Shotaro Uehara

Publication Activity (10 Years)

Years Active: 2018-2023
Publications (10 Years): 19

Top Topics

High Fat Diet Induced

Venous Thromboembolism

Pluripotent Stem Cells

Top Venues

Xenobiotica; the fate of foreign compounds in biological systems

Drug metabolism and disposition: the biological fate of chemicals

This page only lists publications with an associated author ORCID identifier.

Publications

Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Tatsunori Masatani, Hiroshi Yamazaki
Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver. Xenobiotica; the fate of foreign compounds in biological systems (2023)
Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Norie Murayama, Hiroshi Suemizu, Hiroshi Yamazaki
Cytochrome P450 1A2 and 2C Enzymes Autoinduced by Omeprazole in Dog Hepatocytes and Human HepaRG and HepaSH Cells Are Involved in Omeprazole 5-Hydroxylation and Sulfoxidation. Xenobiotica; the fate of foreign compounds in biological systems (2023)
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroaki Kato, Hiroshi Yamazaki, Hiroshi Suemizu
The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers. Drug metabolism and disposition: the biological fate of chemicals 51 (4) (2023)
Hidetaka Kamimura, Shotaro Uehara, Nao Yoneda, Hiroshi Suemizu
Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css-MRTpo method and chimeric mice with humanised livers. Xenobiotica; the fate of foreign compounds in biological systems (2023)
Shotaro Uehara, Norie Murayama, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, Hiroshi Suemizu
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes. Xenobiotica; the fate of foreign compounds in biological systems 52 (3) (2022)
Shogo Matsumoto, Shotaro Uehara, Hidetaka Kamimura, Naoki Cho, Hiroshi Ikeda, Satoshi Maeda, Kensuke Kagiyama, Atsunori Miyata, Hiroshi Suemizu, Kazumasa Fukasawa
Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets. Xenobiotica; the fate of foreign compounds in biological systems 52 (6) (2022)
Yasuhiro Uno, Genki Ushirozako, Shotaro Uehara, Norie Murayama, Yuki Fujiki, Hiroaki Kawaguchi, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki
Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes. Xenobiotica; the fate of foreign compounds in biological systems 52 (7) (2022)
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, Hiroshi Suemizu
UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers. Xenobiotica; the fate of foreign compounds in biological systems 51 (10) (2021)
Tomonori Miura, Yusuke Kamiya, Shotaro Uehara, Norie Murayama, Makiko Shimizu, Hiroshi Suemizu, Hiroshi Yamazaki
Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models. Xenobiotica; the fate of foreign compounds in biological systems 51 (6) (2021)
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki, Hiroshi Suemizu
Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes. Xenobiotica; the fate of foreign compounds in biological systems 51 (5) (2021)
Shogo Matsumoto, Shotaro Uehara, Hidetaka Kamimura, Hiroshi Ikeda, Satoshi Maeda, Machiko Hattori, Megumi Nishiwaki, Kazuhiko Kato, Hiroshi Yamazaki
Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19. Xenobiotica; the fate of foreign compounds in biological systems 51 (4) (2021)
Yasuhiro Uno, Shotaro Uehara, Norie Murayama, Hiroshi Yamazaki
Genetic variants of aldehyde oxidase (AOX) 1 in cynomolgus and rhesus macaques. Xenobiotica; the fate of foreign compounds in biological systems 51 (4) (2021)
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki, Hiroshi Suemizu
Human Aldehyde Oxidase 1-Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes. Drug metabolism and disposition: the biological fate of chemicals 48 (7) (2020)
Akiko Toda, Makiko Shimizu, Shotaro Uehara, Tatsuro Sasaki, Tomonori Miura, Masayuki Mogi, Masahiro Utoh, Hiroshi Suemizu, Hiroshi Yamazaki
Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling. Xenobiotica; the fate of foreign compounds in biological systems 51 (3) (2020)
Shotaro Uehara, Norie Murayama, Hiroshi Yamazaki, Hiroshi Suemizu
Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6. Xenobiotica; the fate of foreign compounds in biological systems 49 (11) (2019)
Shin-Ichiro Ogawa, Shotaro Uehara, Yoshihiko Tsunenari, Hiroyuki Kawai, Hiroshi Suemizu, Hiroshi Yamazaki
Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver. Xenobiotica; the fate of foreign compounds in biological systems 50 (7) (2019)
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki, Hiroshi Suemizu
Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes. Xenobiotica; the fate of foreign compounds in biological systems 50 (6) (2019)
Hidetaka Kamimura, Shotaro Uehara, Hiroshi Suemizu
A novel Css-MRTpo approach to simulate oral plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers. Xenobiotica; the fate of foreign compounds in biological systems 50 (7) (2019)
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, Hiroshi Suemizu
Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanised livers. Xenobiotica; the fate of foreign compounds in biological systems 49 (6) (2018)