MedChemComm

Keyphrases

Publications

volume 10, number 7, 2019

João V de Souza, Sylvia Reznikov, Ruidi Zhu, Agnieszka K Bronowska
Druggability assessment of mammalian Per-Arnt-Sim [PAS] domains using computational approaches. MedChemComm 10 (7) (2019)
Marisa Juanes, Oliver Creese, Francisco Fernández-Trillo, Javier Montenegro
Messenger RNA delivery by hydrazone-activated polymers. MedChemComm 10 (7) (2019)
Atsuhiko Taniguchi, Taka Sawazaki, Yusuke Shimizu, Youhei Sohma, Motomu Kanai
Photophysical properties and application in live cell imaging of B,B-fluoro-perfluoroalkyl BODIPYs. MedChemComm 10 (7) (2019)
Christiane Ehrt, Tobias Brinkjost, Oliver Koch
Binding site characterization - similarity, promiscuity, and druggability. MedChemComm 10 (7) (2019)
Daniel J Cole, Israel Cabeza de Vaca, William L Jorgensen
Computation of protein-ligand binding free energies using quantum mechanical bespoke force fields. MedChemComm 10 (7) (2019)
Kyle C Van de Bittner, Rosannah C Cameron, Leyla Y Bustamante, Rudranuj Bundela, Sarah A Kessans, Jan Vorster, Matthew J Nicholson, Emily J Parker
Nodulisporic acid E biosynthesis: in vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold. MedChemComm 10 (7) (2019)
Abhishek Vartak, Christopher Goins, Vinicius Calado Nogueira de Moura, Celine M Schreidah, Alexander D Landgraf, Boren Lin, Jianyang Du, Mary Jackson, Donald R Ronning, Steven J Sucheck
Biochemical and microbiological evaluation of N-aryl urea derivatives against mycobacteria and mycobacterial hydrolases. MedChemComm 10 (7) (2019)
Piera M Marchetti, Shona M Richardson, Noor M Kariem, Dominic J Campopiano
Synthesis of N-acyl amide natural products using a versatile adenylating biocatalyst. MedChemComm 10 (7) (2019)
Alex J Berkowitz, Abaigeal D Franson, Andreu Gazquez Cassals, Katherine A Donald, Alice J Yu, Aswin K Garimallaprabhakaran, Lynda A Morrison, Ryan P Murelli
Importance of lipophilicity for potent anti-herpes simplex virus-1 activity of α-hydroxytropolones. MedChemComm 10 (7) (2019)
Andrew M Riley, Huanchen Wang, Stephen B Shears, Barry V L Potter
Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7. MedChemComm 10 (7) (2019)
Stephanie Federico, Enrico Margiotta, Silvia Paoletta, Sonja Kachler, Karl-Norbert Klotz, Kenneth A Jacobson, Giorgia Pastorin, Stefano Moro, Giampiero Spalluto
Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example. MedChemComm 10 (7) (2019)
Marco Potowski, Verena B K Kunig, Florian Losch, Andreas Brunschweiger
Synthesis of DNA-coupled isoquinolones and pyrrolidines by solid phase ytterbium- and silver-mediated imine chemistry. MedChemComm 10 (7) (2019)
Alessandro Zorzi, Sara Linciano, Alessandro Angelini
Non-covalent albumin-binding ligands for extending the circulating half-life of small biotherapeutics. MedChemComm 10 (7) (2019)
Amber M Scharnow, Amy E Solinski, William M Wuest
Targeting S. mutans biofilms: a perspective on preventing dental caries. MedChemComm 10 (7) (2019)

volume 10, number 8, 2019

Bronwyn J E Lyons, Natalie C J Strynadka
On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome. MedChemComm 10 (8) (2019)
Kapil Juvale, Althaf Shaik, Sivapriya Kirubakaran
Inhibitors of inosine 5'-monophosphate dehydrogenase as emerging new generation antimicrobial agents. MedChemComm 10 (8) (2019)
Kelly M Craft, Johny M Nguyen, Lawrence J Berg, Steven D Townsend
Methicillin-resistant Staphylococcus aureus (MRSA): antibiotic-resistance and the biofilm phenotype. MedChemComm 10 (8) (2019)
Chandrasekhar Bandari, Erin M Scull, Tejaswi Bavineni, Susan L Nimmo, Eric D Gardner, Ryan C Bensen, Anthony W Burgett, Shanteri Singh
FgaPT2, a biocatalytic tool for alkyl-diversification of indole natural products. MedChemComm 10 (8) (2019)
Elvira Rozhina, Svetlana Batasheva, Anna Danilushkina, Marina Kryuchkova, Marina Gomzikova, Yuliya Cherednichenko, Läysän Nigamatzyanova, Farida Akhatova, Rawil F Fakhrullin
Kaolin alleviates the toxicity of graphene oxide for mammalian cells. MedChemComm 10 (8) (2019)
Hatsuo Yamamura, Kana Isshiki, Yusuke Fujita, Hisato Kato, Takashi Katsu, Kazufumi Masuda, Kayo Osawa, Atsushi Miyagawa
Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes. MedChemComm 10 (8) (2019)
Oliver A Bardell-Cox, Andrew J P White, Luis Aragón, Matthew John Fuchter
Synthetic studies on the reverse antibiotic natural products, the nybomycins. MedChemComm 10 (8) (2019)
Parteek Prasher, Mousmee Sharma
Tailored therapeutics based on 1,2,3-1H-triazoles: a mini review. MedChemComm 10 (8) (2019)
Taylor Kornfuehrer, Alessandra S Eustáquio
Diversification of polyketide structures via synthase engineering. MedChemComm 10 (8) (2019)
Casey J Maguire, Graham J Carlson, Jacob W Ford, Tracy E Strecker, Ernest Hamel, Mary Lynn Trawick, Kevin G Pinney
Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues. MedChemComm 10 (8) (2019)
Xingjian Li, Daniel T Payne, Badarinath Ampolu, Nicholas Bland, Jane T Brown, Mark J Dutton, Catherine A Fitton, Abigail Gulliver, Lee Hale, Daniel Hamza, Geraint Jones, Rebecca Lane, Andrew G Leach, Louise Male, Elena G Merisor, Michael J Morton, Alex S Quy, Ruth A Roberts, Rosanna Scarll, Timothy Schulz-Utermoehl, Tatjana Stankovic, Brett Stevenson, John S Fossey, Angelo Agathanggelou
Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia. MedChemComm 10 (8) (2019)
A Di Giorgio, Maria Duca
Synthetic small-molecule RNA ligands: future prospects as therapeutic agents. MedChemComm 10 (8) (2019)
Ana R N Santos, Helen M Sheldrake, Ali I M Ibrahim, Chhanda Charan Danta, Davide Bonanni, Martina Daga, Simonetta Oliaro-Bosso, Donatella Boschi, Marco Lucio Lolli, Klaus Pors
Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity. MedChemComm 10 (8) (2019)
Christine M DuChane, George W Karpin, Marion Ehrich, Joseph O Falkinham, Joseph S Merola
Iridium piano stool complexes with activity against S. aureus and MRSA: it is past time to truly think outside of the box. MedChemComm 10 (8) (2019)
Radmila R Sharipova, Mayya G Belenok, Bulat F Garifullin, Anastasiya S Sapunova, Alexandra D Voloshina, Olga V Andreeva, Irina Yu Strobykina, Polina V Skvortsova, Yuriy F Zuev, Vladimir E Kataev
Synthesis and anti-cancer activities of glycosides and glycoconjugates of diterpenoid isosteviol. MedChemComm 10 (8) (2019)
Johnathan Dallman, Ashabha Lansakara, Thi Nguyen, Chamitha Weeramange, Wasundara Hulangamuwa, Ryan J Rafferty
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery. MedChemComm 10 (8) (2019)
Panpan Zhang, Shutao Ma
Recent development of leucyl-tRNA synthetase inhibitors as antimicrobial agents. MedChemComm 10 (8) (2019)
Chun-Mei Liu, Jia-Yan Huang, Li-Xin Sheng, Xiao-An Wen, Ke-Guang Cheng
Synthesis and antitumor activity of fluorouracil - oleanolic acid/ursolic acid/glycyrrhetinic acid conjugates. MedChemComm 10 (8) (2019)
Benjamin N Atkinson, David Steadman, Yuguang Zhao, James Sipthorp, Luca Vecchia, Reinis R Ruza, Fiona Jeganathan, Georgie Lines, Sarah Frew, Amy Monaghan, Svend Kjær, Magda Bictash, Edith Yvonne Jones, Paul V Fish
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen. MedChemComm 10 (8) (2019)
Franco Vairoletti, Andrea Medeiros, Pablo Fontán, Jennifer Meléndrez, Carlos Tabárez, Gustavo Salinas, Jaime Franco, Marcelo Alberto Comini, Jenny Saldaña, Vojtech Jancik, Graciela Mahler, Cecilia Saiz
Synthesis of bicyclic 1,4-thiazepines as novel anti-Trypanosoma brucei brucei agents. MedChemComm 10 (8) (2019)
Amanda Mabhula, Vinayak Singh
Drug-resistance in Mycobacterium tuberculosis: where we stand. MedChemComm 10 (8) (2019)
Daniela Passeri, Andrea Carotti, Jose M Ramos Pittol, Gianmario Ciaccioli, Roberto Pellicciari, Saskia W C van Mil, Antimo Gioiello
Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool. MedChemComm 10 (8) (2019)
Ervand G Paronikyan, Petrou Anthi, Maria Fesatidou, Geronikaki Athina, Shushanik Sh Dashyan, Suren S Mamyan, Ruzanna G Paronikyan, Ivetta M Nazaryan, Hasmik H Hakopyan
Derivatives of a new heterocyclic system - pyrano[3,4-c][1,2,4]triazolo[4,3-a]pyridines: synthesis, docking analysis and neurotropic activity. MedChemComm 10 (8) (2019)

volume 10, number 9, 2019

Aurijit Sarkar, Sylvie Garneau-Tsodikova
Resisting resistance: gearing up for war. MedChemComm 10 (9) (2019)
Chungen Li, Yunxiang Tang, Zitai Sang, Yang Yang, Yamin Gao, Tao Yang, Cuiting Fang, Tianyu Zhang, Youfu Luo
Discovery of napabucasin derivatives for the treatment of tuberculosis. MedChemComm 10 (9) (2019)
Sara Linciano, Stefano Pluda, Arianna Bacchin, Alessandro Angelini
Molecular evolution of peptides by yeast surface display technology. MedChemComm 10 (9) (2019)
Jinyun Dong, Guang Huang, Qijing Zhang, Zengtao Wang, Jiahua Cui, Yan Wu, Qingqing Meng, Shaoshun Li
Development of benzochalcone derivatives as selective CYP1B1 inhibitors and anticancer agents. MedChemComm 10 (9) (2019)
Ryan J O Nichol, Abedawn I Khalaf, Kartheek Sooda, Omar Hussain, Hollie B S Griffiths, Roger M Phillips, Farideh A Javid, Colin J Suckling, Simon J Allison, Fraser J Scott
Selective in vitro anti-cancer activity of non-alkylating minor groove binders. MedChemComm 10 (9) (2019)
Vishnu C Damalanka, Scott A Wildman, James W Janetka
Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin. MedChemComm 10 (9) (2019)
Exequiel Oscar Jesus Porta, Ignasi Bofill Verdaguer, Consuelo Perez, Claudia Banchio, Mauro Ferreira de Azevedo, Alejandro Miguel Katzin, Guillermo R Labadie
Repositioning Salirasib as a new antimalarial agent. MedChemComm 10 (9) (2019)
Eric Valeur, Frank Narjes, Christian Ottmann, Alleyn T Plowright
Emerging modes-of-action in drug discovery. MedChemComm 10 (9) (2019)
Elena González-Hernández, Rubén Aparicio, Mercedes Garayoa, M José Montero, M Ángeles Sevilla, Concepción Pérez-Melero
Dihydropyrimidine-2-thiones as Eg5 inhibitors and L-type calcium channel blockers: potential antitumour dual agents. MedChemComm 10 (9) (2019)
Anna A Nazarova, Kseniya N Sedenkova, Dmitry S Karlov, Mstislav I Lavrov, Yuri K Grishin, Tamara S Kuznetsova, Vladimir L Zamoyski, Vladimir V Grigoriev, Elena B Averina, Vladimir A Palyulin
Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series. MedChemComm 10 (9) (2019)
Jorge Peiró Cadahía, Viola Previtali, Nikolaj S Troelsen, Mads Hartvig Clausen
Prodrug strategies for targeted therapy triggered by reactive oxygen species. MedChemComm 10 (9) (2019)
Ekaterina V Matazova, Bayirta V Egorova, Ekaterina A Konopkina, Gleb Yu Aleshin, Anastasia D Zubenko, Artem A Mitrofanov, Kirill V Karpov, Olga A Fedorova, Yurii V Fedorov, Stepan N Kalmykov
Benzoazacrown compound: a highly effective chelator for therapeutic bismuth radioisotopes. MedChemComm 10 (9) (2019)
Risa Nofiani, Benjamin Philmus, Yosi Nindita, Takeshi Tsunoda
3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis. MedChemComm 10 (9) (2019)