Lan Guan

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 57

Top Topics

Molecular Dynamics Simulations

Top Venues

Bioconjugate chemistry

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

Parameswaran Hariharan, Amirhossein Bakhtiiari, Ruibin Liang, Lan Guan
Distinct roles of the major binding residues in the cation-binding pocket of MelB. bioRxiv : the preprint server for biology (2024)
Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick G Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback, Ruibin Liang, Jan Steyaert, Rosa Viner, Lan Guan
Mobile barrier mechanisms for Na + -coupled symport in an MFS sugar transporter. eLife 12 (2024)
Parameswaran Hariharan, Amirhossein Bakhtiiari, Ruibin Liang, Lan Guan
Distinct roles of the major binding residues in the cation-binding pocket of MelB. bioRxiv : the preprint server for biology (2024)
Ruibin Liang, Lan Guan
Atomic-Level Free Energy Landscape Reveals Cooperative Symport Mechanism of Melibiose Transporter. bioRxiv : the preprint server for biology (2024)
Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick G Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback, Ruibin Liang, Jan Steyaert, Rosa Viner, Lan Guan
Mobile barrier mechanisms for Na + -coupled symport in an MFS sugar transporter. eLife 12 (2024)
Parameswaran Hariharan, Amirhossein Bakhtiiari, Ruibin Liang, Lan Guan
Distinct roles of the major binding residues in the cation-binding pocket of MelB. bioRxiv : the preprint server for biology (2024)
Soyoung Yoon, Hyoung Eun Bae, Parameswaran Hariharan, Andreas Nygaard, Baoliang Lan, Menebere Woubshete, Aiman Sadaf, Xiangyu Liu, Claus J Løland, Bernadette Byrne, Lan Guan, Pil Seok Chae
Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization. Bioconjugate chemistry 35 (2) (2024)
Soyoung Yoon, Hyoung Eun Bae, Parameswaran Hariharan, Andreas Nygaard, Baoliang Lan, Menebere Woubshete, Aiman Sadaf, Xiangyu Liu, Claus J Løland, Bernadette Byrne, Lan Guan, Pil Seok Chae
Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization. Bioconjugate chemistry 35 (2) (2024)
Parameswaran Hariharan, Amirhossein Bakhtiiari, Ruibin Liang, Lan Guan
Distinct roles of the major binding residues in the cation-binding pocket of MelB. bioRxiv : the preprint server for biology (2024)
Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick G Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback, Ruibin Liang, Jan Steyaert, Rosa Viner, Lan Guan
Mobile barrier mechanisms for Na + -coupled symport in an MFS sugar transporter. eLife 12 (2024)
Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick G Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback, Ruibin Liang, Jan Steyaert, Rosa Viner, Lan Guan
Mobile barrier mechanisms for Na + -coupled symport in an MFS sugar transporter. eLife 12 (2024)
Soyoung Yoon, Hyoung Eun Bae, Parameswaran Hariharan, Andreas Nygaard, Baoliang Lan, Menebere Woubshete, Aiman Sadaf, Xiangyu Liu, Claus J Løland, Bernadette Byrne, Lan Guan, Pil Seok Chae
Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization. Bioconjugate chemistry 35 (2) (2024)
Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick G Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback, Ruibin Liang, Jan Steyaert, Rosa Viner, Lan Guan
Mobile barrier mechanisms for Na + -coupled symport in an MFS sugar transporter. eLife 12 (2024)
Soyoung Yoon, Hyoung Eun Bae, Parameswaran Hariharan, Andreas Nygaard, Baoliang Lan, Menebere Woubshete, Aiman Sadaf, Xiangyu Liu, Claus J Løland, Bernadette Byrne, Lan Guan, Pil Seok Chae
Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization. Bioconjugate chemistry 35 (2) (2024)
Soyoung Yoon, Hyoung Eun Bae, Parameswaran Hariharan, Andreas Nygaard, Baoliang Lan, Menebere Woubshete, Aiman Sadaf, Xiangyu Liu, Claus J Løland, Bernadette Byrne, Lan Guan, Pil Seok Chae
Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization. Bioconjugate chemistry (2024)
Soyoung Yoon, Hyoung Eun Bae, Parameswaran Hariharan, Andreas Nygaard, Baoliang Lan, Menebere Woubshete, Aiman Sadaf, Xiangyu Liu, Claus J Løland, Bernadette Byrne, Lan Guan, Pil Seok Chae
Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization. Bioconjugate chemistry 35 (2) (2024)
Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick G Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback, Ruibin Liang, Jan Steyaert, Rosa Viner, Lan Guan
Mobile barrier mechanisms for Na + -coupled symport in an MFS sugar transporter. eLife 12 (2024)
Lan Guan
The rapid developments of membrane protein structure biology over the last two decades. BMC biology 21 (1) (2023)
Geok-Lin Chua, Bryan C Tan, Randy Y J Loke, Menglan He, Cheen Fei Chin, Bernice H Wong, Alvin C Y Kuk, Mei Ding, Markus R Wenk, Lan Guan, Federico T Torta, David L Silver
Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport. Proceedings of the National Academy of Sciences of the United States of America 120 (10) (2023)
Geok-Lin Chua, Bryan C Tan, Randy Y J Loke, Menglan He, Cheen Fei Chin, Bernice H Wong, Alvin C Y Kuk, Mei Ding, Markus R Wenk, Lan Guan, Federico T Torta, David L Silver
Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport. Proceedings of the National Academy of Sciences of the United States of America 120 (10) (2023)
Lan Guan
The rapid developments of membrane protein structure biology over the last two decades. BMC biology 21 (1) (2023)
Lan Guan
The rapid developments of membrane protein structure biology over the last two decades. BMC biology 21 (1) (2023)
Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback, Ruibin Liang, Jan Steyaert, Rosa Viner, Lan Guan
Mimicking the regulatory state of a major facilitator superfamily sugar transporter. bioRxiv : the preprint server for biology (2023)
Lan Guan
The rapid developments of membrane protein structure biology over the last two decades. BMC biology 21 (1) (2023)
Geok-Lin Chua, Bryan C Tan, Randy Y J Loke, Menglan He, Cheen Fei Chin, Bernice H Wong, Alvin C Y Kuk, Mei Ding, Markus R Wenk, Lan Guan, Federico T Torta, David L Silver
Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport. Proceedings of the National Academy of Sciences of the United States of America 120 (10) (2023)
Lubna Ghani, Seonghoon Kim, Muhammad Ehsan, Baoliang Lan, Ida H Poulsen, Chandra Dev, Satoshi Katsube, Bernadette Byrne, Lan Guan, Claus J Løland, Xiangyu Liu, Wonpil Im, Pil Seok Chae
Melamine-cored glucosides for membrane protein solubilization and stabilization: importance of water-mediated intermolecular hydrogen bonding in detergent performance. Chemical science 14 (45) (2023)
Lan Guan
The rapid developments of membrane protein structure biology over the last two decades. BMC biology 21 (1) (2023)
Aniruddha Panda, Fabian Giska, Anna L Duncan, Alexander J Welch, Caroline Brown, Rachel McAllister, Parameswaran Hariharan, Jean N D Goder, Jeff Coleman, Sathish Ramakrishnan, Frederic Pincet, Lan Guan, Shyam S Krishnakumar, James E Rothman, Kallol Gupta
Direct determination of oligomeric organization of integral membrane proteins and lipids from intact customizable bilayer. Nature methods (2023)
Lan Guan
The rapid developments of membrane protein structure biology over the last two decades. BMC biology 21 (1) (2023)
Lan Guan
The rapid developments of membrane protein structure biology over the last two decades. BMC biology 21 (1) (2023)
Lubna Ghani, Xiang Zhang, Chastine F Munk, Parameswaran Hariharan, Baoliang Lan, Hong Sik Yun, Bernadette Byrne, Lan Guan, Claus J Løland, Xiangyu Liu, Pil Seok Chae
Tris(hydroxymethyl)aminomethane Linker-Bearing Triazine-Based Triglucosides for Solubilization and Stabilization of Membrane Proteins. Bioconjugate chemistry (2023)
Geok-Lin Chua, Bryan C Tan, Randy Y J Loke, Menglan He, Cheen Fei Chin, Bernice H Wong, Alvin C Y Kuk, Mei Ding, Markus R Wenk, Lan Guan, Federico T Torta, David L Silver
Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport. Proceedings of the National Academy of Sciences of the United States of America 120 (10) (2023)
Lan Guan
Structure and mechanism of membrane transporters. Scientific reports 12 (1) (2022)
Parameswaran Hariharan, Lan Guan
Cooperative binding ensures the obligatory melibiose/Na+ cotransport in MelB. The Journal of general physiology 153 (8) (2021)
Muhammad Ehsan, Haoqing Wang, Cristina Cecchetti, Jonas S Mortensen, Yang Du, Parameswaran Hariharan, Andreas Nygaard, Ho Jin Lee, Lubna Ghani, Lan Guan, Claus J Løland, Bernadette Byrne, Brian K Kobilka, Pil Seok Chae
Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability. ACS chemical biology 16 (9) (2021)
Lan Guan, Parameswaran Hariharan
X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB. Communications biology 4 (1) (2021)
Manabendra Das, Florian Mahler, Parameswaran Hariharan, Haoqing Wang, Yang Du, Jonas S Mortensen, Eugenio Pérez Patallo, Lubna Ghani, David Glück, Ho Jin Lee, Bernadette Byrne, Claus J Løland, Lan Guan, Brian K Kobilka, Sandro Keller, Pil Seok Chae
Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study. Journal of the American Chemical Society 142 (51) (2020)
Muhammad Ehsan, Satoshi Katsube, Cristina Cecchetti, Yang Du, Jonas S Mortensen, Haoqing Wang, Andreas Nygaard, Lubna Ghani, Claus J Løland, Brian K Kobilka, Bernadette Byrne, Lan Guan, Pil Seok Chae
New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability. ACS chemical biology 15 (6) (2020)
Cholpon Tilegenova, D Marien Cortes, Nermina Jahovic, Emily Hardy, Parameswaran Hariharan, Lan Guan, Luis G Cuello
Structure, function, and ion-binding properties of a K+ channel stabilized in the 2,4-ion-bound configuration. Proceedings of the National Academy of Sciences of the United States of America 116 (34) (2019)
Muhammad Ehsan, Yang Du, Iago Molist, Alpay Burak Seven, Parameswaran Hariharan, Jonas Sigurd Mortensen, Lubna Ghani, Claus J Løland, Georgios Skiniotis, Lan Guan, Bernadette Byrne, Brian K Kobilka, Pil Seok Chae
Vitamin E-based glycoside amphiphiles for membrane protein structural studies. Organic & biomolecular chemistry 16 (14) (2019)
Muhammad Ehsan, Ashwani Kumar, Jonas Sigurd Mortensen, Yang Du, Parameswaran Hariharan, Kaavya K Kumar, Betty Ha, Bernadette Byrne, Lan Guan, Brian K Kobilka, Claus J Løland, Pil Seok Chae
Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study. Chemistry, an Asian journal 14 (11) (2019)
Muhammad Ehsan, Yang Du, Jonas S Mortensen, Parameswaran Hariharan, Qianhui Qu, Lubna Ghani, Manabendra Das, Anne Grethen, Bernadette Byrne, Georgios Skiniotis, Sandro Keller, Claus J Loland, Lan Guan, Brian K Kobilka, Pil Seok Chae
Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (49) (2019)
Lubna Ghani, Chastine F Munk, Xiang Zhang, Satoshi Katsube, Yang Du, Cristina Cecchetti, Weijiao Huang, Hyoung Eun Bae, Savvas Saouros, Muhammad Ehsan, Lan Guan, Xiangyu Liu, Claus J Loland, Brian K Kobilka, Bernadette Byrne, Pil Seok Chae
1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization. Journal of the American Chemical Society 141 (50) (2019)
Aiman Sadaf, Manuel Ramos, Jonas S Mortensen, Yang Du, Hyoung Eun Bae, Chastine F Munk, Parameswaran Hariharan, Bernadette Byrne, Brian K Kobilka, Claus J Loland, Lan Guan, Pil Seok Chae
Conformationally Restricted Monosaccharide-Cored Glycoside Amphiphiles: The Effect of Detergent Headgroup Variation on Membrane Protein Stability. ACS chemical biology 14 (8) (2019)
H Ronald Kaback, Lan Guan
It takes two to tango: The dance of the permease. The Journal of general physiology 151 (7) (2019)
Muhammad Ehsan, Manabendra Das, Valerie Stern, Yang Du, Jonas Sigurd Mortensen, Parameswaran Hariharan, Bernadette Byrne, Claus J Løland, Brian K Kobilka, Lan Guan, Pil Seok Chae
Steroid-Based Amphiphiles for Membrane Protein Study: The Importance of Alkyl Spacers for Protein Stability. Chembiochem : a European journal of chemical biology 19 (13) (2018)
Manabendra Das, Yang Du, Jonas Sigurd Mortensen, Parameswaran Hariharan, Hyun Sung Lee, Bernadette Byrne, Claus J Løland, Lan Guan, Brian K Kobilka, Pil Seok Chae
Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy. Chembiochem : a European journal of chemical biology 19 (20) (2018)
Parameswaran Hariharan, Elena Tikhonova, João Medeiros-Silva, Aike Jeucken, Mikhail V Bogdanov, William Dowhan, Jos F Brouwers, Markus Weingarth, Lan Guan
Structural and functional characterization of protein-lipid interactions of the Salmonella typhimurium melibiose transporter MelB. BMC biology 16 (1) (2018)
Hyoung Eun Bae, Yang Du, Parameswaran Hariharan, Jonas Sigurd Mortensen, Kaavya K Kumar, Betty Ha, Manabendra Das, Hyun Sung Lee, Claus J Løland, Lan Guan, Brian K Kobilka, Pil Seok Chae
Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability. Chemical science 10 (4) (2018)
Hazrat Hussain, Yang Du, Elena B Tikhonova, Jonas Sigurd Mortensen, Orquidea M de Castro Ribeiro, Claudia Santillan, Manabendra Das, Muhammad Ehsan, Claus J Løland, Lan Guan, Brian K Kobilka, Bernadette Byrne, Pil Seok Chae
Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability. Chemistry (Weinheim an der Bergstrasse, Germany) 23 (28) (2017)
Aiman Sadaf, Yang Du, Claudia Santillan, Jonas Sigurd Mortensen, Iago Molist, Alpay Burak Seven, Parameswaran Hariharan, Georgios Skiniotis, Claus J Løland, Brian K Kobilka, Lan Guan, Bernadette Byrne, Pil Seok Chae
Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study. Chemical science 8 (12) (2017)
Parameswaran Hariharan, Lan Guan
Thermodynamic cooperativity of cosubstrate binding and cation selectivity of Salmonella typhimurium MelB. The Journal of general physiology 149 (11) (2017)
Hazrat Hussain, Jonas Sigurd Mortensen, Yang Du, Claudia Santillan, Orquidea Ribeiro, Juyeon Go, Parameswaran Hariharan, Claus J Loland, Lan Guan, Brian K Kobilka, Bernadette Byrne, Pil Seok Chae
Tandem malonate-based glucosides (TMGs) for membrane protein structural studies. Scientific reports 7 (1) (2017)
Manabendra Das, Yang Du, Jonas Sigurd Mortensen, Orquidea M de Castro Ribeiro, Parameswaran Hariharan, Lan Guan, Claus J Løland, Brian K Kobilka, Bernadette Byrne, Pil Seok Chae
Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region. Chemical science 8 (2) (2016)
Kyung-Ho Cho, Parameswaran Hariharan, Jonas Sigurd Mortensen, Yang Du, Anne Kathrine Nielsen, Bernadette Byrne, Brian K Kobilka, Claus J Løland, Lan Guan, Pil Seok Chae
Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length. Chembiochem : a European journal of chemical biology 17 (24) (2016)
Kyung-Ho Cho, Orquidea M de Castro Ribeiro, Yang Du, Elena B Tikhonova, Jonas Sigurd Mortensen, Kelsey Markham, Parameswaran Hariharan, Claus J Løland, Lan Guan, Brian K Kobilka, Bernadette Byrne, Pil Seok Chae
Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy. Chemistry (Weinheim an der Bergstrasse, Germany) 22 (52) (2016)
Parameswaran Hariharan, Dhandayuthapani Balasubramaniam, Alan Peterkofsky, H Ronald Kaback, Lan Guan
Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc. Proceedings of the National Academy of Sciences of the United States of America 112 (8) (2015)