Mauro Modesti

ResearcherID Scopus Author ID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 28

Top Topics

Single Molecule

Top Venues

EMBO molecular medicine

Research square

Nature structural & molecular biology

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen L Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Lucio Iovanna
Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras G12D -driven tumors. EMBO molecular medicine 16 (3) (2024)
Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen L Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Lucio Iovanna
Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras G12D -driven tumors. EMBO molecular medicine 16 (3) (2024)
Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen L Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Lucio Iovanna
Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras G12D -driven tumors. EMBO molecular medicine (2024)
Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen L Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Lucio Iovanna
Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras G12D -driven tumors. EMBO molecular medicine 16 (3) (2024)
Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen L Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Lucio Iovanna
Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras G12D -driven tumors. EMBO molecular medicine (2024)
Duc-Duy Vu, Alessio Bonucci, Manon Brenière, Metztli Cisneros-Aguirre, Philippe Pelupessy, Ziqing Wang, Ludovic Carlier, Guillaume Bouvignies, Patricia Cortes, Aneel K Aggarwal, Martin Blackledge, Zoher Gueroui, Valérie Belle, Jeremy M Stark, Mauro Modesti, Fabien Ferrage
Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro. Nature structural & molecular biology (2024)
Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen L Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Lucio Iovanna
Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras G12D -driven tumors. EMBO molecular medicine (2024)
Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen L Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Lucio Iovanna
Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras G12D -driven tumors. EMBO molecular medicine 16 (3) (2024)
Duc-Duy Vu, Alessio Bonucci, Manon Brenière, Metztli Cisneros-Aguirre, Philippe Pelupessy, Ziqing Wang, Ludovic Carlier, Guillaume Bouvignies, Patricia Cortes, Aneel K Aggarwal, Martin Blackledge, Zoher Gueroui, Valérie Belle, Jeremy M Stark, Mauro Modesti, Fabien Ferrage
Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro. Nature structural & molecular biology (2024)
Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen L Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Lucio Iovanna
Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras G12D -driven tumors. EMBO molecular medicine (2024)
Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen L Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Lucio Iovanna
Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras G12D -driven tumors. EMBO molecular medicine 16 (3) (2024)
Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen L Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Lucio Iovanna
Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras G12D -driven tumors. EMBO molecular medicine 16 (3) (2024)
Christopher J Buehl, Noah J Goff, Mariia Mikhova, Steven W Hardwick, Thomas L Blundell, Mauro Modesti, Jens C Schmidt, Amanda K Chaplin, Katheryn Meek
Unravelling the complexities of DNA-PK activation by structure-based mutagenesis. Research square (2023)
Duc-Duy Vu, Alessio Bonucci, Manon Brenière, Metztli Cisneros-Aguirre, Philippe Pelupessy, Ziqing Wang, Ludovic Carlier, Guillaume Bouvignies, Patricia Cortes, Aneel K Aggarwal, Martin Blackledge, Zoher Gueroui, Valérie Belle, Jeremy M Stark, Mauro Modesti, Fabien Ferrage
Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro . bioRxiv : the preprint server for biology (2023)
Katheryn Meek, Christopher Buehl, Noah Goff, Mariia Mikhova, Steven W Hardwick, Thomas L Blundell, Mauro Modesti, Jens Schmidt, Amanda K Chaplin
Unravelling the complexities of DNA-PK activation by structure-based mutagenesis. Research square (2023)
Katheryn Meek, Christopher Buehl, Noah Goff, Mariia Mikhova, Steven W Hardwick, Thomas L Blundell, Mauro Modesti, Jens Schmidt, Amanda K Chaplin
Unravelling the complexities of DNA-PK activation by structure-based mutagenesis. Research square (2023)
Christopher J Buehl, Noah J Goff, Mariia Mikhova, Steven W Hardwick, Thomas L Blundell, Mauro Modesti, Jens C Schmidt, Amanda K Chaplin, Katheryn Meek
Unravelling the complexities of DNA-PK activation by structure-based mutagenesis. Research square (2023)
Christopher J Buehl, Noah J Goff, Mariia Mikhova, Steven W Hardwick, Thomas L Blundell, Mauro Modesti, Jens C Schmidt, Amanda K Chaplin, Katheryn Meek
Unravelling the complexities of DNA-PK activation by structure-based mutagenesis. Research square (2023)
Lu-Lu Bi, Zhenheng Qin, Teng Wang, Yanan Li, Xinshuo Jia, Xia Zhang, Xi-Miao Hou, Mauro Modesti, Xu-Guang Xi, Bo Sun
The convergence of head-on DNA unwinding forks induces helicase oligomerization and activity transition. Proceedings of the National Academy of Sciences of the United States of America 119 (23) (2022)
Rohit Prakash, Yashpal Rawal, Meghan R Sullivan, McKenzie K Grundy, Hélène Bret, Michael J Mihalevic, Hayley L Rein, Jared M Baird, Kristie Darrah, Fang Zhang, Raymond Wang, Tiffany A Traina, Marc R Radke, Scott H Kaufmann, Elizabeth M Swisher, Raphaël Guérois, Mauro Modesti, Patrick Sung, Maria Jasin, Kara A Bernstein
Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants. Proceedings of the National Academy of Sciences of the United States of America 119 (38) (2022)
Rohit Prakash, Thomas Sandoval, Florian Morati, Jennifer A Zagelbaum, Pei Xin Lim, Travis White, Brett Taylor, Raymond Wang, Emilie C B Desclos, Meghan R Sullivan, Hayley L Rein, Kara A Bernstein, Przemek M Krawczyk, Jean Gautier, Mauro Modesti, Fabio Vanoli, Maria Jasin
Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex. Nature communications 12 (1) (2021)
Wei Ting C Lee, Yandong Yin, Michael J Morten, Peter Tonzi, Pam Pam Gwo, Diana C Odermatt, Mauro Modesti, Sharon B Cantor, Kerstin Gari, Tony T Huang, Eli Rothenberg
Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling. Nature communications 12 (1) (2021)
Laura Cheradame, Ida Chiara Guerrera, Julie Gaston, Alain Schmitt, Vincent Jung, Nicolas Goudin, Marion Pouillard, Nina Radosevic-Robin, Mauro Modesti, Jean-Gabriel Judde, Stefano Cairo, Vincent Goffin
STING protects breast cancer cells from intrinsic and genotoxic-induced DNA instability via a non-canonical, cell-autonomous pathway. Oncogene 40 (49) (2021)
Matteo Berti, Federico Teloni, Sofija Mijic, Sebastian Ursich, Jevgenij Fuchs, Maria Dilia Palumbieri, Jana Krietsch, Jonas A Schmid, Edwige B Garcin, Stéphanie Gon, Mauro Modesti, Matthias Altmeyer, Massimo Lopes
Sequential role of RAD51 paralog complexes in replication fork remodeling and restart. Nature communications 11 (1) (2020)
Zhenheng Qin, Lulu Bi, Xi-Miao Hou, Siqi Zhang, Xia Zhang, Ying Lu, Ming Li, Mauro Modesti, Xu-Guang Xi, Bo Sun
Human RPA activates BLM's bidirectional DNA unwinding from a nick. eLife 9 (2020)
Kata Sarlós, Andreas S Biebricher, Anna H Bizard, Julia A M Bakx, Anna G Ferreté-Bonastre, Mauro Modesti, Manikandan Paramasivam, Qi Yao, Erwin J G Peterman, Gijs J L Wuite, Ian D Hickson
Reconstitution of anaphase DNA bridge recognition and disjunction. Nature structural & molecular biology 25 (9) (2018)
Clement Nemoz, Virginie Ropars, Philippe Frit, Amandine Gontier, Pascal Drevet, Jinchao Yu, Raphaël Guérois, Aurelien Pitois, Audrey Comte, Christine Delteil, Nadia Barboule, Pierre Legrand, Sonia Baconnais, Yandong Yin, Satish Tadi, Emeline Barbet-Massin, Imre Berger, Eric Le Cam, Mauro Modesti, Eli Rothenberg, Patrick Calsou, Jean Baptiste Charbonnier
XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining. Nature structural & molecular biology 25 (10) (2018)
Davide Normanno, Aurélie Négrel, Abinadabe J de Melo, Stéphane Betzi, Katheryn Meek, Mauro Modesti
Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining. eLife 6 (2017)