Li-Juan Chen (Lijuan Chen)

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 45

Top Topics

Top Venues

Journal of medicinal chemistry

Journal of chemical information and modeling

Blood cancer journal

Journal of natural products

This page only lists publications with an associated author ORCID identifier.

Publications

Mengshi Hu, Tao Yang, Linyu Yang, Lu Niu, Jinbing Zhu, Ailin Zhao, Mingsong Shi, Xue Yuan, Minghai Tang, Jianhong Yang, Heying Pei, Zhuang Yang, Qiang Chen, Haoyu Ye, Ting Niu, Li-Juan Chen
Correction to: Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2 V617F -induced myeloproliferative neoplasms. Blood cancer journal 14 (1) (2024)
Weichen Bo, Yangqin Duan, Yurong Zou, Ziyan Ma, Tao Yang, Peng Wang, Tao Guo, Zhiyuan Fu, Jianmin Wang, Linchuan Fan, Jie Liu, Taijin Wang, Li-Juan Chen
Local Scaffold Diversity-Contributed Generator for Discovering Potential NLRP3 Inhibitors. Journal of chemical information and modeling 64 (3) (2024)
Mengshi Hu, Tao Yang, Linyu Yang, Lu Niu, Jinbing Zhu, Ailin Zhao, Mingsong Shi, Xue Yuan, Minghai Tang, Jianhong Yang, Heying Pei, Zhuang Yang, Qiang Chen, Haoyu Ye, Ting Niu, Li-Juan Chen
Correction to: Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2 V617F -induced myeloproliferative neoplasms. Blood cancer journal 14 (1) (2024)
Zhiyuan Fu, Yangqin Duan, Heying Pei, Yurong Zou, Minghai Tang, Yong Chen, Tao Yang, Ziyan Ma, Wei Yan, Kaiyue Su, Xiaoying Cai, Tao Guo, Yaxin Teng, Tao Jia, Li-Juan Chen
Discovery of Potent, Specific, and Orally Available NLRP3 Inflammasome Inhibitors Based on Pyridazine Scaffolds for the Treatment of Septic Shock and Peritonitis. Journal of medicinal chemistry (2024)
Peng Wang, Yongting Yuan, Tao Yang, Yurong Zou, Minghai Tang, Ziyan Ma, Weichen Bo, Songhui Qin, Yong Chen, Tao Guo, Zhongning Guo, Jianhong Yang, Mingli Xiang, Li-Juan Chen
Design, Synthesis, and Biological Evaluation of 5-Amino-4-fluoro-1 H -benzo[ d ]imidazole-6-carboxamide Derivatives as Novel and Potential MEK/RAF Complex Inhibitors Based on the "Clamp" Strategy. Journal of medicinal chemistry (2024)
Weichen Bo, Yangqin Duan, Yurong Zou, Ziyan Ma, Tao Yang, Peng Wang, Tao Guo, Zhiyuan Fu, Jianmin Wang, Linchuan Fan, Jie Liu, Taijin Wang, Li-Juan Chen
Local Scaffold Diversity-Contributed Generator for Discovering Potential NLRP3 Inhibitors. Journal of chemical information and modeling (2024)
Weichen Bo, Yangqin Duan, Yurong Zou, Ziyan Ma, Tao Yang, Peng Wang, Tao Guo, Zhiyuan Fu, Jianmin Wang, Linchuan Fan, Jie Liu, Taijin Wang, Li-Juan Chen
Local Scaffold Diversity-Contributed Generator for Discovering Potential NLRP3 Inhibitors. Journal of chemical information and modeling 64 (3) (2024)
Ruijia Zhang, Kaiyue Su, Letian Yang, Huaichuan Duan, Lei Tang, Minghai Tang, Min Zhao, Neng Ye, Xiaoying Cai, Xueqin Jiang, Na Li, Jing Peng, Xinlu Zhang, Lingkai Tang, Qiang Qiu, Li-Juan Chen, Wenshuang Wu, Jianping Hu, Liang Ma, Hao-Yu Ye
Discovery of a Potent, Orally Active, and Long-Lasting P2X7 Receptor Antagonist as a Preclinical Candidate for Delaying the Progression of Chronic Kidney Disease. Journal of medicinal chemistry (2024)
Weichen Bo, Yangqin Duan, Yurong Zou, Ziyan Ma, Tao Yang, Peng Wang, Tao Guo, Zhiyuan Fu, Jianmin Wang, Linchuan Fan, Jie Liu, Taijin Wang, Li-Juan Chen
Local Scaffold Diversity-Contributed Generator for Discovering Potential NLRP3 Inhibitors. Journal of chemical information and modeling 64 (3) (2024)
Weichen Bo, Yangqin Duan, Yurong Zou, Ziyan Ma, Tao Yang, Peng Wang, Tao Guo, Zhiyuan Fu, Jianmin Wang, Linchuan Fan, Jie Liu, Taijin Wang, Li-Juan Chen
Local Scaffold Diversity-Contributed Generator for Discovering Potential NLRP3 Inhibitors. Journal of chemical information and modeling 64 (3) (2024)
Dexin Deng, Yingxue Yang, Yurong Zou, Kongjun Liu, Chufeng Zhang, Minghai Tang, Tao Yang, Yong Chen, Xue Yuan, Yong Guo, Shunjie Zhang, Wenting Si, Bin Peng, Qing Xu, Wen He, Dingguo Xu, Mingli Xiang, Li-Juan Chen
Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening. Journal of medicinal chemistry (2023)
Kongjun Liu, Xue Yuan, Tao Yang, Dexin Deng, Yong Chen, Minghai Tang, Chufeng Zhang, Yurong Zou, Shunjie Zhang, Dan Li, Ming-Song Shi, Yong Guo, Yanting Zhou, Min Zhao, Zhuang Yang, Li-Juan Chen
Discovery, Optimization, and Evaluation of Potent and Selective DNA-PK Inhibitors in Combination with Chemotherapy or Radiotherapy for the Treatment of Malignancies. Journal of medicinal chemistry 67 (1) (2023)
Kongjun Liu, Xue Yuan, Tao Yang, Dexin Deng, Yong Chen, Minghai Tang, Chufeng Zhang, Yurong Zou, Shunjie Zhang, Dan Li, Ming-Song Shi, Yong Guo, Yanting Zhou, Min Zhao, Zhuang Yang, Li-Juan Chen
Discovery, Optimization, and Evaluation of Potent and Selective DNA-PK Inhibitors in Combination with Chemotherapy or Radiotherapy for the Treatment of Malignancies. Journal of medicinal chemistry 67 (1) (2023)
Yong Chen, Shuai Liu, Yuhan Wei, Haoche Wei, Xue Yuan, Baojian Xiong, Minghai Tang, Tao Yang, Zhuang Yang, Hao-Yu Ye, Jianhong Yang, Li-Juan Chen
Discovery of Potent and Selective Phosphatidylinositol 3-Phosphate 5-Kinase (PIKfyve) Inhibitors as Methuosis Inducers. Journal of medicinal chemistry 67 (1) (2023)
Kongjun Liu, Xue Yuan, Tao Yang, Dexin Deng, Yong Chen, Minghai Tang, Chufeng Zhang, Yurong Zou, Shunjie Zhang, Dan Li, Ming-Song Shi, Yong Guo, Yanting Zhou, Min Zhao, Zhuang Yang, Li-Juan Chen
Discovery, Optimization, and Evaluation of Potent and Selective DNA-PK Inhibitors in Combination with Chemotherapy or Radiotherapy for the Treatment of Malignancies. Journal of medicinal chemistry (2023)
Yong Chen, Shuai Liu, Yuhan Wei, Haoche Wei, Xue Yuan, Baojian Xiong, Minghai Tang, Tao Yang, Zhuang Yang, Hao-Yu Ye, Jianhong Yang, Li-Juan Chen
Discovery of Potent and Selective Phosphatidylinositol 3-Phosphate 5-Kinase (PIKfyve) Inhibitors as Methuosis Inducers. Journal of medicinal chemistry 67 (1) (2023)
Kongjun Liu, Xue Yuan, Tao Yang, Dexin Deng, Yong Chen, Minghai Tang, Chufeng Zhang, Yurong Zou, Shunjie Zhang, Dan Li, Ming-Song Shi, Yong Guo, Yanting Zhou, Min Zhao, Zhuang Yang, Li-Juan Chen
Discovery, Optimization, and Evaluation of Potent and Selective DNA-PK Inhibitors in Combination with Chemotherapy or Radiotherapy for the Treatment of Malignancies. Journal of medicinal chemistry 67 (1) (2023)
Yong Chen, Shuai Liu, Yuhan Wei, Haoche Wei, Xue Yuan, Baojian Xiong, Minghai Tang, Tao Yang, Zhuang Yang, Hao-Yu Ye, Jianhong Yang, Li-Juan Chen
Discovery of Potent and Selective Phosphatidylinositol 3-Phosphate 5-Kinase (PIKfyve) Inhibitors as Methuosis Inducers. Journal of medicinal chemistry 67 (1) (2023)
Yong Chen, Shuai Liu, Yuhan Wei, Haoche Wei, Xue Yuan, Baojian Xiong, Minghai Tang, Tao Yang, Zhuang Yang, Hao-Yu Ye, Jianhong Yang, Li-Juan Chen
Discovery of Potent and Selective Phosphatidylinositol 3-Phosphate 5-Kinase (PIKfyve) Inhibitors as Methuosis Inducers. Journal of medicinal chemistry (2023)
Jianhong Yang, Yong Li, Qiang Qiu, Ruihan Wang, Wei Yan, Yamei Yu, Lu Niu, Heying Pei, Haoche Wei, Liang Ouyang, Hao-Yu Ye, Dingguo Xu, Yuquan Wei, Qiang Chen, Li-Juan Chen
Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. Journal of medicinal chemistry 65 (13) (2022)
Linyu Yang, Wanhua Zhang, Qiang Qiu, Zhengying Su, Minghai Tang, Peng Bai, Wenting Si, Zejiang Zhu, Yan Liu, Jianhong Yang, Shuang Kuang, Jiang Liu, Wei Yan, Mingsong Shi, Hao-Yu Ye, Zhuang Yang, Li-Juan Chen
Correction to "Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity". Journal of medicinal chemistry 65 (17) (2022)
Mengshi Hu, Tao Yang, Linyu Yang, Lu Niu, Jinbing Zhu, Ailin Zhao, Mingsong Shi, Xue Yuan, Minghai Tang, Jianhong Yang, Heying Pei, Zhuang Yang, Qiang Chen, Haoyu Ye, Ting Niu, Li-Juan Chen
Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2 V617F -induced myeloproliferative neoplasms. Blood cancer journal 12 (3) (2022)
Kongjun Liu, Wei Zheng, Yong Chen, Minghai Tang, Dan Li, Dexin Deng, Tao Yang, Chufeng Zhang, Jiang Liu, Xue Yuan, Mingsong Shi, Xiandeng Li, Yong Guo, Yanting Zhou, Min Zhao, Li-Juan Chen
Discovery, Optimization, and Evaluation of Potent and Selective PI3Kδ-γ Dual Inhibitors for the Treatment of B-cell Malignancies. Journal of medicinal chemistry 65 (14) (2022)
Xue Yuan, Yong Chen, Minghai Tang, Yuhan Wei, Mingsong Shi, Yingxue Yang, Yanting Zhou, Tao Yang, Jiang Liu, Kongjun Liu, Dexin Deng, Chufeng Zhang, Li-Juan Chen
Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) Inhibitors for the Treatment of Inflammatory Bowel Diseases (IBDs). Journal of medicinal chemistry 65 (13) (2022)
Ruijia Zhang, Feng Hong, Min Zhao, Xiaoying Cai, Xueqin Jiang, Neng Ye, Kaiyue Su, Na Li, Minghai Tang, Xu Ma, Hengfan Ni, Lun Wang, Li Wan, Li-Juan Chen, Wenshuang Wu, Hao-Yu Ye
New Highly Potent NLRP3 Inhibitors: Furanochalcone Velutone F Analogues. ACS medicinal chemistry letters 13 (4) (2022)
Tao Yang, Xue Cui, Minghai Tang, Wenyan Qi, Zejiang Zhu, Mingsong Shi, Linyu Yang, Heying Pei, Wanhua Zhang, Lixin Xie, Yaohui Xu, Zhuang Yang, Li-Juan Chen
Identification of a Novel 2,8-Diazaspiro[4.5]decan-1-one Derivative as a Potent and Selective Dual TYK2/JAK1 Inhibitor for the Treatment of Inflammatory Bowel Disease. Journal of medicinal chemistry 65 (4) (2022)
Lun Wang, Yunhua Zheng, Dan Li, Jianhong Yang, Lei Lei, Wei Yan, Wei Zheng, Minghai Tang, Mingsong Shi, Ruijia Zhang, Xiaoying Cai, Hengfan Ni, Xu Ma, Na Li, Feng Hong, Hao-Yu Ye, Li-Juan Chen
Correction to "Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure". Journal of medicinal chemistry 65 (17) (2022)
Zejiang Zhu, Jiaolin Wen, Yaohui Xu, Heying Pei, Dan Li, Minghai Tang, Peng Bai, Jun He, Zhuang Yang, Li-Juan Chen
Therapeutic efficacy of an injectable formulation of purinostat mesylate in SU-DHL-6 tumour model. Annals of medicine 54 (1) (2022)
Yong Li, Yan Liu, Zejiang Zhu, Wei Yan, Chufeng Zhang, Zhuang Yang, Peng Bai, Minghai Tang, Mingsong Shi, Wen He, Suhong Fu, Jiang Liu, Kai Han, Jiewen Li, Lixin Xie, Haoyu Ye, Jianhong Yang, Li-Juan Chen
Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents. Journal of medicinal chemistry 65 (3) (2022)
Tao Yang, Mengshi Hu, Yong Chen, Mingli Xiang, Minghai Tang, Wenyan Qi, Mingsong Shi, Jun He, Xue Yuan, Chufeng Zhang, Kongjun Liu, Jiewen Li, Zhuang Yang, Li-Juan Chen
Correction to "N-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms". Journal of medicinal chemistry 64 (4) (2021)
Lun Wang, Yunhua Zheng, Dan Li, Jianhong Yang, Lei Lei, Wei Yan, Wei Zheng, Minghai Tang, Mingsong Shi, Ruijia Zhang, Xiaoying Cai, Hengfan Ni, Xu Ma, Na Li, Feng Hong, Hao-Yu Ye, Li-Juan Chen
Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure. Journal of medicinal chemistry 64 (12) (2021)
Linyu Yang, Wanhua Zhang, Qiang Qiu, Zhengying Su, Minghai Tang, Peng Bai, Wenting Si, Zejiang Zhu, Yan Liu, Jianhong Yang, Shuang Kuang, Jiang Liu, Wei Yan, Mingsong Shi, Hao-Yu Ye, Zhuang Yang, Li-Juan Chen
Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity. Journal of medicinal chemistry 64 (20) (2021)
Kongjun Liu, Dan Li, Wei Zheng, Mingsong Shi, Yong Chen, Minghai Tang, Tao Yang, Min Zhao, Dexin Deng, Chufeng Zhang, Jiang Liu, Xue Yuan, Zhuang Yang, Li-Juan Chen
Discovery, Optimization, and Evaluation of Quinazolinone Derivatives with Novel Linkers as Orally Efficacious Phosphoinositide-3-Kinase Delta Inhibitors for Treatment of Inflammatory Diseases. Journal of medicinal chemistry 64 (13) (2021)
Mingsong Shi, Lun Wang, Penghui Li, Jiang Liu, Li-Juan Chen, Dingguo Xu
Dasatinib-SIK2 Binding Elucidated by Homology Modeling, Molecular Docking, and Dynamics Simulations. ACS omega 6 (16) (2021)
Jianhong Yang, Yamei Yu, Yong Li, Wei Yan, Haoyu Ye, Lu Niu, Minghai Tang, Zhoufeng Wang, Zhuang Yang, Heying Pei, Haoche Wei, Min Zhao, Jiaolin Wen, Linyu Yang, Liang Ouyang, Yuquan Wei, Qiang Chen, Wei-Min Li, Li-Juan Chen
Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect. Science advances 7 (21) (2021)
Chufeng Zhang, Wenyan Qi, Yong Li, Minghai Tang, Tao Yang, Kongjun Liu, Yong Chen, Dexin Deng, Mingli Xiang, Li-Juan Chen
Discovery of 3-(4-(2-((1H-Indol-5-yl)amino)-5-fluoropyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile Derivatives as Selective TYK2 Inhibitors for the Treatment of Inflammatory Bowel Disease. Journal of medicinal chemistry 64 (4) (2021)
Xu Ma, Min Zhao, Ming-Hai Tang, Lin-Lin Xue, Rui-Jia Zhang, Ling Liu, Heng-Fan Ni, Xiao-Ying Cai, Shuang Kuang, Feng Hong, Lun Wang, Kai Chen, Huan Tang, Yan Li, Ai-Hua Peng, Jian-Hong Yang, He-Ying Pei, Hao-Yu Ye, Li-Juan Chen
Flavonoids with Inhibitory Effects on NLRP3 Inflammasome Activation from Millettia velutina. Journal of natural products 83 (10) (2020)
Heying Pei, Linlin Xue, Minghai Tang, Huan Tang, Shuang Kuang, Lun Wang, Xu Ma, Xiaoying Cai, Yan Li, Min Zhao, Aihua Peng, Hao-Yu Ye, Li-Juan Chen
Alkaloids from Black Pepper (Piper nigrum L.) Exhibit Anti-Inflammatory Activity in Murine Macrophages by Inhibiting Activation of NF-κB Pathway. Journal of agricultural and food chemistry 68 (8) (2020)
Tao Yang, Mengshi Hu, Yong Chen, Mingli Xiang, Minghai Tang, Wenyan Qi, Mingsong Shi, Jun He, Xue Yuan, Chufeng Zhang, Kongjun Liu, Jiewen Li, Zhuang Yang, Li-Juan Chen
N-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms. Journal of medicinal chemistry 63 (23) (2020)
Tao Yang, Mengshi Hu, Wenyan Qi, Zhuang Yang, Minghai Tang, Jun He, Yong Chen, Peng Bai, Xue Yuan, Chufeng Zhang, Kongjun Liu, Yulin Lu, Mingli Xiang, Li-Juan Chen
Correction to "Discovery of Potent and Orally Effective Dual Janus Kinase 2/FLT3 Inhibitors for the Treatment of Acute Myelogenous Leukemia and Myeloproliferative Neoplasms". Journal of medicinal chemistry 63 (3) (2020)
Min Zhao, Xue Yuan, Ying-He Pei, Hao-Yu Ye, Ai-Hua Peng, Ming-Hai Tang, Da-Le Guo, Yun Deng, Li-Juan Chen
Anti-inflammatory Ellagitannins from Cleidion brevipetiolatum for the Treatment of Rheumatoid Arthritis. Journal of natural products 82 (9) (2019)
Xue Yuan, Yong Chen, Wanhua Zhang, Jun He, Lei Lei, Minghai Tang, Jiang Liu, Muzhou Li, Caixia Dou, Tao Yang, Linyu Yang, Sheng-Yong Yang, Yuquan Wei, Aihua Peng, Ting Niu, Mingli Xiang, Haoyu Ye, Li-Juan Chen
Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia. Journal of medicinal chemistry 62 (8) (2019)
Yong Chen, Xue Yuan, Wanhua Zhang, Minghai Tang, Li Zheng, Fang Wang, Wei Yan, Sheng-Yong Yang, Yuquan Wei, Jun He, Li-Juan Chen
Discovery of Novel Dual Histone Deacetylase and Mammalian Target of Rapamycin Target Inhibitors as a Promising Strategy for Cancer Therapy. Journal of medicinal chemistry 62 (3) (2019)
Yueshan Li, Yu Xiong, Guo Zhang, Liting Zhang, Wei Yang, Jiao Yang, Luyi Huang, Zeen Qiao, Zhuang Miao, Guifeng Lin, Qiu Sun, Ting Niu, Li-Juan Chen, Dawen Niu, Linli Li, Sheng-Yong Yang
Correction to Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model. Journal of medicinal chemistry 62 (6) (2019)
Tao Yang, Mengshi Hu, Wenyan Qi, Zhuang Yang, Minghai Tang, Jun He, Yong Chen, Peng Bai, Xue Yuan, Chufeng Zhang, Kongjun Liu, Yulin Lu, Mingli Xiang, Li-Juan Chen
Discovery of Potent and Orally Effective Dual Janus Kinase 2/FLT3 Inhibitors for the Treatment of Acute Myelogenous Leukemia and Myeloproliferative Neoplasms. Journal of medicinal chemistry 62 (22) (2019)