Jonathan H Clarke (Jonathan Clarke)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 16

Top Venues

Journal of medicinal chemistry

Acta neuropathologica

RSC medicinal chemistry

Proceedings of the National Academy of Sciences of the United States of America

University of Cambridge

University of Cambridge (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Cambridge Sep 01 2015

United Kingdom

Senior Biologist :: Alzheimer's Research UK Drug Discovery Institute

University of Cambridge Oct 01 1999

United Kingdom

SRA :: Pharmacology

Education History

University of Cambridge Oct 01 1991 - Mar 01 1994

United Kingdom

PHD :: Babraham Research Institute

University of Bath Oct 01 1987 - Oct 01 1991

United Kingdom

BSC :: Biological Sciences

Publications

Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durrant
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003. Acta neuropathologica 147 (1) (2024)
Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durrant
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003. Acta neuropathologica 147 (1) (2024)
Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durrant
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003. Acta neuropathologica 147 (1) (2024)
Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durrant
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003. Acta neuropathologica 147 (1) (2024)
Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durrant
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003. Acta neuropathologica 147 (1) (2024)
Gregory G Aldred, Timothy P C Rooney, Henriëtte M G Willems, Helen K Boffey, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K). RSC medicinal chemistry 14 (10) (2023)
Henriëtte M G Willems, Simon Edwards, Helen K Boffey, Stephen J Chawner, Christopher Green, Tamara Romero, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor. RSC medicinal chemistry 14 (5) (2023)
Timothy P C Rooney, Gregory G Aldred, Helen K Boffey, Henriëtte M G Willems, Simon Edwards, Stephen J Chawner, Duncan E Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. Journal of medicinal chemistry 66 (1) (2022)
Timothy P C Rooney, Gregory G Aldred, Helen K Boffey, Henriëtte M G Willems, Simon Edwards, Stephen J Chawner, Duncan E Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. Journal of medicinal chemistry 66 (1) (2022)
Timothy P C Rooney, Gregory G Aldred, Helen K Boffey, Henriëtte M G Willems, Simon Edwards, Stephen J Chawner, Duncan E Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. Journal of medicinal chemistry 66 (1) (2022)
Timothy P C Rooney, Gregory G Aldred, Helen K Boffey, Henriëtte M G Willems, Simon Edwards, Stephen J Chawner, Duncan E Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. Journal of medicinal chemistry 66 (1) (2022)
Timothy P C Rooney, Gregory G Aldred, Helen K Boffey, Henriëtte M G Willems, Simon Edwards, Stephen J Chawner, Duncan E Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. Journal of medicinal chemistry (2022)
Helen K Boffey, Timothy P C Rooney, Henriette M G Willems, Simon Edwards, Christopher Green, Tina Howard, Derek Ogg, Tamara Romero, Duncan E Scott, David Winpenny, James Duce, John Skidmore, Jonathan H Clarke, Stephen P Andrews
Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode. Journal of medicinal chemistry 65 (4) (2022)
Timothy P C Rooney, Gregory G Aldred, Helen K Boffey, Henriëtte M G Willems, Simon Edwards, Stephen J Chawner, Duncan E Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. Journal of medicinal chemistry 66 (1) (2022)
Ismael Al-Ramahi, Sai Srinivas Panapakkam Giridharan, Yu-Chi Chen, Samarjit Patnaik, Nathaniel Safren, Tamotsu Yoshimori, Maria de Haro, Amanda K Wagner Gee, Steven A Titus, Hyunkyung Jeong, Jonathan H Clarke, Dimitri Krainc, Wei Zheng, Robin F Irvine, Sami Barmada, Marc Ferrer, Noel T Southall, Lois S Weisman, Juan Botas, Juan Jose Marugan
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein. eLife 6 (2017)
Simon J Bulley, Alaa Droubi, Jonathan H Clarke, Karen E Anderson, Len R Stephens, Phillip T Hawkins, Robin F Irvine
In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling. Proceedings of the National Academy of Sciences of the United States of America 113 (38) (2016)

Jonathan H Clarke.css-eqlu8i{font-size:small;padding-left:4px;} (Jonathan Clarke)

Publication Activity (10 Years)

Top Topics

Top Venues

Jonathan H Clarke (Jonathan Clarke)