George S Vassiliou (George Vassiliou)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 70

Top Venues

Blood

Nature genetics

Nature communications

eLife

Wellcome Trust Sanger Institute

University of Cambridge (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Wellcome Trust Sanger Institute Jul 01 2006

United Kingdom

Wellcome Trust Senior Fellow in Clinical Science :: Haematological Cancer Genetics

Education History

University of Cambridge Jan 01 2001 - Jun 30 2004

United Kingdom

PHD :: Haematology

Queen Mary University of London Oct 01 1988 - Jun 15 1991

United Kingdom

BSC :: Pharmacology

Publications

Jing Guo, Klaudia Walter, Pedro M Quiros, Muxin Gu, E Joanna Baxter, John Danesh, Emanuele Di Angelantonio, David Roberts, Paola Guglielmelli, Claire N Harrison, Anna L Godfrey, Anthony R Green, George S Vassiliou, Dragana Vuckovic, Jyoti Nangalia, Nicole Soranzo
Inherited polygenic effects on common hematological traits influence clonal selection on JAK2 V617F and the development of myeloproliferative neoplasms. Nature genetics 56 (2) (2024)
Emily Mitchell, George S Vassiliou
T-Cell Cancer after CAR T-Cell Therapy. The New England journal of medicine 390 (22) (2024)
Emily Mitchell, George S Vassiliou
T-Cell Cancer after CAR T-Cell Therapy. The New England journal of medicine 390 (22) (2024)
Linda Zhang, Joanne I Hsu, Etienne D Braekeleer, Chun-Wei Chen, Tajhal D Patel, Alejandra G Martell, Anna G Guzman, Katharina Wohlan, Sarah M Waldvogel, Hidetaka Uryu, Ayala Tovy, Elsa Callen, Rebecca L Murdaugh, Rosemary Richard, Sandra Jansen, Lisenka Vissers, Bert B A de Vries, Andre Nussenzweig, Shixia Huang, Cristian Coarfa, Jamie Anastas, Koichi Takahashi, George S Vassiliou, Margaret A Goodell
SOD1 is a synthetic-lethal target in PPM1D -mutant leukemia cells. eLife 12 (2024)
Jing Guo, Klaudia Walter, Pedro M Quiros, Muxin Gu, E Joanna Baxter, John Danesh, Emanuele Di Angelantonio, David Roberts, Paola Guglielmelli, Claire N Harrison, Anna L Godfrey, Anthony R Green, George S Vassiliou, Dragana Vuckovic, Jyoti Nangalia, Nicole Soranzo
Inherited polygenic effects on common hematological traits influence clonal selection on JAK2 V617F and the development of myeloproliferative neoplasms. Nature genetics 56 (2) (2024)
Linda Zhang, Joanne I Hsu, Etienne D Braekeleer, Chun-Wei Chen, Tajhal D Patel, Alejandra G Martell, Anna G Guzman, Katharina Wohlan, Sarah M Waldvogel, Hidetaka Uryu, Ayala Tovy, Elsa Callen, Rebecca L Murdaugh, Rosemary Richard, Sandra Jansen, Lisenka Vissers, Bert B A de Vries, Andre Nussenzweig, Shixia Huang, Cristian Coarfa, Jamie Anastas, Koichi Takahashi, George S Vassiliou, Margaret A Goodell
SOD1 is a synthetic-lethal target in PPM1D -mutant leukemia cells. eLife 12 (2024)
Linda Zhang, Joanne I Hsu, Etienne D Braekeleer, Chun-Wei Chen, Tajhal D Patel, Alejandra G Martell, Anna G Guzman, Katharina Wohlan, Sarah M Waldvogel, Hidetaka Uryu, Ayala Tovy, Elsa Callen, Rebecca L Murdaugh, Rosemary Richard, Sandra Jansen, Lisenka Vissers, Bert B A de Vries, Andre Nussenzweig, Shixia Huang, Cristian Coarfa, Jamie Anastas, Koichi Takahashi, George S Vassiliou, Margaret A Goodell
SOD1 is a synthetic-lethal target in PPM1D -mutant leukemia cells. eLife 12 (2024)
Emily Mitchell, George S Vassiliou
T-Cell Cancer after CAR T-Cell Therapy. The New England journal of medicine 390 (22) (2024)
Linda Zhang, Joanne I Hsu, Etienne D Braekeleer, Chun-Wei Chen, Tajhal D Patel, Alejandra G Martell, Anna G Guzman, Katharina Wohlan, Sarah M Waldvogel, Hidetaka Uryu, Ayala Tovy, Elsa Callen, Rebecca L Murdaugh, Rosemary Richard, Sandra Jansen, Lisenka Vissers, Bert B A de Vries, Andre Nussenzweig, Shixia Huang, Cristian Coarfa, Jamie Anastas, Koichi Takahashi, George S Vassiliou, Margaret A Goodell
SOD1 is a synthetic-lethal target in PPM1D -mutant leukemia cells. eLife 12 (2024)
Jing Guo, Klaudia Walter, Pedro M Quiros, Muxin Gu, E Joanna Baxter, John Danesh, Emanuele Di Angelantonio, David Roberts, Paola Guglielmelli, Claire N Harrison, Anna L Godfrey, Anthony R Green, George S Vassiliou, Dragana Vuckovic, Jyoti Nangalia, Nicole Soranzo
Inherited polygenic effects on common hematological traits influence clonal selection on JAK2 V617F and the development of myeloproliferative neoplasms. Nature genetics 56 (2) (2024)
Jing Guo, Klaudia Walter, Pedro M Quiros, Muxin Gu, E Joanna Baxter, John Danesh, Emanuele Di Angelantonio, David Roberts, Paola Guglielmelli, Claire N Harrison, Anna L Godfrey, Anthony R Green, George S Vassiliou, Dragana Vuckovic, Jyoti Nangalia, Nicole Soranzo
Inherited polygenic effects on common hematological traits influence clonal selection on JAK2 V617F and the development of myeloproliferative neoplasms. Nature genetics 56 (2) (2024)
Linda Zhang, Joanne I Hsu, Etienne D Braekeleer, Chun-Wei Chen, Tajhal D Patel, Alejandra G Martell, Anna G Guzman, Katharina Wohlan, Sarah M Waldvogel, Hidetaka Uryu, Ayala Tovy, Elsa Callen, Rebecca L Murdaugh, Rosemary Richard, Sandra Jansen, Lisenka Vissers, Bert B A de Vries, Andre Nussenzweig, Shixia Huang, Cristian Coarfa, Jamie Anastas, Koichi Takahashi, George S Vassiliou, Margaret A Goodell
SOD1 is a synthetic-lethal target in PPM1D -mutant leukemia cells. eLife 12 (2024)
Jing Guo, Klaudia Walter, Pedro M Quiros, Muxin Gu, E Joanna Baxter, John Danesh, Emanuele Di Angelantonio, David Roberts, Paola Guglielmelli, Claire N Harrison, Anna L Godfrey, Anthony R Green, George S Vassiliou, Dragana Vuckovic, Jyoti Nangalia, Nicole Soranzo
Inherited polygenic effects on common hematological traits influence clonal selection on JAK2 V617F and the development of myeloproliferative neoplasms. Nature genetics (2024)
Katherine Sturgess, Eliza Yankova, M S Vijayabaskar, Tomoya Isobe, Justyna Rak, Iwo Kucinski, Melania Barile, Natalie A Webster, Maria Eleftheriou, Rebecca Hannah, Malgorzata Gozdecka, George S Vassiliou, Oliver Rausch, Nicola K Wilson, Berthold Göttgens, Konstantinos Tzelepis
Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages. Leukemia (2023)
José Guilherme de Almeida, Emma Gudgin, Martin Besser, William G Dunn, Jonathan Cooper, Torsten Haferlach, George S Vassiliou, Moritz Gerstung
Computational analysis of peripheral blood smears detects disease-associated cytomorphologies. Nature communications 14 (1) (2023)
Muxin Gu, Sruthi Cheloor Kovilakam, William G Dunn, Ludovica Marando, Clea Barcena, Irina Mohorianu, Alexandra Smith, Siddhartha P Kar, Margarete A Fabre, Moritz Gerstung, Catherine A Cargo, Luca Malcovati, Pedro M Quiros, George S Vassiliou
Multiparameter prediction of myeloid neoplasia risk. Nature genetics (2023)
Keith Woodley, Laura S Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M Rattigan, Céline Philippe, Vilma Dembitz, Aoife M S Magee, Ryan Asby, Louie N van de Lagemaat, Christopher Mapperley, Sophie C James, Jochen H M Prehn, Konstantinos Tzelepis, Kevin Rouault-Pierre, George S Vassiliou, Kamil R Kranc, G Vignir Helgason, Brian James Patrick Huntly, Paolo Gallipoli
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nature communications 14 (1) (2023)
Muxin Gu, Sruthi Cheloor Kovilakam, William G Dunn, Ludovica Marando, Clea Barcena, Irina Mohorianu, Alexandra Smith, Siddhartha P Kar, Margarete A Fabre, Moritz Gerstung, Catherine A Cargo, Luca Malcovati, Pedro M Quiros, George S Vassiliou
Author Correction: Multiparameter prediction of myeloid neoplasia risk. Nature genetics (2023)
Linda Zhang, Joanne I Hsu, Etienne D Braekeleer, Chun-Wei Chen, Tajhal D Patel, Hidetaka Urya, Anna G Guzman, Alejandra G Martell, Sarah M Waldvogel, Ayala Tovy, Elsa Callen, Rebecca Murdaugh, Rosemary Richard, Sandra Jansen, Lisenka E L M Vissers, Bert B A de Vries, Andre Nussenzweig, Shixia Huang, Cristian Coarfa, Jamie N Anastas, Koichi Takahashi, George S Vassiliou, Margaret A Goodell
SOD1 is a synthetic lethal target in PPM1D -mutant leukemia cells. bioRxiv : the preprint server for biology (2023)
George S Vassiliou
Telomere Length and Clonal Hematopoiesis. The New England journal of medicine (2023)
Sruthi Cheloor Kovilakam, Muxin Gu, William G Dunn, Ludovica Marando, Clea Barcena, Serena Nik-Zainal, Irina I Mohorianu, Siddhartha Kar, Margarete Alice Fabre, Pedro M Quiros, George S Vassiliou
Prevalence and significance of DDX41 gene variants in the general population. Blood (2023)
Margarete A Fabre, George S Vassiliou
The lifelong natural history of clonal hematopoiesis and its links to myeloid malignancy. Blood (2023)
Juan Li, Matthew J Williams, Hyun Jung Park, Hugo P Bastos, Xiaonan Wang, Daniel Prins, Nicola K Wilson, Carys Johnson, Kendig Sham, Michelle Wantoch, Sam Watcham, Sarah J Kinston, Dean C Pask, Tina L Hamilton, Rachel Sneade, Amie K Waller, Cedric Ghevaert, George S Vassiliou, Elisa Laurenti, David G Kent, Berthold Göttgens, Anthony R Green
STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resist myeloablation and neoplastic expansion. Blood 140 (14) (2022)
Tae-Hoon Shin, Yifan Zhou, Shirley Chen, Stefan Cordes, Max Z Grice, Xing Fan, Byung-Chul Lee, Aisha A Aljanahi, So Gun Hong, Kelli L Vaughan, Julie A Mattison, Steven G Kohama, Margarete Alice Fabre, Naoya Uchida, Selami Demirci, Marcus A F Corat, Jean-Yves Metais, Katherine R Calvo, Manuel Buscarlet, Hannah Natanson, Kathy L McGraw, Alan F List, Lambert Busque, John F Tisdale, George S Vassiliou, Kyung-Rok Yu, Cynthia E Dunbar
A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions. Blood 140 (16) (2022)
Margarete A Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, M S Vijayabaskar, Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas O Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J Campbell, Eoin F McKinney, Francesco Cucca, Moritz Gerstung, George S Vassiliou
The longitudinal dynamics and natural history of clonal haematopoiesis. Nature 606 (7913) (2022)
Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan Azazi, Sarah J Horton, Cecile K Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W Houghton, George S Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D Whetton, Brian James Patrick Huntly
HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia. Blood (2022)
Andrew Muranyi, Tobias Ammer, Anna Kechter, Vijay P S Rawat, Amit U Sinha, Irene Gonzalez-Menendez, Leticia Quintanilla-Fend, Anca Azoitei, Cagatay Günes, Annalisa Mupo, George S Vassiliou, Shiva Bamezai, Christian Buske
Npm1 Haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice. Blood advances (2022)
Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan Azazi, Sarah J Horton, Cecile K Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W Houghton, George S Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D Whetton, Brian James Patrick Huntly
HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia. Blood (2022)
Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan Azazi, Sarah J Horton, Cecile K Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W Houghton, George S Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D Whetton, Brian James Patrick Huntly
HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia. Blood (2022)
Maike Janssen, Christina Schmidt, Peter-Martin Bruch, Maximilian Felix Blank, Christian Rohde, Alexander Waclawiczek, Daniel Heid, Simon Renders, Stefanie Göllner, Lisa Vierbaum, Birgit Besenbeck, Sophie A Herbst, Mareike Knoll, Carolin Kolb, Adriana Przybylla, Katharina Weidenauer, Anne Kathrin Ludwig, Margarete Alice Fabre, Muxin Gu, Richard F Schlenk, Friedrich Stölzel, Martin Bornhäuser, Christoph Röllig, Uwe Platzbecker, Claudia Dorothea Baldus, Hubert Serve, Tim Sauer, Simon Raffel, Caroline Pabst, George S Vassiliou, Binje Vick, Irmela Jeremias, Andreas Trumpp, Jeroen Krijgsveld, Carsten Muller-Tidow, Sascha Dietrich
Venetoclax synergizes with Gilteritinib in FLT3 wildtype high-risk Acute Myeloid Leukemia by suppressing MCL-1. Blood (2022)
Alison E Meyer, Cary Stelloh, Kirthi Pulakanti, Robert Burns, Joseph B Fisher, Katelyn E Heimbruch, Sergey Tarima, Quinlan Furumo, John Brennan, Yongwei Zheng, Aaron D Viny, George S Vassiliou, Sridhar Rao
Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML. Leukemia 36 (8) (2022)
Lavinia Dunsmore, Claudio D Navo, Julie Becher, Enrique Gil de Montes, Ana Guerreiro, Emily A Hoyt, Libby Brown, Viviane Zelenay, Sigitas Mikutis, Jonathan Cooper, Isaia Barbieri, Stefanie Lawrinowitz, Elise Siouve, Esther Martin, Pedro R Ruivo, Tiago Rodrigues, Filipa P da Cruz, Oliver Werz, George S Vassiliou, Peter Ravn, Gonzalo Jiménez-Osés, Gonçalo J L Bernardes
Controlled masking and targeted release of redox-cycling ortho-quinones via a C-C bond-cleaving 1,6-elimination. Nature chemistry 14 (7) (2022)
Yifan Zhou, Ruba Shalhoub, Stephanie N Rogers, Shiqin Yu, Muxin Gu, Margarete Alice Fabre, Pedro M Quiros, Tae-Hoon Shin, Arch Diangson, Wenhan Deng, Shubha Anand, Wenhua Lu, Matthew Cullen, Anna L Godfrey, Jacobus Preller, Jerome Hadjadj, Emmanuelle Jouanguy, Aurélie Cobat, Laurent Abel, Frédéric Rieux-Laucat, Benjamin Terrier, Alain Fischer, Lara Novik, Ingelise J Gordon, Larisa Strom, Martin R Gaudinski, Andrea Lisco, Irini Sereti, Thomas J Gniadek, Andrea Biondi, Bonfanti Paolo, Luisa Imberti, Clifton L Dalgard, Yu Zhang, A Kerry Dobbs, Helen C Su, Luigi Daniele Notarangelo, Colin O Wu, Peter J M Openshaw, Malcolm Gracie Semple, Ziad Mallat, John Kenneth Baillie, Cynthia E Dunbar, George S Vassiliou
Clonal hematopoiesis is not significantly associated with COVID-19 disease severity. Blood 140 (14) (2022)
Shikha Gupta, Oliver M Dovey, Ana Filipa Domingues, Oliwia W Cyran, Caitlin M Cash, George Giotopoulos, Justyna Rak, Jonathan Cooper, Malgorzata Gozdecka, Liza Dijkhuis, Ryan J Asby, Noor Al-Jabery, Victor Hernandez-Hernandez, Sudhakaran Prabakaran, Brian James Patrick Huntly, George S Vassiliou, Cristina Pina
Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis. Science advances 8 (31) (2022)
Emily Mitchell, Michael Spencer Chapman, Nicholas O Williams, Kevin J Dawson, Nicole Mende, Emily F Calderbank, Hyunchul Jung, Thomas Mitchell, Tim H H Coorens, David H Spencer, Heather Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete A Fabre, Krishnaa T A Mahbubani, Federico Abascal, Alex T J Cagan, George S Vassiliou, Joanna Baxter, Iñigo Martincorena, Michael R Stratton, David G Kent, Krishna Chatterjee, Kourosh Saeb Parsy, Anthony R Green, Jyoti Nangalia, Elisa Laurenti, Peter J Campbell
Clonal dynamics of haematopoiesis across the human lifespan. Nature 606 (7913) (2022)
Siddhartha P Kar, Pedro M Quiros, Muxin Gu, Tao Jiang, Jonathan Mitchell, Ryan Langdon, Vivek Iyer, Clea Barcena, M S Vijayabaskar, Margarete A Fabre, Paul Carter, Slavé Petrovski, Stephen Burgess, George S Vassiliou
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis. Nature genetics 54 (8) (2022)
Yoshimitsu Yura, Emiri Miura-Yura, Yasufumi Katanasaka, Kyung-Duk Min, Nicholas W Chavkin, Ariel H Polizio, Hayato Ogawa, Keita Horitani, Heather Doviak, Megan A Evans, Miho Sano, Ying Wang, Katharina Boroviak, George Philippos, Ana Filipa Domingues, George S Vassiliou, Soichi Sano, Kenneth Walsh
The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice. Circulation research 129 (6) (2021)
William G Dunn, Muxin S Gu, Margarete A Fabre, Jonathan Cooper, Josep F Nomdedeu, Laura Koumas, Katerina Nicolaou, Jiangxiang Chi, Paul Costeas, George S Vassiliou
The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients. Annals of hematology (2021)
Faisal Basheer, George S Vassiliou
Mouse Models of Myeloid Malignancies. Cold Spring Harbor perspectives in medicine 11 (1) (2021)
Marina Lafage-Pochitaloff, Bastien Gerby, Véronique Baccini, Laëtitia Largeaud, Vincent Fregona, Nais Prade, Pierre-Yves Juvin, Laura Audrey Jamrog, Pierre Bories, Sylvie Hébrard, Stéphanie Lagarde, Veronique Mansat-De Mas, Oliver M Dovey, Kosuke Yusa, George S Vassiliou, Joop H Jansen, Tobias Tekath, David Rombaut, Geneviève Ameye, Carole Barin, Audrey Bidet, John Boudjarane, Marie-Agnès Collonge-Rame, Carine Gervais, Antoine Ittel, Christine Lefebvre, Isabelle Luquet, Lucienne Michaux, Nathalie Nadal, Helene A Poirel, Isabelle Radford-Weiss, Benedicte Ribourtout, Steven Richebourg, Stephanie Struski, Christine Terré, Isabelle Tigaud, Dominique Penther, Virginie Eclache, Michaela Fontenay, Cyril Broccardo, Eric Delabesse
The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11. Blood advances (2021)
Eliza Yankova, Wesley Blackaby, Mark Albertella, Justyna Rak, Etienne De Braekeleer, Georgia Tsagkogeorga, Ewa S Pilka, Demetrios Aspris, Dan Leggate, Alan G Hendrick, Natalie A Webster, Byron Andrews, Richard Fosbeary, Patrick Guest, Nerea Irigoyen, Maria Eleftheriou, Malgorzata Gozdecka, Joao M L Dias, Andrew J Bannister, Binje Vick, Irmela Jeremias, George S Vassiliou, Oliver Rausch, Konstantinos Tzelepis, Tony Kouzarides
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature 593 (7860) (2021)
Suruchi Pacharne, Oliver M Dovey, Jonathan L Cooper, Muxin Gu, Mathias J Friedrich, Sandeep S Rajan, Maxim Barenboim, Grace Collord, M S Vijayabaskar, Hannes Ponstingl, Etienne D Braekeleer, Ruben Bautista, Milena Mazan, Roland Rad, Konstantinos Tzelepis, Penny Wright, Malgorzata Gozdecka, George S Vassiliou
SETBP1 overexpression acts in the place of class-defining mutations to drive FLT3-ITD-mutant AML. Blood advances 5 (9) (2021)
Silvia Basilico, Xiaonan Wang, Alison Kennedy, Konstantinos Tzelepis, George Giotopoulos, Sarah J Kinston, Pedro M Quiros, Kim Wong, David J Adams, Larissa S Carnevalli, Brian James Patrick Huntly, George S Vassiliou, Fernando J Calero-Nieto, Berthold Göttgens
Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML. Nature communications 11 (1) (2020)
Yan Zi Au, Muxin Gu, Etienne De Braekeleer, Malgorzata Gozdecka, Demetrios Aspris, Yusuke Tarumoto, Jonathan Cooper, Jason S L Yu, Swee Hoe Ong, Xi Chen, Konstantinos Tzelepis, Brian James Patrick Huntly, George S Vassiliou, Kosuke Yusa
KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements. Leukemia 35 (4) (2020)
Dimitrios Papaioannou, Andreas Petri, Oliver M Dovey, Sara Terreri, Eric Wang, Frances A Collins, Lauren A Woodward, Allison E Walker, Deedra Nicolet, Felice Pepe, Prasanthi Kumchala, Marius Bill, Christopher J Walker, Malith Karunasiri, Krzysztof Mrózek, Miranda L Gardner, Virginia Camilotto, Nina Zitzer, Jonathan L Cooper, Xiongwei Cai, Xiaoqing Rong-Mullins, Jessica Kohlschmidt, Kellie J Archer, Michael A Freitas, Yi Zheng, Robert J Lee, Iannis Aifantis, George S Vassiliou, Guramrit Singh, Sakari Kauppinen, Clara D Bloomfield, Adrienne M Dorrance, Ramiro Garzon
Author Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications 11 (1) (2020)
Chi Huu Nguyen, Alexander Michael Grandits, George S Vassiliou, Philipp Bernhard Staber, Gerwin Heller, Rotraud Wieser
Evi1 Counteracts Anti-Leukemic and Stem Cell Inhibitory Effects of All-Trans Retinoic Acid on Flt3-ITD/Npm1c-Driven Acute Myeloid Leukemia Cells. Biomedicines 8 (10) (2020)
George S Vassiliou
Triple-mutant AML: too clever by HLF? Blood 134 (3) (2020)
Hannah J Uckelmann, Stephanie M Kim, Eric M Wong, Charles Hatton, Hugh Giovinazzo, Jayant Y Gadrey, Andrei V Krivtsov, Frank G Rücker, Konstanze Döhner, Gerard M McGeehan, Ross L Levine, Lars Bullinger, George S Vassiliou, Scott A Armstrong
Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia. Science (New York, N.Y.) 367 (6477) (2020)
Dimitrios Papaioannou, Andreas Petri, Oliver M Dovey, Sara Terreri, Eric Wang, Frances A Collins, Lauren A Woodward, Allison E Walker, Deedra Nicolet, Felice Pepe, Prasanthi Kumchala, Marius Bill, Christopher J Walker, Malith Karunasiri, Krzysztof Mrózek, Miranda L Gardner, Virginia Camilotto, Nina Zitzer, Jonathan L Cooper, Xiongwei Cai, Xiaoqing Rong-Mullins, Jessica Kohlschmidt, Kellie J Archer, Michael A Freitas, Yi Zheng, Robert J Lee, Iannis Aifantis, George S Vassiliou, Guramrit Singh, Sakari Kauppinen, Clara D Bloomfield, Adrienne M Dorrance, Ramiro Garzon
Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications 11 (1) (2020)
Sebastian Lange, Thomas Engleitner, Sebastian Mueller, Roman Maresch, Maximilian Zwiebel, Laura González-Silva, Günter Schneider, Ruby Banerjee, Fengtang Yang, George S Vassiliou, Mathias J Friedrich, Dieter Saur, Ignacio Varela, Roland Rad
Analysis pipelines for cancer genome sequencing in mice. Nature protocols 15 (2) (2020)
Dimitrios Papaioannou, Andreas Petri, Oliver M Dovey, Sara Terreri, Eric Wang, Frances A Collins, Lauren A Woodward, Allison E Walker, Deedra Nicolet, Felice Pepe, Prasanthi Kumchala, Marius Bill, Christopher J Walker, Malith Karunasiri, Krzysztof Mrózek, Miranda L Gardner, Virginia Camilotto, Nina Zitzer, Jonathan L Cooper, Xiongwei Cai, Xiaoqing Rong-Mullins, Jessica Kohlschmidt, Kellie J Archer, Michael A Freitas, Yi Zheng, Robert J Lee, Iannis Aifantis, George S Vassiliou, Guramrit Singh, Sakari Kauppinen, Clara D Bloomfield, Adrienne M Dorrance, Ramiro Garzon
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications 10 (1) (2019)
Rebecca Caeser, Miriam Di Re, Joanna A Krupka, Jie Gao, Maribel Lara-Chica, Joao M L Dias, Susanna L Cooke, Rachel Fenner, Zelvera Usheva, Hendrik Friedrich Peter Runge, Philip A Beer, Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S Vassiliou, Brian James Patrick Huntly, Annalisa Mupo, Rachael J M Bashford-Rogers, Daniel James Hodson
Genetic modification of primary human B cells to model high-grade lymphoma. Nature communications 10 (1) (2019)
Julia Weber, Jorge de la Rosa, Carolyn S Grove, Markus Schick, Lena Rad, Olga Baranov, Alexander Strong, Anja Pfaus, Mathias J Friedrich, Thomas Engleitner, Robert Lersch, Rupert Öllinger, Michael Grau, Irene Gonzalez Menendez, Manuela Martella, Ursula Kohlhofer, Ruby Banerjee, Maria A Turchaninova, Anna Scherger, Gary J Hoffman, Julia Hess, Laura B Kuhn, Tim Ammon, Johnny Kim, Günter Schneider, Kristian Unger, Ursula Zimber-Strobl, Mathias F Heikenwälder, Marc Schmidt-Supprian, Fengtang Yang, Dieter Saur, Pentao Liu, Katja Steiger, Dmitriy M Chudakov, Georg Lenz, Leticia Quintanilla-Martinez, Ulrich Keller, George S Vassiliou, Juan Cadiñanos, Allan Bradley, Roland Rad
PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice. Nature communications 10 (1) (2019)
Faisal Basheer, George Giotopoulos, Eshwar Meduri, Haiyang Yun, Milena Mazan, Daniel Sasca, Paolo Gallipoli, Ludovica Marando, Malgorzata Gozdecka, Ryan J Asby, Olivia Sheppard, Monika Dudek, Lars Bullinger, Hartmut Döhner, Richard Dillon, Sylvie Freeman, Oliver Ottmann, Alan Burnett, Nigel Russell, Elli Papaemmanuil, Robert Hills, Peter Campbell, George S Vassiliou, Brian James Patrick Huntly
Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML. The Journal of experimental medicine 216 (4) (2019)
Chi Huu Nguyen, Tobias Glüxam, Angela Schlerka, Katharina Bauer, Alexander M Grandits, Hubert Hackl, Oliver Dovey, Sabine Zöchbauer-Müller, Jonathan L Cooper, George S Vassiliou, Dagmar Stoiber, Rotraud Wieser, Gerwin Heller
SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness. Scientific reports 9 (1) (2019)
Kasper D Rasmussen, Ivan Berest, Sandra Keβler, Koutarou Nishimura, Lucía Simón-Carrasco, George S Vassiliou, Marianne T Pedersen, Jesper Christensen, Judith Barbara Zaugg, Kristian Helin
TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells. Genome research 29 (4) (2019)
Malgorzata Gozdecka, Eshwar Meduri, Milena Mazan, Konstantinos Tzelepis, Monika Dudek, Andrew J Knights, Mercedes Calvo Pardo, Lu Yu, Jyoti S Choudhary, Emmanouil Metzakopian, Vivek Iyer, Haiyang Yun, Naomi Park, Ignacio Varela, Ruben Bautista, Grace Collord, Oliver Dovey, Dimitrios A Garyfallos, Etienne De Braekeleer, Saki Kondo, Jonathan Cooper, Berthold Göttgens, Lars Bullinger, Paul A Northcott, David Adams, George S Vassiliou, Brian James Patrick Huntly
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs. Nature genetics 50 (6) (2018)
Samuel J Taylor, Johanna M Duyvestyn, Samantha A Dagger, Emma J Dishington, Catherine A Rinaldi, Oliver M Dovey, George S Vassiliou, Carolyn S Grove, Wallace Y Langdon
Preventing chemotherapy-induced myelosuppression by repurposing the FLT3 inhibitor quizartinib. Science translational medicine 9 (402) (2018)
Konstantinos Tzelepis, Etienne De Braekeleer, Demetrios Aspris, Isaia Barbieri, M S Vijayabaskar, Wen-Hsin Liu, Malgorzata Gozdecka, Emmanouil Metzakopian, Hamish D Toop, Monika Dudek, Samuel C Robson, Francisco Hermida-Prado, Yu Hsuen Yang, Roya Babaei-Jadidi, Dimitrios A Garyfallos, Hannes Ponstingl, Joao M L Dias, Paolo Gallipoli, Michael Seiler, Silvia Buonamici, Binje Vick, Andrew J Bannister, Roland Rad, Rabinder K Prinjha, John C Marioni, Brian James Patrick Huntly, Jennifer Batson, Jonathan C Morris, Cristina Pina, Allan Bradley, Irmela Jeremias, David O Bates, Kosuke Yusa, Tony Kouzarides, George S Vassiliou
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4. Nature communications 9 (1) (2018)
George S Vassiliou
JAK2 V617F clonal disorders: fate or chance? Blood 128 (8) (2018)
Lynn Quek, Muriel D David, Alison Kennedy, Marlen Metzner, Michael Amatangelo, Alan Shih, Bilyana Stoilova, Cyril Quivoron, Mael Heiblig, Christophe Willekens, Véronique Saada, Samar Alsafadi, M S Vijayabaskar, Andy Peniket, Oliver A Bernard, Sam Agresta, Katharine Yen, Kyle MacBeth, Eytan Stein, George S Vassiliou, Ross Levine, Stephane De Botton, Anjan Thakurta, Virginie Penard-Lacronique, Paresh Vyas
Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib. Nature medicine 24 (8) (2018)
Grace Collord, Inigo Martincorena, Matthew D Young, Letizia Foroni, Niccolo Bolli, Michael R Stratton, George S Vassiliou, Peter J Campbell, Sam Behjati
Recurrent histone mutations in T-cell acute lymphoblastic leukaemia. British journal of haematology 184 (4) (2018)
Rebecca Caeser, Grace Collord, Wen-Qing Yao, Zi Chen, George S Vassiliou, Philip A Beer, Ming-Qing Du, Mike A Scott, George A Follows, Daniel J Hodson
Targeting MEK in vemurafenib-resistant hairy cell leukemia. Leukemia 33 (2) (2018)
Thomas McKerrell, Naomi Park, Jianxiang Chi, Grace Collord, Thaidy Moreno, Hannes Ponstingl, Joao Dias, Petroula Gerasimou, Kiki Melanthiou, Chrystalla Prokopiou, Marios Antoniades, Ignacio Varela, Paul A Costeas, George S Vassiliou
JAK2 V617F hematopoietic clones are present several years prior to MPN diagnosis and follow different expansion kinetics. Blood advances 1 (14) (2017)
Jorge de la Rosa, Julia Weber, Mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil Metzakopian, Alexander Strong, Meng Amy Li, Aurora Astudillo, María Teresa Fernández-García, María Soledad Fernández-García, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Carlos López-Otín, Allan Bradley, Juan Cadiñanos
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes. Nature genetics 49 (5) (2017)
Mathias J Friedrich, Lena Rad, Iraad F Bronner, Alexander Strong, Wei Wang, Julia Weber, Matthew Mayho, Hannes Ponstingl, Thomas Engleitner, Carolyn Grove, Anja Pfaus, Dieter Saur, Juan Cadiñanos, Michael A Quail, George S Vassiliou, Pentao Liu, Allan Bradley, Roland Rad
Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice. Nature protocols 12 (2) (2017)
Oliver M Dovey, Jonathan L Cooper, Annalisa Mupo, Carolyn S Grove, Claire Lynn, Nathalie Conte, Robert M Andrews, Suruchi Pacharne, Konstantinos Tzelepis, M S Vijayabaskar, Paul Green, Roland Rad, Mark Arends, Penny Wright, Kosuke Yusa, Allan Bradley, Ignacio Varela, George S Vassiliou
Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia. Blood 130 (17) (2017)
Grace Collord, Naomi Park, Marina Podestà, Monica Dagnino, Daniela Cilloni, David Jones, Ignacio Varela, Francesco Frassoni, George S Vassiliou
Clonal haematopoiesis is not prevalent in survivors of childhood cancer. British journal of haematology 181 (4) (2017)
Thomas McKerrell, Thaidy Moreno, Hannes Ponstingl, Niccolo Bolli, João M L Dias, German Tischler, Vincenza Colonna, Bridget Manasse, Anthony Bench, David Bloxham, Bram Herman, Danielle Fletcher, Naomi Park, Michael A Quail, Nicla Manes, Clare Hodkinson, Joanna Baxter, Jorge Sierra, Theodora Foukaneli, Alan J Warren, Jianxiang Chi, Paul Costeas, Roland Rad, Brian Huntly, Carolyn Grove, Zemin Ning, Chris Tyler-Smith, Ignacio Varela, Mike Scott, Josep Nomdedeu, Ville Mustonen, George S Vassiliou
Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies. Blood 128 (1) (2016)
Sarah Picaud, Katharina Leonards, Jean-Philippe Lambert, Oliver Dovey, Christopher Wells, Oleg Fedorov, Octovia Monteiro, Takao Fujisawa, Chen-Yi Wang, Hannah Lingard, Cynthia Tallant, Nikzad Nikbin, Lucie Guetzoyan, Richard Ingham, Steven V Ley, Paul E Brennan, Susanne Müller, Anastasia Samsonova, Anne-Claude Gingras, Juerg Schwaller, George S Vassiliou, Stefan Knapp, Panagis Filippakopoulos
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia. Science advances 2 (10) (2016)

George S Vassiliou.css-eqlu8i{font-size:small;padding-left:4px;} (George Vassiliou)

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George S Vassiliou (George Vassiliou)