Sidi Chen

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 48

Top Venues

bioRxiv : the preprint server for biology

Nature biotechnology

Nature communications

Communications biology

The University of Chicago (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

The University of Chicago

United States

PHD

Publications

Lei Peng, Giacomo Sferruzza, Luojia Yang, Liqun Zhou, Sidi Chen
CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors. Cellular & molecular immunology (2024)
Chuanpeng Dong, Feifei Zhang, Emily He, Ping Ren, Nipun Verma, Xinxin Zhu, Di Feng, Hongyu Zhao, Sidi Chen
Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairs. bioRxiv : the preprint server for biology (2024)
Lei Peng, Paul A Renauer, Giacomo Sferruzza, Luojia Yang, Yongji Zou, Zhenghao Fang, Jonathan J Park, Ryan D Chow, Yueqi Zhang, Qianqian Lin, Meizhu Bai, Angelica Sanchez, Yongzhan Zhang, Stanley Z Lam, Lupeng Ye, Sidi Chen
In vivo AAV-SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy. Nature biotechnology (2024)
Chuanpeng Dong, Feifei Zhang, Emily He, Ping Ren, Nipun Verma, Xinxin Zhu, Di Feng, Hongyu Zhao, Sidi Chen
Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairs. bioRxiv : the preprint server for biology (2024)
Nipun Verma, Paul A Renauer, Chuanpeng Dong, Shan Xin, Qianqian Lin, Feifei Zhang, Peter M Glazer, Sidi Chen
Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy. bioRxiv : the preprint server for biology (2024)
Lei Peng, Paul A Renauer, Giacomo Sferruzza, Luojia Yang, Yongji Zou, Zhenghao Fang, Jonathan J Park, Ryan D Chow, Yueqi Zhang, Qianqian Lin, Meizhu Bai, Angelica Sanchez, Yongzhan Zhang, Stanley Z Lam, Lupeng Ye, Sidi Chen
In vivo AAV-SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy. Nature biotechnology (2024)
Lei Peng, Paul A Renauer, Giacomo Sferruzza, Luojia Yang, Yongji Zou, Zhenghao Fang, Jonathan J Park, Ryan D Chow, Yueqi Zhang, Qianqian Lin, Meizhu Bai, Angelica Sanchez, Yongzhan Zhang, Stanley Z Lam, Lupeng Ye, Sidi Chen
In vivo AAV-SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy. Nature biotechnology (2024)
Chuanpeng Dong, Feifei Zhang, Emily He, Ping Ren, Nipun Verma, Xinxin Zhu, Di Feng, Hongyu Zhao, Sidi Chen
Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairs. bioRxiv : the preprint server for biology (2024)
Nipun Verma, Paul A Renauer, Chuanpeng Dong, Shan Xin, Qianqian Lin, Feifei Zhang, Peter M Glazer, Sidi Chen
Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy. bioRxiv : the preprint server for biology (2024)
Lupeng Ye, Stanley Z Lam, Luojia Yang, Kazushi Suzuki, Yongji Zou, Qianqian Lin, Yueqi Zhang, Paul Clark, Lei Peng, Sidi Chen
Therapeutic immune cell engineering with an mRNA : AAV- Sleeping Beauty composite system. bioRxiv : the preprint server for biology (2023)
Feifei Zhang, Guangchuan Wang, Ryan Chow, Emily He, Medha Majety, Yueqi Zhang, Sidi Chen
Multiplexed repression of immunosuppressive genes as combinatorial cancer immunotherapy. bioRxiv : the preprint server for biology (2023)
Matthew B Dong, Kaiyuan Tang, Xiaoyu Zhou, Johanna Shen, Krista Chen, Hyunu R Kim, Jerry Zhou, Hanbing Cao, Erica Vandenbulcke, Yueqi Zhang, Ryan D Chow, Andrew Du, Kazushi Suzuki, Shao-Yu Fang, Medha Majety, Xiaoyun Dai, Sidi Chen
Cas12a/Cpf1 knock-in mice enable efficient multiplexed immune cell engineering. bioRxiv : the preprint server for biology (2023)
Xiaoyu Zhou, Hanbing Cao, Shao-Yu Fang, Ryan D Chow, Kaiyuan Tang, Medha Majety, Meizhu Bai, Matthew B Dong, Paul A Renauer, Xingbo Shang, Kazushi Suzuki, Andre Levchenko, Sidi Chen
CTLA-4 tail fusion enhances CAR-T antitumor immunity. Nature immunology (2023)
Jonathan J Park, Kyoung A V Lee, Stanley Z Lam, Katherine S Moon, Zhenhao Fang, Sidi Chen
Machine learning identifies T cell receptor repertoire signatures associated with COVID-19 severity. Communications biology 6 (1) (2023)
Jonathan J Park, Kyoung A V Lee, Stanley Z Lam, Katherine S Moon, Zhenhao Fang, Sidi Chen
Machine learning identifies T cell receptor repertoire signatures associated with COVID-19 severity. Communications biology 6 (1) (2023)
Jonathan J Park, Kyoung A V Lee, Stanley Z Lam, Katherine S Moon, Zhenhao Fang, Sidi Chen
Machine learning identifies T cell receptor repertoire signatures associated with COVID-19 severity. Communications biology 6 (1) (2023)
Lei Peng, Paul A Renauer, Lupeng Ye, Luojia Yang, Jonathan J Park, Ryan D Chow, Yueqi Zhang, Qianqian Lin, Meizhu Bai, Angelica Sanchez, Yongzhan Zhang, Stanley Z Lam, Sidi Chen
Perturbomics of tumor-infiltrating NK cells. bioRxiv : the preprint server for biology (2023)
Xiaoyu Zhou, Paul A Renauer, Liqun Zhou, Shao-Yu Fang, Sidi Chen
Applications of CRISPR technology in cellular immunotherapy. Immunological reviews (2023)
Lupeng Ye, Stanley Z Lam, Luojia Yang, Kazushi Suzuki, Yongji Zou, Qianqian Lin, Yueqi Zhang, Paul Clark, Lei Peng, Sidi Chen
AAV-mediated delivery of a Sleeping Beauty transposon and an mRNA-encoded transposase for the engineering of therapeutic immune cells. Nature biomedical engineering (2023)
Ping Ren, Yingxia Hu, Lei Peng, Luojia Yang, Kazushi Suzuki, Zhenhao Fang, Meizhu Bai, Liqun Zhou, Yanzhi Feng, Yongji Zou, Yong Xiong, Sidi Chen
Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages. Signal transduction and targeted therapy 8 (1) (2023)
Paul Renauer, Jonathan J Park, Meizhu Bai, Arianny Acosta, Won-Ho Lee, Guang Han Lin, Yueqi Zhang, Xiaoyun Dai, Guangchuan Wang, Youssef Errami, Terence Wu, Paul Clark, Lupeng Ye, Quanjun Yang, Sidi Chen
Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function. bioRxiv : the preprint server for biology (2023)
Xiaoyu Zhou, Hanbing Cao, Shao-Yu Fang, Ryan D Chow, Kaiyuan Tang, Medha Majety, Meizhu Bai, Matthew B Dong, Paul A Renauer, Xingbo Shang, Kazushi Suzuki, Andre Levchenko, Sidi Chen
CTLA-4 tail fusion enhances CAR-T anti-tumor immunity. bioRxiv : the preprint server for biology (2023)
Zhenhao Fang, Valter Vinícius Silva Monteiro, Paul A Renauer, Xingbo Shang, Kazushi Suzuki, Xinyu Ling, Meizhu Bai, Yan Xiang, Andre Levchenko, Carmen J Booth, Carolina Lucas, Sidi Chen
Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens. Cell research (2023)
Syndi Barish, Kathryn Berg, Jeffrey Drozd, Isabella Berglund-Brown, Labeeqa Khizir, Lauren K Wasson, Christine E Seidman, Jonathan G Seidman, Sidi Chen, Martina Brueckner
The H2Bub1-deposition complex is required for human and mouse cardiogenesis. Development (Cambridge, England) 150 (23) (2023)
Jonathan J Park, Kyoung A V Lee, Stanley Z Lam, Katherine S Moon, Zhenhao Fang, Sidi Chen
Machine learning identifies T cell receptor repertoire signatures associated with COVID-19 severity. Communications biology 6 (1) (2023)
Zhenhao Fang, Valter Vinícius Silva Monteiro, Paul A Renauer, Xingbo Shang, Kazushi Suzuki, Xinyu Ling, Meizhu Bai, Yan Xiang, Andre Levchenko, Carmen J Booth, Carolina Lucas, Sidi Chen
Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens. Cell research (2023)
Xiaoyun Dai, Jonathan J Park, Ya-Ying Du, Zhenkun Na, Stanley Z Lam, Ryan D Chow, Paul A Renauer, Jianlei Gu, Shan Xin, Zhiyuan Chu, Cun Liao, Paul Clark, Hongyu Zhao, Sarah A Slavoff, Sidi Chen
Massively parallel knock-in engineering of human T cells. Nature biotechnology (2023)
Paul Renauer, Jonathan J Park, Meizhu Bai, Arianny Acosta, Won-Ho Lee, Guang Han Lin, Yueqi Zhang, Xiaoyun Dai, Guangchuan Wang, Youssef Errami, Terence Wu, Paul Clark, Lupeng Ye, Quan-Jun Yang, Sidi Chen
Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function. Cancer immunology research (2023)
Jennifer S Chen, Ryan D Chow, Eric Song, Tianyang Mao, Benjamin Israelow, Kathy Kamath, Joel Bozekowski, Winston A Haynes, Renata B Filler, Bridget L Menasché, Jin Wei, Mia Madel Alfajaro, Wenzhi Song, Lei Peng, Lauren Carter, Jason S Weinstein, Uthaman Gowthaman, Sidi Chen, Joseph E Craft, John C Shon, Akiko Iwasak, Craig B Wilen, Stephanie C Eisenbarth
High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells. Science immunology 7 (68) (2022)
Lei Peng, Yingxia Hu, Madeleine C Mankowski, Ping Ren, Rita E Chen, Jin Wei, Min Zhao, Tongqing Li, Therese Tripler, Lupeng Ye, Ryan D Chow, Zhenhao Fang, Chunxiang Wu, Matthew B Dong, Matthew Cook, Guilin Wang, Paul Clark, Bryce Nelson, Daryl E Klein, Richard Sutton, Michael S. Diamond, Craig B Wilen, Yong Xiong, Sidi Chen
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Nature communications 13 (1) (2022)
Zhenhao Fang, Lei Peng, Carolina Lucas, Qianqian Lin, Liqun Zhou, Luojia Yang, Yanzhi Feng, Ping Ren, Paul A Renauer, Valter S Monteiro, Anne M Hahn, Jonathan J Park, Xiaoyu Zhou, null null, Nathan D Grubaugh, Craig B Wilen, Sidi Chen
Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2. Cell discovery 8 (1) (2022)
Christoph Bock, Paul Datlinger, Florence Chardon, Matthew A Coelho, Matthew B Dong, Keith A Lawson, Tian Lu, Laetitia Maroc, Thomas M Norman, Bicna Song, Geoff Stanley, Sidi Chen, Mathew Garnett, Wei Li, Jason Moffat, Lei S Qi, Rebecca S Shapiro, Jay Shendure, Jonathan S Weissman, Xiaowei Zhuang
High-content CRISPR screening. Nature reviews. Methods primers 2 (1) (2022)
Ping Ren, Yingxia Hu, Lei Peng, Luojia Yang, Kazushi Suzuki, Zhenhao Fang, Meizhu Bai, Liqun Zhou, Yanzhi Feng, Yong Xiong, Sidi Chen
Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages. bioRxiv : the preprint server for biology (2022)
Zhenhao Fang, Valter Vinícius Silva Monteiro, Anne M Hahn, Nathan D Grubaugh, Carolina Lucas, Sidi Chen
Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5. Cell discovery 8 (1) (2022)
Zhenhao Fang, Lei Peng, Renata Filler, Kazushi Suzuki, Andrew McNamara, Qianqian Lin, Paul A Renauer, Luojia Yang, Bridget L Menasché, Angie Sanchez, Ping Ren, Qiancheng Xiong, Madison Strine, Paul Clark, Chenxiang Lin, Albert I Ko, Nathan D Grubaugh, Craig B Wilen, Sidi Chen
Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2. Nature communications 13 (1) (2022)
Jonathan J Park, Kyoung A V Lee, Stanley Z Lam, Kaiyuan Tang, Sidi Chen
Genome Engineering for Next-Generation Cellular Immunotherapies. Biochemistry (2022)
Ryan D Chow, Medha Majety, Sidi Chen
The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2. Nature communications 12 (1) (2021)
Ryan D Chow, Jennifer S Chen, Johanna Shen, Sidi Chen
A web tool for the design of prime-editing guide RNAs. Nature biomedical engineering 5 (2) (2020)
Lupeng Ye, Jonathan J Park, Matthew B Dong, Quanjun Yang, Ryan D Chow, Lei Peng, Ya-Ying Du, Jianjian Guo, Xiaoyun Dai, Guangchuan Wang, Youssef Errami, Sidi Chen
In vivo CRISPR screening in CD8 T cells with AAV-Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma. Nature biotechnology 37 (11) (2019)
Ryan D Chow, Guangchuan Wang, Lupeng Ye, Adan Codina, Hyunu Ray Kim, Li Shen, Matthew B Dong, Youssef Errami, Sidi Chen
In vivo profiling of metastatic double knockouts through CRISPR-Cpf1 screens. Nature methods 16 (5) (2019)
Guangchuan Wang, Ryan D Chow, Zhigang Bai, Lvyun Zhu, Youssef Errami, Xiaoyun Dai, Matthew B Dong, Lupeng Ye, Xiaoya Zhang, Paul A Renauer, Jonathan J Park, Li Shen, Hanghui Ye, Charles S Fuchs, Sidi Chen
Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity. Nature immunology 20 (11) (2019)
Xiaoyun Dai, Jonathan J Park, Yaying Du, Hyunu R Kim, Guangchuan Wang, Youssef Errami, Sidi Chen
One-step generation of modular CAR-T cells with AAV-Cpf1. Nature methods 16 (3) (2019)
Lupeng Ye, Chengkun Wang, Lingjuan Hong, Ninghe Sun, Danyang Chen, Sidi Chen, Feng Han
Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9. Cell discovery 4 (2018)
Guangchuan Wang, Ryan D Chow, Lupeng Ye, Christopher D Guzman, Xiaoyun Dai, Matthew B Dong, Feng Zhang, Phillip A Sharp, Randall J Platt, Sidi Chen
Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening. Science advances 4 (2) (2018)
Ryan D Chow, Sidi Chen
Sno-derived RNAs are prevalent molecular markers of cancer immunity. Oncogene 37 (50) (2018)
Ryan D Chow, Hyunu Ray Kim, Sidi Chen
Programmable sequential mutagenesis by inducible Cpf1 crRNA array inversion. Nature communications 9 (1) (2018)
Neena K Pyzocha, Sidi Chen
Diverse Class 2 CRISPR-Cas Effector Proteins for Genome Engineering Applications. ACS chemical biology 13 (2) (2017)
Ryan D Chow, Christopher D Guzman, Guangchuan Wang, Florian Schmidt, Mark W Youngblood, Lupeng Ye, Youssef Errami, Matthew B Dong, Michael A Martinez, Sensen Zhang, Paul Renauer, Kaya Bilguvar, Murat Gunel, Phillip A Sharp, Feng Zhang, Randall J Platt, Sidi Chen
AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma. Nature neuroscience 20 (10) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Sidi Chen