Laura M Machesky (L M Machesky, Laura Machesky)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 52

Top Venues

The Journal of pathology

eLife

Nature communications

Journal of cell science

Beatson Institute for Cancer Research

Johns Hopkins School of Medicine (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Beatson Institute for Cancer Research Nov 01 2007

United Kingdom

Professor and Senior Research Group Leader :: Invasion and Metastasis

University of Birmingham Jan 01 1999 - Nov 01 2007

United Kingdom

MRC Career Development Fellow and Senior Fellow :: School of Biosciences

MRC Laboratory for Molecular Cell Biology Jan 01 1996 - Jan 01 1999

United Kingdom

MRC Career Development Fellow :: Cell Biology

MRC Laboratory for Molecular Cell Biology Sep 01 1995 - Sep 01 1996

United Kingdom

Damon Runyon - Walter Winchell Postdoc Fellow :: Cell Biology

MRC Laboratory of Molecular Biology Aug 01 1993 - Sep 01 1995

United Kingdom

Damon Runyon-Walter Winchell Postdoc Fellow :: Cell Biology

Education History

Johns Hopkins School of Medicine Sep 01 1987 - Aug 01 1993

United States

PHD :: Cell Biology and Anatomy

Alma College Oct 01 1983 - Jul 01 1987

United States

BSC :: Biology and Chemistry

Publications

Dmitri Sisario, Markus Spindler, Katharina J Ermer, Noah Grütz, Leo Nicolai, Florian Gaertner, Laura M Machesky, Markus Bender
Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets. Cells 13 (4) (2024)
Selena G Burgess, Nikki R Paul, Mark W Richards, James R Ault, Laurie Askenatzis, Sophie G Claydon, Ryan Corbyn, Laura M Machesky, Richard Bayliss
A nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation. Open biology 14 (3) (2024)
Dmitri Sisario, Markus Spindler, Katharina J Ermer, Noah Grütz, Leo Nicolai, Florian Gaertner, Laura M Machesky, Markus Bender
Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets. Cells 13 (4) (2024)
Savvas Nikolaou, Amelie Juin, Jamie A Whitelaw, Nikki R Paul, Loic Fort, Colin Nixon, Heather J Spence, Sheila Bryson, Laura M Machesky
CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake. eLife 13 (2024)
Amelie Juin, Heather J Spence, Laura M Machesky
Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways. The Journal of pathology 262 (4) (2024)
Valentin Kapitany, Areeba Fatima, Vytautas Zickus, Jamie A Whitelaw, Ewan J McGhee, Robert H Insall, Laura M Machesky, Daniele Faccio
Single-sample image-fusion upsampling of fluorescence lifetime images. Science advances 10 (21) (2024)
Selena G Burgess, Nikki R Paul, Mark W Richards, James R Ault, Laurie Askenatzis, Sophie G Claydon, Ryan Corbyn, Laura M Machesky, Richard Bayliss
A nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation. Open biology 14 (3) (2024)
Roly Megaw, Abigail Moye, Zhixian Zhang, Fay Newton, Fraser McPhie, Laura C Murphy, Lisa McKie, Feng He, Melissa K Jungnickel, Alexander von Kriegsheim, Peter A Tennant, Chloe Brotherton, Christine Gurniak, Alecia K Gross, Laura M Machesky, Theodore G Wensel, Pleasantine Mill
Ciliary tip actin dynamics regulate photoreceptor outer segment integrity. Nature communications 15 (1) (2024)
Roly Megaw, Abigail Moye, Zhixian Zhang, Fay Newton, Fraser McPhie, Laura C Murphy, Lisa McKie, Feng He, Melissa K Jungnickel, Alexander von Kriegsheim, Peter A Tennant, Chloe Brotherton, Christine Gurniak, Alecia K Gross, Laura M Machesky, Theodore G Wensel, Pleasantine Mill
Ciliary tip actin dynamics regulate photoreceptor outer segment integrity. Nature communications 15 (1) (2024)
Amelie Juin, Heather J Spence, Laura M Machesky
Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways. The Journal of pathology 262 (4) (2024)
Selena G Burgess, Nikki R Paul, Mark W Richards, James R Ault, Laurie Askenatzis, Sophie G Claydon, Ryan Corbyn, Laura M Machesky, Richard Bayliss
A nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation. Open biology 14 (3) (2024)
Dmitri Sisario, Markus Spindler, Katharina J Ermer, Noah Grütz, Leo Nicolai, Florian Gaertner, Laura M Machesky, Markus Bender
Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets. Cells 13 (4) (2024)
Dmitri Sisario, Markus Spindler, Katharina J Ermer, Noah Grütz, Leo Nicolai, Florian Gaertner, Laura M Machesky, Markus Bender
Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets. Cells 13 (4) (2024)
Savvas Nikolaou, Amelie Juin, Jamie A Whitelaw, Nikki R Paul, Loic Fort, Colin Nixon, Heather J Spence, Sheila Bryson, Laura M Machesky
CYRI-B mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake. eLife 13 (2024)
Amelie Juin, Heather J Spence, Laura M Machesky
Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways. The Journal of pathology (2024)
Amelie Juin, Heather J Spence, Laura M Machesky
Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways. The Journal of pathology 262 (4) (2024)
Valentin Kapitany, Areeba Fatima, Vytautas Zickus, Jamie A Whitelaw, Ewan J McGhee, Robert H Insall, Laura M Machesky, Daniele Faccio
Single-sample image-fusion upsampling of fluorescence lifetime images. Science advances 10 (21) (2024)
Dmitri Sisario, Markus Spindler, Katharina J Ermer, Noah Grütz, Leo Nicolai, Florian Gaertner, Laura M Machesky, Markus Bender
Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets. Cells 13 (4) (2024)
Roly Megaw, Abigail Moye, Zhixian Zhang, Fay Newton, Fraser McPhie, Laura C Murphy, Lisa McKie, Feng He, Melissa K Jungnickel, Alexander von Kriegsheim, Peter A Tennant, Chloe Brotherton, Christine Gurniak, Alecia K Gross, Laura M Machesky, Theodore G Wensel, Pleasantine Mill
Ciliary tip actin dynamics regulate photoreceptor outer segment integrity. Nature communications 15 (1) (2024)
Savvas Nikolaou, Amelie Juin, Jamie A Whitelaw, Nikki R Paul, Loic Fort, Colin Nixon, Heather J Spence, Sheila Bryson, Laura M Machesky
CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake. eLife 13 (2024)
Savvas Nikolaou, Amelie Juin, Jamie A Whitelaw, Nikki R Paul, Loic Fort, Colin Nixon, Heather J Spence, Sheila Bryson, Laura M Machesky
CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake. eLife 13 (2024)
Roly Megaw, Abigail Moye, Zhixian Zhang, Fay Newton, Fraser McPhie, Laura C Murphy, Lisa McKie, Feng He, Melissa K Jungnickel, Alexander von Kriegsheim, Peter A Tennant, Chloe Brotherton, Christine Gurniak, Alecia K Gross, Laura M Machesky, Theodore G Wensel, Pleasantine Mill
Ciliary tip actin dynamics regulate photoreceptor outer segment integrity. Nature communications 15 (1) (2024)
Savvas Nikolaou, Amelie Juin, Jamie A Whitelaw, Nikki R Paul, Loic Fort, Colin Nixon, Heather J Spence, Sheila Bryson, Laura M Machesky
CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake. eLife 13 (2024)
Amelie Juin, Heather J Spence, Laura M Machesky
Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways. The Journal of pathology 262 (4) (2024)
Selena G Burgess, Nikki R Paul, Mark W Richards, James R Ault, Laurie Askenatzis, Sophie G Claydon, Ryan Corbyn, Laura M Machesky, Richard Bayliss
A nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation. Open biology 14 (3) (2024)
Laura M Machesky
Deadly actin collapse by disulfidptosis. Nature cell biology 25 (3) (2023)
Laura M Machesky
A new Editor-in-Chief and new future for Biology Open. Biology open 12 (6) (2023)
Laura M Machesky
A new Editor-in-Chief and new future for Biology Open. Biology open 12 (6) (2023)
Laura M Machesky
CYRI proteins: controllers of actin dynamics in the cellular 'eat vs walk' decision. Biochemical Society transactions (2023)
Laura M Machesky
A new Editor-in-Chief and new future for Biology Open. Biology open 12 (6) (2023)
Vasileios Papalazarou, James Drew, Amelie Juin, Heather J Spence, Jamie A Whitelaw, Colin Nixon, Manuel Salmeron-Sanchez, Laura M Machesky
Collagen VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche. Journal of cell science 135 (24) (2022)
Vasileios Papalazarou, James Drew, Amelie Juin, Heather J Spence, Jamie A Whitelaw, Colin Nixon, Manuel Salmeron-Sanchez, Laura M Machesky
Collagen VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche. Journal of cell science 135 (24) (2022)
Vasileios Papalazarou, James Drew, Amelie Juin, Heather J Spence, Jamie A Whitelaw, Colin Nixon, Manuel Salmeron-Sanchez, Laura M Machesky
Collagen VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche. Journal of cell science 135 (24) (2022)
Vasileios Papalazarou, James Drew, Amelie Juin, Heather J Spence, Jamie A Whitelaw, Colin Nixon, Manuel Salmeron-Sanchez, Laura M Machesky
Collagen VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche. Journal of cell science 135 (24) (2022)
Vasileios Papalazarou, James Drew, Amelie Juin, Heather J Spence, Jamie A Whitelaw, Colin Nixon, Manuel Salmeron-Sanchez, Laura M Machesky
Collagen VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche. Journal of cell science 135 (24) (2022)
James Drew, Laura M Machesky
The liver metastatic niche: modelling the extracellular matrix in metastasis. Disease models & mechanisms 14 (4) (2021)
Anh Hoang Le, Tamas Yelland, Nikki R Paul, Loic Fort, Savvas Nikolaou, Shehab Ismail, Laura M Machesky
CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation. The Journal of cell biology 220 (9) (2021)
Laura M Machesky, Robert H Insall
WAVE complex regulation by force. Nature cell biology 23 (11) (2021)
Michael F Olson, Laura M Machesky
MICAL2 fine-tunes Arp2/3 for actin branching. The Journal of cell biology 220 (8) (2021)
K A Pickering, K Gilroy, J W Cassidy, S K Fey, Arafath K Najumudeen, Lucas B Zeiger, D F Vincent, David M Gay, J Johansson, R P Fordham, B Miller, W Clark, A Hedley, E B Unal, C Kiel, E McGhee, Laura M Machesky, Colin Nixon, Anna-Karin Johnsson, M Bain, Douglas Strathdee, S R van Hoof, J P Medema, Kurt I Anderson, S M Brachmann, V M Stucke, Angeliki Malliri, M Drysdale, Martin Turner, Luis Serrano, Kevin B Myant, Andrew D Campbell, Owen James Sansom
A RAC-GEF network critical for early intestinal tumourigenesis. Nature communications 12 (1) (2021)
Savvas Nikolaou, Laura M Machesky
The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis. The Journal of pathology 250 (5) (2020)
Vasileios Papalazarou, Tong Zhang, Nikki R Paul, Amelie Juin, Marco Cantini, Oliver D K Maddocks, Manuel Salmeron-Sanchez, Laura M Machesky
The creatine-phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis. Nature metabolism 2 (1) (2020)
Vasileios Papalazarou, Karthic Swaminathan, Farah Jaber-Hijazi, Heather Spence, Ines Lahmann, Colin Nixon, Manuel Salmeron-Sanchez, Hans-Henning Arnold, Klemens Rottner, Laura M Machesky
The Arp2/3 complex is crucial for colonisation of the mouse skin by melanoblasts. Development (Cambridge, England) 147 (22) (2020)
Luke Tweedy, Peter A Thomason, Peggy I Paschke, Kirsty Martin, Laura M Machesky, Michele Zagnoni, Robert H Insall
Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown. Science (New York, N.Y.) 369 (6507) (2020)
Shashi Prakash Singh, Peter A Thomason, Sergio Lilla, Matthias Schaks, Qing Tang, Bruce L Goode, Laura M Machesky, Klemens Rottner, Robert H Insall
Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime. PLoS biology 18 (8) (2020)
Fernanda G Kugeratski, Samuel J Atkinson, Lisa J Neilson, Sergio Lilla, John R P Knight, Jens Serneels, Amelie Juin, Shehab Ismail, David M Bryant, Elke K Markert, Laura M Machesky, Massimilliano Mazzone, Owen James Sansom, Sara R Zanivan
Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science signaling 12 (567) (2019)
Jamie A Whitelaw, Sergio Lilla, Nikki R Paul, Loic Fort, Sara R Zanivan, Laura M Machesky
CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors. Communicative & integrative biology 12 (1) (2019)
Pascal Laurent-Gengoux, Valérie Petit, Zackie Aktary, Stuart J Gallagher, Luke Tweedy, Laura M Machesky, Lionel Larue
Simulation of melanoblast displacements reveals new features of developmental migration. Development (Cambridge, England) 145 (12) (2018)
Hayley T Morris, Loic Fort, Heather J Spence, Rachana Patel, David F Vincent, James Hugh Park, Scott B Snapper, Francis A Carey, Owen James Sansom, Laura M Machesky
Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis. The Journal of pathology 245 (3) (2018)
Vassilis Papalazarou, Manuel Salmeron-Sanchez, Laura M Machesky
Tissue engineering the cancer microenvironment-challenges and opportunities. Biophysical reviews 10 (6) (2018)
Loic Fort, José Miguel Batista, Peter A Thomason, Heather J Spence, Jamie A Whitelaw, Luke Tweedy, Jennifer Greaves, Kirsty J Martin, Kurt I Anderson, Peter Brown, Sergio Lilla, Matthew P Neilson, Petra Tafelmeyer, Sara R Zanivan, Shehab Ismail, David M Bryant Editor, Nicholas C O Tomkinson, Luke H Chamberlain, Grant S Mastick, Robert H Insall, Laura M Machesky
Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature cell biology 20 (10) (2018)
Steven G Thomas, Natalie S Poulter, Danai Bem, Brenda Finney, Laura M Machesky, Stephen P Watson
The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation. Platelets 28 (4) (2016)

Laura M Machesky.css-eqlu8i{font-size:small;padding-left:4px;} (L M Machesky, Laura Machesky)

Publication Activity (10 Years)

Top Topics

Top Venues

Laura M Machesky (L M Machesky, Laura Machesky)