Christian Frezza (C Frezza)

Scopus Author ID ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 79

Top Venues

Nature

Nature communications

The EMBO journal

EMBO molecular medicine

University of Cambridge

Universita degli Studi di Padova (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Cambridge Jan 05 2017

United Kingdom

Programme Leader :: MRC Cancer Unit

University of Cambridge May 01 2012 - Apr 30 2017

United Kingdom

Programme Leader Track :: MRC Cancer Unit

Education History

Universita degli Studi di Padova Jan 01 2005 - Apr 08 2008

Italy

PHD :: Scienze Biomediche

Publications

Sara Clerici, Christine Podrini, Davide Stefanoni, Gianfranco Distefano, Laura Cassina, Maria Elena Steidl, Laura Tronci, Tamara Canu, Marco Chiaravalli, Daniel Spies, Thomas A Bell, Ana Sh Costa, Antonio Esposito, Angelo D'Alessandro, Christian Frezza, Angela Bachi, Alessandra Boletta
Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression. EMBO molecular medicine (2024)
Albert Herms, Bartomeu Colom, Gabriel Piedrafita, Argyro Kalogeropoulou, Ujjwal Banerjee, Charlotte King, Emilie Abby, Kasumi Murai, Irene Caseda, David Fernandez-Antoran, Swee Hoe Ong, Michael W J Hall, Christopher Bryant, Roshan K Sood, Joanna C Fowler, Albert Pol, Christian Frezza, Bart Vanhaesebroeck, Philip H Jones
Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus. Nature genetics (2024)
Johannes Meiser, Christian Frezza
Presenting metabolomics analyses: what is in a number? The EMBO journal (2024)
Marlous Kamp, Jakub Maciej Surmacki, Marc Segarra Mondejar, Tim Young, Karolina Chrabaszcz, Fadwa Joud, Vincent Zecchini, Alyson Speed, Christian Frezza, Sarah Elizabeth Bohndiek
Raman micro-spectroscopy reveals the spatial distribution of fumarate in cells and tissues. Nature communications 15 (1) (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal 43 (11) (2024)
Luca Peruzzotti-Jametti, C M Willis, G Krzak, R Hamel, L Pirvan, Rosana-Bristena Ionescu, J A Reisz, Hiran A Prag, M E Garcia-Segura, V Wu, Y Xiang, B Barlas, Alva M Casey, A M R van den Bosch, Alexandra M Nicaise, L Roth, G R Bates, H Huang, P Prasad, A E Vincent, Christian Frezza, Carlos Pardo-Hernández, Gabriel Balmus, Zoltán Takáts, John C Marioni, Angelo D'Alessandro, Michael P Murphy, Irina I Mohorianu, Stefano Pluchino
Mitochondrial complex I activity in microglia sustains neuroinflammation. Nature (2024)
Luca Peruzzotti-Jametti, C M Willis, G Krzak, R Hamel, L Pirvan, Rosana-Bristena Ionescu, J A Reisz, Hiran A Prag, M E Garcia-Segura, V Wu, Y Xiang, B Barlas, Alva M Casey, A M R van den Bosch, Alexandra M Nicaise, L Roth, G R Bates, H Huang, P Prasad, A E Vincent, Christian Frezza, Carlos Pardo-Hernández, Gabriel Balmus, Zoltán Takáts, John C Marioni, Angelo D'Alessandro, Michael P Murphy, Irina I Mohorianu, Stefano Pluchino
Mitochondrial complex I activity in microglia sustains neuroinflammation. Nature (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal (2024)
Luca Peruzzotti-Jametti, C M Willis, G Krzak, R Hamel, L Pirvan, Rosana-Bristena Ionescu, J A Reisz, Hiran A Prag, M E Garcia-Segura, V Wu, Y Xiang, B Barlas, Alva M Casey, A M R van den Bosch, Alexandra M Nicaise, L Roth, G R Bates, H Huang, P Prasad, A E Vincent, Christian Frezza, Carlos Pardo-Hernández, Gabriel Balmus, Zoltán Takáts, John C Marioni, Angelo D'Alessandro, Michael P Murphy, Irina I Mohorianu, Stefano Pluchino
Mitochondrial complex I activity in microglia sustains neuroinflammation. Nature 628 (8006) (2024)
Sara Clerici, Christine Podrini, Davide Stefanoni, Gianfranco Distefano, Laura Cassina, Maria Elena Steidl, Laura Tronci, Tamara Canu, Marco Chiaravalli, Daniel Spies, Thomas A Bell, Ana Sh Costa, Antonio Esposito, Angelo D'Alessandro, Christian Frezza, Angela Bachi, Alessandra Boletta
Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression. EMBO molecular medicine 16 (6) (2024)
Johannes Meiser, Christian Frezza
Presenting metabolomics analyses: what's in a number? The EMBO journal (2024)
Sara Clerici, Christine Podrini, Davide Stefanoni, Gianfranco Distefano, Laura Cassina, Maria Elena Steidl, Laura Tronci, Tamara Canu, Marco Chiaravalli, Daniel Spies, Thomas A Bell, Ana Sh Costa, Antonio Esposito, Angelo D'Alessandro, Christian Frezza, Angela Bachi, Alessandra Boletta
Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression. EMBO molecular medicine 16 (6) (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal (2024)
Luca Peruzzotti-Jametti, C M Willis, G Krzak, R Hamel, L Pirvan, Rosana-Bristena Ionescu, J A Reisz, Hiran A Prag, M E Garcia-Segura, V Wu, Y Xiang, B Barlas, Alva M Casey, A M R van den Bosch, Alexandra M Nicaise, L Roth, G R Bates, H Huang, P Prasad, A E Vincent, Christian Frezza, Carlos Pardo-Hernández, Gabriel Balmus, Zoltán Takáts, John C Marioni, Angelo D'Alessandro, Michael P Murphy, Irina I Mohorianu, Stefano Pluchino
Mitochondrial complex I activity in microglia sustains neuroinflammation. Nature 628 (8006) (2024)
Sara Clerici, Christine Podrini, Davide Stefanoni, Gianfranco Distefano, Laura Cassina, Maria Elena Steidl, Laura Tronci, Tamara Canu, Marco Chiaravalli, Daniel Spies, Thomas A Bell, Ana Sh Costa, Antonio Esposito, Angelo D'Alessandro, Christian Frezza, Angela Bachi, Alessandra Boletta
Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression. EMBO molecular medicine 16 (6) (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal 43 (11) (2024)
Marlous Kamp, Jakub Maciej Surmacki, Marc Segarra Mondejar, Tim Young, Karolina Chrabaszcz, Fadwa Joud, Vincent Zecchini, Alyson Speed, Christian Frezza, Sarah Elizabeth Bohndiek
Raman micro-spectroscopy reveals the spatial distribution of fumarate in cells and tissues. Nature communications 15 (1) (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal 43 (11) (2024)
Sara Clerici, Christine Podrini, Davide Stefanoni, Gianfranco Distefano, Laura Cassina, Maria Elena Steidl, Laura Tronci, Tamara Canu, Marco Chiaravalli, Daniel Spies, Thomas A Bell, Ana Sh Costa, Antonio Esposito, Angelo D'Alessandro, Christian Frezza, Angela Bachi, Alessandra Boletta
Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression. EMBO molecular medicine 16 (6) (2024)
Luca Peruzzotti-Jametti, C M Willis, G Krzak, R Hamel, L Pirvan, Rosana-Bristena Ionescu, J A Reisz, Hiran A Prag, M E Garcia-Segura, V Wu, Y Xiang, B Barlas, Alva M Casey, A M R van den Bosch, Alexandra M Nicaise, L Roth, G R Bates, H Huang, P Prasad, A E Vincent, Christian Frezza, Carlos Pardo-Hernández, Gabriel Balmus, Zoltán Takáts, John C Marioni, Angelo D'Alessandro, Michael P Murphy, Irina I Mohorianu, Stefano Pluchino
Mitochondrial complex I activity in microglia sustains neuroinflammation. Nature 628 (8006) (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Author Correction: Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal (2024)
Marlous Kamp, Jakub Maciej Surmacki, Marc Segarra Mondejar, Tim Young, Karolina Chrabaszcz, Fadwa Joud, Vincent Zecchini, Alyson Speed, Christian Frezza, Sarah Elizabeth Bohndiek
Raman micro-spectroscopy reveals the spatial distribution of fumarate in cells and tissues. Nature communications 15 (1) (2024)
Maria Elena Steidl, Elisa A Nigro, Anne Kallehauge Nielsen, Roberto Pagliarini, Laura Cassina, Matteo Lampis, Christine Podrini, Marco Chiaravalli, Valeria Mannella, Gianfranco Distefano, Ming Yang, Mariam Aslanyan, Giovanna Musco, Ronald Roepman, Christian Frezza, Alessandra Boletta
Primary cilia sense glutamine availability and respond via asparagine synthetase. Nature metabolism (2023)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature 625 (7994) (2023)
Alexander Hooftman, Christian G Peace, Dylan Gerard Ryan, Emily Anne Day, Ming Yang, Anne F McGettrick, Maureen Yin, Erica N Montano, Lihong Huo, Juliana E Toller-Kawahisa, Vincent Zecchini, Tristram Alexander Jasper Ryan, Alfonso Bolado Carrancio, Alva M Casey, Hiran A Prag, Ana S H Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alexander von Kriegsheim, Michael P Murphy, Caroline Jefferies, Christian Frezza, Luke Anthony John O'Neill
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature (2023)
Alexander Hooftman, Christian G Peace, Dylan Gerard Ryan, Emily Anne Day, Ming Yang, Anne F McGettrick, Maureen Yin, Erica N Montano, Lihong Huo, Juliana E Toller-Kawahisa, Vincent Zecchini, Tristram Alexander Jasper Ryan, Alfonso Bolado Carrancio, Alva M Casey, Hiran A Prag, Ana S H Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alexander von Kriegsheim, Michael P Murphy, Caroline Jefferies, Christian Frezza, Luke Anthony John O'Neill
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature (2023)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature 625 (7994) (2023)
Alexander Hooftman, Christian G Peace, Dylan Gerard Ryan, Emily Anne Day, Ming Yang, Anne F McGettrick, Maureen Yin, Erica N Montano, Lihong Huo, Juliana E Toller-Kawahisa, Vincent Zecchini, Tristram Alexander Jasper Ryan, Alfonso Bolado Carrancio, Alva M Casey, Hiran A Prag, Ana S H Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alexander von Kriegsheim, Michael P Murphy, Caroline Jefferies, Christian Frezza, Luke Anthony John O'Neill
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature 615 (7952) (2023)
Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge M N Wortel, Jordan L Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana S H Costa, Gonçalo C Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dóra Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith A Samarajiwa, Maxine Tran, Thomas J Mitchell, Mark Johnson, Julien Prudent, Christian Frezza
Fumarate induces vesicular release of mtDNA to drive innate immunity. Nature 615 (7952) (2023)
Alexander Hooftman, Christian G Peace, Dylan Gerard Ryan, Emily Anne Day, Ming Yang, Anne F McGettrick, Maureen Yin, Erica N Montano, Lihong Huo, Juliana E Toller-Kawahisa, Vincent Zecchini, Tristram Alexander Jasper Ryan, Alfonso Bolado Carrancio, Alva M Casey, Hiran A Prag, Ana S H Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alexander von Kriegsheim, Michael P Murphy, Caroline Jefferies, Christian Frezza, Luke Anthony John O'Neill
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature 615 (7952) (2023)
Lorea Valcarcel-Jimenez, Christian Frezza
Fumarate hydratase (FH) and cancer: a paradigm of oncometabolism. British journal of cancer (2023)
Alexander Hooftman, Christian G Peace, Dylan Gerard Ryan, Emily Anne Day, Ming Yang, Anne F McGettrick, Maureen Yin, Erica N Montano, Lihong Huo, Juliana E Toller-Kawahisa, Vincent Zecchini, Tristram Alexander Jasper Ryan, Alfonso Bolado Carrancio, Alva M Casey, Hiran A Prag, Ana S H Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alexander von Kriegsheim, Michael P Murphy, Caroline Jefferies, Christian Frezza, Luke Anthony John O'Neill
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature 615 (7952) (2023)
Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge M N Wortel, Jordan L Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana S H Costa, Gonçalo C Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dóra Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith A Samarajiwa, Maxine Tran, Thomas J Mitchell, Mark Johnson, Julien Prudent, Christian Frezza
Fumarate induces vesicular release of mtDNA to drive innate immunity. Nature (2023)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature 625 (7994) (2023)
Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge M N Wortel, Jordan L Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana S H Costa, Gonçalo C Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dóra Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith A Samarajiwa, Maxine Tran, Thomas J Mitchell, Mark Johnson, Julien Prudent, Christian Frezza
Fumarate induces vesicular release of mtDNA to drive innate immunity. Nature (2023)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature 625 (7994) (2023)
Alexander Hooftman, Christian G Peace, Dylan Gerard Ryan, Emily Anne Day, Ming Yang, Anne F McGettrick, Maureen Yin, Erica N Montano, Lihong Huo, Juliana E Toller-Kawahisa, Vincent Zecchini, Tristram Alexander Jasper Ryan, Alfonso Bolado Carrancio, Alva M Casey, Hiran A Prag, Ana S H Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alexander von Kriegsheim, Michael P Murphy, Caroline Jefferies, Christian Frezza, Luke Anthony John O'Neill
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature (2023)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature 625 (7994) (2023)
Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge M N Wortel, Jordan L Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana S H Costa, Gonçalo C Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dóra Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith A Samarajiwa, Maxine Tran, Thomas J Mitchell, Mark Johnson, Julien Prudent, Christian Frezza
Fumarate induces vesicular release of mtDNA to drive innate immunity. Nature (2023)
Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge M N Wortel, Jordan L Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana S H Costa, Gonçalo C Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dóra Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith A Samarajiwa, Maxine Tran, Thomas J Mitchell, Mark Johnson, Julien Prudent, Christian Frezza
Fumarate induces vesicular release of mtDNA to drive innate immunity. Nature 615 (7952) (2023)
Craig B Thompson, Karen H Vousden, Randall S Johnson, Willem H Koppenol, Helmut Sies, Zhimin Lu, Lydia W S Finley, Christian Frezza, Jiyeon Kim, Zeping Hu, Caroline R Bartman
A century of the Warburg effect. Nature metabolism 5 (11) (2023)
Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge M N Wortel, Jordan L Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana S H Costa, Gonçalo C Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dóra Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith A Samarajiwa, Maxine Tran, Thomas J Mitchell, Mark Johnson, Julien Prudent, Christian Frezza
Fumarate induces vesicular release of mtDNA to drive innate immunity. Nature 615 (7952) (2023)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature 625 (7994) (2023)
Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic, Manolis Pasparakis
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature (2023)
Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge M N Wortel, Jordan L Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana S H Costa, Gonçalo C Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dóra Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith A Samarajiwa, Maxine Tran, Thomas J Mitchell, Mark Johnson, Julien Prudent, Christian Frezza
Fumarate induces vesicular release of mtDNA to drive innate immunity. Nature 615 (7952) (2023)
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S H Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R Zecchini, Sabrina H Rossi, Charles E Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent J Gnanapragasam, Anne Y Warren, Grant D Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression. Nature communications 13 (1) (2022)
Angela Riedel, Moutaz Helal, Luisa Pedro, Jonathan J Swietlik, David Shorthouse, Werner Schmitz, Lisa Haas, Timothy Young, Ana S H da Costa, Sarah Davidson, Pranjali Bhandare, Elmar Wolf, Benjamin A Hall, Christian Frezza, Thordur Oskarsson, Jacqueline D Shields
Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma. Cancer immunology research 10 (4) (2022)
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S H Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R Zecchini, Sabrina H Rossi, Charles E Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent J Gnanapragasam, Anne Y Warren, Grant D Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression. Nature communications 13 (1) (2022)
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S H Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R Zecchini, Sabrina H Rossi, Charles E Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent J Gnanapragasam, Anne Y Warren, Grant D Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression. Nature communications 13 (1) (2022)
Lorea Valcarcel Jimenez, Connor Rogerson, Cissy Yong, Christina Schmidt, Ming Yang, Monica Cremades-Rodelgo, Victoria Harle, Victoria Offord, Kim Wong, Ariane Mora, Alyson Speed, Veronica Caraffini, Maxine Gia Binh Tran, Eamonn R Maher, Grant D Stewart, Sakari Vanharanta, David J Adams, Christian Frezza
HIRA loss transforms FH -deficient cells. Science advances 8 (42) (2022)
Upadhyayula S Srinivas, Norbert S C Tay, Patrick Jaynes, Akshaya Anbuselvan, Gokula K Ramachandran, Joanna D Wardyn, Michal Marek Hoppe, Phuong Mai Hoang, Yanfen Peng, Sherlly Lim, May Yin Lee, Praveen C Peethala, Omer An, Akshay Shendre, Bryce W Q Tan, Sherlyn Jemimah, Manikandan Lakshmanan, Longyu Hu, Rekha Jakhar, Karishma Sachaphibulkij, Lina H K Lim, Shazib Pervaiz, Karen Crasta, Henry Yang, Patrick Tan, Chao Liang, Lena Ho, Vartika Khanchandani, Dennis Kappei, Wei Peng Yong, David S P Tan, Matteo Bordi, Silvia Campello, Wai Leong Tam, Christian Frezza, Anand D Jeyasekharan
PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production. Oncogene 41 (13) (2022)
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S H Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R Zecchini, Sabrina H Rossi, Charles E Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent J Gnanapragasam, Anne Y Warren, Grant D Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression. Nature communications 13 (1) (2022)
Rebecca Harris, Ming Yang, Christina Schmidt, Chloe Royet, Yongseok Choi, Amarnath Natarajan, May C Morris, Christian Frezza, Heike Laman
Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells. The Journal of cell biology 221 (7) (2022)
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S H Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R Zecchini, Sabrina H Rossi, Charles E Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent J Gnanapragasam, Anne Y Warren, Grant D Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression. Nature communications 13 (1) (2022)
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S H Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R Zecchini, Sabrina H Rossi, Charles E Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent J Gnanapragasam, Anne Y Warren, Grant D Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression. Nature communications 13 (1) (2022)
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S H Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R Zecchini, Sabrina H Rossi, Charles E Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent J Gnanapragasam, Anne Y Warren, Grant D Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression. Nature communications 13 (1) (2022)
Dylan Gerard Ryan, Christian Frezza
Metabolic symbiosis in pancreatic cancer. Nature cancer 3 (11) (2022)
Jack L Martin, Ana S H Costa, Anja V Gruszczyk, Timothy E Beach, Fay M Allen, Hiran A Prag, Elizabeth C Hinchy, Krishnaa T A Mahbubani, Mazin Hamed, Laura Tronci, Efterpi Nikitopoulou, Andrew M James, Thomas Krieg, Alan J Robinson, Margaret M Huang, Stuart T Caldwell, Angela Logan, Laura Pala, Richard C Hartley, Christian Frezza, Kourosh Saeb Parsy, Michael P Murphy
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation. Nature metabolism 1 (2021)
Jorge Andrade, Chenyue Shi, Ana S H Costa, Jeongwoon Choi, Jaeryung Kim, Anuradha Doddaballapur, Toshiya Sugino, Yu Ting Ong, Marco Castro, Barbara Zimmermann, Manuel Kaulich, Stefan Guenther, Kerstin Wilhelm, Yoshiaki Kubota, Thomas Braun, Gou Young Koh, Ana Rita Grosso, Christian Frezza, Michael Potente
Control of endothelial quiescence by FOXO-regulated metabolites. Nature cell biology 23 (4) (2021)
John S O'Neill, Nathaniel P Hoyle, J Brian Robertson, Rachel S Edgar, Andrew D Beale, Sew Peak Chew, Jason Day, Ana S H Costa, Christian Frezza, Helen C Causton
Author Correction: Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis. Nature communications 12 (1) (2021)
Dylan Gerard Ryan, Ming Yang, Hiran A Prag, Giovanny Rodriguez Blanco, Efterpi Nikitopoulou, Marc Segarra-Mondejar, Christopher A Powell, Timothy Young, Nils Burger, Jan Lj Miljkovic, Michal Minczuk, Michael P Murphy, Alex von Kriegsheim, Christian Frezza
Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism. eLife 10 (2021)
Stanley W K Ng, Foad J Rouhani, Simon F Brunner, Natalia Brzozowska, Sarah J Aitken, Ming Yang, Federico Abascal, Luiza Moore, Efterpi Nikitopoulou, Lia Chappell, Daniel A Leongamornlert, Aleksandra Ivovic, Philip S Robinson, Timothy M Butler, Mathijs A Sanders, Nicholas O Williams, Tim H H Coorens, Jon Teague, Keiran M Raine, Adam P Butler, Yvette Hooks, Beverley Wilson, Natalie Birtchnell, Huw W Naylor, Susan E Davies, Michael R Stratton, Iñigo Martincorena, Raheleh Rahbari, Christian Frezza, Matthew Hoare, Peter J Campbell
Convergent somatic mutations in metabolism genes in chronic liver disease. Nature 598 (7881) (2021)
Aurélien J F Dugourd, Christoph Kuppe, Marco Sciacovelli, Enio Gjerga, Attila Gabor, Kristina B Emdal, Vitor Vieira, Dorte B Bekker-Jensen, Jennifer Kranz, Eric M J Bindels, Ana S H Costa, Abel Sousa, Pedro Beltrao, Miguel Rocha, Jesper Velgaard Olsen, Christian Frezza, Rafael Kramann, Julio Saez-Rodriguez
Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses. Molecular systems biology 17 (1) (2021)
Clément Bodineau, Mercedes Tomé, Sarah Courtois, Ana S H Costa, Marco Sciacovelli, Benoit Rousseau, Elodie Richard, Pierre Vacher, Carlos Parejo-Pérez, Emilie Bessede, Christine Varon, Pierre Soubeyran, Christian Frezza, Piedad Del Socorro Murdoch, Victor H Villar, Raúl V Durán
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis. Nature communications 12 (1) (2021)
Peter S J Bailey, Brian M Ortmann, Anthony W Martinelli, Jack William Houghton, Ana S H Costa, Stephen P Burr, Robin Antrobus, Christian Frezza, James A Nathan
ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex. Nature communications 11 (1) (2020)
Fevzi Demircioglu, Jun Wang, Juliana Candido, Ana S H Costa, Pedro Casado, Beatriz de Luxan Delgado, Louise E Reynolds, Jesus Gomez-Escudero, Emma Newport, Vinothini Rajeeve, Ann-Marie C Baker, Marina Roy-Luzarraga, Trevor A Graham, Julie Foster, Yu Wang, James J Campbell, Rajinder Singh, Penglie Zhang, Thomas J Schall, Frances R Balkwill, Jane Sosabowski, Pedro Rodriguez Cutillas, Christian Frezza, Patricia Sancho, Kairbaan Hodivala-Dilke
Cancer associated fibroblast FAK regulates malignant cell metabolism. Nature communications 11 (1) (2020)
John S O'Neill, Nathaniel P Hoyle, J Brian Robertson, Rachel S Edgar, Andrew D Beale, Sew Peak Chew, Jason Day, Ana S H Costa, Christian Frezza, Helen C Causton
Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis. Nature communications 11 (1) (2020)
Sarah-Maria Fendt, Christian Frezza, Ayelet Erez
Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy. Cancer discovery 10 (12) (2020)
Patrizia Romani, Lorea Valcarcel-Jimenez, Christian Frezza, Sirio Dupont
Crosstalk between mechanotransduction and metabolism. Nature reviews. Molecular cell biology 22 (1) (2020)
Cissy Yong, Grant D Stewart, Christian Frezza
Oncometabolites in renal cancer. Nature reviews. Nephrology 16 (3) (2019)
Payam A Gammage, Carlos Pardo-Hernández, Marie-Lune Simard, Ana S H Costa, Edoardo Gaude, Christopher A Powell, Lindsey Van Haute, Beverly J McCann, Pedro Rebelo-Guiomar, Raffaele Cerutti, Lei Zhang, Edward J Rebar, Massimo Zeviani, Christian Frezza, James Bruce Stewart, Michal Minczuk
Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo. Nature medicine 24 (11) (2018)
Timothy I Johnson, Ana S H Costa, Ashley N Ferguson, Christian Frezza
Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation. Cell death & disease 9 (9) (2018)
Christine Podrini, Isaline Rowe, Roberto Pagliarini, Ana S H Costa, Marco Chiaravalli, Ivano Di Meo, Hyunho Kim, Gianfranco Distefano, Valeria Tiranti, Feng Qian, Diego di Bernardo, Christian Frezza, Alessandra Boletta
Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways. Communications biology 1 (2018)
Thomas M Connor, Simon Hoer, Andrew Mallett, Daniel P Gale, Aurora Gomez-Duran, Viktor Posse, Robin Antrobus, Pablo Moreno, Marco Sciacovelli, Christian Frezza, Jennifer Duff, Neil S Sheerin, John Andrew Sayer, Margaret Ashcroft, Michael S Wiesener, Gavin Hudson, Claes M Gustafsson, Patrick F Chinnery, Patrick H Maxwell
Mutations in mitochondrial DNA causing tubulointerstitial kidney disease. PLoS genetics 13 (3) (2017)
Nunzio Iraci, Edoardo Gaude, Tommaso Leonardi, Ana S H Costa, Chiara Cossetti, Luca Peruzzotti-Jametti, Joshua D Bernstock, Harpreet K Saini, Maurizio Gelati, Angelo Luigi Vescovi, Carlos Bastos, Nuno Faria, Luigi G Occhipinti, Anton J Enright, Christian Frezza, Stefano Pluchino
Extracellular vesicles are independent metabolic units with asparaginase activity. Nature chemical biology 13 (9) (2017)
Edoardo Gaude, Christian Frezza
Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival. Nature communications 7 (2016)
Marco Sciacovelli, Christian Frezza
Fumarate drives EMT in renal cancer. Cell death and differentiation 24 (1) (2016)

Christian Frezza.css-eqlu8i{font-size:small;padding-left:4px;} (C Frezza)

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Christian Frezza (C Frezza)