Georgios Skiniotis

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 51

Top Topics

Molecular Dynamics Simulations

Structural Basis

Binding Protein

Top Venues

Science (New York, N.Y.)

Nature communications

Nature structural & molecular biology

This page only lists publications with an associated author ORCID identifier.

Publications

Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) 384 (6702) (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) 384 (6702) (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) 384 (6702) (2024)
Feng He, Cheng-Guo Wu, Yang Gao, Sabrina N Rahman, Magda Zaoralová, Makaía M Papasergi-Scott, Ting-Jia Gu, Michael J Robertson, Alpay B Seven, Lingjun Li, Jesper Mosolff Mathiesen, Georgios Skiniotis
Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor. Nature 626 (8001) (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) 384 (6702) (2024)
Feng He, Cheng-Guo Wu, Yang Gao, Sabrina N Rahman, Magda Zaoralová, Makaía M Papasergi-Scott, Ting-Jia Gu, Michael J Robertson, Alpay B Seven, Lingjun Li, Jesper Mosolff Mathiesen, Georgios Skiniotis
Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor. Nature 626 (8001) (2024)
Makaía M Papasergi-Scott, Guillermo Pérez Hernández, Hossein Batebi, Yang Gao, Gözde Eskici, Alpay B Seven, Ouliana Panova, Daniel Hilger, Marina Casiraghi, Feng He, Luis Maul, Peter Gmeiner, Brian K Kobilka, Peter W Hildebrand, Georgios Skiniotis
Time-resolved cryo-EM of G-protein activation by a GPCR. Nature 629 (8014) (2024)
Hossein Batebi, Guillermo Pérez Hernández, Sabrina N Rahman, Baoliang Lan, Antje Kamprad, Mingyu Shi, David Speck, Johanna K S Tiemann, Ramon Guixà-Gonzaléz, Franziska Reinhardt, Peter F Stadler, Makaía M Papasergi-Scott, Georgios Skiniotis, Patrick Scheerer, Brian K Kobilka, Jesper M Mathiesen, Xiangyu Liu, Peter W Hildebrand
Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor. Nature structural & molecular biology (2024)
Makaía M Papasergi-Scott, Guillermo Pérez Hernández, Hossein Batebi, Yang Gao, Gözde Eskici, Alpay B Seven, Ouliana Panova, Daniel Hilger, Marina Casiraghi, Feng He, Luis Maul, Peter Gmeiner, Brian K Kobilka, Peter W Hildebrand, Georgios Skiniotis
Time-resolved cryo-EM of G-protein activation by a GPCR. Nature (2024)
Feng He, Cheng-Guo Wu, Yang Gao, Sabrina N Rahman, Magda Zaoralová, Makaía M Papasergi-Scott, Ting-Jia Gu, Michael J Robertson, Alpay B Seven, Lingjun Li, Jesper Mosolff Mathiesen, Georgios Skiniotis
Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor. Nature (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) (2024)
Makaía M Papasergi-Scott, Guillermo Pérez Hernández, Hossein Batebi, Yang Gao, Gözde Eskici, Alpay B Seven, Ouliana Panova, Daniel Hilger, Marina Casiraghi, Feng He, Luis Maul, Peter Gmeiner, Brian K Kobilka, Peter W Hildebrand, Georgios Skiniotis
Time-resolved cryo-EM of G-protein activation by a GPCR. Nature (2024)
Makaía M Papasergi-Scott, Guillermo Pérez Hernández, Hossein Batebi, Yang Gao, Gözde Eskici, Alpay B Seven, Ouliana Panova, Daniel Hilger, Marina Casiraghi, Feng He, Luis Maul, Peter Gmeiner, Brian K Kobilka, Peter W Hildebrand, Georgios Skiniotis
Time-resolved cryo-EM of G-protein activation by a GPCR. Nature (2024)
Feng He, Cheng-Guo Wu, Yang Gao, Sabrina N Rahman, Magda Zaoralová, Makaía M Papasergi-Scott, Ting-Jia Gu, Michael J Robertson, Alpay B Seven, Lingjun Li, Jesper Mosolff Mathiesen, Georgios Skiniotis
Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor. Nature 626 (8001) (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) 384 (6702) (2024)
Feng He, Cheng-Guo Wu, Yang Gao, Sabrina N Rahman, Magda Zaoralová, Makaía M Papasergi-Scott, Ting-Jia Gu, Michael J Robertson, Alpay B Seven, Lingjun Li, Jesper Mosolff Mathiesen, Georgios Skiniotis
Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor. Nature (2024)
Makaía M Papasergi-Scott, Guillermo Pérez Hernández, Hossein Batebi, Yang Gao, Gözde Eskici, Alpay B Seven, Ouliana Panova, Daniel Hilger, Marina Casiraghi, Feng He, Luis Maul, Peter Gmeiner, Brian K Kobilka, Peter W Hildebrand, Georgios Skiniotis
Time-resolved cryo-EM of G-protein activation by a GPCR. Nature 629 (8014) (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) 384 (6702) (2024)
Makaía M Papasergi-Scott, Guillermo Pérez Hernández, Hossein Batebi, Yang Gao, Gözde Eskici, Alpay B Seven, Ouliana Panova, Daniel Hilger, Marina Casiraghi, Feng He, Luis Maul, Peter Gmeiner, Brian K Kobilka, Peter W Hildebrand, Georgios Skiniotis
Time-resolved cryo-EM of G-protein activation by a GPCR. Nature (2024)
Makaía M Papasergi-Scott, Guillermo Pérez Hernández, Hossein Batebi, Yang Gao, Gözde Eskici, Alpay B Seven, Ouliana Panova, Daniel Hilger, Marina Casiraghi, Feng He, Luis Maul, Peter Gmeiner, Brian K Kobilka, Peter W Hildebrand, Georgios Skiniotis
Time-resolved cryo-EM of G-protein activation by a GPCR. Nature 629 (8014) (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) (2024)
Feng He, Cheng-Guo Wu, Yang Gao, Sabrina N Rahman, Magda Zaoralová, Makaía M Papasergi-Scott, Ting-Jia Gu, Michael J Robertson, Alpay B Seven, Lingjun Li, Jesper Mosolff Mathiesen, Georgios Skiniotis
Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor. Nature (2024)
Fangyu Liu, Cheng-Guo Wu, Chia-Ling Tu, Isabella S Glenn, Justin G Meyerowitz, Anat Levit Kaplan, Jiankun Lyu, Zhiqiang Cheng, Olga O Tarkhanova, Yurii S Moroz, John J Irwin, Wenhan Chang, Brian K Shoichet, Georgios Skiniotis
Large library docking identifies positive allosteric modulators of the calcium-sensing receptor. Science (New York, N.Y.) 385 (6715) (2024)
Feng He, Cheng-Guo Wu, Yang Gao, Sabrina N Rahman, Magda Zaoralová, Makaía M Papasergi-Scott, Ting-Jia Gu, Michael J Robertson, Alpay B Seven, Lingjun Li, Jesper Mosolff Mathiesen, Georgios Skiniotis
Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor. Nature (2024)
Feng He, Cheng-Guo Wu, Yang Gao, Sabrina N Rahman, Magda Zaoralová, Makaía M Papasergi-Scott, Ting-Jia Gu, Michael J Robertson, Alpay B Seven, Lingjun Li, Jesper Mosolff Mathiesen, Georgios Skiniotis
Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor. Nature 626 (8001) (2024)
Makaía M Papasergi-Scott, Guillermo Pérez Hernández, Hossein Batebi, Yang Gao, Gözde Eskici, Alpay Burak Seven, Ouliana Panova, Daniel Hilger, Marina Casiraghi, Feng He, Luis Maul, Peter Gmeiner, Brian K Kobilka, Peter W Hildebrand, Georgios Skiniotis
Time-resolved cryo-EM of G protein activation by a GPCR. bioRxiv : the preprint server for biology (2023)
Kaavya Krishna Kumar, Michael J Robertson, Elina Thadhani, Haoqing Wang, Carl-Mikael Suomivuori, Alexander S Powers, Lipin Ji, Spyros P Nikas, Ron O Dror, Asuka Inoue, Alexandros Makriyannis, Georgios Skiniotis, Brian K Kobilka
Structural basis for activation of CB1 by an endocannabinoid analog. Nature communications 14 (1) (2023)
Kaavya Krishna Kumar, Michael J Robertson, Elina Thadhani, Haoqing Wang, Carl-Mikael Suomivuori, Alexander S Powers, Lipin Ji, Spyros P Nikas, Ron O Dror, Asuka Inoue, Alexandros Makriyannis, Georgios Skiniotis, Brian K Kobilka
Structural basis for activation of CB1 by an endocannabinoid analog. Nature communications 14 (1) (2023)
Kaavya Krishna Kumar, Michael J Robertson, Elina Thadhani, Haoqing Wang, Carl-Mikael Suomivuori, Alexander S Powers, Lipin Ji, Spyros P Nikas, Ron O Dror, Asuka Inoue, Alexandros Makriyannis, Georgios Skiniotis, Brian K Kobilka
Structural basis for activation of CB1 by an endocannabinoid analog. Nature communications 14 (1) (2023)
Qianhui Qu, Weijiao Huang, Deniz Aydin, Joseph M Paggi, Alpay B Seven, Haoqing Wang, Soumen Chakraborty, Tao Che, Jeffrey F DiBerto, Michael J Robertson, Asuka Inoue, Carl-Mikael Suomivuori, Bryan L Roth, Susruta Majumdar, Ron O Dror, Brian K Kobilka, Georgios Skiniotis
Insights into distinct signaling profiles of the µOR activated by diverse agonists. Nature chemical biology (2022)
Naotaka Tsutsumi, Shoji Maeda, Qianhui Qu, Martin Vögele, Kevin M Jude, Carl-Mikael Suomivuori, Ouliana Panova, Deepa Waghray, Hideaki E Kato, Andrew Velasco, Ron O Dror, Georgios Skiniotis, Brian K Kobilka, K Christopher Garcia
Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins. Science advances 8 (3) (2022)
Abdelfattah Faouzi, Haoqing Wang, Saheem A Zaidi, Jeffrey F DiBerto, Tao Che, Qianhui Qu, Michael J Robertson, Manish K Madasu, Amal El Daibani, Balazs R Varga, Tiffany Zhang, Claudia Ruiz, Shan Liu, Jin Xu, Kevin Appourchaux, Samuel T Slocum, Shainnel O Eans, Michael D Cameron, Ream Al-Hasani, Ying Xian Pan, Bryan L Roth, Jay P McLaughlin, Georgios Skiniotis, Vsevolod Katritch, Brian K Kobilka, Susruta Majumdar
Structure-based design of bitopic ligands for the µ-opioid receptor. Nature (2022)
Ximena Barros-Álvarez, Robert M Nwokonko, Alexander Vizurraga, Donna Matzov, Feng He, Makaía M Papasergi-Scott, Michael J Robertson, Ouliana Panova, Eliane Hadas Yardeni, Alpay B Seven, Frank E Kwarcinski, Hongyu Su, Maria Claudia Peroto, Justin G Meyerowitz, Moran Shalev-Benami, Gregory G Tall, Georgios Skiniotis
The tethered peptide activation mechanism of adhesion GPCRs. Nature 604 (7907) (2022)
Anat Levit Kaplan, Danielle N Confair, Kuglae Kim, Ximena Barros-Álvarez, Ramona M Rodriguiz, Ying Yang, Oh Sang Kweon, Tao Che, John D McCorvy, David N Kamber, James P Phelan, Luan Carvalho Martins, Vladimir M Pogorelov, Jeffrey F DiBerto, Samuel T Slocum, Xi-Ping Huang, Manish Kumar Jain, Michael J Robertson, Ouliana Panova, Alpay B Seven, Autumn Q Wetsel, William C Wetsel, John J Irwin, Georgios Skiniotis, Brian K Shoichet, Bryan L Roth, Jonathan A Ellman
Bespoke library docking for 5-HT 2A receptor agonists with antidepressant activity. Nature 610 (7932) (2022)
Justin G Meyerowitz, Michael J Robertson, Ximena Barros-Álvarez, Ouliana Panova, Robert M Nwokonko, Yang Gao, Georgios Skiniotis
The oxytocin signaling complex reveals a molecular switch for cation dependence. Nature structural & molecular biology 29 (3) (2022)
Geng Chen, Xiankun Wang, Qi-Wen Liao, Yun-Jun Ge, Haizhan Jiao, Qiang Chen, Yezhou Liu, Wenping Lyu, Lizhe Zhu, Gydo C P van Zundert, Michael J Robertson, Georgios Skiniotis, Yang Du, Hongli Hu, Richard D Ye
Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns. Nature communications 13 (1) (2022)
Michael J Robertson, Justin G Meyerowitz, Ouliana Panova, Kenneth Borrelli, Georgios Skiniotis
Plasticity in ligand recognition at somatostatin receptors. Nature structural & molecular biology 29 (3) (2022)
Michael J Robertson, Makaía M Papasergi-Scott, Feng He, Alpay B Seven, Justin G Meyerowitz, Ouliana Panova, Maria Claudia Peroto, Tao Che, Georgios Skiniotis
Structure determination of inactive-state GPCRs with a universal nanobody. Nature structural & molecular biology (2022)
Luke F Pennington, Pascal Gasser, Silke Kleinboelting, Chensong Zhang, Georgios Skiniotis, Alexander Eggel, Theodore S Jardetzky
Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nature communications 12 (1) (2021)
Alpay B Seven, Ximena Barros-Álvarez, Marine de Lapeyrière, Makaía M Papasergi-Scott, Michael J Robertson, Chensong Zhang, Robert M Nwokonko, Yang Gao, Justin G Meyerowitz, Jean-Philippe Rocher, Dominik Schelshorn, Brian K Kobilka, Jesper Mosolff Mathiesen, Georgios Skiniotis
G-protein activation by a metabotropic glutamate receptor. Nature 595 (7867) (2021)
Lei Han, Qianhui Qu, Deniz Aydin, Ouliana Panova, Michael J Robertson, Yan Xu, Ron O Dror, Georgios Skiniotis, Liang Feng
Structure and mechanism of the SGLT family of glucose transporters. Nature (2021)
Yang Gao, Michael J Robertson, Sabrina N Rahman, Alpay B Seven, Chensong Zhang, Justin G Meyerowitz, Ouliana Panova, Fadil M Hannan, Rajesh V Thakker, Hans Bräuner-Osborne, Jesper Mosolff Mathiesen, Georgios Skiniotis
Asymmetric activation of the calcium-sensing receptor homodimer. Nature 595 (7867) (2021)
Daniel Hilger, Kaavya Krishna Kumar, Hongli Hu, Mie Fabricius Pedersen, Evan S O'Brien, Lise Giehm, Christine Jennings, Gözde Eskici, Asuka Inoue, Michael T Lerch, Jesper Mosolff Mathiesen, Georgios Skiniotis, Brian K Kobilka
Structural insights into differences in G protein activation by family A and family B GPCRs. Science (New York, N.Y.) 369 (6503) (2020)
Makaía M Papasergi-Scott, Michael J Robertson, Alpay B Seven, Ouliana Panova, Jesper Mosolff Mathiesen, Georgios Skiniotis
Structures of metabotropic GABAB receptor. Nature 584 (7820) (2020)
Shoji Maeda, Qianhui Qu, Michael J Robertson, Georgios Skiniotis, Brian K Kobilka
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science (New York, N.Y.) 364 (6440) (2019)
Muhammad Ehsan, Yang Du, Iago Molist, Alpay Burak Seven, Parameswaran Hariharan, Jonas Sigurd Mortensen, Lubna Ghani, Claus J Løland, Georgios Skiniotis, Lan Guan, Bernadette Byrne, Brian K Kobilka, Pil Seok Chae
Vitamin E-based glycoside amphiphiles for membrane protein structural studies. Organic & biomolecular chemistry 16 (14) (2019)
Shoji Maeda, Antoine Koehl, Hugues Matile, Hongli Hu, Daniel Hilger, Gebhard F X Schertler, Aashish Manglik, Georgios Skiniotis, Roger J P Dawson, Brian K Kobilka
Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nature communications 9 (1) (2018)
Kalli Kappel, Shiheng Liu, Kevin P Larsen, Georgios Skiniotis, Elisabetta Viani Puglisi, Joseph D Puglisi, Z Hong Zhou, Rui Zhao, Rachel J Hagey
De novo computational RNA modeling into cryo-EM maps of large ribonucleoprotein complexes. Nature methods 15 (11) (2018)
Moran Shalev-Benami, Yan Zhang, Haim Rozenberg, Yuko Nobe, Masato Taoka, Donna Matzov, Ella Zimmerman, Anat Bashan, Toshiaki Isobe, Charles L Jaffe, Ada Yonath, Georgios Skiniotis
Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin. Nature communications 8 (1) (2017)
Min Su, Emily Z Guo, Xinqiang Ding, Yan Li, Jeffrey T Tarrasch, Charles L Brooks Iii, Zhaohui Xu, Georgios Skiniotis
Mechanism of Vps4 hexamer function revealed by cryo-EM. Science advances 3 (4) (2017)
Aiman Sadaf, Yang Du, Claudia Santillan, Jonas Sigurd Mortensen, Iago Molist, Alpay Burak Seven, Parameswaran Hariharan, Georgios Skiniotis, Claus J Løland, Brian K Kobilka, Lan Guan, Bernadette Byrne, Pil Seok Chae
Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study. Chemical science 8 (12) (2017)