John Skidmore

Publication Activity (10 Years)

Years Active: 2022-2024
Publications (10 Years): 16

Top Topics

Epithelial Mesenchymal Transition

Cognitive Impairment

Cerebrospinal Fluid

Top Venues

Journal of medicinal chemistry

Acta neuropathologica

RSC medicinal chemistry

Nature neuroscience

This page only lists publications with an associated author ORCID identifier.

Publications

Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durrant
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003. Acta neuropathologica 147 (1) (2024)
Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durrant
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003. Acta neuropathologica 147 (1) (2024)
Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durrant
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003. Acta neuropathologica 147 (1) (2024)
Simon R Stockwell, Duncan E Scott, Gerhard Fischer, Estrella Guarino, Timothy P C Rooney, Tzu-Shean Feng, Tommaso Moschetti, Rajavel Srinivasan, Esther Alza, Alice Asteian, Claudio Dagostin, Anna Alcaide, Mathieu Rocaboy, Beata Blaszczyk, Alicia Higueruelo, Xuelu Wang, Maxim Rossmann, Trevor R Perrior, Tom L Blundell, David R Spring, Grahame McKenzie, Chris Abell, John Skidmore, Ashok R Venkitaraman, Marko Hyvönen
Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents. Journal of medicinal chemistry (2024)
Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durrant
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003. Acta neuropathologica 147 (1) (2024)
Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durrant
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003. Acta neuropathologica 147 (1) (2024)
Nils Korte, Anna Barkaway, Jack A Wells, Felipe Freitas, Huma Sethi, Stephen P Andrews, John Skidmore, Beth Stevens, David Attwell
Inhibiting Ca 2+ channels in Alzheimer's disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia. Nature neuroscience (2024)
Gregory G Aldred, Timothy P C Rooney, Henriëtte M G Willems, Helen K Boffey, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K). RSC medicinal chemistry 14 (10) (2023)
Henriëtte M G Willems, Simon Edwards, Helen K Boffey, Stephen J Chawner, Christopher Green, Tamara Romero, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor. RSC medicinal chemistry 14 (5) (2023)
Timothy P C Rooney, Gregory G Aldred, Helen K Boffey, Henriëtte M G Willems, Simon Edwards, Stephen J Chawner, Duncan E Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. Journal of medicinal chemistry 66 (1) (2022)
Timothy P C Rooney, Gregory G Aldred, Helen K Boffey, Henriëtte M G Willems, Simon Edwards, Stephen J Chawner, Duncan E Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. Journal of medicinal chemistry 66 (1) (2022)
Timothy P C Rooney, Gregory G Aldred, Helen K Boffey, Henriëtte M G Willems, Simon Edwards, Stephen J Chawner, Duncan E Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. Journal of medicinal chemistry 66 (1) (2022)
Timothy P C Rooney, Gregory G Aldred, Helen K Boffey, Henriëtte M G Willems, Simon Edwards, Stephen J Chawner, Duncan E Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. Journal of medicinal chemistry 66 (1) (2022)
Timothy P C Rooney, Gregory G Aldred, Helen K Boffey, Henriëtte M G Willems, Simon Edwards, Stephen J Chawner, Duncan E Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. Journal of medicinal chemistry (2022)
Helen K Boffey, Timothy P C Rooney, Henriette M G Willems, Simon Edwards, Christopher Green, Tina Howard, Derek Ogg, Tamara Romero, Duncan E Scott, David Winpenny, James Duce, John Skidmore, Jonathan H Clarke, Stephen P Andrews
Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode. Journal of medicinal chemistry 65 (4) (2022)
Timothy P C Rooney, Gregory G Aldred, Helen K Boffey, Henriëtte M G Willems, Simon Edwards, Stephen J Chawner, Duncan E Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H Clarke, Stephen P Andrews
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. Journal of medicinal chemistry 66 (1) (2022)