Sergio C Chai

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 13

Top Topics

Molecular Dynamics Simulations

Structural Basis

Capillary Electrophoresis

Top Venues

Nature communications

Journal of medicinal chemistry

Nucleic acids research

Cancer research

This page only lists publications with an associated author ORCID identifier.

Publications

Efren Garcia-Maldonado, Andrew D Huber, Sergio C Chai, Stanley Nithianantham, Yongtao Li, Jing Wu, Shyaron Poudel, Darcie J Miller, Jayaraman Seetharaman, Taosheng Chen
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nature communications 15 (1) (2024)
Efren Garcia-Maldonado, Andrew D Huber, Sergio C Chai, Stanley Nithianantham, Yongtao Li, Jing Wu, Shyaron Poudel, Darcie J Miller, Jayaraman Seetharaman, Taosheng Chen
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nature communications 15 (1) (2024)
Efren Garcia-Maldonado, Andrew D Huber, Sergio C Chai, Stanley Nithianantham, Yongtao Li, Jing Wu, Shyaron Poudel, Darcie J Miller, Jayaraman Seetharaman, Taosheng Chen
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nature communications 15 (1) (2024)
Efren Garcia-Maldonado, Andrew D Huber, Sergio C Chai, Stanley Nithianantham, Yongtao Li, Jing Wu, Shyaron Poudel, Darcie J Miller, Jayaraman Seetharaman, Taosheng Chen
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nature communications 15 (1) (2024)
Caroline R Buchholz, Molly S Sneddon, Joseph E McPherson, Sourav Das, Clifford T Gee, Michael J Grillo, Sergio C Chai, Richard E Lee, Taosheng Chen, Daniel A Harki, Anang A Shelat, William C K Pomerantz
Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors. ACS medicinal chemistry letters 14 (10) (2023)
Andrew D Huber, Shyaron Poudel, Jing Wu, Darcie J Miller, Wenwei Lin, Lei Yang, Monicah N Bwayi, Mary Ashley Rimmer, Rebecca R Florke Gee, Jayaraman Seetharaman, Sergio C Chai, Taosheng Chen
A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR. Nucleic acids research (2023)
Monicah N Bwayi, Efren Garcia-Maldonado, Sergio C Chai, Boer Xie, Shirish Chodankar, Andrew D Huber, Jing Wu, Kavya Annu, William C Wright, Hyeong-Min Lee, Jayaraman Seetharaman, Jingheng Wang, Cameron D Buchman, Junmin Peng, Taosheng Chen
Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation. Nucleic acids research 50 (6) (2022)
Yongtao Li, Wenwei Lin, Sergio C Chai, Jing Wu, Kavya Annu, Taosheng Chen
Design and Optimization of 1 H -1,2,3-Triazole-4-carboxamides as Novel, Potent, and Selective Inverse Agonists and Antagonists of PXR. Journal of medicinal chemistry (2022)
Yongtao Li, Wenwei Lin, William C Wright, Sergio C Chai, Jing Wu, Taosheng Chen
Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70. Journal of medicinal chemistry 64 (3) (2021)
Jingheng Wang, Cameron D Buchman, Jayaraman Seetharaman, Darcie J Miller, Andrew D Huber, Jing Wu, Sergio C Chai, Efren Garcia-Maldonado, William C Wright, Jude Chenge, Taosheng Chen
Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5. Journal of the American Chemical Society 143 (44) (2021)
P Jake Slavish, Liying Chi, Mi-Kyung Yun, Lyudmila Tsurkan, Nancy E Martinez, Barbara Jonchere, Sergio C Chai, Michele Connelly, M Brett Waddell, Sourav Das, Geoffrey A Neale, Zhenmei Li, William R Shadrick, Rachelle R Olsen, Kevin W Freeman, Jonathan A Low, Jeanine E Price, Brandon M Young, Nagakumar Bharatham, Vincent A Boyd, Jun Yang, Richard E Lee, Marie Morfouace, Martine F Roussel, Taosheng Chen, Daniel Savic, R Kiplin Guy, Stephen W White, Anang A Shelat, Philip M Potter
Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer. Cancer research 80 (17) (2020)
William C Wright, Jude Chenge, Jingheng Wang, Hazel M Girvan, Lei Yang, Sergio C Chai, Andrew D Huber, Jing Wu, Peter O Oladimeji, Andrew W Munro, Taosheng Chen
Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5. Journal of medicinal chemistry 63 (3) (2020)
Wenwei Lin, Monicah Bwayi, Jing Wu, Yongtao Li, Sergio C Chai, Andrew D Huber, Taosheng Chen
CITCO Directly Binds to and Activates Human Pregnane X Receptor. Molecular pharmacology 97 (3) (2019)