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Kristian Helin (K Helin)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2015-2023
Publications (10 Years): 48

Top Venues

Nature

Leukemia

Nature communications

Blood

Sloan Kettering Institute

University of Copenhagen (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Sloan Kettering Institute Sep 1o 2018

United States

Member :: Helin lab

Education History

University of Copenhagen Feb 1o 1988 - Jun 25o 1991

Denmark

PHD

Publications

Helene Damhofer, Kristian Helin
EZH2i unlocks PDAC immune surveillance. Nature cancer 4 (6) (2023)
Mette Louise Trempenau, Mikkel Bruhn Schuster, Sachin Pundhir, Mafalda Araujo Pereira, Adrija Kalvisa, Marta Tapia, Jinyu Su, Ying Ge, Bauke de Boer, Alexander Balhuizen, Frederik Otzen Bagger, Pavel Shliaha, Patrycja Sroczynska, Julian Walfridsson, Kirsten Grønbaek, Kim Theilgaard-Mönch, Ole N Jensen, Kristian Helin, Bo Torben Porse
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes. Leukemia (2023)
Stine L Hansen, Hjalte L Larsen, Laura M Pikkupeura, Grzegorz J Maciag, Jordi Guiu, Iris Müller, Ditte L Clement, Christina Mueller, Jens Vilstrup Johansen, Kristian Helin, Mads Lerdrup, Kim Bak Jensen
An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate. Science advances 9 (28) (2023)
Chang Huang, Kristian Helin
Catching active enhancers via H2B N-terminal acetylation. Nature genetics (2023)
Mette Louise Trempenau, Mikkel Bruhn Schuster, Sachin Pundhir, Mafalda Araujo Pereira, Adrija Kalvisa, Marta Tapia, Jinyu Su, Ying Ge, Bauke de Boer, Alexander Balhuizen, Frederik Otzen Bagger, Pavel Shliaha, Patrycja Sroczynska, Julian Walfridsson, Kirsten Grønbaek, Kim Theilgaard-Mönch, Ole N Jensen, Kristian Helin, Bo Torben Porse
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes. Leukemia 37 (3) (2023)
Hua Wang, Zheng Fan, Pavel V Shliaha, Matthew M Miele, Ronald C Hendrickson, Xuejun Jiang, Kristian Helin
Publisher Correction: H3K4me3 regulates RNA polymerase II promoter-proximal pause-release. Nature (2023)
Mette Louise Trempenau, Mikkel Bruhn Schuster, Sachin Pundhir, Mafalda Araujo Pereira, Adrija Kalvisa, Marta Tapia, Jinyu Su, Ying Ge, Bauke de Boer, Alexander Balhuizen, Frederik Otzen Bagger, Pavel Shliaha, Patrycja Sroczynska, Julian Walfridsson, Kirsten Grønbaek, Kim Theilgaard-Mönch, Ole N Jensen, Kristian Helin, Bo Torben Porse
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes. Leukemia 37 (3) (2023)
Hua Wang, Zheng Fan, Pavel V Shliaha, Matthew M Miele, Ronald C Hendrickson, Xuejun Jiang, Kristian Helin
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release. Nature 615 (7951) (2023)
Hua Wang, Zheng Fan, Pavel V Shliaha, Matthew M Miele, Ronald C Hendrickson, Xuejun Jiang, Kristian Helin
Author Correction: H3K4me3 regulates RNA polymerase II promoter-proximal pause-release. Nature (2023)
Mette Louise Trempenau, Mikkel Bruhn Schuster, Sachin Pundhir, Mafalda Araujo Pereira, Adrija Kalvisa, Marta Tapia, Jinyu Su, Ying Ge, Bauke de Boer, Alexander Balhuizen, Frederik Otzen Bagger, Pavel Shliaha, Patrycja Sroczynska, Julian Walfridsson, Kirsten Grønbaek, Kim Theilgaard-Mönch, Ole N Jensen, Kristian Helin, Bo Torben Porse
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes. Leukemia 37 (3) (2023)
Mette Louise Trempenau, Mikkel Bruhn Schuster, Sachin Pundhir, Mafalda Araujo Pereira, Adrija Kalvisa, Marta Tapia, Jinyu Su, Ying Ge, Bauke de Boer, Alexander Balhuizen, Frederik Otzen Bagger, Pavel Shliaha, Patrycja Sroczynska, Julian Walfridsson, Kirsten Grønbaek, Kim Theilgaard-Mönch, Ole N Jensen, Kristian Helin, Bo Torben Porse
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes. Leukemia 37 (3) (2023)
Hua Wang, Zheng Fan, Pavel V Shliaha, Matthew M Miele, Ronald C Hendrickson, Xuejun Jiang, Kristian Helin
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release. Nature (2023)
Helene Damhofer, Kristian Helin
EZH2i unlocks PDAC immune surveillance. Nature cancer 4 (6) (2023)
Hua Wang, Zheng Fan, Pavel V Shliaha, Matthew M Miele, Ronald C Hendrickson, Xuejun Jiang, Kristian Helin
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release. Nature 615 (7951) (2023)
Hua Wang, Zheng Fan, Pavel V Shliaha, Matthew M Miele, Ronald C Hendrickson, Xuejun Jiang, Kristian Helin
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release. Nature 615 (7951) (2023)
Hua Wang, Zheng Fan, Pavel V Shliaha, Matthew M Miele, Ronald C Hendrickson, Xuejun Jiang, Kristian Helin
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release. Nature 615 (7951) (2023)
Mette Louise Trempenau, Mikkel Bruhn Schuster, Sachin Pundhir, Mafalda Araujo Pereira, Adrija Kalvisa, Marta Tapia, Jinyu Su, Ying Ge, Bauke de Boer, Alexander Balhuizen, Frederik Otzen Bagger, Pavel Shliaha, Patrycja Sroczynska, Julian Walfridsson, Kirsten Grønbaek, Kim Theilgaard-Mönch, Ole N Jensen, Kristian Helin, Bo Torben Porse
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes. Leukemia 37 (3) (2023)
Aliaksandra Radzisheuskaya, Isabel Peña-Rømer, Eugenia Lorenzini, Richard Koche, Yingqian Zhan, Pavel V Shliaha, Alexandra J Cooper, Zheng Fan, Daria Shlyueva, Jens V Johansen, Ronald C Hendrickson, Kristian Helin
An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions. The EMBO journal (2023)
Mette Louise Trempenau, Mikkel Bruhn Schuster, Sachin Pundhir, Mafalda Araujo Pereira, Adrija Kalvisa, Marta Tapia, Jinyu Su, Ying Ge, Bauke de Boer, Alexander Balhuizen, Frederik Otzen Bagger, Pavel Shliaha, Patrycja Sroczynska, Julian Walfridsson, Kirsten Grønbaek, Kim Theilgaard-Mönch, Ole N Jensen, Kristian Helin, Bo Torben Porse
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes. Leukemia (2023)
Hua Wang, Zheng Fan, Pavel V Shliaha, Matthew M Miele, Ronald C Hendrickson, Xuejun Jiang, Kristian Helin
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release. Nature 615 (7951) (2023)
Jianhuang Lin, Dajiang Guo, Heng Liu, Wei Zhou, Chen Wang, Iris Müller, Andrew V Kossenkov, Ronny Drapkin, Benjamin G Bitler, Kristian Helin, Rugang Zhang
The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity. Cancer immunology research 9 (12) (2022)
Aditya Sankar, Faizaan Mohammad, Arun Kumar Sundaramurthy, Hua Wang, Mads Lerdrup, Tulin Tatar, Kristian Helin
Histone editing elucidates the functional roles of H3K27 methylation and acetylation in mammals. Nature genetics 54 (6) (2022)
Bing Li, Wenbin An, Hua Wang, Timour Baslan, Shoron Mowla, Aishwarya Krishnan, Wenbin Xiao, Richard P Koche, Ying Liu, Sheng F Cai, Zhijian Xiao, Andriy Derkach, Ilaria Iacobucci, Charles G Mullighan, Kristian Helin, Scott W Lowe, Ross L Levine, Raajit K Rampal
BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation. Blood 139 (25) (2022)
Jan-Erik Messling, Karl Agger, Kasper L Andersen, Kristina Kromer, Hanna Maria Kuepper, Anders H Lund, Kristian Helin
Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia. Blood (2021)
Xiaokang Wang, Wojciech Rosikiewicz, Yurii Sedkov, Tanner C Martinez, Baranda S Hansen, Patrick Schreiner, Jesper Christensen, Beisi Xu, Shondra M Pruett-Miller, Kristian Helin, Hans-Martin Herz
PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands. Life science alliance 5 (1) (2021)
Iris Müller, Ann Sophie Moroni, Daria Shlyueva, Sudeep Sahadevan, Erwin M Schoof, Aliaksandra Radzisheuskaya, Jonas W Højfeldt, Tülin Tatar, Richard P Koche, Chang Huang, Kristian Helin
MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells. Nature communications 12 (1) (2021)
Sarah H Kim, Arnaud Da Cruz Paula, Thais Basili de Oliveira, Higinio Dopeso, Rui Bi, Fresia Pareja, Edaise M Da Silva, Rodrigo Gularte-Mérida, Zhen Sun, Sho Fujisawa, Caitlin G Smith, Lorenzo Ferrando, Ana Paula Martins Sebastião, Yonina Bykov, Anqi Li, Catarina Silveira, Charles W Ashley, Anthe Stylianou, Pier Selenica, Wesley R Samore, Achim A Jungbluth, Dmitriy Zamarin, Nadeem R Abu-Rustum, Kristian Helin, Robert A Soslow, Jorge Sergio Reis-Filho, Esther Oliva, Britta Weigelt
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary. Nature communications 11 (1) (2020)
Petros Kolovos, Koutarou Nishimura, Aditya Sankar, Simone Sidoli, Paul A Cloos, Kristian Helin, Jesper Christensen
PR-DUB maintains the expression of critical genes through FOXK1/2- and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination. Genome research 30 (8) (2020)
Aditya Sankar, Mads Lerdrup, Adeel Manaf, Jens Vilstrup Johansen, Javier Martin Gonzalez, Rehannah Borup, Robert Blanshard, Arne Klungland, Klaus Hansen, Claus Yding Andersen, John Arne Dahl, Kristian Helin, Eva R Hoffman
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes. Nature cell biology 22 (4) (2020)
Friederike Pastore, Neha Bhagwat, Alessandro Pastore, Aliaksandra Radzisheuskaya, Abdul Karzai, Aishwarya Krishnan, Bing Li, Robert L Bowman, Wenbin Xiao, Aaron D Viny, Anouar Zouak, Young C Park, Keith B Cordner, Stephanie Braunstein, Jesper L V Maag, Alexander Grego, Jaanvi Mehta, Min Wang, Hong Lin, Benjamin H Durham, Richard P Koche, Raajit K Rampal, Kristian Helin, Peggy Scherle, Kris Vaddi, Ross L Levine
PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2V617F-Mutant MPN. Cancer discovery 10 (11) (2020)
Stine Emilie Weis-Banke, Mads Lerdrup, Daniela Kleine-Kohlbrecher, Faizaan Mohammad, Simone Sidoli, Ole Nørregaard Jensen, Toshihiko Yanase, Tomoko Nakamura, Akira Iwase, Anthe Stylianou, Nadeem R Abu-Rustum, Carol Aghajanian, Robert Soslow, Arnaud Da Cruz Paula, Richard P Koche, Britta Weigelt, Jesper Christensen, Kristian Helin, Paul A C Cloos
Mutant FOXL2C134W Hijacks SMAD4 and SMAD2/3 to Drive Adult Granulosa Cell Tumors. Cancer research 80 (17) (2020)
Karl Agger, Koutarou Nishimura, Satoru Miyagi, Jan-Erik Messling, Kasper Dindler Rasmussen, Kristian Helin
The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance. Blood 134 (14) (2019)
Aliaksandra Radzisheuskaya, Pavel V Shliaha, Vasily V Grinev, Eugenia Lorenzini, Sergey Kovalchuk, Daria Shlyueva, Vladimir A Gorshkov, Ronald C Hendrickson, Ole Nørregaard Jensen, Kristian Helin
PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia. Nature structural & molecular biology 26 (11) (2019)
Kasper D Rasmussen, Ivan Berest, Sandra Keβler, Koutarou Nishimura, Lucía Simón-Carrasco, George S Vassiliou, Marianne T Pedersen, Jesper Christensen, Judith Barbara Zaugg, Kristian Helin
TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells. Genome research 29 (4) (2019)
Shuchi Agrawal-Singh, Mads Lerdrup, Ana-Luisa R Gomes, Harmen J G van de Werken, Jens Vilstrup Johansen, Robin Andersson, Albin Sandelin, Kristian Helin, Klaus Hansen
PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells. eLife 8 (2019)
Jonas W Højfeldt, Anne Laugesen, Berthe M Willumsen, Helene Damhofer, Lin Hedehus, Andrey Tvardovskiy, Faizaan Mohammad, Ole Nørregaard Jensen, Kristian Helin
Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2. Nature structural & molecular biology 25 (3) (2018)
Hui Li, Qi Yao, Alberto Garcia Mariscal, Xudong Wu, Justus Hülse, Esben Pedersen, Kristian Helin, Esther Von Stebut, Caroline Vinkel, Simon Francis Thomsen, Alexandra Avgustinova, Salvador Aznar Benitah, Paola Lovato, Hanne Norsgaard, Mette Sidsel Mortensen, Lone Veng, Björn Rozell, Cord Brakebusch
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Nature communications 9 (1) (2018)
Aditya Sankar, Susanne Marije Kooistra, Javier Martin Gonzalez, Claes Ohlsson, Matti Poutanen, Kristian Helin
Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development. Development (Cambridge, England) 144 (18) (2017)
Faizaan Mohammad, Simon Weissmann, Benjamin Leblanc, Deo P Pandey, Jonas W Højfeldt, Itys Comet, Chunqin Zheng, Jens Vilstrup Johansen, Nicolas Rapin, Bo Torben Porse, Andrey Tvardovskiy, Ole Nørregaard Jensen, Nagore G Olaciregui, Cinzia Lavarino, Mariona Suñol, Carmen de Torres, Jaume Catala-Mora, Angel M Carcaboso, Kristian Helin
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas. Nature medicine 23 (4) (2017)
Kasper Dindler Rasmussen, Kristian Helin
Role of TET enzymes in DNA methylation, development, and cancer. Genes & development 30 (7) (2016)
Aliaksandra Radzisheuskaya, Daria Shlyueva, Iris Müller, Kristian Helin
Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. Nucleic acids research 44 (18) (2016)
Marianne Terndrup Pedersen, Susanne Marije Kooistra, Aliaksandra Radzisheuskaya, Anne Laugesen, Jens Vilstrup Johansen, Daniel Geoffrey Hayward, Jakob Nilsson, Karl Agger, Kristian Helin
Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development. The EMBO journal 35 (14) (2016)
Karl Agger, Satoru Miyagi, Marianne Terndrup Pedersen, Susanne M Kooistra, Jens Vilstrup Johansen, Kristian Helin
Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells. Genes & development 30 (11) (2016)
L Scourzic, L Couronné, M T Pedersen, V Della Valle, M Diop, E Mylonas, J Calvo, E Mouly, C K Lopez, N Martin, M Fontenay, A Bender, S Guibert, P Dubreuil, P Dessen, N Droin, F Pflumio, M Weber, P Gaulard, Kristian Helin, T Mercher, O A Bernard
DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice. Leukemia 30 (6) (2016)
Vincenzo Riso, Marco Cammisa, Harpreet Kukreja, Zahra Anvar, Gaetano Verde, Angela Sparago, Basilia Acurzio, Shraddha Lad, Enza Lonardo, Aditya Sankar, Kristian Helin, Robert Feil, Annalisa Fico, Claudia Angelini, Giovanna Grimaldi, Andrea Riccio
ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells. Nucleic acids research 44 (17) (2016)
Sarah Cooper, Anne Grijzenhout, Elizabeth Underwood, Katia Ancelin, Tianyi Zhang, Tatyana B Nesterova, Burcu Anil-Kirmizitas, Andrew Bassett, Susanne M Kooistra, Karl Agger, Kristian Helin, Edith Heard, Neil Brockdorff
Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nature communications 7 (2016)
Kasper Dindler Rasmussen, Kristian Helin
TET1: an epigenetic guardian of lymphomagenesis. Nature immunology 16 (6) (2015)
Marta Montes, Morten M Nielsen, Giulia Maglieri, Anders Jacobsen, Jonas Højfeldt, Shuchi Agrawal-Singh, Klaus Hansen, Kristian Helin, Harmen J G van de Werken, Jakob S Pedersen, Anders Henrik Lund
The lncRNA MIR31HG regulates p16(INK4A) expression to modulate senescence. Nature communications 6 (2015)

Kristian Helin.css-eqlu8i{font-size:small;padding-left:4px;} (K Helin)

Publication Activity (10 Years)

Top Topics

Top Venues

Kristian Helin (K Helin)