Manolis Pasparakis (M Pasparakis)

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 48

Top Topics

Top Venues

Nature communications

Cell death and differentiation

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Remzi Onur Eren, Göksu Gökberk Kaya, Robin Schwarzer, Manolis Pasparakis
IKKε and TBK1 prevent RIPK1 dependent and independent inflammation. Nature communications 15 (1) (2024)
Lioba Koerner, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Theresa Wagner, Huipeng Jiao, Manolis Pasparakis
ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis. Cell death and differentiation 31 (7) (2024)
Masahiro Nagata, Yasmin Carvalho Schäfer, Laurens Wachsmuth, Manolis Pasparakis
A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses. The EMBO journal (2024)
Remzi Onur Eren, Göksu Gökberk Kaya, Robin Schwarzer, Manolis Pasparakis
IKKε and TBK1 prevent RIPK1 dependent and independent inflammation. Nature communications 15 (1) (2024)
Lioba Koerner, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Theresa Wagner, Huipeng Jiao, Manolis Pasparakis
ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis. Cell death and differentiation 31 (7) (2024)
Remzi Onur Eren, Göksu Gökberk Kaya, Robin Schwarzer, Manolis Pasparakis
IKKε and TBK1 prevent RIPK1 dependent and independent inflammation. Nature communications 15 (1) (2024)
Lioba Koerner, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Theresa Wagner, Huipeng Jiao, Manolis Pasparakis
ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis. Cell death and differentiation 31 (7) (2024)
Remzi Onur Eren, Göksu Gökberk Kaya, Robin Schwarzer, Manolis Pasparakis
IKKε and TBK1 prevent RIPK1 dependent and independent inflammation. Nature communications 15 (1) (2024)
Lioba Koerner, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Theresa Wagner, Huipeng Jiao, Manolis Pasparakis
ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis. Cell death and differentiation (2024)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature 625 (7994) (2023)
Takayuki Imanishi, Midori Unno, Natsumi Yoneda, Yasutaka Motomura, Miho Mochizuki, Takaharu Sasaki, Manolis Pasparakis, Takashi Saito
RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8. Science advances 9 (4) (2023)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature 625 (7994) (2023)
Takayuki Imanishi, Midori Unno, Natsumi Yoneda, Yasutaka Motomura, Miho Mochizuki, Takaharu Sasaki, Manolis Pasparakis, Takashi Saito
RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8. Science advances 9 (4) (2023)
Takayuki Imanishi, Midori Unno, Natsumi Yoneda, Yasutaka Motomura, Miho Mochizuki, Takaharu Sasaki, Manolis Pasparakis, Takashi Saito
RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8. Science advances 9 (4) (2023)
Takayuki Imanishi, Midori Unno, Natsumi Yoneda, Yasutaka Motomura, Miho Mochizuki, Takaharu Sasaki, Manolis Pasparakis, Takashi Saito
RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8. Science advances 9 (4) (2023)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature 625 (7994) (2023)
Fabian Schorn, J Paul Werthenbach, Mattes Hoffmann, Mila Daoud, Johanna Stachelscheid, Lars M Schiffmann, Ximena Hildebrandt, Su Ir Lyu, Nieves Peltzer, Alexander Quaas, Domagoj Vucic, John Silke, Manolis Pasparakis, Hamid Kashkar
cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. The EMBO journal (2023)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature 625 (7994) (2023)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature 625 (7994) (2023)
Lioba Koerner, Marcel Schmiel, Tsun-Po Yang, Martin Peifer, Reinhard Buttner, Manolis Pasparakis
NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer. Cell death and differentiation (2023)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature 625 (7994) (2023)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature (2023)
Huipeng Jiao, Manolis Pasparakis
Inducing Z-DNA overcomes immune checkpoint blockade resistance. Cell research 32 (10) (2022)
Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann, Masahiro Nagata, Göksu Gökberk Kaya, Nikos Oikonomou, Vangelis Kondylis, Manuel Rogg, Martin Diebold, Simon E Tröder, Elena I Rugarli, Marco Prinz, Christoph Schell, George R Young, George Kassiotis, Manolis Pasparakis
ADAR1 averts fatal type I interferon induction by ZBP1. Nature 607 (7920) (2022)
Vangelis Kondylis, Farina Schneider, Fabian Schorn, Nikos Oikonomou, Beate Katharina Straub, Sabine Werner, Philip Rosenstiel, Manolis Pasparakis
p62 Promotes Survival and Hepatocarcinogenesis in Mice with Liver-Specific NEMO Ablation. Cancers 14 (10) (2022)
Sebastian J Theobald, Jessica Gräb, Melanie Fritsch, Isabelle Suárez, Hannah S Eisfeld, Sandra Winter, Maximilian Koch, Christoph Hölscher, Manolis Pasparakis, Hamid Kashkar, Jan Rybniker
Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages. Cell death discovery 7 (1) (2021)
Jan Wenzel, Josephine Lampe, Helge Müller-Fielitz, Raphael Schuster, Marietta Zille, Kristin Müller, Markus Krohn, Jakob Körbelin, Linlin Zhang, Umit Ozorhan, Vanessa Neve, Julian U G Wagner, Denisa Bojkova, Mariana Shumliakivska, Yun Jiang, Anke Fähnrich, Fabian Ott, Valentin Sencio, Cyril Robil, Susanne Pfefferle, Florent Sauve, Caio Fernando Ferreira Coêlho, Jonas Franz, Frauke Spiecker, Beate Lembrich, Sonja Binder, Nina Feller, Peter König, Hauke Busch, Ludovic Collin, Roberto Villaseñor, Olaf Jöhren, Hermann Clemens Altmeppen, Manolis Pasparakis, Stefanie Dimmeler, Jindrich Cinatl, Klaus Püschel, Matija Zelic, Dimitry Ofengeim, Christine Stadelmann, François Trottein, Ruben Nogueiras, Rolf Hilgenfeld, Markus Glatzel, Vincent Prevot, Markus Schwaninger
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nature neuroscience 24 (11) (2021)
Hannah Schünke, Ulrike Göbel, Ivan Đikić, Manolis Pasparakis
OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nature communications 12 (1) (2021)
Alan Herbert, Andrew H-J Wang, Thomas M Jovin, Edward S Mocarski, Manolis Pasparakis, Karen M Vasquez
Concern over use of the term Z-DNA. Nature 594 (7863) (2021)
Snehlata Kumari, Trieu-My Van, Daniela Preukschat, Hannah Schuenke, Marijana Basic, André Bleich, Ulf Klein, Manolis Pasparakis
NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation. Life science alliance 4 (6) (2021)
Annika Hausmann, Boas Felmy, Leo Kunz, Sanne Kroon, Dorothée Lisa Berthold, Giverny Ganz, Ioana Sandu, Toshihiro Nakamura, Nathan Sébastien Zangger, Yang Zhang, Tamas Dolowschiak, Stefan Alexander Fattinger, Markus Furter, Anna Angelika Müller-Hauser, Manja Barthel, Katerina Vlantis, Laurens Wachsmuth, Jan Kisielow, Luigi Tortola, Danijela Heide, Mathias F Heikenwälder, Annette Oxenius, Manfred Kopf, Timm Schroeder, Manolis Pasparakis, Mikael Erik Sellin, Wolf-Dietrich Hardt
Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF. The Journal of experimental medicine 218 (11) (2021)
Mar Cabeza-Cabrerizo, Carlos M Minutti, Mariana Pereira da Costa, Ana Cardoso, Robert P Jenkins, Justina Kulikauskaite, Michael D Buck, Cécile Piot, Neil C Rogers, Stefania Crotta, Lynne Whittaker, Hector Huerga Encabo, John W McCauley, Judith E Allen, Manolis Pasparakis, Andreas Wack, Erik Sahai, Caetano Reis E Sousa
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity. Science immunology 6 (65) (2021)
Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krueger, Mathieu J M Bertrand, Vangelis Kondylis, Manolis Pasparakis
Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation. Nature communications 11 (1) (2020)
Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R Young, George Kassiotis, William J Kaiser, Manolis Pasparakis
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature 580 (7803) (2020)
L M Schiffmann, J P Werthenbach, F Heintges-Kleinhofer, J M Seeger, M Fritsch, S D Günther, S Willenborg, Susanne Brodesser, C Lucas, Christian Jüngst, M C Albert, F Schorn, A Witt, C T Moraes, C J Bruns, Manolis Pasparakis, M Krönke, S A Eming, O Coutelle, Hamid Kashkar
Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth. Nature communications 11 (1) (2020)
Dario Priem, Michael Devos, Sarah Druw, Arne Martens, Karolina Slowicka, Adrian T Ting, Manolis Pasparakis, Wim Declercq, Peter Vandenabeele, Geert van Loo, Mathieu J M Bertrand
Correction: A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms. Cell death & disease 11 (1) (2020)
Masanori Gomi Naito, Daichao Xu, Palak Amin, Jinwoo Lee, Huibing Wang, Wanjin Li, Michelle Kelliher, Manolis Pasparakis, Junying Yuan
Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke. Proceedings of the National Academy of Sciences of the United States of America 117 (9) (2020)
Jessica Gräb, Isabelle Suárez, Edeltraud van Gumpel, Sandra Winter, Fynn Schreiber, Anna Esser, Christoph Hölscher, Melanie Fritsch, Marc Herb, Michael Schramm, Laurens Wachsmuth, Christian Pallasch, Manolis Pasparakis, Hamid Kashkar, Jan Rybniker
Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition. Nature communications 10 (1) (2019)
Dario Priem, Michael Devos, Sarah Druwé, Arne Martens, Karolina Slowicka, Adrian T Ting, Manolis Pasparakis, Wim Declercq, Peter Vandenabeele, Geert van Loo, Mathieu J M Bertrand
A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms. Cell death & disease 10 (10) (2019)
Apostolos Polykratis, Arne Martens, Remzi Onur Eren, Yoshitaka Shirasaki, Mai Yamagishi, Yoshifumi Yamaguchi, Sotaro Uemura, Masayuki Miura, Bernhard Holzmann, George Kollias, Marietta Armaka, Geert van Loo, Manolis Pasparakis
A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain. Nature cell biology 21 (6) (2019)
Santosh Krishna-Subramanian, Stephan Singer, Marietta Armaka, Jesus M Banales, Kerstin Holzer, Peter Schirmacher, Henning Walczak, George Kollias, Manolis Pasparakis, Vangelis Kondylis
RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury. Cell death and differentiation 26 (12) (2019)
Vangelis Kondylis, Snehlata Kumari, Katerina Vlantis, Manolis Pasparakis
The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation. Immunological reviews 277 (1) (2018)
Ariadne Androulidaki, Laurens Wachsmuth, Apostolos Polykratis, Manolis Pasparakis
Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes. PloS one 13 (3) (2018)
Marietta Armaka, Caroline Ospelt, Manolis Pasparakis, George Kollias
The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts. Nature communications 9 (1) (2018)
Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke, Henning Walczak
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L. Nature communications 9 (1) (2018)
Akshay A D'Cruz, Mary Speir, Meghan Bliss-Moreau, Sylvia Dietrich, Shu Wang, Alyce A Chen, Mathilde Gavillet, Arshed Al-Obeidi, Kate E Lawlor, James E Vince, Michelle A Kelliher, Razqallah Hakem, Manolis Pasparakis, David A Williams, Maria Ericsson, Ben A Croker
The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils. Science signaling 11 (546) (2018)
Joanne A O'Donnell, Jesse Lehman, Justine E Roderick, Dalia Martinez-Marin, Matija Zelic, Ciara Doran, Nicole Hermance, Stephen Lyle, Manolis Pasparakis, Katherine A Fitzgerald, Ann Marshak-Rothstein, Michelle A Kelliher
Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity. Journal of immunology (Baltimore, Md. : 1950) 200 (2) (2017)
Vanesa Fernández-Majada, Patrick-Simon Welz, Maria A Ermolaeva, Michael Schell, Alexander Adam, Felix Dietlein, David Komander, Reinhard Büttner, Roman K Thomas, Björn Schumacher, Manolis Pasparakis
The tumour suppressor CYLD regulates the p53 DNA damage response. Nature communications 7 (2016)