Nicholas R J Gascoigne (Nicholas Rj Gascoigne)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2014-2024
Publications (10 Years): 29

Top Topics

Positive Breast Cancer

Trypanosoma Cruzi

Top Venues

Nature immunology

Nature communications

Cellular & molecular immunology

NPJ biofilms and microbiomes

This page only lists publications with an associated author ORCID identifier.

Publications

Yahui Long, Kok Siong Ang, Raman Sethi, Sha Liao, Yang Heng, Lynn van Olst, Shuchen Ye, Chengwei Zhong, Jinmiao Chen, Di Zhang, Immanuel Kwok, Nazihah Husna, Min Jian, Lai Guan Ng, Ao Chen, Nicholas R J Gascoigne, David Gate, Rong Fan, Xue Liu, Jinmiao Chen
Deciphering spatial domains from spatial multi-omics with SpatialGlue. Nature methods (2024)
Yahui Long, Kok Siong Ang, Raman Sethi, Sha Liao, Yang Heng, Lynn van Olst, Shuchen Ye, Chengwei Zhong, Jinmiao Chen, Di Zhang, Immanuel Kwok, Nazihah Husna, Min Jian, Lai Guan Ng, Ao Chen, Nicholas R J Gascoigne, David Gate, Rong Fan, Xue Liu, Jinmiao Chen
Deciphering spatial domains from spatial multi-omics with SpatialGlue. Nature methods (2024)
Lei Deng, Lukasz Wojciech, Chin Wen Png, Yan Qin Dorinda Kioh, Geok Choo Ng, Eric Chun Yong Chan, Yongliang Zhang, Nicholas R J Gascoigne, Kevin Shyong-Wei Tan
Colonization with ubiquitous protist Blastocystis ST1 ameliorates DSS-induced colitis and promotes beneficial microbiota and immune outcomes. NPJ biofilms and microbiomes 9 (1) (2023)
Lukasz Wojciech, Chin Wen Png, Eileen Yiling Koh, Yan Qin Dorinda Kioh, Lei Deng, Ziteng Wang, Liang-Zhe Wu, Maryam Hamidinia, Desmond Wh Tung, Wei Zhang, Sven Pettersson, Eric Chun Yong Chan, Yongliang Zhang, Kevin Shyong-Wei Tan, Nicholas R J Gascoigne
A tryptophan metabolite made by a gut microbiome eukaryote induces pro-inflammatory T cells. The EMBO journal (2023)
Huey Yee Teo, Haiyan Liu, Kylie Su Mei Yong, Yonghao Liu, Yu Mei, Zuhairah Binte Hanafi, Ying Zhu, Yen Leong Chua, Nicholas R J Gascoigne, Qingfeng Chen, Haiyan Liu
IL12/18/21 pre-activation enhances the anti-tumor efficacy of expanded γδT cells and overcomes resistance to anti-PD-L1 treatment. Cancer immunology research (2023)
Namrata Gautam, Lukasz Wojciech, Jiawei Yap, Yen Leong Chua, Eyan Mw Ding, Don Cn Sim, Alrina Sm Tan, Patricia J Ahl, Mukul Prasad, Desmond Wh Tung, John E Connolly, Giulia Adriani, Joanna Brzostek, Nicholas R J Gascoigne
Themis controls T cell activation, effector functions, and metabolism of peripheral CD8 + T cells. Life science alliance 6 (12) (2023)
Lei Deng, Lukasz Wojciech, Chin Wen Png, Yan Qin Dorinda Kioh, Geok Choo Ng, Eric Chun Yong Chan, Yongliang Zhang, Nicholas R J Gascoigne, Kevin Shyong-Wei Tan
Colonization with ubiquitous protist Blastocystis ST1 ameliorates DSS-induced colitis and promotes beneficial microbiota and immune outcomes. NPJ biofilms and microbiomes 9 (1) (2023)
Jian Tang, Xian Jia, Jian Li, Junchen Dong, Jiayu Wang, Wanyun Li, Yuzhen Zhu, Yanyan Hu, Bowen Hou, Chunjie Lin, Yu Cong, Tong Ren, Changsheng Yan, Hongying Yang, Qian Lai, Haiping Zheng, Yuzhou Bao, Namrata Gautam, Hong-Rui Wang, Bing Xu, Xiao Lei Chen, Qing Li, Nicholas R J Gascoigne, Guo Fu
Themis suppresses the effector function of CD8 + T cells in acute viral infection. Cellular & molecular immunology (2023)
Lei Deng, Lukasz Wojciech, Chin Wen Png, Yan Qin Dorinda Kioh, Geok Choo Ng, Eric Chun Yong Chan, Yongliang Zhang, Nicholas R J Gascoigne, Kevin Shyong-Wei Tan
Colonization with ubiquitous protist Blastocystis ST1 ameliorates DSS-induced colitis and promotes beneficial microbiota and immune outcomes. NPJ biofilms and microbiomes 9 (1) (2023)
Bowen Hou, Yanyan Hu, Yuzhen Zhu, Xiaocui Wang, Wanyun Li, Jian Tang, Xian Jia, Jiayu Wang, Yu Cong, Minxue Quan, Hongying Yang, Haiping Zheng, Yuzhou Bao, Xiao Lei Chen, Hong-Rui Wang, Bing Xu, Nicholas R J Gascoigne, Guo Fu
SHP-1 Regulates CD8+ T Cell Effector Function but Plays a Subtle Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific Nonredundant Functional Relay. Journal of immunology (Baltimore, Md. : 1950) (2023)
Liang-Zhe Wu, Renu Balyan, Joanna Brzostek, Xiang Zhao, Nicholas R J Gascoigne
Time required for commitment to T cell proliferation depends on TCR affinity and cytokine response. EMBO reports (2022)
Yongchao Liu, Yu Cong, Yujia Niu, Yin Yuan, Fancheng Tan, Qian Lai, Yanyan Hu, Bowen Hou, Jian Li, Chunjie Lin, Haiping Zheng, Junchen Dong, Jian Tang, Qinwei Chen, Joanna Brzostek, Xueqin Zhang, Xiao Lei Chen, Hong-Rui Wang, Nicholas R J Gascoigne, Bing Xu, Shu-Hai Lin, Guo Fu
Themis is indispensable for IL-2 and IL-15 signaling in T cells. Science signaling 15 (721) (2022)
Ling Wu, Joanna Brzostek, Shvetha Sankaran, Qianru Wei, Jiawei Yap, Triscilla Y Y Tan, Junyun Lai, Paul A MacAry, Nicholas R J Gascoigne
Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell Model. Cancers 13 (4) (2021)
Heng Boon Low, Zhen Lim Wong, Bangyuan Wu, Li Ren Kong, Chin Wen Png, Yik-Lam Cho, Chun-Wei Li, Fengchun Xiao, Xuan Xin, Henry Yang, Jia Min Loo, Fiona Yi Xin Lee, Iain Bee Huat Tan, Ramanuj DasGupta, Han-Ming Shen, Herbert Schwarz, Nicholas R J Gascoigne, Boon Cher Goh, Xiaohong Xu, Yongliang Zhang
DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death. Nature communications 12 (1) (2021)
Lei Deng, Lukasz Wojciech, Nicholas R J Gascoigne, Guangneng Peng, Kevin Shyong-Wei Tan
New insights into the interactions between Blastocystis, the gut microbiota, and host immunity. PLoS pathogens 17 (2) (2021)
Pirooz Zareie, Christopher Szeto, Carine Farenc, Sachith D Gunasinghe, Elizabeth Motunrayo Kolawole, Angela Nguyen, Chantelle Blyth, Xavier Y X Sng, Jasmine Li, Claerwen M Jones, Alex J Fulcher, Jesica R Jacobs, Qianru Wei, Lukasz Wojciech, Jan Petersen, Nicholas R J Gascoigne, Brian D Evavold, Katharina Gaus, Stephanie Gras, Jamie Rossjohn, Nicole L La Gruta
Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling. Science (New York, N.Y.) 372 (6546) (2021)
Ling Wu, Qianru Wei, Joanna Brzostek, Nicholas R J Gascoigne
Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells. Cellular & molecular immunology 17 (6) (2020)
Mukul Prasad, Elijah W Chen, Sue-Anne Toh, Nicholas R J Gascoigne
Autoimmune responses and inflammation in type 2 diabetes. Journal of leukocyte biology 107 (5) (2020)
Mukul Prasad, Joanna Brzostek, Namrata Gautam, Renu Balyan, Vasily Rybakin, Nicholas R J Gascoigne
Themis regulates metabolic signaling and effector functions in CD4+ T cells by controlling NFAT nuclear translocation. Cellular & molecular immunology 18 (9) (2020)
Qianru Wei, Joanna Brzostek, Shvetha Sankaran, Javier Casas, Lois Shi-Qi Hew, Jiawei Yap, Xiang Zhao, Lukasz Wojciech, Nicholas R J Gascoigne
Lck bound to coreceptor is less active than free Lck. Proceedings of the National Academy of Sciences of the United States of America 117 (27) (2020)
Joanna Brzostek, Namrata Gautam, Xiang Zhao, Elijah W Chen, Monika Mehta, Desmond W H Tung, Yen Leong Chua, Jiawei Yap, Su H Cho, Shvetha Sankaran, Vasily Rybakin, Guo Fu, Nicholas R J Gascoigne
T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis. Nature immunology 21 (2) (2020)
Renu Balyan, Joanna Brzostek, Nicholas R J Gascoigne
CD8+ T cells have commitment issues. Nature immunology 19 (8) (2019)
Yue Gu, Yee Hwa Wong, Chong Wai Liew, Conrad E Z Chan, Tanusya M Murali, Jiawei Yap, Chien Tei Too, Kiren Purushotorman, Maryam Hamidinia, Abbas El Sahili, Angeline T H Goh, Rachel Z C Teo, Kathryn J Wood, Brendon J Hanson, Nicholas R J Gascoigne, Julien Lescar, Anantharaman Vathsala, Paul A MacAry
Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01. Nature communications 10 (1) (2019)
Mario Brameshuber, Florian Kellner, Benedikt K Rossboth, Haisen Ta, Kevin Alge, Eva Sevcsik, Janett Göhring, Markus Axmann, Florian Baumgart, Nicholas R J Gascoigne, Simon J Davis, Hannes Stockinger, Gerhard J Schütz, Johannes B Huppa
Monomeric TCRs drive T cell antigen recognition. Nature immunology 19 (5) (2018)
Monika Mehta, Joanna Brzostek, Elijah W Chen, Desmond W H Tung, Shuting Chen, Shvetha Sankaran, Jiawei Yap, Vasily Rybakin, Nicholas R J Gascoigne
Themis-associated phosphatase activity controls signaling in T cell development. Proceedings of the National Academy of Sciences of the United States of America 115 (48) (2018)
Elijah W Chen, Joanna Brzostek, Nicholas R J Gascoigne, Vasily Rybakin
Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation. Scientific reports 8 (1) (2018)
Xiang Zhao, Shvetha Sankaran, Jiawei Yap, Chien Tei Too, Zi Zong Ho, Garry Dolton, Mateusz Legut, Ee Chee Ren, Andrew K Sewell, Antonio Bertoletti, Paul A MacAry, Joanna Brzostek, Nicholas R J Gascoigne
Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature communications 9 (1) (2018)
Joanna Brzostek, Nicholas R J Gascoigne
Vive la peptide différence! Nature immunology 17 (8) (2017)
Junyun Lai, Joanna Ai Ling Choo, Wei Jian Tan, Chien Tei Too, Min Zin Oo, Manuel A Suter, Fatimah Bte Mustafa, Nalini Srinivasan, Conrad En Zuo Chan, Andrew Guo Xian Lim, Youjia Zhong, Soh Ha Chan, Brendon J Hanson, Nicholas R J Gascoigne, Paul A MacAry
TCR-like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus-transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants. Scientific reports 7 (1) (2017)
Kok-Fai Kong, Guo Fu, Yaoyang Zhang, Tadashi Yokosuka, Javier Casas, Ann J Canonigo-Balancio, Stephane Becart, Gisen Kim, John R Yates, Mitchell Kronenberg, Takashi Saito, Nicholas R J Gascoigne, Amnon Altman
Protein kinase C-η controls CTLA-4-mediated regulatory T cell function. Nature immunology 15 (5) (2014)