xu, Fei Mao, Jin Zhu, Xiaokang Li, Lubin Jiang, Jian Li
Discovery of Novel Plasmodium falciparum HDAC1 Inhibitors with Dual-Stage Antimalarial Potency and Improved Safety Based on the Clinical Anticancer Drug Candidate Quisinostat. Journal of medicinal chemistry 64 (4) (2021)
Yunyuan Huang, Yixiang Xu, Rongrong Song, Shuaishuai Ni, Jiaqi Liu, Yanhong Xu, Yanliang Ren, Li Rao, Yingjie Wang, Lin Wei, Lingling Feng, Chen Su, Chao Peng, Jian Li, Jian Wan
Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction. Journal of medicinal chemistry 63 (11) (2020)
Zhenghui Huang, Ruoxi Li, Tongke Tang, Dazheng Ling, Manjiong Wang, Dandan Xu, Maoxin Sun, Lulu Zheng, Feng Zhu, Hui Min, Rachasak Boonhok, Yan Ding, Yuhao Wen, Yicong Chen, Xiaokang Li, Yuxi Chen, Taiping Liu, Jiping Han, Jun Miao, Qiang Fang, Yaming Cao, Yun Tang, Jie Cui, Wenyue Xu, Liwang Cui, Jin Zhu, Gary Wong, Jian Li, Lubin Jiang
A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1. Cell discovery 6 (1) (2020)
Xiaokang Li, Wenjing Qiu, Jinwen Li, Xi Chen, Yulu Hu, Ying Gao, Donglei Shi, Xinming Li, Huiling Lin, Zelan Hu, Guoqiang Dong, Chunquan Sheng, Bei Jiang, Conglong Xia, Chu-Young Kim, Yuan Guo, Jian Li
First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase. Chemical science 11 (28) (2020)
Linghao Hu, Hongxuan Feng, Hongguang Zhang, Songda Yu, Qinyuan Zhao, Wei Wang, Fengxia Bao, Xun Ding, Jiajing Hu, Manjiong Wang, Yixiang Xu, Zengrui Wu, Xiaokang Li, Yun Tang, Fei Mao, Xiaoyan Chen, Hai Yan Zhang, Jian Li
Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents. Journal of medicinal chemistry 63 (3) (2020)
Shuaishuai Ni, Baoli Li, Yixiang Xu, Fei Mao, Xiaokang Li, Lefu Lan, Jin Zhu, Jian Li
Targeting virulence factors as an antimicrobial approach: Pigment inhibitors. Medicinal research reviews 40 (1) (2019)
Jin Li, Xinchi Yin, Bin Li, Xiaokang Li, Yuanjiang Pan, Jian Li, Yuan Guo
Spiropyran in Situ Switching: A Real-Time Fluorescence Strategy for Tracking DNA G-Quadruplexes in Live Cells. Analytical chemistry 91 (8) (2019)
Changjin Ji, Na Liu, Jie Tu, Zhuang Li, Guiyan Han, Jian Li, Chunquan Sheng
Drug Repurposing of Haloperidol: Discovery of New Benzocyclane Derivatives as Potent Antifungal Agents against Cryptococcosis and Candidiasis. ACS infectious diseases 6 (5) (2019)
Yixiang Xu, Jian Zhang, Huan Wang, Fei Mao, Keting Bao, Wenwen Liu, Jin Zhu, Xiaokang Li, Haiyan Zhang, Jian Li
Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents. ACS chemical neuroscience 10 (1) (2018)
Wei Ni, Huan Wang, Xiaokang Li, Xinyu Zheng, Manjiong Wang, Jian Zhang, Qi Gong, Dazheng Ling, Fei Mao, Haiyan Zhang, Jian Li
Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5). ACS chemical neuroscience 9 (7) (2018)
Dongliang Guan, Feifei Chen, Lun Xiong, Feng Tang, null Faridoon, Yunguang Qiu, Naixia Zhang, Likun Gong, Jian Li, Lefu Lan, Wei Huang
Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci. Journal of medicinal chemistry 61 (1) (2018)
Baoli Li, Shuaishuai Ni, Feifei Chen, Fei Mao, Hanwen Wei, Yifu Liu, Jin Zhu, Lefu Lan, Jian Li
Discovery of Potent Benzocycloalkane Derived Diapophytoene Desaturase Inhibitors with an Enhanced Safety Profile for the Treatment of MRSA, VISA, and LRSA Infections. ACS infectious diseases 4 (3) (2018)
Baoli Li, Shuaishuai Ni, Fei Mao, Feifei Chen, Yifu Liu, Hanwen Wei, Wenhua Chen, Jin Zhu, Lefu Lan, Jian Li
Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. Journal of medicinal chemistry 61 (1) (2017)
Xiaokang Li, Huan Wang, Yixiang Xu, Wenwen Liu, Qi Gong, Wei Wang, Xiaoxia Qiu, Jin Zhu, Fei Mao, Haiyan Zhang, Jian Li
Novel Vilazodone-Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation. ACS chemical neuroscience 8 (12) (2017)
Yan Jiang, Chun-Lin Zhuang, Long Chen, Junjie Lu, Guoqiang Dong, Zhenyuan Miao, Wannian Zhang, Jian Li, Chunquan Sheng
Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors. Journal of medicinal chemistry 60 (22) (2017)
Weiqiang Lu, Xue Yao, Ping Ouyang, Ningning Dong, Dang Wu, Xingwu Jiang, Zengrui Wu, Chen Zhang, Zhongyu Xu, Yun Tang, Shien Zou, Mingyao Liu, Jian Li, Minghua Zeng, Ping Lin, Feixiong Cheng, Jin Huang
Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. Journal of medicinal chemistry 60 (5) (2017)
Fei Mao, Huan Wang, Wei Ni, Xinyu Zheng, Manjiong Wang, Keting Bao, Dazheng Ling, Xiaokang Li, Yixiang Xu, Haiyan Zhang, Jian Li
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease. ACS chemical neuroscience 9 (2) (2017)
Yifu Liu, Zuoquan Xie, Dan Zhao, Jin Zhu, Fei Mao, Shuai Tang, Hui Xu, Cheng Luo, Meiyu Geng, Min Huang, Jian Li
Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors. Journal of medicinal chemistry 60 (6) (2017)
Shuaishuai Ni, Hanwen Wei, Baoli Li, Feifei Chen, Yifu Liu, Wenhua Chen, Yixiang Xu, Xiaoxia Qiu, Xiaokang Li, Yanli Lu, Wenwen Liu, Linhao Hu, Dazheng Lin, Manjiong Wang, Xinyu Zheng, Fei Mao, Jin Zhu, Lefu Lan, Jian Li
Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. Journal of medicinal chemistry 60 (19) (2017)
Yanli Lu, Fei Mao, Xiaokang Li, Xinyu Zheng, Manjiong Wang, Qing Xu, Jin Zhu, Jian Li
Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRα) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs). Journal of medicinal chemistry 60 (12) (2017)
Yanan Xie, Xiaowei Wu, Chunpu Li, Jiang Wang, Jian Li, Hong Liu
Ruthenium(II)-Catalyzed Redox-Neutral [3+2] Annulation of Indoles with Internal Alkynes via C-H Bond Activation: Accessing a Pyrroloindolone Scaffold. The Journal of organic chemistry 82 (10) (2017)