Liang Ouyang

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 49

Top Topics

Vascular Endothelial Growth Factor

Top Venues

Journal of medicinal chemistry

Signal transduction and targeted therapy

Medicinal research reviews

This page only lists publications with an associated author ORCID identifier.

Publications

Aoxue Wang, Wen Shuai, Chengyong Wu, Junping Pei, Panpan Yang, Xin Wang, Shutong Li, Jiaxi Liu, Yu-Xi Wang, Guan Wang, Liang Ouyang
Design, Synthesis, and Biological Evaluation of Dual Inhibitors of EGFR L858R/T790M /ACK1 to Overcome Osimertinib Resistance in Nonsmall Cell Lung Cancers. Journal of medicinal chemistry (2024)
Wen Shuai, Huan Xiao, Panpan Yang, Yiwen Zhang, Faqian Bu, Yongya Wu, Qiu Sun, Guan Wang, Liang Ouyang
Structure-Guided Discovery and Preclinical Assessment of Novel (Thiophen-3-yl)aminopyrimidine Derivatives as Potent ERK1/2 Inhibitors. Journal of medicinal chemistry 67 (8) (2024)
Fu Peng, Minru Liao, Wenke Jin, Wei Liu, Zixiang Li, Zhichao Fan, Ling Zou, Siwei Chen, Lingjuan Zhu, Qian Zhao, Gu Zhan, Liang Ouyang, Cheng Peng, Bo Han, Jin Zhang, Leilei Fu
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis. Signal transduction and targeted therapy 9 (1) (2024)
Bin Yu, Liang Ouyang
Journal of Medicinal Chemistry Collection: Drug Discovery in China. Journal of medicinal chemistry (2024)
Fu Peng, Minru Liao, Wenke Jin, Wei Liu, Zixiang Li, Zhichao Fan, Ling Zou, Siwei Chen, Lingjuan Zhu, Qian Zhao, Gu Zhan, Liang Ouyang, Cheng Peng, Bo Han, Jin Zhang, Leilei Fu
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis. Signal transduction and targeted therapy 9 (1) (2024)
Fu Peng, Minru Liao, Wenke Jin, Wei Liu, Zixiang Li, Zhichao Fan, Ling Zou, Siwei Chen, Lingjuan Zhu, Qian Zhao, Gu Zhan, Liang Ouyang, Cheng Peng, Bo Han, Jin Zhang, Leilei Fu
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis. Signal transduction and targeted therapy 9 (1) (2024)
Aoxue Wang, Wen Shuai, Chengyong Wu, Junping Pei, Panpan Yang, Xin Wang, Shutong Li, Jiaxi Liu, Yu-Xi Wang, Guan Wang, Liang Ouyang
Design, Synthesis, and Biological Evaluation of Dual Inhibitors of EGFR L858R/T790M /ACK1 to Overcome Osimertinib Resistance in Nonsmall Cell Lung Cancers. Journal of medicinal chemistry 67 (4) (2024)
Aoxue Wang, Wen Shuai, Chengyong Wu, Junping Pei, Panpan Yang, Xin Wang, Shutong Li, Jiaxi Liu, Yu-Xi Wang, Guan Wang, Liang Ouyang
Design, Synthesis, and Biological Evaluation of Dual Inhibitors of EGFR L858R/T790M /ACK1 to Overcome Osimertinib Resistance in Nonsmall Cell Lung Cancers. Journal of medicinal chemistry 67 (4) (2024)
Wen Shuai, Huan Xiao, Panpan Yang, Yiwen Zhang, Faqian Bu, Yongya Wu, Qiu Sun, Guan Wang, Liang Ouyang
Structure-Guided Discovery and Preclinical Assessment of Novel (Thiophen-3-yl)aminopyrimidine Derivatives as Potent ERK1/2 Inhibitors. Journal of medicinal chemistry (2024)
Lun Tan, Chengyong Wu, Jifa Zhang, Quanwei Yu, Xiye Wang, Lele Zhang, Meiyi Ge, Zhijia Wang, Liang Ouyang, Yu-Xi Wang
Design, Synthesis, and Biological Evaluation of Heterocyclic-Fused Pyrimidine Chemotypes Guided by X-ray Crystal Structure with Potential Antitumor and Anti-multidrug Resistance Efficacy Targeting the Colchicine Binding Site. Journal of medicinal chemistry (2023)
Lun Tan, Chengyong Wu, Jifa Zhang, Quanwei Yu, Xiye Wang, Lele Zhang, Meiyi Ge, Zhijia Wang, Liang Ouyang, Yu-Xi Wang
Design, Synthesis, and Biological Evaluation of Heterocyclic-Fused Pyrimidine Chemotypes Guided by X-ray Crystal Structure with Potential Antitumor and Anti-multidrug Resistance Efficacy Targeting the Colchicine Binding Site. Journal of medicinal chemistry 66 (5) (2023)
Wen Shuai, Faqian Bu, Yumeng Zhu, Yongya Wu, Huan Xiao, Xiaoli Pan, Jifa Zhang, Qiu Sun, Guan Wang, Liang Ouyang
Discovery of Novel Indazole Chemotypes as Isoform-Selective JNK3 Inhibitors for the Treatment of Parkinson's Disease. Journal of medicinal chemistry (2023)
Wen Shuai, Faqian Bu, Yumeng Zhu, Yongya Wu, Huan Xiao, Xiaoli Pan, Jifa Zhang, Qiu Sun, Guan Wang, Liang Ouyang
Discovery of Novel Indazole Chemotypes as Isoform-Selective JNK3 Inhibitors for the Treatment of Parkinson's Disease. Journal of medicinal chemistry 66 (2) (2023)
Yang Li, Yun Liu, Dan Zhang, Juncheng Chen, Gaoxia Yang, Pan Tang, Chengcan Yang, Jie Liu, Jifa Zhang, Liang Ouyang
Discovery, Synthesis, and Evaluation of Novel Dual Inhibitors of a Vascular Endothelial Growth Factor Receptor and Poly(ADP-Ribose) Polymerase for BRCA Wild-Type Breast Cancer Therapy. Journal of medicinal chemistry (2023)
Junping Pei, Guan Wang, Aoxue Wang, Chengyong Wu, Xiaoli Pan, Wen Shuai, Faqian Bu, Yumeng Zhu, Yu-Xi Wang, Liang Ouyang, Weimin Li
Design, Synthesis, and Antitumor Activity of Potent and Selective EGFR L858R/T790M Inhibitors and Identification of a Combination Therapy to Overcome Acquired Resistance in Models of Non-small-cell Lung Cancer. Journal of medicinal chemistry (2023)
Wen Shuai, Faqian Bu, Yumeng Zhu, Yongya Wu, Huan Xiao, Xiaoli Pan, Jifa Zhang, Qiu Sun, Guan Wang, Liang Ouyang
Discovery of Novel Indazole Chemotypes as Isoform-Selective JNK3 Inhibitors for the Treatment of Parkinson's Disease. Journal of medicinal chemistry 66 (2) (2023)
Lun Tan, Chengyong Wu, Jifa Zhang, Quanwei Yu, Xiye Wang, Lele Zhang, Meiyi Ge, Zhijia Wang, Liang Ouyang, Yu-Xi Wang
Design, Synthesis, and Biological Evaluation of Heterocyclic-Fused Pyrimidine Chemotypes Guided by X-ray Crystal Structure with Potential Antitumor and Anti-multidrug Resistance Efficacy Targeting the Colchicine Binding Site. Journal of medicinal chemistry 66 (5) (2023)
Dan Zhang, Jifa Zhang, Yuxi Wang, Guan Wang, Pan Tang, Yun Liu, Yiwen Zhang, Liang Ouyang
Targeting epigenetic modifications in Parkinson's disease therapy. Medicinal research reviews (2023)
Wen Shuai, Faqian Bu, Yumeng Zhu, Yongya Wu, Huan Xiao, Xiaoli Pan, Jifa Zhang, Qiu Sun, Guan Wang, Liang Ouyang
Discovery of Novel Indazole Chemotypes as Isoform-Selective JNK3 Inhibitors for the Treatment of Parkinson's Disease. Journal of medicinal chemistry 66 (2) (2023)
Jiayu Wang, Jifa Zhang, Jiaxing Wang, Xinyue Hu, Liang Ouyang, Yu-Xi Wang
Small-Molecule Modulators Targeting Toll-like Receptors for Potential Anticancer Therapeutics. Journal of medicinal chemistry (2023)
Lun Tan, Chengyong Wu, Jifa Zhang, Quanwei Yu, Xiye Wang, Lele Zhang, Meiyi Ge, Zhijia Wang, Liang Ouyang, Yu-Xi Wang
Design, Synthesis, and Biological Evaluation of Heterocyclic-Fused Pyrimidine Chemotypes Guided by X-ray Crystal Structure with Potential Antitumor and Anti-multidrug Resistance Efficacy Targeting the Colchicine Binding Site. Journal of medicinal chemistry 66 (5) (2023)
Wentao Tang, Congcong Lin, Quanwei Yu, Dan Zhang, Yun Liu, Lele Zhang, Zhilan Zhou, Jifa Zhang, Liang Ouyang
Novel Medicinal Chemistry Strategies Targeting CDK5 for Drug Discovery. Journal of medicinal chemistry (2023)
Jianhong Yang, Yong Li, Qiang Qiu, Ruihan Wang, Wei Yan, Yamei Yu, Lu Niu, Heying Pei, Haoche Wei, Liang Ouyang, Hao-Yu Ye, Dingguo Xu, Yuquan Wei, Qiang Chen, Li-Juan Chen
Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. Journal of medicinal chemistry 65 (13) (2022)
Lun Tan, Jifa Zhang, Yu-Xi Wang, Xiye Wang, Yanyan Wang, Zhixiong Zhang, Wen Shuai, Guan Wang, Juncheng Chen, Chengdi Wang, Liang Ouyang, Wei-Min Li
Development of Dual Inhibitors Targeting Epidermal Growth Factor Receptor in Cancer Therapy. Journal of medicinal chemistry 65 (7) (2022)
Juncheng Chen, Pan Tang, Yu-Xi Wang, Jiaxing Wang, Chengcan Yang, Yang Li, Gaoxia Yang, Fengbo Wu, Jifa Zhang, Liang Ouyang
Targeting Bromodomain-Selective Inhibitors of BET Proteins in Drug Discovery and Development. Journal of medicinal chemistry 65 (7) (2022)
Jifa Zhang, Chengcan Yang, Pan Tang, Juncheng Chen, Dan Zhang, Yang Li, Gaoxia Yang, Yun Liu, Yiwen Zhang, Yu-Xi Wang, Jie Liu, Liang Ouyang
Discovery of 4-Hydroxyquinazoline Derivatives as Small Molecular BET/PARP1 Inhibitors That Induce Defective Homologous Recombination and Lead to Synthetic Lethality for Triple-Negative Breast Cancer Therapy. Journal of medicinal chemistry 65 (9) (2022)
Jifa Zhang, Lele Zhang, Jiaxing Wang, Liang Ouyang, Yu-Xi Wang
Polo-like Kinase 1 Inhibitors in Human Cancer Therapy: Development and Therapeutic Potential. Journal of medicinal chemistry 65 (15) (2022)
Yumeng Zhu, Wen Shuai, Min Zhao, Xiaoli Pan, Junping Pei, Yongya Wu, Faqian Bu, Aoxue Wang, Liang Ouyang, Guan Wang
Unraveling the Design and Discovery of c-Jun N-Terminal Kinase Inhibitors and Their Therapeutic Potential in Human Diseases. Journal of medicinal chemistry 65 (5) (2022)
Weirong Lai, Shengyan Zhao, Qinhuai Lai, Wei Zhou, Mengdan Wu, Xiaohua Jiang, Xin Wang, Yujia Peng, Xian Wei, Liang Ouyang, Lantu Gou, Hao Chen, Yu-Xi Wang, Jinliang Yang
Design, Synthesis, and Bioevaluation of a Novel Hybrid Molecular Pyrrolobenzodiazepine-Anthracenecarboxyimide as a Payload for Antibody-Drug Conjugate. Journal of medicinal chemistry 65 (17) (2022)
Wen Liu, Meijing Wang, Lihong Shen, Yuyu Zhu, Hongyue Ma, Bo Liu, Liang Ouyang, Wenjie Guo, Qiang Xu, Yang Sun
SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice. Signal transduction and targeted therapy 6 (1) (2021)
Yang Li, Gaoxia Yang, Chengcan Yang, Pan Tang, Juncheng Chen, Jifa Zhang, Jie Liu, Liang Ouyang
Targeting Autophagy-Related Epigenetic Regulators for Cancer Drug Discovery. Journal of medicinal chemistry 64 (16) (2021)
Junping Pei, Xiaoli Pan, Aoxue Wang, Wen Shuai, Faqian Bu, Pan Tang, Shuai Zhang, Yiwen Zhang, Guan Wang, Liang Ouyang
Developing potent LC3-targeting AUTAC tools for protein degradation with selective autophagy. Chemical communications (Cambridge, England) 57 (97) (2021)
Yang Li, Gaoxia Yang, Jifa Zhang, Pan Tang, Chengcan Yang, Guan Wang, Juncheng Chen, Jie Liu, Lan Zhang, Liang Ouyang
Discovery, Synthesis, and Evaluation of Highly Selective Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) Inhibitor for the Potential Treatment of Metastatic Triple-Negative Breast Cancer. Journal of medicinal chemistry 64 (16) (2021)
Minru Liao, Jin Zhang, Guan Wang, Leiming Wang, Jie Liu, Liang Ouyang, Bo Liu
Small-Molecule Drug Discovery in Triple Negative Breast Cancer: Current Situation and Future Directions. Journal of medicinal chemistry 64 (5) (2021)
Aoxue Wang, Junping Pei, Wen Shuai, Congcong Lin, Lu Feng, Yu-Xi Wang, Feng Lin, Liang Ouyang, Guan Wang
Small Molecules Targeting Activated Cdc42-Associated Kinase 1 (ACK1/TNK2) for the Treatment of Cancers. Journal of medicinal chemistry 64 (22) (2021)
Jin Zhang, Ling Zou, Danfeng Shi, Jie Liu, Jifa Zhang, Rongyan Zhao, Guan Wang, Lan Zhang, Liang Ouyang, Bo Liu
Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer. Journal of medicinal chemistry 64 (19) (2021)
Lu Feng, Guan Wang, Yi Chen, Gu He, Bo Liu, Jie Liu, Cheng-Ming Chiang, Liang Ouyang
Dual-target inhibitors of bromodomain and extra-terminal proteins in cancer: A review from medicinal chemistry perspectives. Medicinal research reviews (2021)
Jifa Zhang, Pan Tang, Ling Zou, Jin Zhang, Juncheng Chen, Chengcan Yang, Gu He, Bo Liu, Jie Liu, Cheng-Ming Chiang, Guan Wang, Tinghong Ye, Liang Ouyang
Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy. Journal of medicinal chemistry 64 (24) (2021)
Pan Tang, Jifa Zhang, Jie Liu, Cheng-Ming Chiang, Liang Ouyang
Targeting Bromodomain and Extraterminal Proteins for Drug Discovery: From Current Progress to Technological Development. Journal of medicinal chemistry 64 (5) (2021)
Junping Pei, Guan Wang, Lu Feng, Jifa Zhang, Tingting Jiang, Qiu Sun, Liang Ouyang
Targeting Lysosomal Degradation Pathways: New Strategies and Techniques for Drug Discovery. Journal of medicinal chemistry 64 (7) (2021)
Wen Shuai, Guan Wang, Yiwen Zhang, Faqian Bu, Sicheng Zhang, Duane D Miller, Wei Li, Liang Ouyang, Yu-Xi Wang
Recent Progress on Tubulin Inhibitors with Dual Targeting Capabilities for Cancer Therapy. Journal of medicinal chemistry 64 (12) (2021)
Guan Wang, Yuqian Zhao, Yao Liu, Dejuan Sun, Yongqi Zhen, Jie Liu, Leilei Fu, Lan Zhang, Liang Ouyang
Discovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types. Journal of medicinal chemistry 63 (8) (2020)
Jifa Zhang, Liang Ouyang
Proteolysis-targeting chimeras in breast cancer therapy. Future medicinal chemistry 12 (24) (2020)
Yi Chen, Guan Wang, Liang Ouyang
Promising inhibitors targeting Mpro: an ideal strategy for anti-SARS-CoV-2 drug discovery. Signal transduction and targeted therapy 5 (1) (2020)
Shaobo Ruan, Rou Xie, Lin Qin, Meinan Yu, Wei Xiao, Chuan Hu, Wenqi Yu, Zhiyong Qian, Liang Ouyang, Qin He, Huile Gao
Aggregable Nanoparticles-Enabled Chemotherapy and Autophagy Inhibition Combined with Anti-PD-L1 Antibody for Improved Glioma Treatment. Nano letters 19 (11) (2019)
Yi Chen, Guan Wang, Haoyang Cai, Yang Sun, Liang Ouyang, Bo Liu
Deciphering the Rules of in Silico Autophagy Methods for Expediting Medicinal Research. Journal of medicinal chemistry 62 (15) (2019)
Lan Zhang, Liang Ouyang, Yongzhi Guo, Jin Zhang, Bo Liu
UNC-51-like Kinase 1: From an Autophagic Initiator to Multifunctional Drug Target. Journal of medicinal chemistry 61 (15) (2018)
Liang Ouyang, Lan Zhang, Shouyue Zhang, Dahong Yao, Yuqian Zhao, Guan Wang, Leilei Fu, Peng Lei, Bo Liu
Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson's Disease Treatment. Journal of medicinal chemistry 61 (7) (2018)
Lan Zhang, Leilei Fu, Shouyue Zhang, Jin Zhang, Yuqian Zhao, Yaxin Zheng, Gu He, Shengyong Yang, Liang Ouyang, Bo Liu
Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chemical science 8 (4) (2017)