Nicholas C O Tomkinson

Scopus Author ID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 31

Top Topics

Top Venues

The Journal of organic chemistry

ACS chemical biology

Journal of medicinal chemistry

RSC chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Thomas Grunshaw, Susanna H Wood, Stephen Sproules, Andrew J Parrott, Alison Nordon, Peter D P Shapland, Katherine M P Wheelhouse, Nicholas C O Tomkinson
A Mechanistic Investigation of the N -Hydroxyphthalimide Catalyzed Benzylic Oxidation Mediated by Sodium Chlorite. The Journal of organic chemistry 89 (11) (2024)
Francesco Rianjongdee, David S Palmer, Stephen D Pickett, Peter Pogány, Nicholas C O Tomkinson, Darren V S Green
bbSelect - An Open-Source Tool for Performing a 3D Pharmacophore-Driven Diverse Selection of R-Groups. Journal of chemical information and modeling (2024)
Francesco Rianjongdee, David S Palmer, Stephen D Pickett, Peter Pogány, Nicholas C O Tomkinson, Darren V S Green
bbSelect - An Open-Source Tool for Performing a 3D Pharmacophore-Driven Diverse Selection of R-Groups. Journal of chemical information and modeling 64 (12) (2024)
Thomas Grunshaw, Susanna H Wood, Stephen Sproules, Andrew J Parrott, Alison Nordon, Peter D P Shapland, Katherine M P Wheelhouse, Nicholas C O Tomkinson
A Mechanistic Investigation of the N -Hydroxyphthalimide Catalyzed Benzylic Oxidation Mediated by Sodium Chlorite. The Journal of organic chemistry (2024)
Thomas Grunshaw, Susanna H Wood, Stephen Sproules, Andrew J Parrott, Alison Nordon, Peter D P Shapland, Katherine M P Wheelhouse, Nicholas C O Tomkinson
A Mechanistic Investigation of the N -Hydroxyphthalimide Catalyzed Benzylic Oxidation Mediated by Sodium Chlorite. The Journal of organic chemistry 89 (11) (2024)
Thomas Grunshaw, Susanna H Wood, Stephen Sproules, Andrew J Parrott, Alison Nordon, Peter D P Shapland, Katherine M P Wheelhouse, Nicholas C O Tomkinson
A Mechanistic Investigation of the N -Hydroxyphthalimide Catalyzed Benzylic Oxidation Mediated by Sodium Chlorite. The Journal of organic chemistry 89 (11) (2024)
Arron Aatkar, Aini Vuorinen, Oliver E Longfield, Katharine Gilbert, Rachel Peltier-Heap, Craig D Wagner, Francesca Zappacosta, Katrin Rittinger, Chun-Wa Chung, David House, Nicholas C O Tomkinson, Jacob T Bush
Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments. ACS chemical biology (2023)
Arron Aatkar, Aini Vuorinen, Oliver E Longfield, Katharine Gilbert, Rachel Peltier-Heap, Craig D Wagner, Francesca Zappacosta, Katrin Rittinger, Chun-Wa Chung, David House, Nicholas C O Tomkinson, Jacob T Bush
Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments. ACS chemical biology (2023)
Henry J Braddick, William J Tipping, Liam T Wilson, Harry S Jaconelli, Emma K Grant, Karen Faulds, Duncan Graham, Nicholas C O Tomkinson
Determination of Intracellular Esterase Activity Using Ratiometric Raman Sensing and Spectral Phasor Analysis. Analytical chemistry (2023)
Ross P Thomas, Emma K Grant, Eleanor R Dickinson, Francesca Zappacosta, Lee J Edwards, Michael M Hann, David House, Nicholas C O Tomkinson, Jacob T Bush
Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry. RSC medicinal chemistry 14 (4) (2023)
Arron Aatkar, Aini Vuorinen, Oliver E Longfield, Katharine Gilbert, Rachel Peltier-Heap, Craig D Wagner, Francesca Zappacosta, Katrin Rittinger, Chun-Wa Chung, David House, Nicholas C O Tomkinson, Jacob T Bush
Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments. ACS chemical biology (2023)
Brett Cosgrove, Emma K Grant, Sophie Bertrand, Kenneth D Down, Don O Somers, John P Evans, Nicholas C O Tomkinson, Michael D Barker
Covalent targeting of non-cysteine residues in PI4KIIIβ. RSC chemical biology 4 (12) (2023)
Arron Aatkar, Aini Vuorinen, Oliver E Longfield, Katharine Gilbert, Rachel Peltier-Heap, Craig D Wagner, Francesca Zappacosta, Katrin Rittinger, Chun-Wa Chung, David House, Nicholas C O Tomkinson, Jacob T Bush
Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments. ACS chemical biology (2023)
Ross P Thomas, Emma K Grant, Eleanor R Dickinson, Francesca Zappacosta, Lee J Edwards, Michael M Hann, David House, Nicholas C O Tomkinson, Jacob T Bush
Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry. RSC medicinal chemistry 14 (4) (2023)
Philip G Humphreys, Stephen J Atkinson, Paul Bamborough, Rino A Bit, Chun-Wa Chung, Peter D Craggs, Leanne Cutler, Rob Davis, Alan Ferrie, GangLi Gong, Laurie J Gordon, Matthew Gray, Lee A Harrison, Thomas G Hayhow, Andrea Haynes, Nick Henley, David J Hirst, Ian D Holyer, Matthew J Lindon, Cerys Lovatt, David Lugo, Scott McCleary, Judit Molnar, Qendresa Osmani, Chris Patten, Alex G S Preston, Inmaculada Rioja, Jonathan T Seal, Nicholas Smithers, Fenglai Sun, Dalin Tang, Simon Taylor, Natalie H Theodoulou, Clare Thomas, Robert J Watson, Christopher R Wellaway, Linrong Zhu, Nicholas C O Tomkinson, Rab K Prinjha
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate. Journal of medicinal chemistry 65 (3) (2022)
William J Tipping, Andrew S Merchant, Rebecca Fearon, Nicholas C O Tomkinson, Karen Faulds, Duncan Graham
Temporal imaging of drug dynamics in live cells using stimulated Raman scattering microscopy and a perfusion cell culture system. RSC chemical biology 3 (9) (2022)
William J Tipping, Liam T Wilson, Connie An, Aristea Anna Leventi, Alastair W Wark, Corinna Wetherill, Nicholas C O Tomkinson, Karen Faulds, Duncan Graham
Stimulated Raman scattering microscopy with spectral phasor analysis: applications in assessing drug-cell interactions. Chemical science 13 (12) (2022)
Liam T Wilson, William J Tipping, Corinna Wetherill, Zoe Henley, Karen Faulds, Duncan Graham, Simon P Mackay, Nicholas C O Tomkinson
Mitokyne: A Ratiometric Raman Probe for Mitochondrial pH. Analytical chemistry 93 (37) (2021)
Ross P Thomas, Rachel E Heap, Francesca Zappacosta, Emma K Grant, Peter Pogány, Stephen Besley, David J Fallon, Michael M Hann, David House, Nicholas C O Tomkinson, Jacob T Bush
A direct-to-biology high-throughput chemistry approach to reactive fragment screening. Chemical science 12 (36) (2021)
Michael A Clegg, Natalie H Theodoulou, Paul Bamborough, Chun-Wa Chung, Peter D Craggs, Emmanuel H Demont, Laurie J Gordon, Gemma M Liwicki, Alex Phillipou, Nicholas C O Tomkinson, Rab K Prinjha, Philip G Humphreys
Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors. ACS medicinal chemistry letters 12 (8) (2021)
Julie C L Fournier, John P Evans, Francesca Zappacosta, Daniel A Thomas, Vipulkumar K Patel, Gemma V White, Sebastien Campos, Nicholas C O Tomkinson
Acetylation of the Catalytic Lysine Inhibits Kinase Activity in PI3Kδ. ACS chemical biology 16 (9) (2021)
Simon C C Lucas, Stephen J Atkinson, Paul Bamborough, Heather Barnett, Chun-Wa Chung, Laurie Gordon, Darren J Mitchell, Alexander Phillipou, Rab K Prinjha, Robert J Sheppard, Nicholas C O Tomkinson, Robert J Watson, Emmanuel H Demont
Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode. Journal of medicinal chemistry 63 (10) (2020)
Michael A Clegg, Paul Bamborough, Chun-Wa Chung, Peter D Craggs, Laurie Gordon, Paola Grandi, Melanie Leveridge, Matthew Lindon, Gemma M Liwicki, Anne-Marie Michon, Judit Molnar, Inmaculada Rioja, Peter E Soden, Natalie H Theodoulou, Thilo Werner, Nicholas C O Tomkinson, Rab K Prinjha, Philip G Humphreys
Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains. Journal of medicinal chemistry 63 (11) (2020)
Jonathan M Curle, Marina C Perieteanu, Philip G Humphreys, Alan R Kennedy, Nicholas C O Tomkinson
Alkene Syn- and Anti-Oxyamination with Malonoyl Peroxides. Organic letters 22 (4) (2020)
Carolina Locatelli, Kimon Lemonidis, Christine Salaun, Nicholas C O Tomkinson, Luke H Chamberlain
Identification of key features required for efficient S-acylation and plasma membrane targeting of sprouty-2. Journal of cell science 133 (21) (2020)
Peter R Clark, Glynn D Williams, Jerome F Hayes, Nicholas C O Tomkinson
A Scalable Metal-, Azide-, and Halogen-Free Method for the Preparation of Triazoles. Angewandte Chemie (International ed. in English) 59 (17) (2020)
Michael A Clegg, Nicholas C O Tomkinson, Rab K Prinjha, Philip G Humphreys
Advancements in the Development of non-BET Bromodomain Chemical Probes. ChemMedChem 14 (4) (2019)
Carla Alamillo-Ferrer, Jonathan M Curle, Stuart C Davidson, Simon C C Lucas, Stephen J Atkinson, Matthew Campbell, Alan R Kennedy, Nicholas C O Tomkinson
Alkene Oxyamination Using Malonoyl Peroxides: Preparation of Pyrrolidines and Isoxazolidines. The Journal of organic chemistry 83 (12) (2018)
Loic Fort, José Miguel Batista, Peter A Thomason, Heather J Spence, Jamie A Whitelaw, Luke Tweedy, Jennifer Greaves, Kirsty J Martin, Kurt I Anderson, Peter Brown, Sergio Lilla, Matthew P Neilson, Petra Tafelmeyer, Sara R Zanivan, Shehab Ismail, David M Bryant Editor, Nicholas C O Tomkinson, Luke H Chamberlain, Grant S Mastick, Robert H Insall, Laura M Machesky
Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature cell biology 20 (10) (2018)
Przemyslaw Frei, D Heulyn Jones, Steven T Kay, Jayde A McLellan, Blair F Johnston, Alan R Kennedy, Nicholas C O Tomkinson
Regioselective Reaction of Heterocyclic N-Oxides, an Acyl Chloride, and Cyclic Thioethers. The Journal of organic chemistry 83 (3) (2018)
D Heulyn Jones, Steven T Kay, Jayde A McLellan, Alan R Kennedy, Nicholas C O Tomkinson
Regioselective Three-Component Reaction of Pyridine N-Oxides, Acyl Chlorides, and Cyclic Ethers. Organic letters 19 (13) (2017)