Robert William Huigens (Robert W Huigens, Robert W Huigens Iii)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 22

Top Venues

ACS infectious diseases

Journal of medicinal chemistry

Organic & biomolecular chemistry

Chembiochem : a European journal of chemical biology

University of Florida

North Carolina State University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Florida Apr 01 2013

United States

Assistant Professor :: Medicinal Chemistry

Education History

North Carolina State University Aug 15 2004 - Jul 22 2009

United States

PHD :: Chemistry (Advisor: Christian Melander)

Publications

Daniel C Schultz, Alejandra Chávez-Riveros, Michael G Goertzen, Beau R Brummel, Raphaella A Paes, Natalia M Santos, Srinivasarao Tenneti, Khalil A Abboud, James R Rocca, Gustavo Seabra, Chenglong Li, Debopam Chakrabarti, Robert William Huigens
Chloroformate-mediated ring cleavage of indole alkaloids leads to re-engineered antiplasmodial agents. Organic & biomolecular chemistry (2024)
Ke Liu, Tao Xiao, Hongfen Yang, Manyun Chen, Qiwen Gao, Beau R Brummel, Yousong Ding, Robert William Huigens
Design, synthesis and evaluation of halogenated phenazine antibacterial prodrugs targeting nitroreductase enzymes for activation. RSC medicinal chemistry 14 (8) (2023)
Derek A Leas, Daniel C Schultz, Robert William Huigens
Chemical Reactions of Indole Alkaloids That Enable Rapid Access to New Scaffolds for Discovery. SynOpen (2017) 7 (2) (2023)
Tao Xiao, Ke Liu, Qiwen Gao, Manyun Chen, Young S Kim, Shouguang Jin, Yousong Ding, Robert William Huigens
Design, Synthesis, and Evaluation of Carbonate-Linked Halogenated Phenazine-Quinone Prodrugs with Improved Water-Solubility and Potent Antibacterial Profiles. ACS infectious diseases (2023)
Ke Liu, Yasmeen Abouelhassan, Yanping Zhang, Shouguang Jin, Robert William Huigens
Transcript Profiling of Nitroxoline-Treated Biofilms Shows Rapid Up-regulation of Iron Acquisition Gene Clusters. ACS infectious diseases 8 (8) (2022)
Ke Liu, Massimiliano Brivio, Tao Xiao, Verrill M Norwood, Young S Kim, Shouguang Jin, Antonio Papagni, Luca Vaghi, Robert William Huigens
Modular Synthetic Routes to Fluorine-Containing Halogenated Phenazine and Acridine Agents That Induce Rapid Iron Starvation in Methicillin-Resistant Staphylococcus aureus Biofilms. ACS infectious diseases 8 (2) (2022)
Robert William Huigens, Hongfen Yang, Ke Liu, Young S Kim, Shouguang Jin
An ether-linked halogenated phenazine-quinone prodrug model for antibacterial applications. Organic & biomolecular chemistry 19 (30) (2022)
Robert William Huigens, Beau R Brummel, Srinivasarao Tenneti, Aaron T Garrison, Tao Xiao
Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery. Molecules (Basel, Switzerland) 27 (3) (2022)
Hongfen Yang, Shivani Kundra, Michaelle Chojnacki, Ke Liu, Marisa A Fuse, Yasmeen Abouelhassan, Dimitris Kallifidas, Peilan Zhang, Guangtao Huang, Shouguang Jin, Yousong Ding, Hendrik Luesch, Kyle H Rohde, Paul M Dunman, José A Lemos, Robert William Huigens
A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents. Journal of medicinal chemistry 64 (11) (2021)
Hongfen Yang, Ke Liu, Shouguang Jin, Robert William Huigens
Design, synthesis and biological evaluation of a halogenated phenazine-erythromycin conjugate prodrug for antibacterial applications. Organic & biomolecular chemistry 19 (7) (2021)
Verrill M Norwood, Claribel Murillo-Solano, Michael G Goertzen, Beau R Brummel, David L Perry, James R Rocca, Debopam Chakrabarti, Robert William Huigens
Ring Distortion of Vincamine Leads to the Identification of Re-Engineered Antiplasmodial Agents. ACS omega 6 (31) (2021)
Nicholas G Paciaroni, David L Perry, Verrill M Norwood, Claribel Murillo Solano, Jennifer E Collins, Srinivasarao Tenneti, Debopam Chakrabarti, Robert William Huigens
Re-Engineering of Yohimbine's Biological Activity through Ring Distortion: Identification and Structure-Activity Relationships of a New Class of Antiplasmodial Agents. ACS infectious diseases 6 (2) (2020)
Verrill M Norwood, Ariana C Brice-Tutt, Shainnel O Eans, Heather M Stacy, Guqin Shi, Ranjala Ratnayake, James R Rocca, Khalil A Abboud, Chenglong Li, Hendrik Luesch, Jay P McLaughlin, Robert William Huigens
Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine's Biological Activity. Journal of medicinal chemistry 63 (10) (2020)
Robert William Huigens
Targeting bacterial biofilms with persister-killing agents. Future medicinal chemistry 13 (3) (2020)
Ke Liu, Robert William Huigens
Instructive Advances in Chemical Microbiology Inspired by Nature's Diverse Inventory of Molecules. ACS infectious diseases 6 (4) (2020)
Verrill M Norwood, Robert William Huigens
Harnessing the Chemistry of the Indole Heterocycle to Drive Discoveries in Biology and Medicine. Chembiochem : a European journal of chemical biology 20 (18) (2019)
Yasmeen Abouelhassan, Peilan Zhang, Yousong Ding, Robert William Huigens
Rapid kill assessment of an N-arylated NH125 analogue against drug-resistant microorganisms. MedChemComm 10 (5) (2019)
Yasmeen Abouelhassan, Aaron T Garrison, Hongfen Yang, Alejandra Chávez-Riveros, Gena M Burch, Robert William Huigens
Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. Journal of medicinal chemistry 62 (17) (2019)
Robert William Huigens, Yasmeen Abouelhassan, Hongfen Yang
Phenazine Antibiotic-Inspired Discovery of Bacterial Biofilm-Eradicating Agents. Chembiochem : a European journal of chemical biology 20 (23) (2019)
Robert William Huigens
The Path to New Halogenated Quinolines With Enhanced Activities Against Staphylococcus epidermidis. Microbiology insights 11 (2018)
Yasmeen Abouelhassan, Yanping Zhang, Shouguang Jin, Robert William Huigens
Transcript Profiling of MRSA Biofilms Treated with a Halogenated Phenazine Eradicating Agent: A Platform for Defining Cellular Targets and Pathways Critical to Biofilm Survival. Angewandte Chemie (International ed. in English) 57 (47) (2018)
Aaron T Garrison, Yasmeen Abouelhassan, Hongfen Yang, Hussain H Yousaf, Tho J Nguyen, Robert William Huigens
Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria. MedChemComm 8 (4) (2016)

Robert William Huigens.css-eqlu8i{font-size:small;padding-left:4px;} (Robert W Huigens, Robert W Huigens Iii)

Publication Activity (10 Years)

Top Topics

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Robert William Huigens (Robert W Huigens, Robert W Huigens Iii)