James H Hurley

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 68

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Science advances

Nature

The Journal of cell biology

University of California, Berkeley

UC San Francisco (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of California, Berkeley Jul 01 2013

United States

Professor :: Molecular and Cell Biology

Education History

UC San Francisco

United States

PHD :: Biophysics

Publications

Elias Adriaenssens, Stefan Schaar, Annan S I Cook, Jan F M Stuke, Justyna Sawa-Makarska, Thanh Ngoc Nguyen, Xuefeng Ren, Martina Schuschnig, Julia Romanov, Grace Khuu, Michael Lazarou, Gerhard Hummer, James H Hurley, Sascha Martens
Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery. bioRxiv : the preprint server for biology (2024)
Dan A Tudorica, Bishal Basak, Alexia S Puerta Cordova, Grace Khuu, Kevin M Rose, Michael Lazarou, Erika L F Holzbaur, James H Hurley
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. The Journal of cell biology 223 (7) (2024)
Dan A Tudorica, Bishal Basak, Alexia S Puerta Cordova, Grace Khuu, Kevin M Rose, Michael Lazarou, Erika L F Holzbaur, James H Hurley
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. The Journal of cell biology 223 (7) (2024)
Kevin M Rose, Tyler Jepson, Sankalp Shukla, Alex Maya-Romero, Martin Edward Kampmann, Ke Xu, James H Hurley
Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Dan A Tudorica, Bishal Basak, Alexia S Puerta Cordova, Grace Khuu, Kevin M Rose, Michael Lazarou, Erika L F Holzbaur, James H Hurley
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. The Journal of cell biology 223 (7) (2024)
Sankalp Shukla, Wei Chen, Shanlin Rao, Serim Yang, Chenxi Ou, Kevin P Larsen, Gerhard Hummer, Phyllis I Hanson, James H Hurley
Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca 2+ -sensor ALG-2. Proceedings of the National Academy of Sciences of the United States of America 121 (9) (2024)
Kevin M Rose, Tyler Jepson, Sankalp Shukla, Alex Maya-Romero, Martin Edward Kampmann, Ke Xu, James H Hurley
Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Sankalp Shukla, Wei Chen, Shanlin Rao, Serim Yang, Chenxi Ou, Kevin P Larsen, Gerhard Hummer, Phyllis I Hanson, James H Hurley
Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca 2+ -sensor ALG-2. Proceedings of the National Academy of Sciences of the United States of America 121 (9) (2024)
Shanlin Rao, Marvin Skulsuppaisarn, Lisa M Strong, Xuefeng Ren, Michael Lazarou, James H Hurley, Gerhard Hummer
Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore. Science advances 10 (6) (2024)
Shanlin Rao, Marvin Skulsuppaisarn, Lisa M Strong, Xuefeng Ren, Michael Lazarou, James H Hurley, Gerhard Hummer
Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore. Science advances 10 (6) (2024)
Dan A Tudorica, Bishal Basak, Alexia S Puerta Cordova, Grace Khuu, Kevin M Rose, Michael Lazarou, Erika L F Holzbaur, James H Hurley
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. The Journal of cell biology 223 (7) (2024)
Shanlin Rao, Marvin Skulsuppaisarn, Lisa M Strong, Xuefeng Ren, Michael Lazarou, James H Hurley, Gerhard Hummer
Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore. Science advances 10 (6) (2024)
Sankalp Shukla, Wei Chen, Shanlin Rao, Serim Yang, Chenxi Ou, Kevin P Larsen, Gerhard Hummer, Phyllis I Hanson, James H Hurley
Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca 2+ -sensor ALG-2. Proceedings of the National Academy of Sciences of the United States of America 121 (9) (2024)
Sankalp Shukla, Wei Chen, Shanlin Rao, Serim Yang, Chenxi Ou, Kevin P Larsen, Gerhard Hummer, Phyllis I Hanson, James H Hurley
Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca 2+ -sensor ALG-2. Proceedings of the National Academy of Sciences of the United States of America 121 (9) (2024)
Sankalp Shukla, Wei Chen, Shanlin Rao, Serim Yang, Chenxi Ou, Kevin P Larsen, Gerhard Hummer, Phyllis I Hanson, James H Hurley
Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca 2+ -sensor ALG-2. Proceedings of the National Academy of Sciences of the United States of America 121 (9) (2024)
Kevin M Rose, Tyler Jepson, Sankalp Shukla, Alex Maya-Romero, Martin Edward Kampmann, Ke Xu, James H Hurley
Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Dan A Tudorica, Bishal Basak, Alexia S Puerta Cordova, Grace Khuu, Kevin M Rose, Michael Lazarou, Erika L F Holzbaur, James H Hurley
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. The Journal of cell biology 223 (7) (2024)
Kevin M Rose, Tyler Jepson, Sankalp Shukla, Alex Maya-Romero, Martin Edward Kampmann, Ke Xu, James H Hurley
Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Kevin M Rose, Tyler Jepson, Sankalp Shukla, Alex Maya-Romero, Martin Edward Kampmann, Ke Xu, James H Hurley
Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Kevin M Rose, Tyler Jepson, Sankalp Shukla, Alex Maya-Romero, Martin Edward Kampmann, Ke Xu, James H Hurley
Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Yuichiro Iwamoto, Anna A Ye, Cyna R Shirazinejad, James H Hurley, David G Drubin
Kinetic investigation reveals an HIV-1 Nef-dependent increase in AP-2 recruitment and productivity at endocytic sites. bioRxiv : the preprint server for biology (2023)
Zhicheng Cui, Gennaro Napolitano, Mariana E G de Araujo, Alessandra Esposito, Jlenia Monfregola, Lukas A Huber, Andrea Balabio, James H Hurley
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature 614 (7948) (2023)
Yuichiro Iwamoto, Anna A Ye, Cyna R Shirazinejad, James H Hurley, David G Drubin
Kinetic investigation reveals an HIV-1 Nef-dependent increase in AP-2 recruitment and productivity at endocytic sites. bioRxiv : the preprint server for biology (2023)
Kevin Rose, Tyler Jepson, Sankalp Shukla, Alex Maya-Romero, Martin Edward Kampmann, Ke Xu, James H Hurley
Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes. bioRxiv : the preprint server for biology (2023)
Zhicheng Cui, Gennaro Napolitano, Mariana E G de Araujo, Alessandra Esposito, Jlenia Monfregola, Lukas A Huber, Andrea Balabio, James H Hurley
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature (2023)
Xuefeng Ren, Thanh Ngoc Nguyen, Wai Kit Lam, Cosmo Z Buffalo, Michael Lazarou, Adam L Yokom, James H Hurley
Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation. Science advances 9 (7) (2023)
Sankalp Shukla, Wei Chen, Shanlin Rao, Serim Yang, Chenxi Ou, Kevin P Larsen, Gerhard Hummer, Phyllis I Hanson, James H Hurley
Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca 2+ -sensor ALG-2. bioRxiv : the preprint server for biology (2023)
Zhicheng Cui, Gennaro Napolitano, Mariana E G de Araujo, Alessandra Esposito, Jlenia Monfregola, Lukas A Huber, Andrea Balabio, James H Hurley
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature 614 (7948) (2023)
Xuefeng Ren, Thanh Ngoc Nguyen, Wai Kit Lam, Cosmo Z Buffalo, Michael Lazarou, Adam L Yokom, James H Hurley
Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation. Science advances 9 (7) (2023)
Zhicheng Cui, Gennaro Napolitano, Mariana E G de Araujo, Alessandra Esposito, Jlenia Monfregola, Lukas A Huber, Andrea Balabio, James H Hurley
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature 614 (7948) (2023)
Xuefeng Ren, Thanh Ngoc Nguyen, Wai Kit Lam, Cosmo Z Buffalo, Michael Lazarou, Adam L Yokom, James H Hurley
Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation. Science advances 9 (7) (2023)
Zhicheng Cui, Gennaro Napolitano, Mariana E G de Araujo, Alessandra Esposito, Jlenia Monfregola, Lukas A Huber, Andrea Balabio, James H Hurley
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature 614 (7948) (2023)
Zhicheng Cui, Gennaro Napolitano, Mariana E G de Araujo, Alessandra Esposito, Jlenia Monfregola, Lukas A Huber, Andrea Balabio, James H Hurley
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature 614 (7948) (2023)
Zhicheng Cui, Gennaro Napolitano, Mariana E G de Araujo, Alessandra Esposito, Jlenia Monfregola, Lukas A Huber, Andrea Balabio, James H Hurley
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature (2023)
Zhicheng Cui, Gennaro Napolitano, Mariana E G de Araujo, Alessandra Esposito, Jlenia Monfregola, Lukas A Huber, Andrea Balabio, James H Hurley
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature (2023)
Xuefeng Ren, Thanh Ngoc Nguyen, Wai Kit Lam, Cosmo Z Buffalo, Michael Lazarou, Adam L Yokom, James H Hurley
Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation. Science advances 9 (7) (2023)
Zhicheng Cui, Gennaro Napolitano, Mariana E G de Araujo, Alessandra Esposito, Jlenia Monfregola, Lukas A Huber, Andrea Balabio, James H Hurley
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature (2023)
Annan S I Cook, James H Hurley
Toward a standard model for autophagosome biogenesis. The Journal of cell biology 222 (7) (2023)
Richard M Hooy, Yuichiro Iwamoto, Dan A Tudorica, Xuefeng Ren, James H Hurley
Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat. Science advances 8 (42) (2022)
A King Cada, Mark R Pavlin, Juan P Castillo, Alexander B Tong, Kevin P Larsen, Xuefeng Ren, Adam L Yokom, Feng-Ching Tsai, Jamie V Shiah, Patricia M Bassereau, Carlos J Bustamante, James H Hurley
Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1. Proceedings of the National Academy of Sciences of the United States of America 119 (29) (2022)
Ying Liu, Pengbiao Xu, Sophie Rivara, Chong Liu, Jonathan Ricci, Xuefeng Ren, James H Hurley, Andrea Ablasser
Clathrin-associated AP-1 controls termination of STING signalling. Nature 610 (7933) (2022)
Rachel M Jansen, James H Hurley
Longin domain GAP complexes in nutrient signalling, membrane traffic and neurodegeneration. FEBS letters (2022)
Liv E Jensen, Shanlin Rao, Martina Schuschnig, A King Cada, Sascha Martens, Gerhard Hummer, James H Hurley
Membrane curvature sensing and stabilization by the autophagic LC3 lipidation machinery. Science advances 8 (50) (2022)
Rachel M Jansen, Roberta Peruzzo, Simon A Fromm, Adam L Yokom, Roberto Zoncu, James H Hurley
Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation. Science advances 8 (37) (2022)
Liv E Jensen, Shanlin Rao, Martina Schuschnig, A King Cada, Sascha Martens, Gerhard Hummer, James H Hurley
Membrane curvature sensing and stabilization by the autophagic LC3 lipidation machinery. Science advances 8 (50) (2022)
Sankalp Shukla, Kevin P Larsen, Chenxi Ou, Kevin M Rose, James H Hurley
In vitro reconstitution of calcium-dependent recruitment of the human ESCRT machinery in lysosomal membrane repair. Proceedings of the National Academy of Sciences of the United States of America 119 (35) (2022)
Liv E Jensen, Shanlin Rao, Martina Schuschnig, A King Cada, Sascha Martens, Gerhard Hummer, James H Hurley
Membrane curvature sensing and stabilization by the autophagic LC3 lipidation machinery. Science advances 8 (50) (2022)
Ming-Yuan Su, Simon A Fromm, Jonathan Remis, Daniel B Toso, James H Hurley
Structural basis for the ARF GAP activity and specificity of the C9orf72 complex. Nature communications 12 (1) (2021)
Chunmei Chang, Liv E Jensen, James H Hurley
Autophagosome biogenesis comes out of the black box. Nature cell biology 23 (5) (2021)
Thomas G Flower, Cosmo Z Buffalo, Richard M Hooy, Marc Allaire, Xuefeng Ren, James H Hurley
Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein. Proceedings of the National Academy of Sciences of the United States of America 118 (2) (2021)
Chunmei Chang, Xiaoshan Shi, Liv E Jensen, Adam L Yokom, Dorotea Fracchiolla, Sascha Martens, James H Hurley
Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy. Science advances 7 (17) (2021)
Thomas G Flower, James H Hurley
Crystallographic molecular replacement using an in silico-generated search model of SARS-CoV-2 ORF8. Protein science : a publication of the Protein Society 30 (4) (2021)
Lisa M Strong, Chunmei Chang, Julia F Riley, C Alexander Boecker, Thomas G Flower, Cosmo Z Buffalo, Xuefeng Ren, Andrea K H Stavoe, Erika L F Holzbaur, James H Hurley
Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy. eLife 10 (2021)
Mark Remec Pavlin, James H Hurley
The ESCRTs - converging on mechanism. Journal of cell science 133 (18) (2020)
Simon A Fromm, Rosalie E Lawrence, James H Hurley
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9. Nature structural & molecular biology 27 (11) (2020)
Thomas G Flower, Yoshinori Takahashi, Arpa Hudait, Kevin M Rose, Nicholas Tjahjono, Alexander J Pak, Adam L Yokom, Xinwen Liang, Hong-Gang Wang, Fadila Bouamr, Gregory A Voth, James H Hurley
A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission. Nature structural & molecular biology 27 (6) (2020)
Mark M Painter, Gretchen E Zimmerman, Madeline S Merlino, Andrew W Robertson, Valeri H Terry, Xuefeng Ren, Megan R McLeod, Lyanne Gomez-Rodriguez, Kirsten A Garcia, Jolie A Leonard, Kay E Leopold, Andrew J Neevel, Jay Lubow, Eli Olson, Alicja Piechocka-Trocha, David R Collins, Ashootosh Tripathi, Malini Raghavan, Bruce D Walker, James H Hurley, David H Sherman, Kathleen L Collins
Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 117 (38) (2020)
Hersh K Bhargava, Keisuke Tabata, Jordan M Byck, Maho Hamasaki, Daniel P Farrell, David Baker, Frank DiMaio, Young Jun Im, Tamotsu Yoshimori, James H Hurley
Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex. Proceedings of the National Academy of Sciences of the United States of America 117 (29) (2020)
Ming-Yuan Su, Simon A Fromm, Roberto Zoncu, James H Hurley
Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD. Nature 585 (7824) (2020)
Xiaoshan Shi, Chunmei Chang, Adam L Yokom, Liv E Jensen, James H Hurley
The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment. eLife 9 (2020)
Johannes Schöneberg, Mark Remec Pavlin, Shannon Yan, Maurizio Righini, Il-Hyung Lee, Lars-Anders Carlson, Amir Houshang Bahrami, Daniel H Goldman, Xuefeng Ren, Gerhard Hummer, Carlos J Bustamante, James H Hurley
ATP-dependent force generation and membrane scission by ESCRT-III and Vps4. Science (New York, N.Y.) 362 (6421) (2019)
Rosalie E Lawrence, Simon A Fromm, Yangxue Fu, Adam L Yokom, Do Jin Kim, Ashley M Thelen, Lindsey N Young, Chun-Yan Lim, Avi J Samelson, James H Hurley, Roberto Zoncu
Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex. Science (New York, N.Y.) 366 (6468) (2019)
Benjamin G Horst, Adam L Yokom, Daniel J Rosenberg, Kyle L Morris, Michal Hammel, James H Hurley, Michael A Marletta
Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy. eLife 8 (2019)
Lindsey N Young, Felix Goerdeler, James H Hurley
Structural pathway for allosteric activation of the autophagic PI 3-kinase complex I. Proceedings of the National Academy of Sciences of the United States of America 116 (43) (2019)
James H Hurley, Ludger Johannes
Retro Styles for Vesicle Coats. Biochemistry 58 (6) (2019)
Ursula Schulze-Gahmen, James H Hurley
Structural mechanism for HIV-1 TAR loop recognition by Tat and the super elongation complex. Proceedings of the National Academy of Sciences of the United States of America 115 (51) (2018)
Ursula Schulze-Gahmen, Ignacia Echeverria, Goran Stjepanovic, Yun Bai, Huasong Lu, Dina Schneidman-Duhovny, Jennifer A Doudna, Qiang Zhou, Andrej Sali, James H Hurley
Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex. eLife 5 (2016)
Lars-Anders Carlson, Yun Bai, Sarah C Keane, Jennifer A Doudna, James H Hurley
Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies. eLife 5 (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

James H Hurley