David Komander

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 42

Top Topics

Top Venues

Nature communications

The Journal of experimental medicine

The EMBO journal

This page only lists publications with an associated author ORCID identifier.

Publications

Sophia Davidson, Yuri Shibata, Sophie Collard, Hongyu Zheng, Klara Kong, June M Sun, Pawat Laohamonthonkul, Anthony Cerra, Tobias Kratina, null null, null null, Margaret W Y Li, Carolyn Russell, Anna van Beek, Edwin P Kirk, Rebecca Walsh, Jubran Theeb Alqanatish, Abdullah Almojali, Wafaa Alsewairi, Abdulrahman Alrasheed, Najoua Lalaoui, Paul E Gray, David Komander, Seth L Masters
Dominant negative OTULIN-related autoinflammatory syndrome. The Journal of experimental medicine 221 (6) (2024)
Zhong Yan Gan, Sylvie Callegari, Thanh Ngoc Nguyen, Nicholas S Kirk, Andrew Leis, Michael Lazarou, Grant Dewson, David Komander
Interaction of PINK1 with nucleotides and kinetin. Science advances 10 (3) (2024)
Sophia Davidson, Yuri Shibata, Sophie Collard, Hongyu Zheng, Klara Kong, June M Sun, Pawat Laohamonthonkul, Anthony Cerra, Tobias Kratina, null null, null null, Margaret W Y Li, Carolyn Russell, Anna van Beek, Edwin P Kirk, Rebecca Walsh, Jubran Theeb Alqanatish, Abdullah Almojali, Wafaa Alsewairi, Abdulrahman Alrasheed, Najoua Lalaoui, Paul E Gray, David Komander, Seth L Masters
Dominant negative OTULIN-related autoinflammatory syndrome. The Journal of experimental medicine 221 (6) (2024)
Bernhard C Lechtenberg, David Komander
Just how big is the ubiquitin system? Nature structural & molecular biology (2024)
Sophia Davidson, Yuri Shibata, Sophie Collard, Hongyu Zheng, Klara Kong, June M Sun, Pawat Laohamonthonkul, Anthony Cerra, Tobias Kratina, null null, null null, Margaret W Y Li, Carolyn Russell, Anna van Beek, Edwin P Kirk, Rebecca Walsh, Jubran Theeb Alqanatish, Abdullah Almojali, Wafaa Alsewairi, Abdulrahman Alrasheed, Najoua Lalaoui, Paul E Gray, David Komander, Seth L Masters
Dominant negative OTULIN-related autoinflammatory syndrome. The Journal of experimental medicine 221 (6) (2024)
Sophia Davidson, Yuri Shibata, Sophie Collard, Hongyu Zheng, Klara Kong, June M Sun, Pawat Laohamonthonkul, Anthony Cerra, Tobias Kratina, null null, null null, Margaret W Y Li, Carolyn Russell, Anna van Beek, Edwin P Kirk, Rebecca Walsh, Jubran Theeb Alqanatish, Abdullah Almojali, Wafaa Alsewairi, Abdulrahman Alrasheed, Najoua Lalaoui, Paul E Gray, David Komander, Seth L Masters
Dominant negative OTULIN-related autoinflammatory syndrome. The Journal of experimental medicine 221 (6) (2024)
Bernhard C Lechtenberg, David Komander
Just how big is the ubiquitin system? Nature structural & molecular biology 31 (2) (2024)
Giang Dien Thanh Nguyen, Brendan Townsend, Prajakta Gosavi Kulkarni, Keri-Lyn Kozul, Soo Siang Ooi, Denaye N Eldershaw, Saroja Weeratunga, Meihan Liu, Mathew Jk Jones, S Sean Millard, Dominic Ch Ng, Michele Pagano, Alexis Bonfim-Melo, Tobias Schneider, David Komander, Michael Lazarou, Brett M Collins, Julia K Pagan
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4 . EMBO reports 25 (8) (2024)
Giang Dien Thanh Nguyen, Brendan Townsend, Prajakta Gosavi Kulkarni, Keri-Lyn Kozul, Soo Siang Ooi, Denaye N Eldershaw, Saroja Weeratunga, Meihan Liu, Mathew Jk Jones, S Sean Millard, Dominic Ch Ng, Michele Pagano, Alexis Bonfim-Melo, Tobias Schneider, David Komander, Michael Lazarou, Brett M Collins, Julia K Pagan
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4 . EMBO reports 25 (8) (2024)
Giang Dien Thanh Nguyen, Brendan Townsend, Prajakta Gosavi Kulkarni, Keri-Lyn Kozul, Soo Siang Ooi, Denaye N Eldershaw, Saroja Weeratunga, Meihan Liu, Mathew Jk Jones, S Sean Millard, Dominic Ch Ng, Michele Pagano, Alexis Bonfim-Melo, Tobias Schneider, David Komander, Michael Lazarou, Brett M Collins, Julia K Pagan
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4 . EMBO reports 25 (8) (2024)
Xinyu Wu, Margareta Go, Julie V Nguyen, Nathan W Kuchel, Bernadine G C Lu, Kathleen Zeglinski, Kym N Lowes, Dale J Calleja, Jeffrey P Mitchell, Guillaume L Lessene, David Komander, Matthew E Call, Melissa J Call
Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape. Nature communications 15 (1) (2024)
Bernhard C Lechtenberg, David Komander
Just how big is the ubiquitin system? Nature structural & molecular biology 31 (2) (2024)
Giang Dien Thanh Nguyen, Brendan Townsend, Prajakta Gosavi Kulkarni, Keri-Lyn Kozul, Soo Siang Ooi, Denaye N Eldershaw, Saroja Weeratunga, Meihan Liu, Mathew Jk Jones, S Sean Millard, Dominic Ch Ng, Michele Pagano, Alexis Bonfim-Melo, Tobias Schneider, David Komander, Michael Lazarou, Brett M Collins, Julia K Pagan
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4 . EMBO reports 25 (8) (2024)
Zhong Yan Gan, Sylvie Callegari, Thanh Ngoc Nguyen, Nicholas S Kirk, Andrew Leis, Michael Lazarou, Grant Dewson, David Komander
Interaction of PINK1 with nucleotides and kinetin. Science advances 10 (3) (2024)
Xinyu Wu, Margareta Go, Julie V Nguyen, Nathan W Kuchel, Bernadine G C Lu, Kathleen Zeglinski, Kym N Lowes, Dale J Calleja, Jeffrey P Mitchell, Guillaume L Lessene, David Komander, Matthew E Call, Melissa J Call
Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape. Nature communications 15 (1) (2024)
Xinyu Wu, Margareta Go, Julie V Nguyen, Nathan W Kuchel, Bernadine G C Lu, Kathleen Zeglinski, Kym N Lowes, Dale J Calleja, Jeffrey P Mitchell, Guillaume L Lessene, David Komander, Matthew E Call, Melissa J Call
Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape. Nature communications 15 (1) (2024)
Giang Dien Thanh Nguyen, Brendan Townsend, Prajakta Gosavi Kulkarni, Keri-Lyn Kozul, Soo Siang Ooi, Denaye N Eldershaw, Saroja Weeratunga, Meihan Liu, Mathew Jk Jones, S Sean Millard, Dominic Ch Ng, Michele Pagano, Alexis Bonfim-Melo, Tobias Schneider, David Komander, Michael Lazarou, Brett M Collins, Julia K Pagan
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4 . EMBO reports (2024)
Sophia Davidson, Yuri Shibata, Sophie Collard, Hongyu Zheng, Klara Kong, June M Sun, Pawat Laohamonthonkul, Anthony Cerra, Tobias Kratina, null null, null null, Margaret W Y Li, Carolyn Russell, Anna van Beek, Edwin P Kirk, Rebecca Walsh, Jubran Theeb Alqanatish, Abdullah Almojali, Wafaa Alsewairi, Abdulrahman Alrasheed, Najoua Lalaoui, Paul E Gray, David Komander, Seth L Masters
Dominant negative OTULIN-related autoinflammatory syndrome. The Journal of experimental medicine 221 (6) (2024)
Zhong Yan Gan, Sylvie Callegari, Thanh Ngoc Nguyen, Nicholas S Kirk, Andrew Leis, Michael Lazarou, Grant Dewson, David Komander
Interaction of PINK1 with nucleotides and kinetin. Science advances 10 (3) (2024)
Xinyu Wu, Margareta Go, Julie V Nguyen, Nathan W Kuchel, Bernadine G C Lu, Kathleen Zeglinski, Kym N Lowes, Dale J Calleja, Jeffrey P Mitchell, Guillaume L Lessene, David Komander, Matthew E Call, Melissa J Call
Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape. Nature communications 15 (1) (2024)
Bianca D M van Tol, Bjorn R van Doodewaerd, Guinevere S M Lageveen-Kammeijer, Bas C Jansen, Cami M P Talavera Ormeño, Paul J M Hekking, Aysegul Sapmaz, Robbert Q Kim, Angeliki Moutsiopoulou, David Komander, Dana L E Vergoossen, Gerbrand J van der Heden van Noort, Huib Ovaa, Paul P Geurink
Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes. Nature communications 14 (1) (2023)
Mary-Louise Wilde, Ushma Ruparel, Theresa Klemm, V Vern Lee, Dale J Calleja, David Komander, Christopher J Tonkin
Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii . Life science alliance 6 (6) (2023)
Grant Dewson, Pieter Johan Adam Eichhorn, David Komander
Deubiquitinases in cancer. Nature reviews. Cancer (2023)
Mary-Louise Wilde, Ushma Ruparel, Theresa Klemm, V Vern Lee, Dale J Calleja, David Komander, Christopher J Tonkin
Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii . Life science alliance 6 (6) (2023)
Bianca D M van Tol, Bjorn R van Doodewaerd, Guinevere S M Lageveen-Kammeijer, Bas C Jansen, Cami M P Talavera Ormeño, Paul J M Hekking, Aysegul Sapmaz, Robbert Q Kim, Angeliki Moutsiopoulou, David Komander, Dana L E Vergoossen, Gerbrand J van der Heden van Noort, Huib Ovaa, Paul P Geurink
Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes. Nature communications 14 (1) (2023)
Bianca D M van Tol, Bjorn R van Doodewaerd, Guinevere S M Lageveen-Kammeijer, Bas C Jansen, Cami M P Talavera Ormeño, Paul J M Hekking, Aysegul Sapmaz, Robbert Q Kim, Angeliki Moutsiopoulou, David Komander, Dana L E Vergoossen, Gerbrand J van der Heden van Noort, Huib Ovaa, Paul P Geurink
Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes. Nature communications 14 (1) (2023)
Yuri Shibata, David Komander
Linear ubiquitin chains break blood vessel branches. Cell research 31 (10) (2022)
Zhong Yan Gan, Sylvie Callegari, Simon A Cobbold, Thomas R Cotton, Michael J Mlodzianoski, Alexander F Schubert, Niall D Geoghegan, Kelly L Rogers, Andrew Leis, Grant Dewson, Alisa Glukhova, David Komander
Activation mechanism of PINK1. Nature 602 (7896) (2021)
Zikou Liu, Laura F Dagley, Kristy Shield-Artin, Samuel N Young, Aleksandra Bankovacki, Xiangyi Wang, Michelle Tang, Jason Howitt, Che A Stafford, Ueli Nachbur, Cheree Fitzgibbon, Sarah E Garnish, Andrew Ian Webb, David Komander, James G Murphy, Joanne M Hildebrand, John Silke
Oligomerization-driven MLKL ubiquitylation antagonizes necroptosis. The EMBO journal 40 (23) (2021)
Marlene F Schmidt, Zhong Yan Gan, David Komander, Grant Dewson
Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities. Cell death and differentiation 28 (2) (2021)
Alexander F Schubert, Justine V Nguyen, Tyler G Franklin, Paul P Geurink, Cameron G Roberts, Daniel J Sanderson, Lauren N Miller, Huib Ovaa, Kay Hofmann, Jonathan N Pruneda, David Komander
Identification and characterization of diverse OTU deubiquitinases in bacteria. The EMBO journal 39 (15) (2020)
Linda J Visser, Chiara Aloise, Kirby N Swatek, Gisselle N Medina, Karin M Olek, Huib H Rabouw, Raoul J de Groot, Martijn A Langereis, Teresa de Los Santos, David Komander, Tim Skern, Frank J M van Kuppeveld
Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression. PLoS pathogens 16 (7) (2020)
Rune Busk Damgaard, Helen E Jolin, Michael E D Allison, Susan E Davies, Hannah L Titheradge, Andrew N J McKenzie, David Komander
OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer. Cell death and differentiation 27 (5) (2020)
Theresa Klemm, Gregor Ebert, Dale J Calleja, Cody C Allison, Lachlan W Richardson, Jonathan P Bernardini, Bernadine G C Lu, Nathan W Kuchel, Christoph Grohmann, Yuri Shibata, Zhong Yan Gan, James P Cooney, Marcel Doerflinger, Amanda E Au, Timothy R Blackmore, Gerbrand J van der Heden van Noort, Paul P Geurink, Huib Ovaa, Janet Newman, Alan Riboldi-Tunnicliffe, Peter E Czabotar, Jeffrey P Mitchell, Rebecca Feltham, Bernhard C Lechtenberg, Kym N Lowes, Grant Dewson, Marc Pellegrini, Guillaume L Lessene, David Komander
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2. The EMBO journal 39 (18) (2020)
Rune Busk Damgaard, Paul R Elliott, Kirby N Swatek, Eamonn R Maher, Polina Stepensky, Orly Elpeleg, David Komander, Yackov Berkun
OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death. EMBO molecular medicine 11 (3) (2020)
Michael J Clague, Sylvie Urbé, David Komander
Breaking the chains: deubiquitylating enzyme specificity begets function. Nature reviews. Molecular cell biology 20 (6) (2020)
Marie E Morrow, Michael T Morgan, Marcello Clerici, Katerina Growkova, Ming Yan, David Komander, Titia K Sixma, Michal Simicek, Cynthia Wolberger
Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins. EMBO reports 19 (10) (2018)
Jonathan N Pruneda, Robert J Bastidas, Erithelgi Bertsoulaki, Kirby N Swatek, Balaji Santhanam, Michael J Clague, Raphael H Valdivia, Sylvie Urbé, David Komander
A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation. Nature microbiology 3 (12) (2018)
Kirby N Swatek, Martina Aumayr, Jonathan N Pruneda, Linda J Visser, Stephen Berryman, Anja F Kueck, Paul P Geurink, Huib Ovaa, Frank J M van Kuppeveld, Tobias J Tuthill, Tim Skern, David Komander
Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. Proceedings of the National Academy of Sciences of the United States of America 115 (10) (2018)
Christina Gladkova, Alexander F Schubert, Jane L Wagstaff, Jonathan N Pruneda, Stefan Mv Freund, David Komander
An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1. The EMBO journal 36 (24) (2017)
Jessica Noad, Alexander von der Malsburg, Claudio Pathe, Martin A Michel, David Komander, Felix Randow
LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB. Nature microbiology 2 (2017)
Malte Gersch, Christina Gladkova, Alexander F Schubert, Martin A Michel, Sarah Maslen, David Komander
Mechanism and regulation of the Lys6-selective deubiquitinase USP30. Nature structural & molecular biology 24 (11) (2017)