Michael Lazarou

Scopus Author ID Scopus Author ID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 51

Top Topics

Nlrp Inflammasome

Top Venues

Science advances

The EMBO journal

The Journal of cell biology

Cell death and differentiation

This page only lists publications with an associated author ORCID identifier.

Publications

Elias Adriaenssens, Stefan Schaar, Annan S I Cook, Jan F M Stuke, Justyna Sawa-Makarska, Thanh Ngoc Nguyen, Xuefeng Ren, Martina Schuschnig, Julia Romanov, Grace Khuu, Michael Lazarou, Gerhard Hummer, James H Hurley, Sascha Martens
Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery. bioRxiv : the preprint server for biology (2024)
Dan A Tudorica, Bishal Basak, Alexia S Puerta Cordova, Grace Khuu, Kevin M Rose, Michael Lazarou, Erika L F Holzbaur, James H Hurley
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. The Journal of cell biology 223 (7) (2024)
Tahnee L Saunders, Simon P Windley, Gediminas Gervinskas, Katherine R Balka, Caitlin L Rowe, Rachael Lane, Maximilien Tailler, Thanh Ngoc Nguyen, Georg Ramm, Michael Lazarou, Dominic De Nardo, Benjamin T Kile, Kate McArthur
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy. Cell death and differentiation 31 (3) (2024)
Dan A Tudorica, Bishal Basak, Alexia S Puerta Cordova, Grace Khuu, Kevin M Rose, Michael Lazarou, Erika L F Holzbaur, James H Hurley
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. The Journal of cell biology 223 (7) (2024)
Dan A Tudorica, Bishal Basak, Alexia S Puerta Cordova, Grace Khuu, Kevin M Rose, Michael Lazarou, Erika L F Holzbaur, James H Hurley
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. The Journal of cell biology 223 (7) (2024)
Zhong Yan Gan, Sylvie Callegari, Thanh Ngoc Nguyen, Nicholas S Kirk, Andrew Leis, Michael Lazarou, Grant Dewson, David Komander
Interaction of PINK1 with nucleotides and kinetin. Science advances 10 (3) (2024)
Tahnee L Saunders, Simon P Windley, Gediminas Gervinskas, Katherine R Balka, Caitlin L Rowe, Rachael Lane, Maximilien Tailler, Thanh Ngoc Nguyen, Georg Ramm, Michael Lazarou, Dominic De Nardo, Benjamin T Kile, Kate McArthur
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy. Cell death and differentiation 31 (3) (2024)
Tahnee L Saunders, Simon P Windley, Gediminas Gervinskas, Katherine R Balka, Caitlin L Rowe, Rachael Lane, Maximilien Tailler, Thanh Ngoc Nguyen, Georg Ramm, Michael Lazarou, Dominic De Nardo, Benjamin T Kile, Kate McArthur
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy. Cell death and differentiation 31 (3) (2024)
Shanlin Rao, Marvin Skulsuppaisarn, Lisa M Strong, Xuefeng Ren, Michael Lazarou, James H Hurley, Gerhard Hummer
Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore. Science advances 10 (6) (2024)
Shanlin Rao, Marvin Skulsuppaisarn, Lisa M Strong, Xuefeng Ren, Michael Lazarou, James H Hurley, Gerhard Hummer
Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore. Science advances 10 (6) (2024)
Dan A Tudorica, Bishal Basak, Alexia S Puerta Cordova, Grace Khuu, Kevin M Rose, Michael Lazarou, Erika L F Holzbaur, James H Hurley
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. The Journal of cell biology 223 (7) (2024)
Tahnee L Saunders, Simon P Windley, Gediminas Gervinskas, Katherine R Balka, Caitlin L Rowe, Rachael Lane, Maximilien Tailler, Thanh Ngoc Nguyen, Georg Ramm, Michael Lazarou, Dominic De Nardo, Benjamin T Kile, Kate McArthur
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy. Cell death and differentiation (2024)
Elias Adriaenssens, Thanh Ngoc Nguyen, Justyna Sawa-Makarska, Grace Khuu, Martina Schuschnig, Stephen Shoebridge, Marvin Skulsuppaisarn, Emily Maria Watts, Kitti Dora Csalyi, Benjamin Scott Padman, Michael Lazarou, Sascha Martens
Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD. Nature structural & molecular biology (2024)
Shanlin Rao, Marvin Skulsuppaisarn, Lisa M Strong, Xuefeng Ren, Michael Lazarou, James H Hurley, Gerhard Hummer
Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore. Science advances 10 (6) (2024)
Giang Dien Thanh Nguyen, Brendan Townsend, Prajakta Gosavi Kulkarni, Keri-Lyn Kozul, Soo Siang Ooi, Denaye N Eldershaw, Saroja Weeratunga, Meihan Liu, Mathew Jk Jones, S Sean Millard, Dominic Ch Ng, Michele Pagano, Alexis Bonfim-Melo, Tobias Schneider, David Komander, Michael Lazarou, Brett M Collins, Julia K Pagan
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4 . EMBO reports 25 (8) (2024)
Giang Dien Thanh Nguyen, Brendan Townsend, Prajakta Gosavi Kulkarni, Keri-Lyn Kozul, Soo Siang Ooi, Denaye N Eldershaw, Saroja Weeratunga, Meihan Liu, Mathew Jk Jones, S Sean Millard, Dominic Ch Ng, Michele Pagano, Alexis Bonfim-Melo, Tobias Schneider, David Komander, Michael Lazarou, Brett M Collins, Julia K Pagan
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4 . EMBO reports 25 (8) (2024)
Giang Dien Thanh Nguyen, Brendan Townsend, Prajakta Gosavi Kulkarni, Keri-Lyn Kozul, Soo Siang Ooi, Denaye N Eldershaw, Saroja Weeratunga, Meihan Liu, Mathew Jk Jones, S Sean Millard, Dominic Ch Ng, Michele Pagano, Alexis Bonfim-Melo, Tobias Schneider, David Komander, Michael Lazarou, Brett M Collins, Julia K Pagan
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4 . EMBO reports 25 (8) (2024)
Tahnee L Saunders, Simon P Windley, Gediminas Gervinskas, Katherine R Balka, Caitlin L Rowe, Rachael Lane, Maximilien Tailler, Thanh Ngoc Nguyen, Georg Ramm, Michael Lazarou, Dominic De Nardo, Benjamin T Kile, Kate McArthur
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy. Cell death and differentiation 31 (3) (2024)
Giang Dien Thanh Nguyen, Brendan Townsend, Prajakta Gosavi Kulkarni, Keri-Lyn Kozul, Soo Siang Ooi, Denaye N Eldershaw, Saroja Weeratunga, Meihan Liu, Mathew Jk Jones, S Sean Millard, Dominic Ch Ng, Michele Pagano, Alexis Bonfim-Melo, Tobias Schneider, David Komander, Michael Lazarou, Brett M Collins, Julia K Pagan
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4 . EMBO reports 25 (8) (2024)
Zhong Yan Gan, Sylvie Callegari, Thanh Ngoc Nguyen, Nicholas S Kirk, Andrew Leis, Michael Lazarou, Grant Dewson, David Komander
Interaction of PINK1 with nucleotides and kinetin. Science advances 10 (3) (2024)
Tahnee L Saunders, Simon P Windley, Gediminas Gervinskas, Katherine R Balka, Caitlin L Rowe, Rachael Lane, Maximilien Tailler, Thanh Ngoc Nguyen, Georg Ramm, Michael Lazarou, Dominic De Nardo, Benjamin T Kile, Kate McArthur
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy. Cell death and differentiation 31 (3) (2024)
Giang Dien Thanh Nguyen, Brendan Townsend, Prajakta Gosavi Kulkarni, Keri-Lyn Kozul, Soo Siang Ooi, Denaye N Eldershaw, Saroja Weeratunga, Meihan Liu, Mathew Jk Jones, S Sean Millard, Dominic Ch Ng, Michele Pagano, Alexis Bonfim-Melo, Tobias Schneider, David Komander, Michael Lazarou, Brett M Collins, Julia K Pagan
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4 . EMBO reports (2024)
Dan A Tudorica, Bishal Basak, Alexia S Puerta Cordova, Grace Khuu, Kevin M Rose, Michael Lazarou, Erika L F Holzbaur, James H Hurley
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. The Journal of cell biology 223 (7) (2024)
Zhong Yan Gan, Sylvie Callegari, Thanh Ngoc Nguyen, Nicholas S Kirk, Andrew Leis, Michael Lazarou, Grant Dewson, David Komander
Interaction of PINK1 with nucleotides and kinetin. Science advances 10 (3) (2024)
Louise Uoselis, Runa S J Lindblom, Wai Kit Lam, Catharina J Küng, Marvin Skulsuppaisarn, Grace Khuu, Thanh Ngoc Nguyen, Danielle L Rudler, Aleksandra Filipovska, Ralf Bernd Schittenhelm, Michael Lazarou
Temporal landscape of mitochondrial proteostasis governed by the UPR mt . Science advances 9 (38) (2023)
Xuefeng Ren, Thanh Ngoc Nguyen, Wai Kit Lam, Cosmo Z Buffalo, Michael Lazarou, Adam L Yokom, James H Hurley
Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation. Science advances 9 (7) (2023)
Xuefeng Ren, Thanh Ngoc Nguyen, Wai Kit Lam, Cosmo Z Buffalo, Michael Lazarou, Adam L Yokom, James H Hurley
Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation. Science advances 9 (7) (2023)
Xuefeng Ren, Thanh Ngoc Nguyen, Wai Kit Lam, Cosmo Z Buffalo, Michael Lazarou, Adam L Yokom, James H Hurley
Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation. Science advances 9 (7) (2023)
Xuefeng Ren, Thanh Ngoc Nguyen, Wai Kit Lam, Cosmo Z Buffalo, Michael Lazarou, Adam L Yokom, James H Hurley
Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation. Science advances 9 (7) (2023)
Thanh Ngoc Nguyen, Michael Lazarou
A unifying model for the role of the ATG8 system in autophagy. Journal of cell science 135 (11) (2022)
Tetsushi Kataura, Elsje G Otten, Yoana Rabanal-Ruiz, Elias Adriaenssens, Francesca Urselli, Filippo Scialo, Lanyu Fan, Graham R Smith, William M Dawson, Xingxiang Chen, Wyatt W Yue, Agnieszka K Bronowska, Bernadette Carroll, Sascha Martens, Michael Lazarou, Viktor I Korolchuk
NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy. The EMBO journal 42 (5) (2022)
Tetsushi Kataura, Elsje G Otten, Yoana Rabanal-Ruiz, Elias Adriaenssens, Francesca Urselli, Filippo Scialo, Lanyu Fan, Graham R Smith, William M Dawson, Xingxiang Chen, Wyatt W Yue, Agnieszka K Bronowska, Bernadette Carroll, Sascha Martens, Michael Lazarou, Viktor I Korolchuk
NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy. The EMBO journal 42 (5) (2022)
Tetsushi Kataura, Elsje G Otten, Yoana Rabanal-Ruiz, Elias Adriaenssens, Francesca Urselli, Filippo Scialo, Lanyu Fan, Graham R Smith, William M Dawson, Xingxiang Chen, Wyatt W Yue, Agnieszka K Bronowska, Bernadette Carroll, Sascha Martens, Michael Lazarou, Viktor I Korolchuk
NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy. The EMBO journal (2022)
Tetsushi Kataura, Elsje G Otten, Yoana Rabanal-Ruiz, Elias Adriaenssens, Francesca Urselli, Filippo Scialo, Lanyu Fan, Graham R Smith, William M Dawson, Xingxiang Chen, Wyatt W Yue, Agnieszka K Bronowska, Bernadette Carroll, Sascha Martens, Michael Lazarou, Viktor I Korolchuk
NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy. The EMBO journal 42 (5) (2022)
Tetsushi Kataura, Elsje G Otten, Yoana Rabanal-Ruiz, Elias Adriaenssens, Francesca Urselli, Filippo Scialo, Lanyu Fan, Graham R Smith, William M Dawson, Xingxiang Chen, Wyatt W Yue, Agnieszka K Bronowska, Bernadette Carroll, Sascha Martens, Michael Lazarou, Viktor I Korolchuk
NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy. The EMBO journal 42 (5) (2022)
Vojo P Deretic, Michael Lazarou
A guide to membrane atg8ylation and autophagy with reflections on immunity. The Journal of cell biology 221 (7) (2022)
Tetsushi Kataura, Elsje G Otten, Yoana Rabanal-Ruiz, Elias Adriaenssens, Francesca Urselli, Filippo Scialo, Lanyu Fan, Graham R Smith, William M Dawson, Xingxiang Chen, Wyatt W Yue, Agnieszka K Bronowska, Bernadette Carroll, Sascha Martens, Michael Lazarou, Viktor I Korolchuk
NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy. The EMBO journal 42 (5) (2022)
Selma Dahmane, Adeline Kerviel, Dustin R Morado, Kasturika Shankar, Björn Ahlman, Michael Lazarou, Nihal Altan-Bonnet, Lars-Anders Carlson
Membrane-assisted assembly and selective secretory autophagy of enteroviruses. Nature communications 13 (1) (2022)
Thanh Ngoc Nguyen, Benjamin Scott Padman, Michael Lazarou
ATG4s: above and beyond the Atg8-family protein lipidation system. Autophagy 17 (9) (2021)
Julian M Carosi, Thanh Ngoc Nguyen, Michael Lazarou, Sharad Kumar, Timothy J Sargeant
ATG8ylation of proteins: A way to cope with cell stress? The Journal of cell biology 220 (11) (2021)
Ryan G Gaudet, Shiwei Zhu, Anushka Halder, Bae-Hoon Kim, Clinton J Bradfield, Shuai Huang, Dijin Xu, Agnieszka Maminska, Thanh Ngoc Nguyen, Michael Lazarou, Erdem Karatekin, Kallol Gupta, John D MacMicking
A human apolipoprotein L with detergent-like activity kills intracellular pathogens. Science (New York, N.Y.) 373 (6552) (2021)
Sung-Eun Nam, Yiu Wing Sunny Cheung, Thanh Ngoc Nguyen, Michael Gong, Samuel Chan, Michael Lazarou, Calvin K Yip
Insights on autophagosome-lysosome tethering from structural and biochemical characterization of human autophagy factor EPG5. Communications biology 4 (1) (2021)
Suresh Kumar, Ashish Jain, Seong Won Choi, Gustavo Peixoto Duarte da Silva, Lee Allers, Michal H Mudd, Ryan Scott Peters, Jan Haug Anonsen, Tor-Erik Rusten, Michael Lazarou, Vojo P Deretic
Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB. Autophagy 16 (12) (2020)
Suresh Kumar, Ashish Jain, Seong Won Choi, Gustavo Peixoto Duarte da Silva, Lee Allers, Michal H Mudd, Ryan Scott Peters, Jan Haug Anonsen, Tor Erik Rusten, Michael Lazarou, Vojo P Deretic
Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens. Nature cell biology 22 (8) (2020)
Thanh Ngoc Nguyen, Michael Lazarou
Rebellious autophagy proteins bypass ATG8 lipidation, taking their own path to autophagic degradation. The EMBO journal 39 (24) (2020)
Yuexi Gu, Yakubu Princely Abudu, Suresh Kumar, Bhawana Bissa, Seong Won Choi, Jingyue Jia, Michael Lazarou, Eeva-Liisa Eskelinen, Terje Johansen, Vojo P Deretic
Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs. The EMBO journal 38 (22) (2019)
Benjamin Scott Padman, Thanh Ngoc Nguyen, Louise Uoselis, Marvin Skulsuppaisarn, Lan K Nguyen, Michael Lazarou
LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy. Nature communications 10 (1) (2019)
Koji Yamano, Michael Lazarou
YoungMito 2018: Report on the 1st International Mitochondria Meeting for Young Scientists. Genes to cells : devoted to molecular & cellular mechanisms 23 (10) (2018)
Jonathan P Bernardini, Jason M Brouwer, Iris Kl Tan, Jarrod J Sandow, Shuai Huang, Che A Stafford, Aleksandra Bankovacki, Christopher D Riffkin, Ahmad Z Wardak, Peter E Czabotar, Michael Lazarou, Grant Dewson
Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy. The EMBO journal 38 (2) (2018)
Lisa M Lindqvist, Daniel Frank, Kate McArthur, Toby A Dite, Michael Lazarou, Jonathan S Oakhill, Benjamin T Kile, David L Vaux
Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion. Cell death and differentiation 25 (4) (2017)
Thanh Ngoc Nguyen, Benjamin Scott Padman, Joanne L Usher, Viola Oorschot, Georg Ramm, Michael Lazarou
Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation. The Journal of cell biology 215 (6) (2016)